The article presents the main results of mathematical modelling of the destruction of glazing of enclosing building structures with translucent elements under fire conditions. The authors analyse literature data on calculating the fire resistance of enclosing building structures with glazing. The results show that improving methods for predicting the fire resistance of glazing is relevant. Mathematical models for the numerical study of the behaviour of glazing under the thermal influence of the standard fire temperature regime are substantiated. Mathematical models of the heat transfer process involve using a non-stationary differential equation of heat conduction with boundary conditions of the third kind, accounting for the convective and radiant heat exchange between the air in the room with the fire and the glazing. As a criterion for the destruction of glazing under the influence of fire, the authors establish the temperature resistance parameter, which is determined based on the mechanical characteristics of the glass. The article highlights the relevant data on the study of temperature indicators and the mechanism of glazing failure, using mathematical modelling with well-founded mathematical models. It obtains the results of the thermal calculation by applying the finite difference method for solving the non-stationary differential equation of thermal conductivity. The methodology for determining the time of glazing failure under the influence of the standard temperature regime of a fire using the calculation parameters obtained based on well-founded mathematical models is substantiated. An analysis of the adequacy of the obtained calculation data was carried out by comparing them with the results of experimental studies using statistical criteria. As a result of the analysis, the authors confirmed the validity of the calculation data. A complete factorial experiment was conducted based on well-founded mathematical models, which revealed the regularities of the dependence of the parameters of thermomechanical processes in single-layer glass on its structural characteristics. The revealed regularities have the form of linear regression dependences of the destruction time on the thickness of the glazing and the maximum length of the glass panel without bars. Using the regularities of the dependence of the parameters of thermomechanical processes in single-layer glazing on its structural characteristics, the authors constructed reference tables for evaluating the fire resistance of enclosing structures with glazing. The research obtained new scientific data on the study of the behaviour of glazing of enclosing building structures under the thermal influence of fire through mathematical modelling, which is the basis for improving the methods of calculating the fire resistance of enclosing structures with translucent elements. Keywords: enclosing building structures, glazing, fire resistance limit, calculation method, glass heat resistance.