This study examines the relationship between access to state cash transfers, food security and the sustainability of single-mother households in the rural Umkhanyakude Municipal area in Kwa-Zulu Natal province, South Africa. We explored the socio-economic impact of COVID-19 and cash transfers as a primary contributor to the economic well-being of single mothers from low-income rural communities. We also focus on financial transfers from non-state sources such as non-governmental organisations, kin and non-kin support systems. The sustainable livelihoods framework provides an analytical tool to understand how cash transfers from the state enable single mothers to navigate challenges during the pandemic. Drawing on interviews with 16 women from a rural community in Umkhanyakude, we analyse the distribution of family income to meet household expenses and the survival strategies such as livelihood activities initiated by single mothers to sustain households. The challenges and constraints that limit their livelihood outcomes, such as menial state support and financial constraints to sustain their economic activities are highlighted. Three key themes are discussed in this paper: the socio-economic impact of COVID-19 on food security, cash transfers as a strategy for reducing food insecurity, and access to sustainable livelihood activities to reduce food insecurities. This paper contributes to understanding single mothers' roles as actors and beneficiaries of the South African social protection system. It highlights opportunities for various state and non-state agents to advocate and support self-initiated economic activities in single-mother households.