Non-spatial Discrimination Task Research Articles

Trait affective differences influence behavioral flexibility in virtual spatial and non-spatial discrimination tasks

Affect and cognitive control processes are closely related, however, most studies have assessed state affect or affective disorders. The current study investigates the relationship between individual differences in trait affectivity and flexibility in spatial navigation and stimulus discrimination tasks. Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and the Positive and Negative Affectivity Scale (PANAS) were given to 82 participants followed by an intradimensional/extradimensional (ID/ED) set-shifting task in which navigation was reinforced based on visual stimuli colocalized with a goal or based on the spatial location of the goal. Higher BDI and NA predicted greater trials-to-criteria during ED shift, but not initial learning or ID shifting. Participants who failed to meet criteria during either ID or ED set-shifting (N = 16) had significantly higher scores for NA, BDI, and BAI compared to individuals who successfully met criterion (N = 56) with this relationship being primarily observed in males. The current findings indicate that negative affectivity is associated with poor performance in behavioral flexibility.

Chronic intermittent ethanol exposure leads to alterations in brain-derived neurotrophic factor within the frontal cortex and impaired behavioral flexibility in both adolescent and adult rats

Chronic intermittent exposure to ethanol (EtOH; CIE) that produces binge-like levels of intoxication has been associated with age-dependent deficits in cognitive functioning. Male Sprague–Dawley rats were exposed to CIE (5g/kg, 25% EtOH, 13 intragastric gavages) beginning at three ages: early adolescence (postnatal day [PD] 28), mid-adolescence (PD35) and adulthood (PD72). In experiment 1, rats were behaviorally tested following CIE. Spatial memory was not affected by CIE, but adult CIE rats were impaired at acquiring a non-spatial discrimination task and subsequent reversal tasks. Rats exposed to CIE during early or mid-adolescence were impaired on the first reversal, demonstrating transient impairment in behavioral flexibility. Blood EtOH concentrations negatively correlated with performance on reversal tasks. Experiment 2 examined changes in brain-derived neurotrophic factor (BDNF) levels within the frontal cortex (FC) and hippocampus (HPC) at four time points: during intoxication, 24 h after the final EtOH exposure (acute abstinence), 3 weeks following abstinence (recovery) and after behavioral testing. HPC BDNF levels were not affected by CIE at any time point. During intoxication, BDNF was suppressed in the FC, regardless of the age of exposure. However, during acute abstinence, reduced FC BDNF levels persisted in early adolescent CIE rats, whereas adult CIE rats displayed an increase in BDNF levels. Following recovery, neurotrophin levels in all CIE rats recovered. Our results indicate that intermittent binge-like EtOH exposure leads to acute disruptions in FC BDNF levels and long-lasting behavioral deficits. However, the type of cognitive impairment and its duration differ depending on the age of exposure.

Examination of configural association theory and conflict resolution model through hippocampal theta activity

The configural association theory and the conflict resolution model both propose a hippocampal function in the non-spatial Go/No-go stimulus discrimination task. The first theory suggests a critical role of the hippocampus in the formation of configural representations for compound stimuli in which multiple stimuli are simultaneously presented. The second theory relates to explaining how the hippocampus is important in no-go response for conflict stimulus with incompatible goals or response tendencies. While the theories presented have been perceived in different contexts towards joining the hippocampal functions and the associated non-spatial discrimination tasks, together they also indicate that hippocampus is associated with learning a negative patterning task. Current update in the context of electrophysiological approaches is indicative of reductions in hippocampal theta power due to the compound stimulus of negative patterning tasks. However, this is indicative of hippocampal theta powers not being relational to compound stimulus of feature negative task. These results showed that the decline in hippocampal theta activity was elicited by behavioral inhibition for conflict stimuli having overlapping elements. This finding strongly supports the conflict resolution model and suggests a hippocampal role in learning of behavioral inhibition for conflict stimulus during non-spatial stimulus discrimination tasks.

Investigating the time course of tactile reflexive attention using a non-spatial discrimination task

Peripheral cues are thought to facilitate responses to stimuli presented at the same location because they lead to exogenous attention shifts. Facilitation has been observed in numerous studies of visual and auditory attention, but there have been only four demonstrations of tactile facilitation, all in studies with potential confounds. Three studies used a spatial (finger versus thumb) discrimination task, where the cue could have provided a spatial framework that might have assisted the discrimination of subsequent targets presented on the same side as the cue. The final study circumvented this problem by using a non-spatial discrimination; however, the cues were informative and interspersed with visual cues which may have affected the attentional effects observed. In the current study, therefore, we used a non-spatial tactile frequency discrimination task following a non-informative tactile white noise cue. When the target was presented 150ms after the cue, we observed faster discrimination responses to targets presented on the same side compared to the opposite side as the cue; by 1000ms, responses were significantly faster to targets presented on the opposite side to the cue. Thus, we demonstrated that tactile attentional facilitation can be observed in a non-spatial discrimination task, under unimodal conditions and with entirely non-predictive cues. Furthermore, we provide the first demonstration of significant tactile facilitation and tactile inhibition of return within a single experiment.

Multisensory interactions follow the hands across the midline: Evidence from a non-spatial visual–tactile congruency task

Crossing the hands over, whether across the body midline or with respect to each other, leads to measurable changes in spatial compatibility, spatial attention, and frequently to a general decrement in discrimination performance for tactile stimuli. The majority of multisensory crossed hands effects, however, have been demonstrated with explicit or implicit spatial discrimination tasks, raising the question of whether non-spatial discrimination tasks also show spatial effects when the hands are crossed. We designed a novel, non-spatial tactile discrimination task to address this issue. Participants made speeded discriminations of single- versus double-pulse vibrotactile targets, while trying to ignore simultaneous visual distractor stimuli, in both hands uncrossed and hands crossed postures. Tactile discrimination performance was significantly affected by the visual distractors (demonstrating a significant crossmodal congruency effect) and was affected most by visual distractors in the same external location as the tactile target (i.e., spatial modulation), regardless of the posture (uncrossed or crossed) of the hands (i.e., spatial ‘remapping’ of visual–tactile interactions). Finally, crossing the hands led to a general performance decrement with visual distractors, but not in a control task with unimodal visual or tactile judgements. These results demonstrate, for the first time, significant spatial and postural modulations of crossmodal congruency effects in a non-spatial discrimination task.

Inhibition of Return and Repetition Priming Effects in Localization and Discrimination Tasks.

Inhibition of return (IOR) refers to slower responding to a stimulus that is presented at the same, rather than a different location as a preceding, spatially nonpredictive, stimulus. Repetition priming refers to speeded responding to a stimulus that duplicates the visual characteristics of a stimulus that precedes it. IOR and repetition priming effects interact in nonspatial discrimination tasks but not in localization tasks; three experiments examined whether this is due to processing differences or due to response differences between tasks. Two stimuli, S1 and S2, occurred on each trial. In Experiment 1, S1 and S2 were both peripheral arrows; in Experiment 2, S1 was a central arrow and S2 was a peripheral nondirectional rectangle; in Experiment 3, S1 was a peripheral nondirectional rectangle and S2 was a peripheral arrow. S1 never required a response; S2 required a localization or a discrimination response. Despite evidence that form information was likely extracted from the arrow stimuli, the localization task revealed no repetition priming: IOR occurred regardless of shared visual identity of the S1 and S2 arrows. The discrimination task revealed IOR only when the visual identity changed from S1 to S2; otherwise, facilitation occurred. These results suggest that IOR is masked by repetition priming only when the response depends on the explicit processing of form information; repetition priming does not occur when such information is extracted automatically but is task (and response) irrelevant.

Do hippocampal pyramidal cells signal non-spatial as well as spatial information?

It is generally agreed that the rat hippocampus is involved in spatial memory. Whether this is its sole or primary function, or merely one component of a broader function, is still debated. It has been suggested, for example, that the hippocampus stores information about flexible relations between stimuli, both spatial and non-spatial. In this paper, I reiterate the basic tenet of the cognitive map theory that the processing and storage of spatial information is the primary and perhaps the exclusive role of the hippocampus in the rat, and that data that appear to contradict this have been misinterpreted. These data are found in reports of non-spatial correlates of unit activity recorded in the awake animals and reports of deficits on non-spatial tasks following hippocampal lesions. In this paper, I examine both claims and suggest alternative explanations of the data. The first part of the paper contains a review of some of the properties of hippocampal place cells, which might be misinterpreted as non-spatial in "non-spatial" tasks. For example, if an animal is trained to carry out a sequence of stereotyped actions in different parts of an environment, there will be a strong correlation between the performance of each behaviour and the animal's location, and it is necessary to rule out the locational correlate as the cause of the firing pattern. The second part of the paper looks at the results of experiments on conditioning and non-spatial discrimination tasks and concludes that the results are less supportive of a more general relational theory of hippocampal function than has been suggested. Furthermore, there is often a discrepancy between the correlates of unit firing in non-spatial tasks and the absence of an effect of hippocampal damage on these same or similar tasks. It is concluded that, contrary to the claims of its detractors, the cognitive map theory is still the theory of hippocampal function that is most clearly specified, makes the most testable predictions, and for which there is the strongest experimental support.

Age-dependent intensity-difference thresholds in pigeons

Recent studies have reported age-related deficits in visual acuity and changes in retinal morphology in pigeons. The experiment reported here was designed to determine the effects of age on intensity difference thresholds in pigeons. Six subjects, age 2–17 yr, were trained to discriminate between two stimuli that differed in luminance. When this training was complete, the subjects were presented with a series of stimulus comparisons ranging from 0.08 to 0.43 log unit. Threshold was calculated by determining the luminance difference that corresponded to 75% correct. These data were pooled with 56 intensity-difference thresholds that had been collected from pigeons of various ages over a 20 yr period using the same procedure. A regression analysis that was performed on the pooled data set gave the result b = 0.0038, d.f. = 61 P < 0.05, r 2 = 0.066 which indicates that age accounted for approx. 7% of the variance in intensity-difference threshold. This finding, although statistically significant, indicates that as pigeons age their ability to perform this type of non-spatial discrimination task is not greatly impaired. This finding suggests that deficits associated with a spatial visual task in pigeons, such as visual acuity, are task specific and are not due to a global performance deficit.

Lack of task specificity and absence of posttraining effects of atropine on learning.

Three experiments are reported whose purpose was to examine the effect of the cholinergic antagonist atropine on the acquisition of different learning tasks known to be sensitive or insensitive to impairment by hippocampal lesions; on the retention of performance acquired in the absence of the drug; and on memory consolidation immediately after daily training trials. In Experiment 1, atropine sulfate (10 or 50 mg/kg, ip), injected 30 min prior to training, severely impaired learning of both spatial and nonspatial discrimination tasks when compared with saline or atropine methylnitrate (50 mg/kg). In Experiment 2, atropine sulfate (50 mg/kg) also impaired spatial discrimination accuracy in rats previously trained to asymptote under drug-free conditions. These deficits were not due to either peripheral drug effects or gross sensorimotor impairments. In Experiment 3, daily posttraining injections of atropine sulfate (50 mg/kg) failed to influence either learning or subsequent retention of place navigation in rats that were trained to find a single hidden escape platform. The data confirm that profound learning deficits occur when training is conducted under atropine but offer no support to the hypothesis that cholinergic neurons play an important role in memory consolidation or other posttraining processes. Furthermore, these results point to dissimilarities between the behavioral impairments induced by cholinergic blockade and hippocampal lesions under appropriate test regimes.

Object discrimination by rats: The role of frontal and hippocampal systems in retention and reversal

The present experiment was designed to determine whether the reversal deficit in nonspatial discrimination tasks following frontal or hippocampal system damage was a result of the spatial components of those tasks, or a general reversal deficit. Rats were trained to choose between two objects based on the stimulus characteristics of the objects themselves; neither the absolute location of the objects in the test arena nor the position of the objects with respect to the rat accurately predicted the correct choice. Rats with either frontal cortex or fimbria-fornix lesions performed worse than controls in both postoperative retention and reversal of the object discrimination. The performance of rats with frontal cortex damage was impaired during the first two postoperative reversals; but not during subsequent reversals. The performance of rats with fornix lesions was impaired only on the first postoperative reversal. These data demonstrate that the nonspatial reversal impairment following damage to either the frontal cortical or hippocampal systems is the result of a general reversal deficit, and is not due to the spatial components of nonspatial tasks.