We present a new formulation and novel scaling relations for natural convection boundary layers on horizontal surfaces with weak transpiration velocities Vi, for intermediate Schmidt numbers (or Prandtl numbers Pr) 1<Sc<20. Using characteristic scales derived from integral boundary layer equations, we define a new similarity variable η=(y/x)(Rex/Grx)1/4/Sc1/5 that has Vi within it, where Rex and Grx are the local Reynolds and Grashof numbers based on Vi and the concentration difference ΔC, respectively. Using η, and the dimensionless transpiration velocity ξ=(Rex/Grx1/5)5/4 as a non-similarity variable, we obtain novel, reduced, non-similar boundary layer equations. Numerical solution of these reduced boundary layer equations using a local non-similarity approach gives us the profiles of horizontal velocity and concentration, boundary layer thicknesses, wall shear stress, and mass flux as functions of Sc, for various ξ in the range ξ<1. Using normalizing functions, we then obtain scaling relations for these parameters; we observe extended similarity where the non-similarity parameter ξ itself appears in the obtained similarity scaling relations.