Recognizing the economy’s growing reliance on global energy landscape transformation on wind power deployment, as well as the general reality that renewable facilities require lower operational but higher up-front inputs than fossil-based power systems, this paper focuses on the life-cycle burdens of wind power systems and their substitution benefits compared with coal-fired power systems. The estimation considers the consumption of nonrenewable sources of energy, emissions of greenhouse gases, and other environmental resource factors that have received significantly less research attention, such as industrial land use, water use, PM2.5, SO2, NOX, and Hg emissions. The scope of this study differs from earlier ones in that it includes a comprehensive description of all the equipment, materials, and services used, as opposed to earlier studies that either omit crucial supporting infrastructure or just focus on the plant’s physical structure as its primary materials. Results based on a typical plant in China show that the state-of-the-art onshore wind power systems can provide significant reductions in nonrenewable energy use (9.2 MJ/kWh) and GHG emissions (782.8 GtCO2/kWh). To produce an equivalent amount of electricity, wind power systems require more than three times industrial land use and almost one-third of industrial water use of that for traditional coal-fired power systems. The avoided SO2, Hg, PM2.5, and NOX emissions per unit of electricity generation account for 60.6%-89.3% of the total air pollution emissions induced by supercritical coal-fired power systems. By integrating 3797 operating plant-specific data and fixed-point wind energy information, this study scales up results of the single plant to a country level. The macro picture implies different opportunities born by wind power systems in easing multiple resource and environmental pressures, highlighting the significance of designing hierarchical strategies to improve penetration levels of wind power. By 2050, cumulative climate benefits obtained from onshore wind power technology are predicted to reach 74.2 Gt CO2, achieving around 17.2%-45.5% of the national carbon-neutral goal.