Introduction. The identification of specific responses generated by religious traditions to present-day global challenges actualizes the rethinking of astrology as a traditional understanding of the world structure and influence of natural forces on man in Tibetan Buddhism. Goals. The study attempts an evaluation of astrology as a form of sacred knowledge in the Tibetan Buddhist tradition from the perspective of understanding its principles of ecology. Materials and methods. To facilitate this, the work employs a systematic approach of cultural anthropology according to which sacred astrological knowledge is viewed as an integral element to the specified religious tradition. The paper focuses on The White Beryl: A Treatise on [Tibetan] Astrology by Desi Sangye Gyatso, as well as works by modern Tibetan astrologers. Results. Tibetan astrology arose from integrated Indian, Chinese and ancient Tibetan ideas about the influence of natural elements on human life, and is a required tool in Tibetan medicine. Those ideas are based on some esoteric premises of the Buddhist Kalachakra Tantra which articulates the relationship between external natural cycles and internal human energy ones, as well as suggests methods of restoring the latter’s balance. In the Tibetan Buddhist tradition, sacred astrological knowledge is widely popular both in cult practices and non-religious activities. Astrologers draw prediction and natal charts, calculate favorable periods for rituals, healing practices, harvesting, weddings, funerals, etc. The three Lamrim-derived motives — to improve this lifetime, gain liberation from samsaric suffering, achieve enlightenment for the sake of universal well-being — may accordingly direct the intentions of Buddhists toward the use of sacred astrological knowledge to solve problematic situations, identify oneself, understand others, restore the balance of external and internal cycles. With due account of that followers of Tibetan Buddhism are basically oriented to altruism and rationalism, the paper presumes astrology can be considered a form of sacred knowledge instrumental in understanding (and implementing) principles of ecology. Restoration of balance in man-nature interaction through the rational use of astrological knowledge for the common good predetermines the sacredness of ecological knowledge in the Tibetan Buddhist tradition.