The failure mode of thermal barrier coatings (TBC) systems in aeroengine turbine blades is very complex because of the harsh service conditions. A peridynamic (PD) model is established to simulate the damage evolution of TBC with uniform thermally grown oxide (TGO) growth under cycle load. The peridynamic differential operator is introduced to solve the zero-energy mode, and thermo-elastic deformation is considered. Moreover, the influence of high-temperature holding time, initial oxide layer thickness, and interface morphology on the evolution of the stress distribution and interface damage is discussed. The newly proposed PD model can effectively capture the interface cracking of TBC systems and it is conducive to the study of the failure of TBC systems.