The aim of this work is to present a natural convective and squeezing flow model of two-dimensional couple stress nanofluid which is flowing on the sensory surface with variable fluid viscosity. The fluid flowing on a microcantilever sensory surface and squeezing is happening at free stream. The sensor is also useful to detect the movement of fluid and the variations in thermal and solutal rates. The Cattaneo–Christov model is adopted along with nanoparticle and chemical reaction to explore the transmission of heat and mass rates. The analysis of heat transmission in non-Newtonian couple stress fluid flowing on squeezed sensory surface by using the Cattaneo–Christov heat conduction model has various industrial and scientific applications including the polymer processing, wastewater treatment, chemical reactors, biomedical flows, cooling and heating processes in industries, heat exchangers, microfluidics, oil and gas industries. All the assumptions are applied in the basic governing laws laws and then we get the model of the partial differential equations. The governing model of equations is transmuted into ordinary differential equations form via the transformations and then the numerical results of these ODE’s are examined with a well-defined numerical technique “Shooting Method”. For higher inputs of couple stress, squeezing index and permeability velocity, the fluid’s internal velocity decreases. Because of the Prandtl number and thermal relaxation coefficient, the heat transfer mechanism slows down. Mass transfer increases for greater inputs of the thermal diffusivity coefficient and decreases due to concentration relaxation. Further, the numerical dependency of emerging parameters on the skin friction is illustrated in tabular form. The parametric effects on the model (velocity, temperature and concentration) are introduced using numerical values shown in the table.