Non-neutralizing Monoclonal Antibodies Research Articles

Monoclonal antibodies to polioviruses. Production of specific monoclonal antibodies to the Sabin vaccine strains.

Murine lymphocyte hybridomas which produce neutralizing or non-neutralizing monoclonal antibodies to different type 1, 2 or 3 poliovirus strains were isolated. The majority of these monoclonal antibodies reacted with antigenic determinants present on different poliovirus strains of the same type. However, hybridomas producing monoclonal antibodies specific for each of the three Sabin vaccine strains were also generated.