INTRODUCTION Chronic non-healing ulceration is a common ailment that can be found all over the world Chronic wounds are those that have not undergone a timely and ordered reparative process to restore anatomic and functional integrity. Poor wound healing may be caused by a number of factors, including ischemia, infection, advanced age, malnutrition, diabetes, venous insufficiency, and renal disease. It has been demonstrated that L-lysine monohydrochloride, also known as L-lysine, is effective in promoting therapeutic angiogenesis in wound healing. MATERIALS AND METHODS STUDY POPULATION AND SAMPLE SIZE: All patients admitted with clinical diagnosis of “NON HEALING NON MALIGNANT ULCERS” under General Surgery care in SRM MEDICAL COLLEGE HOSPITAL AND RESEARCH CENTRE would be taken as Subjects for this study with a sample size of 84 with 42 in each group. All patients presenting with complaints of non-healing, non- malignant ulcers were randomly assigned to receive either Treatment A (topical L-lysine with mechanical debridement) or Treatment B (the control) (betadine with debridement) INCLUSION CRITERIA: Patients of any age or gender who are suffering from noncancerous ulcers that are chronic and do not heal, regardless of their socioeconomic. EXCLUSION CRITERIA: 1. Patients who are suffering from osteomyelitis, ischemic ulcers, and malignant ulcers 2. Patients who are currently receiving chemotherapy, Corticosteroids, or immunosuppressantS RESULTS The difference in mean of Wound dimension, Rate of granulation tissue formation between study group was statistically significant. (p value <0.05). When compared to conventional care the rate of closure was three times faster with lysine gel treatment. DISCUSSION In our study, the graft failure was very minimal in both the groups The difference in mean of Wound dimension, Rate of granulation tissue formation between study groups was statistically significant. Majority of the patients did not develop complications in both the groups. However, Pain was the common complication in lysine group and infection was the common complication in conventional treatment group To achieve the best augmentation of the ulcer closure, treatment must start as soon as the initial wound is debrided CONCLUSION The use of topical l-lysine with debridement in chronic non-healing ulcers is effective treatment strategy in bringing better clinical outcomes, recommending its use from the initial phase of ulcer treatment. We recommend that lysine can be used over the conventional treatment which is beneficial in cosmetic wound appearance size and increased rate of granulation. This is also found to be useful in bypassing the complications of ulcers such as pain and infection. Therefore, we advise topic al lysine as an effective treatment in chronic non-healing ulcers