Abstract. This paper develops an actionable interdisciplinary model that quantifies and assesses uncertainties in water resource allocation under climate change. To achieve this objective, we develop an innovative socio-ecological grand ensemble that combines climate, hydrological, and microeconomic ensemble experiments with a widely used decision support system for water resource planning and management. Each system is populated with multiple models (multi-model), which we use to evaluate the impacts of multiple climate scenarios and policies (multi-scenario, multi-forcing) across systems so as to identify plausible futures where water management policies meet or miss their objectives and to explore potential tipping points. The application of the methods is exemplified by a study conducted in the Douro River basin (DRB), an agricultural basin located in central Spain. Our results show how marginal climate changes can trigger non-linear water allocation changes in the decision support systems (DSSs) and/or non-linear adaptive responses of irrigators to water shortages. For example, while some irrigators barely experience economic losses (average profit and employment fall by < 0.5 %) under mild water allocation reductions of 5 % or lower, profit and employment fall by up to 12 % (∼ 24 ×) when water allocation is reduced by 10 % or less (∼ 2×). This substantiates the relevance of informing the potential natural and socio-economic impacts of adaptation strategies and related uncertainties for identifying robust decisions.