This paper studies the straight-line path-following problem on the lateral plane for fixed-wing unmanned aerial vehicles (FWUAVs) which are susceptible to uncertainties. Firstly, based on the natural frame’s location on the prescribed reference paths, the command yaw angle (which is the basis for yaw angle control system design) is solved analytically by combining it with the errors of path following, attack angle, sideslip angle, attitude angles, and geometric parameters of the prescribed reference paths. Secondly, by considering complicated dynamic characteristics, a linear extended state observer is designed to estimate uncertainties such as nonlinearities, couplings, and unmodeled dynamics whose estimated values are incorporated into the continuous-time predictive controllers for feedback compensation. Finally, numerical simulations are conducted to demonstrate the advantages of the proposed method, including reduced tracking errors and enhanced robustness in the closed-loop system, as compared to the conventional nonlinear dynamic inversion and sliding mode control approaches.