Objective To investigate the influencing factors of mental fatigue in patients with cerebral apoplexy. Methods Using a hospital-based case-control method, total 358 patients with cerebral apoplexy from Tangshan Gong Ren Hospital were recruited from October 2016 to May 2017.A total of 175 subjects were fatigue group(MFS≥10.5), the remaining 183 individuals were non-fatigue group (MFS<10.5). All the patients with stroke were investigated with MFS, MMSE, SAS, SDS and homemade general scale. Results The total MFS score(17.68±5.06)vs(5.70±2.15) and dimensions score of fatigue perception(6.86±2.17)vs(2.12±1.15), cognition fatigue(3.58±1.54)vs(1.12±0.93), increased sensitivity(5.90±2.05)vs(1.95±1.20), changes of sleep(1.35±0.82)vs(0.51±0.62) in the fatigue group were higher than those of the non-fatigue group, total score.Multivariate Logistic regression showed that income below expenditure (β=0.608, OR=1.836, 95%CI=1.037-3.252), cognitive dysfunction (β=1.886, OR=6.594, 95%CI=3.276-13.275), mild anxiety(β=0.770, OR=2.160, 95%CI=1.069-4.364), moderate anxiety(β=1.157, OR=3.181, 95%CI=1.230-8.228), severe anxiety (β=1.295, OR=3.651, 95%CI=1.096-12.160), moderate and severe depression (β=1.318, OR=3.738, 95%CI=1.318-10.602) were the influencing factors of mental fatigue in stroke patients. Conclusion Income below expenditure, cognitive dysfunction, mild anxiety, moderate anxiety, severe anxiety, moderate and severe depression are the potential risk factors of mental fatigue in stroke patients. Key words: Cerebral apoplexy; Mental fatigue; Influencing factors