Non-exercise Group Research Articles

Exercise Alters FBF1-Regulated Novel-miRNA-1135 Associated with Hydrolethalus Syndrome 1 in Rheumatoid Arthritis: A Preliminary Study.

Hydrolethalus Syndrome 1 (HYDS1) is a rare disorder that occurs commonly in Finnish infants but originates from the mother. This autosomal recessive syn-drome is associated with the FBF1, which is usually expressed in the centriole. The FBF1 is an inheritable arthritis disease phenotype that includes rheumatoid arthritis. Several studies have investigated males with FBF1 mutation carriers also related to arthritis diseases, including those under rheumatoid arthritis conditions, which revealed the possibility of conferring the gene mutation to the next generation of offspring. Nonetheless, there are some complications of FBF1 mutation with target miRNAs that can be affected by exercise. The objective of this study was to evaluate the different exercises that can be utilized to suppress the FBF1 mutation targeted by Novel-rno-miRNAs-1135 as a biomarker and assess the effectiveness of exercise in mitigating the FBF1 mutation. Four exercise interventional groups were divided into exercise and non-exercise groups. One hundred microliter pristane-induced arthritis (PIA) was injected at the dorsal re-gion of the tails of rodents and introduced to the two PIA interventional groups. On day forty-five, all animals were euthanized, and total RNA was extracted from the blood samples of ro-dents, while polymerase chain reaction (PCR) was amplified by using 5-7 primers. Computeri-zation was used for miRNA regulation and analysis of target gene candidates. The novel-rno-miRNA-1135 was downregulated to FBF1 in exercise groups. The exercise was found to have no significant impact in terms of change in novel-rno-miRNA-1135 regulation of FBF1 expression. Exercise has no impact on novel-rno-miRNA-1135 targeted for FBF1 in autoso-mal recessive disease.

Effectiveness of exercise intervention in improving physical and mental status of patients with alcohol use disorders: A systematic review and meta-analysis.

This meta-analysis and systematic review examined the effects of an exercise intervention on alcohol dependence and physical and mental states in patients with alcohol use disorder (AUD). PubMed, Web of Science, Cochrane Library, EBSCO, and Embase. Randomized controlled trials published in English from the inception of the database until June 30, 2024, were included. All forms of exercise intervention (aerobic, resistance, yoga, mixed exercise, etc.) were included in the study, using an exercise intervention for patients with AUD and a non-exercise control group. Studies that excluded acute exercise or did not describe a specific intervention program; duplicate publications; review articles, conference articles, etc.; and studies that did not report appropriate outcome metrics. This protocol was prepared according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses protocol standard. The risk of bias was assessed via the Cochrane risk-of-bias tool as described by the Cochrane Handbook for Systematic Reviews and Interventions. Alcohol dependence (number of drinks per day, number of drinks per week, AUDIT), physical and mental status [maximal oxygen uptake (VO2 max), resting heart rate, anxiety state, depression state, stress level]. Seventeen RCTs with a total of 1,905 patients with alcohol use disorders were included as subjects, and the results revealed that the exercise intervention had a significant effect on alcohol dependence, the number of drinks per day and the AUDIT score, the exercise intervention also had a significant effect on physical and mental status, VO2max, the resting heart rate, the anxiety state, the depression state, and the stress level. High heterogeneity in the number of drinks per day, anxiety, depression and stress outcomes (I2 > 50%), but Egger's test showed no publication bias for all outcome indicators (p > 0.05). Exercise intervention can effectively reduce alcohol dependence and significantly improve the physical and mental states of AUD patients, and exercise intervention as an adjunct to the treatment of AUD patients is significantly effective.

Association of Exercise with Better Olfactory Performance and Higher Functional Connectivity Between the Olfactory Cortex and the Prefrontal Cortex: A Resting-State Functional Near-Infrared Spectroscopy Study.

Background: Olfactory deterioration is suggested to be a predictor of some neurodegenerative diseases. Recent studies indicate that physical exercise has a positive relationship with olfactory performance, and a subregion in the prefrontal cortex (PFC) may play an important role in olfactory processing. The PFC is not only related to olfactory function but it also engages in complex functions such as cognition and emotional processing. Methodology: Our study compared the functional connectivity between the olfactory cortex and the PFC in healthy individuals who exercised regularly and healthy persons who did not. Those who exercised more than three times/week for at least 30 min each time were considered the exercise group, and those who did not meet this exercise criteria were considered the nonexercise group. We also assessed their odor threshold. Participants were aged 55 years or older, and the two groups were balanced for age, sex, body mass index, and educational level. Results: We found that compared with individuals who did not exercise, exercisers had a significantly lower threshold for detecting odors. In addition, the olfactory cortex had stronger connectivity with the PFC in exercisers than in nonexercisers. More specifically, when the PFC was grouped into three subregions, namely, the ventrolateral prefrontal cortex (VLPFC), dorsolateral prefrontal cortex (DLPFC), and frontopolar cortex (FPA), Pearson correlation analysis revealed stronger connectivity between the VLPFC and the orbitofrontal cortex (OFC), between the OFC and the FPA, and between the left and right OFC hemispheres in the exercisers. In addition, Granger causality indicated higher directional connectivity from the DLPFC to the OFC in exercisers than in nonexercisers. Conclusion: Our findings indicated that the exercise group not only had better olfactory performance but also had stronger functional connectivity between the olfactory cortex and the PFC than nonexercise group.

Regular exercise suppresses steatosis-associated liver cancer development by degrading E2F1 and c-Myc via circadian gene upregulation.

Regular exercise is believed to suppress cancer progression. However, the precise molecular mechanisms by which exercise prevents cancer development remain unclear. In this study, using a steatosis-associated liver cancer mouse model, we found that regular exercise at a speed of 18 m/min for 20 min daily suppressed liver cancer development. To explore the underlying mechanisms, we examined the gene expression profiles in the livers of the exercise and non-exercise groups. The expressions of circadian genes, such as Per1 and Cry2, were upregulated in the exercise group. As circadian rhythm disruption is known to cause various diseases, including cancer, improving circadian rhythm through exercise could contribute to cancer prevention. We further found that the expression of a series of E2F1 and c-Myc target genes that directly affect the proliferation of cancer cells was downregulated in the exercise group. However, the expression of E2F1 and c-Myc was transcriptionally unchanged but degraded at the post-translational level by exercise. Cry2, which is regulated by the Skp1-Cul1-FBXL3 (SCFFBXL3) ubiquitin ligase complex by binding to FBXL3, can form a complex with E2F1 and c-Myc, which we think is the mechanism to degrade them. Our study revealed a previously unknown mechanism by which exercise prevents cancer development.

Exercise and tumor proteome: insights from a neuroblastoma model.

The impact of exercise on pediatric tumor biology is essentially unknown. We explored the effects of regular exercise on tumor proteome profile (as assessed with liquid chromatography with tandem mass spectrometry) in a mouse model of one of the most aggressive childhood malignancies, high-risk neuroblastoma (HR-NB). Tumor samples of 14 male mice (aged 6-8 wk) that were randomly allocated into an exercise (5-wk combined aerobic and resistance training) or nonexercise control group (6 and 8 mice/group, respectively) were analyzed. The Search Tool for the Retrieval of Interacting Genes/Proteins database was used to generate a protein-protein interaction (PPI) network and enrichment analyses. The Systems Biology Triangle (SBT) algorithm was applied for analyses at the functional category level. Tumors of exercised mice showed a higher and lower abundance of 101 and 150 proteins, respectively, than controls [false discovery rate (FDR) < 0.05]. These proteins were enriched in metabolic pathways, amino acid metabolism, regulation of hormone levels, and peroxisome proliferator-activated receptor signaling (FDR < 0.05). The SBT algorithm indicated that 184 and 126 categories showed a lower and higher abundance, respectively, in the tumors of exercised mice (FDR < 0.01). Categories with lower abundance were involved in energy production, whereas those with higher abundance were related to transcription/translation, apoptosis, and tumor suppression. Regular exercise altered the abundance of hundreds of intratumoral proteins and molecular pathways, particularly those involved in energy metabolism, apoptosis, and tumor suppression. These findings provide preliminary evidence of the molecular mechanisms underlying the potential effects of exercise in HR-NB.NEW & NOTEWORTHY We used liquid chromatography with tandem mass spectrometry to explore the impact of a 5-wk exercise intervention on the tumor proteome profile in a mouse model of one of the most aggressive childhood malignancies, high-risk neuroblastoma. Exercise altered the abundance of hundreds of proteins and pathways, particularly those involved in energy metabolism and tumor suppression. These molecular changes could mediate, at least partly, the potential antitumorigenic effects of exercise.

Metabolic syndrome and its clinical and laboratory indicators in relation to outdoor physical activities: walking, Nordic walking, and cycling

Aim of the study is to investigate the relationship between outdoor walking and sports activities and the clinical and laboratory indicators of metabolic syndrome. Data for the research were collected through the use of questionnaires, anthropometric measurements, and laboratory tests. Using the National Diabetes Federation guidelines, the data were analyzed to determine whether the respondent had metabolic syndrome. Data analysis was conducted on a sample of 380 patients with metabolic syndrome. The study was conducted through quantitative analysis of cross-sectional data. The descriptive part involved conducting variable frequency and cross-tabulation analysis. Odds ratios were calculated using univariate and multivariate logistic regression models. The odds of increased glycosylated hemoglobin (HbA1c) were 1.8-fold lower in the physically active group than in the non-exercise group (the adjusted odds ratio model for sex, age, and smoking (aOR) = 0.56, 95% confidence interval (CI) 0.34–0.95). The odds of reduced high-density cholesterol (HDL-cholesterol) were three times lower in the physically active group than in the non-exercise group (aOR = 0.29, 95% CI 0.18–0.48). The odds of obesity were 3.7 times lower among patients who exercised than among those who did not (aOR = 0.27, 95% CI 0.10–0.68). Outdoor physical activities have a statistically significant effect on HbA1c levels, HDL-cholesterol, and obesity in patients with metabolic syndrome. Metabolic syndrome patients can be advised to engage in physical activities in order to improve their health.

Effects of 12-weeks resistance training and vitamin E supplementation on aminotransferases, CTRP-2, and CTRP-9 levels in males with nonalcoholic fatty liver disease: a double-blind, randomized trial

BackgroundNonalcoholic fatty liver disease (NAFLD) involves excessive liver fat accumulation and is closely linked to oxidative stress, which contributes to liver inflammation and damage. This study aimed to evaluate how interventions such as resistance training (RT) and vitamin E supplementation (VES) can modulate markers of NAFLD and key proteins regulating glucose and lipid metabolism, such as C1Q/TNF-related proteins (CTRPs).MethodsForty participants with NAFLD (mean age: 32.4 ± 8.2 years) were randomly assigned to one of four groups for 12 weeks: placebo (PLB), VES, PLB + RT, and VES + RT. VES was administered at 800 IU/day in a double-blind manner. The RT regimen included eight exercises at 60–80% of one-repetition maximum (1RM), with three sets of 8–12 repetitions, performed three times per week. Pre- and post-intervention assessments included body composition, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lipid profile, glycemic control, CTRP-2, CTRP-9, and 1RM evaluations.ResultsFollowing the interventions, there was a significant improvement in body composition, lipid profile, glycemic control, and 1RM indices in the exercise groups compared to non-exercise groups (p < 0.05). AST and ALT levels decreased in all groups (p < 0.05) compared to the PLB group. There was also a significant difference between the VES + RT group and both the VES and PLB + RT groups (p < 0.05). CTRP-2 and CTRP-9 levels decreased in the exercise groups compared to non-exercise groups (p < 0.05), and their changes showed a marked correlation with body composition, lipid profile, and glycemic control indices (p < 0.05).ConclusionsThis study highlights the benefits of RT on various health parameters among NAFLD patients. While adding VES to RT resulted in greater decreases in aminotransferases, it did not provide further improvements in other variables. Additionally, enhancements in body composition, lipid profile, and glycemic control indices were possibly associated with decreased levels of CTRPs.Trial registrationRegistered retrospectively in the Iranian Registry of Clinical Trials (IRCT20220601055056N1) on December 21, 2023. Access at https://irct.behdasht.gov.ir/trial/69231.

Recreational beach tennis training reduces ambulatory blood pressure in adults with hypertension: a randomized clinical trial.

To determine the effect of 12 weeks of beach tennis training on 24-h ambulatory blood pressure in adults with essential hypertension. This was a randomized, single-blinded, two-arm, parallel superiority trial. Forty-two participants aged 35-65 years with a previous diagnosis of hypertension were randomized into 12 weeks of beach tennis training group (two sessions per week lasting 45-60 min) or a nonexercising control group. Ambulatory 24 h (primary outcome) and office blood pressure, heart rate at rest, cardiorespiratory fitness, and muscle strength were assessed at baseline and after the intervention period. Generalized estimating equation analyses were employed to examine the main effects of the interventions. In the beach tennis group, night-time systolic (-9 mmHg, P = 0.023), diastolic (-4 mmHg, P = 0.026), and mean arterial pressure (-7 mmHg, P = 0.023) decreased after 12 weeks of training. The office SBP/DBP (-6 mmHg, P = 0.016/-6 mmHg, P = 0.001) also decreased in the beach tennis group. Heart rate at rest decreased in the beach tennis group (-4 bpm, P = 0.012) but increased in the control group (6 bpm, P = 0.005). The lower and upper limb muscle strength increased in the beach tennis group after training. However, no such changes were observed in the control group. A 12-week recreational beach tennis training significantly reduced office and ambulatory BP among untrained adults with essential hypertension. Additionally, participation in this sport has led to improvements in physical fitness and overall cardiovascular risk profiles.This clinical trial was registered at Clinicaltrials.gov (NCT03909321).

Standard Deviation of Individual Response for VO2max Following Exercise Interventions: A Systematic Review and Meta-analysis.

Although numerous attempts to demonstrate inter-individual differences in trainability across various outcomes have been unsuccessful, the investigation of maximal oxygen consumption (VO2max) trainability warrants further study. Our objective was to conduct the first systematic review and meta-analysis to evaluate inter-individual differences in VO2max trainability across aerobic exercise training protocols utilizing non-exercising comparator groups. We conducted a literature search across three databases: EMBASE, PubMed and SCOPUS. The search strategy incorporated two main concepts: aerobic exercise training and VO2max. Studies were included if they used human participants, employed standardized and supervised exercise training, reported absolute or relative VO2max, included a non-exercise comparator group, reported VO2max change scores for non-exercise and exercise groups and provided the standard deviation (SD) of change for all groups. We calculated the SD of individual response (SDIR) to estimate the presence of inter-individual differences in trainability across all studies. The literature search generated 32,968 studies, 24 of which were included in the final analysis. Our findings indicated that (1) the majority of variation in observed change scores following an intervention is due to measurement error, (2) calculating SDIR within a single study would not yield sufficient accuracy of SDIR due to generally small sample sizes and (3) meta-analysis of across studies does not provide strong evidence for a positive value. Overall, our meta-analysis demonstrated that there is not strong evidence supporting the existence of VO2max trainability across single interventions. As such, it appears unlikely that clinically relevant predictors of VO2max response will be discovered. Registration can be found online ( https://doi.org/10.17605/OSF.IO/X9VU3 ).

Effects of Exercise on the Inter-Session Accuracy of sEMG-Based Hand Gesture Recognition.

Surface electromyography (sEMG) is commonly used as an interface in human-machine interaction systems due to their high signal-to-noise ratio and easy acquisition. It can intuitively reflect motion intentions of users, thus is widely applied in gesture recognition systems. However, wearable sEMG-based gesture recognition systems are susceptible to changes in environmental noise, electrode placement, and physiological characteristics. This could result in significant performance degradation of the model in inter-session scenarios, bringing a poor experience to users. Currently, for noise from environmental changes and electrode shifting from wearing variety, numerous studies have proposed various data-augmentation methods and highly generalized networks to improve inter-session gesture recognition accuracy. However, few studies have considered the impact of individual physiological states. In this study, we assumed that user exercise could cause changes in muscle conditions, leading to variations in sEMG features and subsequently affecting the recognition accuracy of model. To verify our hypothesis, we collected sEMG data from 12 participants performing the same gesture tasks before and after exercise, and then used Linear Discriminant Analysis (LDA) for gesture classification. For the non-exercise group, the inter-session accuracy declined only by 2.86%, whereas that of the exercise group decreased by 13.53%. This finding proves that exercise is indeed a critical factor contributing to the decline in inter-session model performance.

Comparison of Workplace Posture on Heart Rate Variability between Exercising and Non-Exercising Traffic Police

Background: This study aimed to investigate heart rate variability among traffic police officers and compare these parameters between exercising and non-exercising groups. Heart rate variability is an important marker of cardiac autonomic function. Understanding the impact of exercise on heart rate variability among traffic police officers can provide valuable insights into strategies for improving their cardiovascular well-being. Materials and Methods: This comparative correctional study was conducted among forty-two healthy traffic police officers. The participants were divided into exercising and non-exercising groups based on their physical activity levels. Heart rate variability was measured using standard technique. Data was analysed using Microsoft Excel and SPSS version 16. The heart rate variability values were non parametric. So, data were expressed as median interquartile range and comparison between two groups was done with Mann-Whitney U test. p&lt;0.05 was considered significant. Results: The results revealed that a higher proportion of traffic police officers were in the exercising group. Heart rate variability analysis showed significantly higher median values of RMSSD (58.42 ms vs. 41.30 ms), NN50 (80.00 vs. 24.00), pNN50% (36.56% vs. 11.820%) and HF power (1079.40 ms² vs. 368.000 ms²) in the exercising group. Additionally, the exercising group exhibited a lower LF/HF ratio (0.61 vs. 1.60). Although not statistically significant, heart rate was less in exercising group (73.61±6.93bpmvs. 72.93± 7.79bpm). Conclusion: The study suggests that even with prolonged workplace posture, exercise among traffic police can have higher heart rate variability and parasympathetic dominance, a positive indicator for cardiovascular health.

Gut microbiome related to metabolic diseases after moderate-to-vigorous intensity exercise

Background objectivesThe purpose of this study is to investigate changes in gut microbiota related to metabolic diseases after moderate and high-intensity exercise. A total of 24 participants were divided into three groups: Non-Exercise Group (NEG, n = 8, 28.6 ± 5.3 years, 176.0 ± 7.8 cm, 81.3 ± 14.6 kg), Moderate Intensity Exercise Group (MIEG, n = 8, 26.5 ± 3.3 years, 176.9 ± 5.0 cm, 75.4 ± 9.5 kg), and Vigorous Intensity Exercise Group (VIEG, n = 8, 30.6 ± 5.9 years, 174.2 ± 3.5 cm, 77.8 ± 12.2 kg). MethodsThe participants were selected by assessing physical activity, gut health status, presence of diseases, recent disease diagnoses, and dietary disorders. Those who reported any presence disease or recent disease diagnosis were excluded from the current study. Stool samples were collected after a 10-h fast for gut microbiome analysis. MIEG participants trained at 40–59 % heart rate reserve (HRR) for at least 150 min per week, while VIEG participants trained at ≥ 60 % HRR for at least 90 min per week. After 4 weeks, all participants provided stool samples for gut microbiome analysis.Data analysis was conducted using the Wilcoxon test, with statistical significance set at ≤ 0.05. ResultsThe results indicated an increase in Prevotella in MIEG, while Veillonella, Dorea_formicigenerans, and Dorea_longicatena exhibited a decrease (p < 0.05). In VIEG, there was an increase in Bacteroides, Butyricimonas, Odoribacter, and Alistipes (p < 0.05). ConclusionThese modified microbial groups were associated with factors related to metabolic diseases, including inflammatory bowel disease, obesity, colorectal cancer, diabetes, hypertension, metabolic liver diseases, and ischemic heart diseases. Additional research is essential to delve into the relationship between exercise and these alterations in the microbiome.

Effects of different exercise interventions on cardiopulmonary function in male tobacco-dependent college students

ABSTRACT This study investigated the effects of different exercise interventions on cardiopulmonary function in male tobacco-dependent college students. Forty-five male tobacco-dependent college students were recruited as the tobacco-dependent (TB) group, and 45 non-tobacco-dependent college students were recruited as the control group. The TB group was randomly assigned to three subgroups: non-exercise (NE), high-intensity interval training (HIIT), and moderate-intensity continuous training (MICT). The HIIT and MICT groups underwent a 10-week exercise training, while the NE group received no intervention. Cardiac parameters, including maximal oxygen uptake (VO2max), heart rate max (HRmax), and heart rate reserve (HRR), and pulmonary indicators, including forced vital capacity (FVC), forced expiratory volume in one second (FEV1), vital capacity (VC), maximum ventilation volume (MVV), and peak expiratory flow (PEF) were investigated. The results showed that the TB group had significantly lower cardiopulmonary function than the control group. The degree of tobacco dependence was negatively correlated with VO2max, FVC, FEV1, FEV1/FVC, and MVV. Furthermore, both HIIT and MICT training improved cardiopulmonary function. HIIT training exhibited superior efficacy compared to MICT in improving HRmax, HRR, FVC, FEV1, FEV1/FVC, and PEF. In conclusion, tobacco dependence adversely affects cardiopulmonary function in male college students. Both HIIT and MICT effectively improved cardiopulmonary function, with HIIT showing superior efficacy.

스포츠 리듬운동을 이용한 기능성 인지보행훈련이 발달 장애 아동의 보행패턴과 인지능력에 미치는 영향

Objectives The purpose of this study was to help neurological disorders seen of the trends of children with developmental disabilities and improve their quality of life by investigating the functional cognitive gait in using the sports rhythm training on gait pattern and cognitive function in trends of children with developmental disabilities. Methods In order to achieve the purpose of this study, 39 trends of children with developmental disabilities at N located in K city, were selected at random and allocated 13 trends of children with developmental disabilities each for the Non Exercise group (NEG), Deficient Exercise group(DEG), Over Exercise group (OEG) and measured kinematic gait pattern and cognitive function before and after the experiment. The data obtained from this study were analyzed using the SPSS 26.0 statistical program the two-way repeated measures ANOVA and Bonferroni post-hoc test was performed. Results The conclusions obtained through this study were as follows. First, as a result of analyzing the change of gait pattern to functional cognitive gait in using the sports rhythm training program, there were significantly improved in velocity, cadence, step length, stride length in OEG compared with NEG and DEG after 24 weeks. Second, as a result of analyzing the change of cognitive function according to functional cognitive gait in using the sports rhythm training, there were significantly improved in body part, number display, movement, operation in OEG compared with NEG and DEG after 24 weeks. Conclusions As conclusions, this study confirmed that the functional cognitive gait in using the sports rhythm training program could improve the gait pattern and cognitive function in the trends of children with developmental disabilities.

Vitamin D levels and bone mineral density of middle-aged premenopausal female football and volleyball players in Japan: a cross-sectional study

BackgroundThe number of football teams in senior categories has increased. As outdoor sports entail players being exposed to sunlight, playing football may contribute to maintaining vitamin D stores and body mineral density while preventing osteoporosis. This study aimed to determine the bone mineral density and vitamin D levels in middle-aged premenopausal female football players.MethodsParticipants were premenopausal females in their 40s. We evaluated bone mineral density of the second to the fourth lumbar vertebrae and femoral neck, serum 25-hydroxy vitamin D (25-OHD) levels, which is an indicator of vitamin D stores, and body composition. In addition, we administered a questionnaire survey on exercise habits and lifestyle. Ninety-two participants were categorised into three groups: the football group (n = 27), volleyball group (n = 40), and non-exercise group (n = 25).ResultsBone mineral density was higher in the football and volleyball groups than in the non-exercise group (P < 0.01). The volleyball group had a significantly higher bone mineral density of the lumbar spine and femoral neck than the non-exercise group (P < 0.01). The football group had a significantly higher bone mineral density of the femoral neck than the non-exercise group (P < 0.01). Although the football group had played fewer years than the volleyball group (P < 0.01), serum 25-OHD levels were the highest in the football group and were significantly higher than those in the volleyball and non-exercise groups (P < 0.01).ConclusionsMiddle-aged premenopausal football players had higher body vitamin D levels and bone mineral densities than non-active females. These results suggest that playing football may contribute to the prevention of osteoporosis.Trial registrationUMIN Clinical Trials Registry UMIN000054235. 2024/04/23. Retrospectively registered.

The Role of Exercise: Physical Fitness Changes Caused by Hypocaloric Diet and Exercise in Men Who Are Overweight

Objective There is evidence showing the effect of hypocaloric diet and increasing physical activity on weight loss. However, the effect of these factors on body composition and functional capacity remains unclear. Also, it is not clear which type of exercise (aerobic, resistance) has effective health benefits for men who are overweight. The aim of this study is to investigate whether a 12-week combined exercise or walking intervention combined with a hypocaloric diet provides improvements in body composition and functional capacity of men who are overweight compared to those who do not exercise. Methods 60 healthy adult men who are overweight were randomized and divided into 3 groups: 1: Hypocaloric Diet + Combined Exercise; 2: Hypocaloric Diet + Walking; 3: Hypocaloric Diet. The exercise groups were trained for 12 wk, 3 days a week and 60 min (60 min\\3 days\\12 wk). Body composition was determined with Bioelectrical Impedance Analysis (BIA) device, strength parameters with MicroFet 2, functional capacity with 6-min walking test. Results Improvement was observed in all groups at the end of 12 wk. The greatest improvement was in the combined exercise group. While the values of the combined exercise group increased in Skeletal Muscle Mass, there was a decline in the walking and non-exercising group. Basal Metabolism was maintained in combined exercise, but a decrease occurred in the non-exercising group. Muscle force increased in combined exercise; however, it was maintained in the legs in the walking group. Cardiorespiratory fitness was at best level in walking group, but there was no difference between combined exercise. Conclusions As a result, a hypocaloric diet without an exercise prescription is sufficient to lose weight in the short term (12 wk) at a certain level. But exercise is more important for body composition, weight management and functional capacity. Long-term and in-depth studies should be conducted to interpret the results better.

Relationship of atherogenic index of plasma with exercise, obesity and biochemical parameters

Aims: It is well-known that regular moderate-intensity aerobic exercise has positive effects on various health indicators, including obesity and cardiovascular diseases (CVD) and atherogenic index of plasma (AIP) is defined as a highly sensitive predictor of plasma atherogenicity and cardiovascular risk. Furthermore, it is known that physical activity has a reducing effect on AIP with its ability to decrease visceral fat and its positive impact on blood lipids. Additionally, large-scale AIP screenings are recommended for the early detection of obese individuals and effective intervention. This study aims to determine the relationship between regular exercise and cardiometabolic parameters and obesity based on current data. Methods: The study involved a total of 126 participants aged 18-65 and it was conducted in the form of file screening, where the medical history reports of all patients were examined, and systemic physical findings were assessed. Fasting blood samples were used to determine the lipid profile. Anthropometric measurements and biochemical parameters of the participants were determined and AIP was calculated using the formula AIP=log10 (TG/HDL-C). Participants were categorized into groups based on their exercise status, BMI, and AIP risks, and the data of the study groups were evaluated statistically. Results: Participants were divided into two groups based on exercise status, and in the exercise group, body mass index (BMI), body weight, waist circumference, AIP, and triglyceride levels were found to be lower, while high-density lipoprotein (HDL) levels were higher compared to the non-exercise group. In all participants, moderate-intensity exercise was negatively correlated with AIP, body weight, BMI, waist circumference, triglyceride, and low-density lipoprotein (LDL) levels; and positively correlated with HDL levels. Conclusion: The relationships uncovered in this study among exercise, cardiometabolic parameters, and obesity status are expected to contribute to future research, especially in studies focusing on the impact of exercise on CVD and obesity.

The efficacy of exercise training for improving body composition in patients with breast cancer: A systematic review and meta-analysis of randomized controlled trials

Objectives To evaluate the efficacy of exercise in improving body composition in patients with breast cancer; the effects of exercise on weight and BMI were evaluated as secondary outcomes. Data sources Cochrane Library, EMBASE, PubMed and Web of Science were searched for randomized controlled trials published in English from database inception to 29 November 2023. Methods The effects of exercise on body composition in patients with breast cancer were explored. After separately extracting the data, two reviewers assessed the overall quality of the evidence as well as the methodological quality of the included studies. Results Fourteen studies with 1241 participants were included, of which 12 studies were eligible for meta-analysis. Exercise significantly reduced body fat (mean difference [MD], −0.33; 95% CI, −0.37 to −0.29; P < 0.00001) and increased lean mass (MD, 0.42; 95% CI, 0.34 to 0.49; P < 0.00001) in patients with breast cancer. Further, exercise intervention was associated with increased BMI of patients with breast cancer (MD, 0.03; 95% CI, 0.01 to 0.06; P = 0.01), while no significant difference in weight was detected between the exercise and the non-exercise groups. Subgroup analysis results showed that only resistance exercise reduced fat mass (MD, −0.22; 95% CI, −0.27 to −0.16; P < 0.00001). Conclusions Exercise effectively improves body composition in patients with breast cancer. Clinicians should encourage patients to engage in exercise and develop optimized exercise prescriptions.

#1192 Impact of intradialytic exercise on all-cause mortality in frail patients undergoing hemodialysis: a three-year multicenter cohort study

Abstract Background and Aims Frailty prevalence is notably high among older hemodialysis patients, correlating with poorer prognoses. Prior smaller-scale studies have underscored the benefits of various exercise interventions in individuals with Chronic Kidney Disease and those receiving dialysis treatments. Addressing frailty in older hemodialysis patients by exercise therapy is crucial for healthcare professionals aiming to enhance patient outcomes. Despite this, a standardized exercise therapy protocol for this demographic has not been broadly implemented in clinical practice. Our study sought to evaluate the impact of intradialytic resistance exercise programs on the prognosis of frail individuals undergoing hemodialysis. Method This retrospective, multicenter, non-randomized clinical trial encompassed 2006 participants (mean age 70.1±11.7 years) from 17 outpatient clinics within the Kaikoukai Medical Group. Enrollment spanned from April to December 2018, with patients stratified according to baseline frailty levels, determined by the Japanese Frailty Criteria for the Diagnosis of Frailty in the Elderly. In this study, patients meeting the criteria for frailty or pre-frailty, as defined by the Japanese Criteria for Health and Social Services (J-CHS), were collectively classified as 'frail’. Participants were invited to join a voluntary exercise program during dialysis, which included stretching and four types of resistance exercises using elastic tubes. The cohort was divided into four groups based on their frailty status and participation in the exercise program. Patient outcomes were monitored until either death or the study's conclusion in December 2021. Kaplan-Meier and log-rank analyses were utilized to assess prognostic differences among the groups, with significance levels adjusted using the Bonferroni correction. Ethical approval was granted by the Nagoya Kyoritsu Hospital's ethical committee. Results The study comprised 112 non-frail exercising, 398 frail exercising, 205 non-frail non-exercising, and 1287 frail non-exercising patients. Over the study period (median 25 months), mortality was recorded in 338 (16.9%) patients, including 8 (7.1%) non-frail exercising, 50 (12.6%) frail exercising, 16 (7.8%) non-frail non-exercising, and 264 (20.5%) frail non-exercising participants. Prognostic analysis revealed that the frail non-exercising group had a significantly poorer prognosis than both the non-frail exercising and non-frail non-exercising groups, as well as the frail exercising group (p&amp;lt;0.05). Conclusion This investigation is pioneering in establishing a link between intradialytic resistance exercise interventions and prognosis in frail patients. The findings indicate that, although frail patients inherently face a more challenging prognosis, participation in intradialytic exercise can yield substantial improvements. Therefore, clinicians are encouraged to advocate for exercise therapy as a means to enhance prognosis in frail patients undergoing hemodialysis.

Current Status and Barriers of Exercise in Individuals with Spinal Cord Injuries in Korea: A Survey.

This study investigated exercise participation, health status, and barriers to exercise in 109 individuals with spinal cord injury (SCI) using a self-report questionnaire. The responses of the exercise and non-exercise groups were statistically analyzed using t-tests or Fisher's exact test. Significant differences were observed in the cause of injury and the American Spinal Injury Association Impairment Scale between the groups. The non-exercise group had a higher incidence of traumatic and complete injuries. Demographic factors such as gender, age, income level, and marital status did not significantly influence exercise participation. The exercise group reported lower pain scores, less inconvenience from complications, and higher activity and participation scores. However, less than half of the individuals with SCI met the recommended exercise intensity, and community facility usage was low. Barriers to exercise participation included severe disabilities, lack of time, insufficient exercise information, and lack of facility accessibility. To enhance exercise among individuals with SCI, it is essential to develop and extend exercise programs tailored to individual physical factors and a comprehensive understanding of barriers. Prioritizing community-based data management, alongside developing social systems and health policies, is crucial to overcome barriers to exercise participation for individuals with SCI.