Nondysphoric Individuals Research Articles

The Effects of Affective Expectations on Willingness to Expend Cognitive Effort in Dysphoric and Non-Dysphoric Individuals

The Effects of Affective Expectations on Willingness to Expend Cognitive Effort in Dysphoric and Non-Dysphoric Individuals

Theory of mind in dysphoric and non­-dysphoric adults: An ERP study of true-­ and false-­belief reasoning

ABSTRACT Theory of mind (ToM) – the understanding that others’ behaviors are connected with internal mental states – is an important part of everyday social cognition. There is increasing behavioral evidence that ToM reasoning can be affected by mood. To gain insight into the ways sad mood may affect the underlying mechanisms of ToM reasoning, we recorded event-related brain potentials (ERPs) as dysphoric (N = 16) and non-dysphoric (N = 24) participants reasoned about a protagonist’s true or false beliefs about an object’s location. Results showed significant group effects on early components of the ERP – individuals in the dysphoric group showed greater amplitudes for the anterior N1 and N2/P2 components relative to those in the non-dysphoric group. Later in the ERP, non-dysphoric individuals showed evidence of neurocognitive dissociations between true and false belief. Dysphoric individuals, however, did not show evidence for these later dissociations. This evidence suggests that dysphoria may be associated with effortful reasoning about other’s mental states, even when that effort is not necessary (i.e., when reasoning about true beliefs). We discuss the implications of these findings for understanding how mood affects ToM reasoning and for how especially deliberative ToM processing in dysphoria may lead to social difficulties.

Contextual goal-dependent attention flexibility or rule-based learning? An investigation of a new attention flexibility paradigm

Background & objectivesDeficits in the ability to process contextual changes have been proposed to be crucial for emotion dysregulation. A recent study found evidence for the role of contextual changes in exacerbating attention switching towards valence-specific goals using a novel attention flexibility paradigm. Despite the task indicating good reliability, the role of rule-based learning has not been clarified in this paradigm. Therefore, we examined whether the novel attention flexibility task is an index of context-based attention switching or does it reflect impact of rule-based learning on attention. MethodWe employed a neutral version of the attention flexibility task. A sample of dysphoric and non-dysphoric participants were introduced to neutral contexts which required them to shift between neutral categories of pictures depending upon the cueing shape. ResultsThere was an existence of a switch cost for shifting between different rules owing to the features of the rules. Further, non-dysphorics were faster at set-shifting between different rules as compared to dysphoric individuals. However, unlike in the affective version of the attention flexibility task, we found no significant differences between dysphoric and non-dysphoric individuals in attention switching patterns owing to switching between different rules. LimitationsAlthough the current study aimed to replicate the design of the previous study, a depressed patient sample must be employed to further clarify the different aspects of the attention flexibility paradigm. ConclusionOur findings were able to clarify the non-existent role of rule-based learning in the attention flexibility paradigm.

Manipulating avoidance motivation to modulate attention bias for negative information in dysphoria: An eye-tracking study

Background and objectivesInstrumentality plays a key role in guiding attention, such that stimuli associated with achieving current goals of an individual prioritize attention. However, in depression, attention is prioritized to negative stimuli even when they are not relevant to current goals. In the current study, we tested whether attention is prioritized to stimuli that are associated with avoidance of imminent negative consequences over negative affective stimuli. MethodsUsing an eye-tracking based attention engagement-disengagement task, we presented pairs of negative faces, and neutral faces associated with avoidance of punishment (white noise and lost money) to a group of dysphoric and non-dysphoric individuals. ResultsFirst, we replicated previous evidence on difficulties to disengage attention from negative stimuli, when prompted to direct eye-gaze towards simple neutral stimuli, in dysphoric compared to non-dysphoric individuals. Further, we found that both dysphoric and non-dysphoric individuals were faster to disengage their attention from negative pictures when prompted to direct eye-gaze towards punishment avoidance-related neutral stimuli, versus towards simple neutral stimuli. LimitationsAlthough we seek to clarify the attention processes underlying depression, the current study employed a sub-clinical sample in order to serve as proof-of-concept study. ConclusionsOur results indicate that stimuli instrumental to the goal of avoiding negative consequences receive preference in the attention system over simple negative affective stimuli. Our findings suggest that manipulating the instrumentality of avoidance motivation can effectively modulate the attention bias for negative information in dysphoria, and also possibly in depression, akin to the modulation patterns in non-dysphoric individuals.

The effect of dysphoria on the relationship between autobiographical memories and the self

ABSTRACT Two experiments investigated the bi-directional relationship between episodic autobiographical memories (ABMs) and semantic self-images in dysphoric and nondysphoric individuals. Participants in Experiment 1 generated positive and negative “I am” statements, which were then used to cue specific ABMs. Nondysphoric participants generated similar numbers of ABMs to positive and negative cues, suggesting both positive and negative self-images are supported by clusters of specific ABMs. The same was observed in dysphoric participants, but phenomenological ratings showed that they rated positive ABMs as less vivid, and negative ABMs more central to their life story, than the nondysphoric group. Participants in Experiment 2 retrieved positive or negative ABMs and then generated “I am” self-statements. Retrieving positive ABMs increased the positivity of self-statements in the nondysphoric but not the dysphoric group. These findings suggest the interaction between ABMs and self-images functions to promote a positive view of the self, but this is disrupted in dysphoria.

Contextual Changes Influence Attention Flexibility Towards New Goals

The ability to flexibly process affective information underlies resilient adaptation to changing situations. However, the impact of social contextual changes on affective flexibility has not been examined yet, although this may be crucial to understand how attention operates when changing situations require allocation of different emotional goals. In a novel eye-tracking task, participants had to deploy the goals to attend to positive or negative facial expressions based on contextual cues. We found that dysphorics, compared to non-dysphorics, were faster in switching to negative goals, but slower in switching to positive goals, when the context remained constant. However, when the context changed, dysphorics showed an even faster switch to negative goals, while non-dysphorics became more adept at switching towards positive goals. These results suggest that contextual changes exacerbate the negativity and positivity biases exhibited by dysphoric and non-dysphoric individuals, respectively. The study provides evidence for the key role played by contextual changes in guiding attention allocation and thereby emotion regulation processes. These findings provide preliminary evidence for the role of contextual inflexibility in dysphoria. Results need to be replicated in a clinical sample to further clarify the role of inflexibility over the course of depression.

Diminished Anticipatory and Consummatory Pleasure in Dysphoria: Evidence From an Experience Sampling Study.

Anhedonia, the experience of diminished pleasure, is a core feature of major depressive disorder and is often present long before the diagnosis of depression. Most previous studies have investigated anhedonia with self-report measures of trait anhedonia or with behavioral paradigms using laboratory stimuli, and the real-time characteristics of hedonic processing in subclinical depression remain under-investigated. We used the experience sampling method to evaluate momentary experience of hedonic feelings in the context of daily life. Dysphoric (n = 49) and non-dysphoric (n = 51) college students completed assessments of their current positive affect (PA), as well as state anticipatory and consummatory pleasure, 3 or 4 times a day every day for 2 weeks. The results showed that dysphoric individuals reported less state anticipatory and consummatory pleasure compared with non-dysphoric individuals. Moreover, significant time-lagged associations between anticipatory pleasure and follow-up consummatory pleasure were found in the whole sample, after adjustment for current PA. The current findings thus hold considerable promise in advancing our understanding of anhedonia as well as the important role of state anticipatory pleasure in relation to depression.

The phenomenological characteristics of autobiographical future thinking in dysphoric and non-dysphoric individuals

Depressive symptoms are associated with deficits in objectively-rated detail and specificity in autobiographical future thinking for personally-relevant events. However, how depressive symptoms might affect the subjective, phenomenal characteristics of future thinking in general is not well understood. This study examined future thinking as self-reported by dysphoric (n = 79; probable major depression on the Patient Health Questionnaire and very or extremely difficult impact on functioning) and non-dysphoric adults (n = 79; as defined by normal range on the PHQ) that were matched on age and gender. The dysphoric group reported more frequent thoughts about their future in general, particularly for the long-term future, which persisted after controlling for emotional-valence. Dysphoric individuals perceived their future thinking as being more frequently vivid and detailed, more often involving mental imagery and inner speech, more often involuntary, more often unrealistic or implausible, more negatively-valenced, and more often from a third-person perspective. The findings indicate differences in the phenomenology of thinking about one's future among dysphoric individuals, some of which contrast with prior research findings. The implications for understanding autobiographical future thinking in depression are discussed, and studies are indicated to further clarify the content, function, and context of future thinking in altered affective states.

The vividness of imagining emotional feelings in positive situations is attenuated in non-clinical dysphoria and predicts the experience of positive emotional feelings.

The vividness of imagining emotional feelings in positive situations (EFP) in non-clinically dysphoric and non-dysphoric individuals and its relation to dysphoric and positive feelings was examined. Participants were university students in Study 1 (N=106, 84 women; 18-45 years), in Study 2 (N=43, 39 women; 20-47 years), in Study 3 (N=109, 92 women; 18-50 years) who filled out a set of questionnaires assessing depressive symptoms, cognition measures, and then completed an affective imagery task, using a cross-sectional design. Non-clinically dysphoric participants imagined less vividly EFP than non-dysphoric participants. The vividness of imagining EFP accounted for group differences in positive feelings beyond positive and negative cognition and negative mood. In addition to deficits in the general imagery of positive events, the attenuation of vividness of EFP in non-clinical dysphoric individuals warrants attention as a separate pathway by which non-clinically dysphoric individuals develop deficiencies of conscious positive feelings.

Feeling happy when feeling down: The effectiveness of positive mental imagery in dysphoria

Background and objectivesMental imagery can evoke strong emotional responses, but imagery perspective can influence the response, with observer perspective reducing emotionality. This is important provided that positive imagery can be an effective mood repair strategy in healthy individuals. However, (sub-clinical) depressed individuals tend to spontaneously adopt an observer perspective. We investigated whether positive imagery would result in a similar emotional response in dysphoric and non-dysphoric individuals when instructed and trained to use field perspective imagery. Additionally, we compared the emotional response in dysphoric individuals who received instructions to dysphoric individuals who received no instructions on processing mode during positive memory recall. MethodsDysphoric and non-dysphoric individuals completed a mood induction procedure imagining positive or neutral memories. They received instructions and practice in the use of field perspective imagery. An additional control group of dysphoric individuals recalled positive memories without receiving instructions on processing mode. ResultsDysphoric and non-dysphoric individuals who received instructions on field perspective imagery reported similar use of field and observer perspective imagery, and a similar positive emotional response. Dysphoric individuals who did not receive specific instructions, as compared to those who did, reported greater use of observer perspective and lower levels of positive affect afterwards. LimitationsA dysphoric sample limits generalization to clinically depressed individuals, although these individuals are at risk for developing depression. However, mental imagery used in relapse prevention is likely targeting sub-clinical populations. ConclusionsProviding practice in field perspective imagery could potentially improve the effectiveness of positive memory recall as a mood repair strategy in (sub-clinically) depressed individuals, and may therefore have important therapeutic benefits.

Modulation of Physiological Responses as Indices of Attentional Bias in Dysphoria

The experimental results on attentional bias in depression have been contradictory. Research on physiological correlates that validate attentional bias have been scarce. The aim of the present study was to evaluate physiological responses associated with attentional bias in dysphoria. Heart rate and the galvanic skin response were recorded in 30 dysphoric individuals and 30 nondysphoric individuals while they performed an emotional Stroop task. Dysphoric individuals exhibited attentional bias and heart rate deceleration in response to unpleasant words. Nondysphoric individuals exhibited attentional bias toward pleasant words, accompanied by a higher skin conductance response. These results suggest that heart rate deceleration in response to unpleasant words correlated with attentional bias in dysphoric individuals.

Appetitive and aversive motivation in dysphoria: A time-domain and time-frequency study of response inhibition

The study of emotional response inhibition could provide novel insight into dysphoria-related deficits in appetitive and aversive motivational systems. Therefore, dysphoric (N=21) and nondysphoric (N=21) participants completed an emotional Go/Nogo paradigm, including the presentation of pleasant, neutral and unpleasant pictures. Behavioral measures [reaction times (RTs), accuracy to Go and Nogo stimuli] and neural correlates (Go/Nogo-N2 and Go/Nogo-P3) of response inhibition were compared between the two groups. Time-frequency analysis was also used as a novel approach to disentangle the multiple processes underlying time-domain ERP data. A reduced Go/Nogo effect for P3 and oscillatory delta activity was found in response to pleasant and neutral, but not unpleasant, stimuli in dysphoric relative to nondysphoric individuals. These findings showed that dysphoric individuals need a reduced and/or less effortful response inhibition to pleasant stimuli, suggesting that dysphoria is characterized by under-engagement of appetitive rather than over-engagement of aversive motivational system.

Accounting for Depressive Realism in Contingency Judgments: Attentional Processing Differences

The purpose of this series of experiments was to determine the necessary conditions for eliciting depressive realism in a contingency judgment task and to compare the explanatory power of divergent theoretical accounts for this phenomenon. Across a series of experiments, groups of dysphoric and non-dysphoric undergraduate students (n1 = 46; n2 = 60) completed contingency judgment tasks, after which they estimated their control over the task. Depressive realism was elicited when the method of responding to the task was manipulated. Only when participants faced a choice between a “pressing” response option and a “not pressing” response option did dysphoric participants make more accurate judgments of control than non-dysphoric participants, F(1, 59) = 11.24, p < .05. The evidence for a boundary condition identified in the current paper suggests important attentional differences between dysphoric and non-dysphoric individuals that must be explained by any theoretical account of depressive realism.

Neural Correlates of Mental State Decoding in Dysphoria: An Event‐Related Potential Study

Depression is often associated with profound social and interpersonal functioning impairments. Negative interpersonal experiences may lead depressed individuals to withdraw from social interaction, which may in turn exacerbate the depression state (Rippere, 1980). As a result, it is of theoretical and clinical importance to understand the mechanisms underlying these social deficits. Researchers have applied the theory‐of‐mind framework to better understand the impaired social functioning in depressed individuals. Theory of mind refers to the everyday ability to attribute mental states (i.e., beliefs, desires, emotions) to others to both understand and predict their behaviour (Wellman, 1990). Research has found that individuindividuals with dysphoria (i.e. elevated scores on a measure of depression symptoms, but not necessarily a diagnosis of clinical depression) demonstrate enhanced mental state judgments (Harkness, Sabbagh, Jacobson, Chowdrey, &amp; Chen, 2005). This study will determine neural mechanisms that may underlie this phenomenon by examining whether differences in brain activity exist between dysphoric and nondysphoric groups during mental states decoding. I will record electrophysiological data while participants are judging the mental states from pictures of eyes. Based on previous research (Sabbagh, Moulson, &amp; Harkness, 2004), I anticipate that mental state decoding will be associated with the right inferior frontal and right anterior temporal regions of the brain. Furthermore, I hypothesize that dysphoric individuals will have greater activations in these brain regions and make significantly more accurate judgments than nondysphoric individuals when making mental state judgments.

Emotional modulation of alpha asymmetry in dysphoria: results from an emotional imagery task

Studies on electroencephalographic (EEG) alpha band asymmetry at rest have reported that, compared to healthy controls, dysphoric and clinically depressed individuals often display relatively less left- than right-sided cortical activity at anterior scalp sites, and the opposite pattern at posterior scalp sites. It has also been shown that depression-related differences in alpha lateralization at anterior and posterior sites are more likely to emerge during emotional tasks and during visuospatial tasks, respectively, rather than during resting conditions. However, although it is the well-established that posterior cortical activity plays a key role also in emotional processing in healthy individuals, the influence of dysphoria on posterior alpha asymmetry sites during an emotional task has yet to be examined. To this end, dysphoric (n=23) and nondysphoric (n=24) individuals performed an emotional imagery task including pleasant, neutral, and unpleasant narratives. The group with, but not without, dysphoria showed reduced left relative to right cortical activity at anterior sites, irrespective of emotional condition. By contrast, at posterior sites, individuals with dysphoria showed reduced right relative to left parietal activity during unpleasant, but not pleasant and neutral, imagery condition compared to nondysphoric individuals. Results at anterior scalp sites provide further evidence for the presence of a stable pattern of reduced approach motivation in dysphoric individuals. The association between dysphoria and right relative to left parietal hypoactivation in response to unpleasant imagery suggests that dysphoric individuals are more likely to use state-dependent dysfunctional strategies to regulate negative emotions compared to nondysphoric individuals.

Dysphoria is associated with reduced cardiac vagal withdrawal during the imagery of pleasant scripts: Evidence for the positive attenuation hypothesis

The present study investigated emotional responding in dysphoric individuals. Dysphoric (N=25) and nondysphoric (N=29) individuals completed an emotional imagery task, including pleasant, neutral and unpleasant emotional-eliciting scripts. Self-reported valence and arousal, and measures of cardiac autonomic activity were collected during the task. Compared to nondysphoric controls, dysphoric individuals showed a reduced heart rate increase to pleasant scripts. Less vagal withdrawal in response to pleasant scripts was also found in dysphoric, but not in nondysphoric, individuals. Conversely, no differences between groups in autonomic responding to unpleasant scripts and in subjective measures were noted. Overall, our data showed that dysphoria is characterized by blunted cardiac autonomic reactivity in response to positive rather than negative emotional stimuli. The present findings also suggest that the lack of vagal suppression may reflect a reduced sensitivity to positive environmental stimuli, which, in turn, has been implicated in the development of major depression in dysphoric individuals.

An Eye Tracking Study of the Time Course of Attention to Positive and Negative Images in Dysphoric and Non-dysphoric Individuals

Researchers studying selective attention in depressed and dysphoric individuals have documented biases in the allocation of attention to emotional information (Gotlib &amp; Joormann, 2010; Yiend, 2010). Recent studies using eye gaze tracking have shown that when images are presented for extended durations (5–30 seconds), depressed and dysphoric individuals attend to depression-related images more than never depressed individuals and attend to positive images less (Armstrong &amp; Olatunji, 2012). The present study used eye gaze tracking and time course analyses to look for differences between dysphoric and non-dysphoric individuals in their attention to emotional images over time. Participants viewed sets of four images (a depression-related image, a threat-related image, a positive image, and a neutral image) while their eye fixations were tracked and recorded throughout a 10-second presentation. The time course analyses, which divided each 10-second presentation into 2-second intervals, revealed that group differences in attention to positive and depression-related images emerged only after 4 seconds had elapsed and then persisted for the remainder of the 10-second presentation. Dysphoric and non-dysphoric participants were further distinguished by the temporal profiles of their attention to positive and depression-related images. The implications for researchers' understanding of attention to emotion in dysphoria and depression are discussed.

I don’t care about others’ approval: Dysphoric individuals show reduced effort mobilization for obtaining a social reward

Past research on reduced reward responsiveness in depression and dysphoria has mainly focused on monetary rewards. However, social rewards are important motivators and might be especially impaired in depression. The present study tested the hypothesis that nondysphoric individuals would mobilize more effort during a memory task without a clear performance standard when anticipating social approval for good performance. In contrast, dysphoric individuals were expected to be less sensitive to this reward and to mobilize less effort. Effort mobilization in this 2 (dysphoric vs. nondysphoric) × 2 (no reward vs. social approval) between-persons study was operationalized by participants’ cardiovascular reactivity. Results confirmed that nondysphorics had higher reactivity of systolic blood pressure, diastolic blood pressure, and heart rate when expecting to enter their name in the alleged “best list”, whereas dysphorics had lower cardiovascular reactivity. The present study expands evidence for reduced reward responsiveness in depression and dysphoria from an effort mobilization perspective by demonstrating reduced effort-related cardiovascular reactivity to social rewards.

Mental time travel in dysphoria: Differences in the content and subjective experience of past and future episodes.

Previous research has shown that depressed individuals demonstrate a number of biases in their ability to retrieve past events and simulate future events. The current study investigated the content and phenomenological experience of past and future events in dysphoric and non-dysphoric individuals. Results indicated that dysphoric, compared with non-dysphoric, individuals reported fewer positive events across both temporal directions. Furthermore, phenomenological characteristics ratings suggested that dysphoric individuals saw future, but not past, events as less vivid, coherent, sensorially detailed, bodily experienced, emotionally intense and important with respect to their life story and identity. These findings are discussed with reference to theories regarding the functions of 'mental time travel', in particular how the muted subjective experience of future episodes in depression may impair future planning, problem-solving and self regulation.

An examination of trait, spontaneous and instructed emotion regulation in dysphoria

Depression is thought to be characterised by impaired emotion regulation, although the mechanisms of that regulation are not yet well understood. The present study examined trait, spontaneous and instructed emotion regulation in dysphoric (n = 66) and non-dysphoric (n = 86) participants. Participants were randomly assigned to use reappraisal while watching a sadness-inducing film clip (instructed emotion regulation condition) or were not given specific viewing instructions (spontaneous emotion regulation condition). Participants also completed trait measures of emotion regulation. Dysphoric individuals reported greater spontaneous use of rumination and suppression than non-dysphoric individuals, and these strategies were associated with greater negative emotional reactivity to the sadness-inducing film clip. Both participant groups were able to effectively use reappraisal when instructed to do so. The clinical implications of these findings and future research directions are discussed.