Tobacco Non-consumers Research Articles

Comparative proteomics of oral squamous cell carcinoma tissue in consumers and non-consumers of tobacco

Comparative proteomics of oral squamous cell carcinoma tissue in consumers and non-consumers of tobacco

The role of social support and self-control in tobacco consumption: a cross-sectional study among tobacco consumers and non-consumers

IntroductionTobacco use is recognized as one of the most important causes of preventable death due to non-communicable diseases and disability worldwide. The present study was conducted with the aim of comparing social support and self-control between tobacco consumers and non-consumers in Hormozgan Province.MethodsThe present cross-sectional study was conducted on the adult population above the age of 15 years living in Hormozgan province. A total number of 1,631 subjects were selected using a convenient sampling method. An online questionnaire was used to collect the data, which consisted of three sections: demographic information, Zimet’s perceived social support and Tangney’s self-control questionnaires. In the present study, Cronbach’s alpha coefficients of social support and self-control questionnaires were 0.886 and 0.721, respectively. Data were analyzed using chi-squared test, Mann-Whitney U-test, and logistic regression analysis with SPSS software (v. 25).ResultsAmong the participants, 842 (51.6%) reported to be tobacco non-consumers, and 789 (48.4%) reported to be consumers. The mean scores of perceived social support among the consumers and non-consumers were 4.6 ± 1.012 and 4.93 ± 0.518, respectively. The mean scores of self-control among the consumers and non-consumers were 2.74 ± 0.356 and 2.75 ± 0.354, respectively. There was a significant difference among tobacco consumers and non-consumers in gender, age, education level and job status (p < 0.001). The results showed that the mean scores of social support, support received from family and others were significantly higher in non-consumers than in consumers (p < 0.001). There was no statistically significant difference between the mean scores of self-control, self-discipline, and impulse control in consumers and non-consumers (p > 0.05).ConclusionAccording to our findings, tobacco consumers received more social support from family and others compared to non-consumers. Considering the important role of perceived support in tobacco consumption, this variable should receive copious attention in developing interventions and trainings, especially family education workshops.

Study of cardiovascular disease biomarkers among tobacco consumers. Part 3: evaluation and comparison with the US National Health and Nutrition Examination Survey

Cardiovascular disease (CVD) biomarkers of biological effect (BoBE), including hematologic biomarkers, serum lipid-related biomarkers, other serum BoBE, and one physiological biomarker, were evaluated in adult cigarette smokers (SMK), smokeless tobacco consumers (STC), and non-consumers of tobacco (NTC). Data from adult males and females in the US National Health and Nutrition Examination Survey and a single site, cross-sectional study of healthy US males were analyzed and compared. Within normal clinical reference ranges, statistically significant differences were observed consistently for fibrinogen, C-reactive protein (CRP), hematocrit, mean cell volume, mean cell hemoglobin, hemoglobin, white blood cells, monocytes, lymphocytes, and neutrophils in comparisons between SMK and NTC; for CRP, white blood cells, monocytes, and lymphocytes in comparisons between SMK and STC; and for folate in comparisons with STC and NTC. Results provide evidence for differences in CVD BoBE associated with the use of different tobacco products, and provide evidence of a risk continuum among tobacco products and support for the concept of tobacco harm reduction.

Study of cardiovascular disease biomarkers among tobacco consumers, part 1: biomarkers of exposure

A study was conducted to evaluate biomarkers of biological effect and physiological assessments related to cardiovascular disease (CVD) among adult male cigarette smokers (SMK), moist snuff consumers (MSC) and non-consumers of tobacco (NTC). Additionally, biomarkers of tobacco and tobacco smoke exposure (BoE) were measured in spot urines and are reported here. Except for the BoE to nicotine and NNK, BoE were generally greater in SMK compared with MSC, and BoE were generally not different in comparisons of MSC and NTC. Results demonstrated that MSC had lower systemic exposures to many harmful and potentially harmful constituents than SMK, which is consistent with epidemiological data that indicate a differential in CVD risk between these groups.

Activity of Serum and Salivary a-Amylase in Habitual Adult Tobacco Consumers

Introduction: Tobacco consumption alters many biological parameters, as well as α-amylase activity. This research work aims to study the activity of serum and salivary alpha-amylase in habitual adult tobacco consumers. Methods: We carried out a cross-sectional descriptive and analytical study on 234 adults (54 smokers, 60 snuffers, 60 chewers and 60 tobacco non-consumers). Serum and salivary alpha-amylase was measured using kinetic enzymatic method. ANOVA, and Kruskal-Wallis test were used to compare averages according to cases. Linear regression enabled to establish relationships between duration of consumption, quantity of tobacco consumption, as well as serum and salivary α-amylase activity. Results and conclusion: The mean activity of serum (UI/L) and salivary (104 UI/L) alpha-amylase was respectively 110.53 ± 73.35 and 17.34 ± 17 for smokers, 109.69 ± 58.20 and 9.90 ± 9.44 for snuffers, 92.63 ± 48.84 and 5.61 ± 5.38 for chewers and 120.14 ± 71.99 and 8.73 ± 6.14 for tobacco non-consumers. A significant difference was observed as regards salivary alpha-amylase between smokers and chewers (p<0.001), and between snuffers and chewers (p=0.002). The mean activity of serum and salivary alpha-amylase was substantially higher in tobacco non-consumers than in chewers (p=0.01 and 0.02, respectively). Correlation was lower and significant in chewers between mean activity, salivary alpha-amylase and duration of tobacco consumption (r=0.35; inclination p=0.006). Serum and salivary alpha-amylase activity varies according to tobacco consumption mode. Subsequent studies are required to specify the mechanisms put at stake.

Cadmium exposure and tobacco consumption: Biomarkers and risk assessment

To investigate whether cadmium has an independent role in diseases associated with tobacco consumption, epidemiology data were reviewed, biomonitoring data were analyzed, and probabilistic risk assessment (PRA) was performed. Results from previous epidemiology studies have indicated that there are adverse health effects potentially in common between cadmium exposure and tobacco consumption. Analysis of publically available biomonitoring data showed that blood (B–Cd) and urine (U–Cd) cadmium were higher in cigarette smokers compared with smokeless tobacco (SLT) consumers, and B–Cd and U–Cd in SLT consumers were not significantly different than in non-consumers of tobacco. Comparison with previously established biomonitoring equivalent (BE) values indicated that B–Cd and U–Cd in the majority of these cigarette smokers and SLT consumers did not exceed the blood and urine BEs. Results of the PRA showed that the mean hazard estimate was below a generally accepted regulatory threshold for SLT consumers, but not for cigarette smokers. In total, this evaluation indicated that cadmium exposures in tobacco consumers differed by product category consumed; cadmium in tobacco may not be associated with tobacco consumption related diseases; if cadmium in tobacco contributes to tobacco consumption related diseases, differences in hazard and/or risk may exist by product category.

Arsenic exposure and tobacco consumption: Biomarkers and risk assessment

Arsenic is measurable in tobacco and cigarette mainstream smoke (MSS). Whether arsenic has an independent role in diseases associated with tobacco consumption is not known. Epidemiology and biomonitoring data and probabilistic risk assessment (PRA) methods were used to investigate this potential association. Analysis of data from the National Health and Nutrition Examination Survey (NHANES) showed that urine arsenic concentrations in tobacco consumers were not different or were lower than levels in non-consumers of tobacco. Additionally, urine arsenic levels from NHANES tobacco consumers were five-times or more lower than levels reported in epidemiology studies to be associated with adverse health effects. Results of PRA indicated that mean non-cancer hazard estimates and mean incremental lifetime cancer risk estimates were within accepted ranges. Taken together, these results suggest that arsenic may not be independently associated with tobacco consumption or diseases related to tobacco consumption.

Sensitivity and specificity of a reagent-impregnated test strip in identifying smokeless tobacco users

This study was designed to determine the sensitivity and specificity of a reagent-impregnated test strip in identifying habitual snuff users and tobacco chewers. Urine specimens were obtained from smokeless tobacco users and controls and blind tested on-site using a reagent-impregnated test strip. Samples also were sent to our university hospital lab for cotinine and nicotine analysis by gas chromatography (GC). The test strip results were compared with GC results and self-reported use of snuff and chewing tobacco. A total of 61 subjects enrolled in the study: 26 snuff users, 25 tobacco chewers, and 10 nonconsumers of nicotine. Using GC assessment of nicotine and cotinine (>or=200 ng/ml) as the standard, we found the sensitivity of the test strip to be 96% (25/26) for snuff users and 96% (24/25) for tobacco chewers. When compared with self-report, the sensitivity of the test strip was 92.3% (24/26) for snuff users and 84% (21/25) for tobacco chewers. The specificity for nonusers of nicotine was 100% (10/10) for both the self-report and GC conditions. These results suggest that a reagent-impregnated test strip is a rapid, valid, and user-friendly means of differentiating smokeless tobacco users from nonconsumers of tobacco. The intensity of the pink color on the test strip is proportional to the amount of nicotine or its metabolites present in urine and therefore offers a semiquantitative measure of nicotine consumption.