Abstract Our purpose is to establish nonexistence results concerning complete noncompact mean curvature flow solitons with polynomial volume growth immersed in certain semi-Riemannian warped products, under mild constraints on the warping and soliton functions. Applications to self-shrinkers in the Euclidean space, as well as to mean curvature flow solitons in other important warped product models such as the Schwarzschild and Reissner-Nordström spaces, and Robertson-Walker spacetimes such as the Einstein-de Sitter spacetime, are also given. Furthermore, we study the nonexistence of entire solutions to the mean curvature flow equation. Our approach is based on a suitable conformal change of metric jointly with a maximum principle for complete noncompact Riemannian manifolds with polynomial volume growth due to Alías et al.