Non-carcinogenic Human Health Risks Research Articles

Groundwater quality assessment in the La Mojana region of northern Colombia: implications for consumption, irrigation, and human health risks

Water quality is one of the most relevant issues related to water management, with water pollution and access to clean water for drinking and irrigation being common issues in developing countries. Groundwater is an available water source, especially where surface sources are scarce or unsuitable. In this sense, studies to improve knowledge of aquifers should be undertaken where information on groundwater resources is not available. In the current study, 50 groundwater samples were collected from rural and urban wells used by local communities for human consumption and to irrigate local crops. Several indices for drinking water and irrigation use have been used for the assessment of water quality. Conversely, the carcinogenic and noncarcinogenic human health risks due to exposure to heavy metals in the groundwater were estimated, as were the predominant hydrochemical characteristics. The groundwater water quality index (GWQI) shows values < 100 for all the samples; groundwater is recommended for drinking after disinfection. By contrast, the irrigation water quality index (IWQI) shows that 80% of groundwater samples pose a potential threat to irrigation, with restriction categories ranging from high to severe. The individual hazard quotients were < 1. However, the multielement and multipathway hazard index (HI) for children and adults were > 1, whereas As and Mn had a higher contribution to the HI. The Piper trilinear diagram shows that hydrochemical facies of Ca2+ and HCO3− are significantly dominant. By contrast, weathering of rocks and atmospheric precipitation is the dominant factors regulating the chemistry of groundwater in the aquifer system of La Mojana. Our findings indicate that there are significant potential noncarcinogenic health risks for local populations exposed to groundwater.

Integrated risk assessment and human health hazards via dietary intake of OCPs from cereal crops cultivated across river chenab

The current study aimed to employ integrated risk assessment models to estimate carcinogenic and non-carcinogenic human health risks of organochlorine pesticides (OCPs) from Pakistan. GIS-based geostatistical technique was used to classify OCPs' polluted risk zones using risk indexes. The residual level of ∑OCPs detected in wheat and rice ranged from 1.78 to 12.46 ng g−1 and 4.92–18.19 ng g−1, respectively with the prevalence of DDD, DDE and HCH. The distribution pattern revealed a significantly higher concentration towards downstream region, suggesting industrial and agricultural activities as a pollution source in the area. Single pollution index (SPI) was employed for the identification of pollution zones. The findings of SPI for detected OCPs were found (0.7 < Pi < 1), respectively, depicting minimal pollution at the studied sites. Furthermore, risk assessment results reflected non-cancer risk (>1) for studied ∑OCPs. However, the suggested USEPA value for tolerable carcinogenic risk is < 10−6 (one in a million) which was found higher for DDD, DDE, HCH, CT, and HC in the current study. Consequently, the carcinogenic risk in the study area indicated the need for an assessment, monitoring, and reporting program grounded on laws that can reduce pollution and exposure levels to pesticides in Pakistan for good health and well-being.

Element contamination of the Orange-Vaal River basin, South Africa: a One Health approach

Numerous low-income groups and rural communities depend on fish as an inexpensive protein source worldwide, especially in developing countries. These communities are constantly exposed to various pollutants when they frequently consume polluted fish. The largest river basin in South Africa is the Orange-Vaal River basin, and several anthropogenic impacts, especially gold mining activities and industrial and urban effluents, affect this basin. The Department of Environment, Forestry and Fisheries in South Africa has approved the much-anticipated National Freshwater (Inland) Wild Capture Fisheries Policy in 2021. The aims of this study were (1) to analyze element concentrations in the widely distributed Clarias gariepinus from six sites from the Orange-Vaal River basin and (2) to determine the carcinogenic and non-carcinogenic human health risks associated with fish consumption. The bioaccumulation of eight potentially toxic elements (As, Cd, Cr, Cu, Hg, Ni, Pb, Zn) was assessed in C. gariepinus from sites with different anthropogenic sources. The human health risks were determined to assess the potential risks posed by consuming contaminated C. gariepinus from these sites. Carcinogenic health risks were associated with fish consumption, where it ranged between 21 and 75 out of 10,000 people having the probability to develop cancer from As exposure. The cancer risk between the sites ranged between 1 and 7 out of 10,000 people to developing cancer from Cr exposure. A high probability of adverse non-carcinogenic health risks is expected if the hazard quotient (HQ) is higher than one. The HQ in C. gariepinus from the six sites ranged between 1.5 and 5.6 for As, while for Hg, it was between 1.8 and 5.1. These results highlight the need for monitoring programs of toxic pollutants in major river systems and impoundments in South Africa, especially with the new fisheries policy, as there are possible human health risks associated with the consumption of contaminated fish.Graphical

Hydrogeochemical evolution processes, groundwater quality, and non-carcinogenic risk assessment of nitrate-enriched groundwater to human health in different seasons in the Hawler (Erbil) and Bnaslawa Urbans, Iraq

The main objectives of this research are to assess groundwater, a primary source of drinking water in the urban areas of Hawler (Erbil) and Bnaslawa in northern Iraq, and the non-carcinogenic human health risks of nitrate contamination associated with drinking water quality. For this purpose, twenty-seven groundwater samples were collected from wells to assess the hydrogeochemical characteristics and groundwater quality for both natural and anthropogenic purposes during the wet (May 2020) and dry (September 2020) seasons. During the wet and dry seasons, NO3− in groundwater ranged from 14.00 to 61.00 mg/L and 12.00 to 60.00 mg/L, with an average value of 35.70 and 29.00 mg/L, respectively. Approximately 25.92% of the samples exceeded the permissible limit of the WHO (2011) drinking water standard. The ratios of NO3−/Na+ vs. Cl−/Na+ and SO42−/Na+ vs. NO3−/Na+ indicate the effect of agricultural activities and wastewater leaking from cesspools or septic tanks on the quality of groundwater during the wet and dry seasons. The entropy weighted water quality index method ranked 62.5% and 75% of the urban groundwater as not recommended for drinking, and the remaining samples are moderately suitable in both wet and dry seasons. The non-carcinogenic human health risk assessment displayed that during the wet and dry seasons, 29.6% and 25.9% of adults, 48% and 30% of children, and 48.1% and 29.6% of infants were exposed to increased concentrations of nitrate in groundwater. Due to high nitrate in drinking water, non-carcinogenic human health risk levels vary as infant > child > adults. The main findings obtained from this study can assist policymakers in better understanding the hydrogeochemical properties of groundwater in terms of drinking water safety, thereby facilitating the management of water resources to take the necessary measures.

Ecological risk assessment, source identification and spatial distribution of organic contaminants in terms of mucilage threat in streams of Çanakkale Strait Basin (Türkiye)

In this study, the spatial distributions of organic contamination stressors in water of fluvial habitats in the Çanakkale Strait (ÇS) watershed were investigated and the data were assessed in terms of human health and mucilage threat. Seven significant riverine ecosystems flowing into the ÇS were defined in the basin. Water samples were taken in the spring season (2023), when the phytoplankton communities reach their highest densities. Then they were tested for a total of 8 limnological parameters.The Nutrient Pollution Index (NPI) and Water Quality Index (WQI) were applied to assess the comprehensive quality characteristics of waters. The Hazard Quotient (HQ) and Hazard Index (HI) were applied to indicate the prospective non-carcinogenic human health risks of organic stressors. Principal Component Analysis (PCA) and Cluster Analysis (CA) were applied to categorize the investigated habitats and define the sources of investigated contamination parameters. Also, Geographic Information System (GIS) was used to make an effective assessment through visualization.The determined spatial mean values of the measured variables in ÇS watershed as follows: 18.21 °C for temperature, 8.51 mg/L for DO, 4.57 NTU for turbidity, 3.95 mg/L for suspended solids, 1.11 mg/L for NO3–N, 0.012 mg/L for NO2–N; 0.173 mg/L for PO4–P and 2.32 mg/L for BOD. It has been determined that the organic pollution loads and water temperature values of the investigated sub-basins increase from the upstream to the downstream locations and Çanakkale Stream was recorded as the riskiest fluvial habitat for the ÇS watershed. According to the results of health risk assessment indices, non-carcinogenic risks of organic pollutants would not be expected for all age groups.

Pesticide residues in drinking water treatment plants and human health risk assessment: a case study from Northern Iran.

These days, the presence of pesticide residues in drinking water sources is a serious concern. In drinking water treatment plants (DWTPs), various methods have been proposed to remove pesticide residues. This study was designed with the objectives of monitoring the occurrence and seasonal variations of pesticides in the output of drinking water treatment plants in two Northern provinces of Iran, Gilan and Golestan, and identifying their human health risks. Seventeen pesticide residues from different chemical structures were determined by using a gas chromatograph-mass spectrometer (GC-MS). The results showed that only Alachlor, Diazinon, Fenitrothion, Malathion, and Chlorpyrifos were detected. The pesticide concentrations ranged from ND to 405.3ng/L and were higher in the first half-year period. The total non-carcinogenic human health risks was in safe range for infants, children, and adults (HI < 1). The carcinogenic human health risks of Alachlor for infants, children, and adults were in the range of 4.3 × 10-7 to 1.3 × 10-6, 2.0 × 10-7 to 9.6 × 10-7, and 1.1 × 10-7 to 5.5 × 10-7, respectively. These values do not pose health risks for adults and children, but may present a possible cancer risk for infants in two DWTPs of Golestan. In conclusion, considering the possibility of exposure to these pesticides through other routes, simultaneously, it is suggested to carry out a study that examines the level of risk by considering all exposure routes. We also propose stricter regulations for the sale and use of pesticides in Iran.

Representative coal gangue in China: Physical and chemical properties, heavy metal coupling mechanism and risk assessment

Based on the source and distribution of coal gangue (CG) in China, this study introduces the current situation of CG storage in China and the problems existing in the process of CG utilization. For the benefit of solve the difficulty of CG utilization and the risk control of heavy metals (HMs), representative CG samples were selected, and the chemical composition of CG was analyzed according to the microscopic test results. The main reasons for the difficulty of mineral composition and resource utilization were revealed, and the specific environmental protection utilization regulation model of CG samples was constructed, the carbon emission value of CG products was studied by life cycle method, and the broad prospects of CG products under the background of the times were revealed. The heavy metal leaching amount of CG samples in representative areas was detected. Three kinds of HM soil safety evaluation methods and human health risk assessment (HHRS) methods were used to evaluate soil environmental safety, carcinogenic and non-carcinogenic human health risks. The results showed that the characteristic HMs in CG were As, Pb and Cr. The valence states of As, Pb and Cr in CG were As3+, As5+, Pb2+, Pb4+, Cr3+ and Cr6+, respectively. The valence states of As, Pb and Cr in CG were mainly carbonate-bound state and metal oxide-bound state, which exist in the layered silicate minerals of a triclinic system dominated by kaolinite. Considering that the HMs in CG are finally ingested into the human body through the soil, while constructing a complete HM environmental safety control system, based on the relevant environmental quality standards and the HHRS of HMs, the risk control system and control limits of characteristic HMs in CG resource utilization were established, in order to provide theoretical guidance for the high-value environmental protection utilization of CG.

Risk surveillance with spatial distribution of Organochlorine Pesticides (OCPs) from sedimentary samples of Chenab River

A pioneering study employed a holistic geostatistical approach to predict the spatial variability of a non sampled area in the Chenab River, Pakistan, using kriging interpolation for organochlorine pesticide (OCP)-polluted risk zones. The Present research intended to investigate the carcinogenic and non-carcinogenic human health risks, contamination levels, and spatial variation of OCPs in the Chenab River, Pakistan. The residual OCP content in sediment samples (n = 120) ranged from 0.056 to 32.14 ng/g. DDE and α-HCH were prevalent among all the samples analyzed, with mean concentrations of 15.84 ± 8.02 and 12.45 ± 6.72 ng/g, respectively. The order of magnitude of OCPs in sediment samples was DDTs > α-HCH > chlorothalonil > heptachlor > endosulfan > aldrin > dieldrin. The findings of the single (SPI) and Nemerow (Nel) pollution index of α-HCH, heptachlor, and aldrin depicted the Chenab River as a serious pollution risk zone. The outcomes of the Pearson correlation coefficient analysis represent the positive correlation among all OCPs, revealing the common origin. Distribution trends showed substantially higher (p < 0.05) contents of analyzed OCPs along the downstream zone. With regards to USEPA human health hazard assessment model, the estimated non-carcinogenic (ΣHI) and non-carcinogenic (ΣTCR) risk ranged from 1.1 × 10−5 to 1.0 × 10−1, 4.0 × 10−8 to 3.2 × 10−4 respectively. TCR >10−4 illustrated a substantial cancer health risk posed by α-HCH, heptachlor, aldrin, and dieldrin in the downstream zone. We recommend the urgent cessation of the ongoing discharge of OCPs into the Chenab River, which needs to be highlighted owing to the significant cancer risk to public health to ensure the good health and wellbeings.

Development of machine-learning-based models for identifying the sources of nitrate and fluoride in groundwater and predicting their human health risks

AbstractThis research aimed to identify the main sources of groundwater pollution and assess the non-carcinogenic human health risk resulting from nitrate and fluoride contamination. These goals were achieved by employing unsupervised and supervised machine algorithms, including principal component analysis (PCA) and multilayer perceptron artificial neural networks (MLP-ANN). Thirty-seven groundwater samples were analyzed for twelve physical and chemical parameters, including pH, EC, TDS, TH, Cl, F, SO4, NO3, Ca, Mg, Na, and HCO3, and the initial investigation indicated that except for Cl, F, Ca, and Mg, all the parameters are above the guidelines of the World Health Organization (WHO). PCA indicated that mineral dissolution is the main source of F, while high NO3 concentration primarily resulted from agricultural operation due to extensive use of nitrogen and calcium-based fertilizers. Consequently, the non-carcinogenic human health risk (HHR) for children and adults is evaluated based on NO3 and F. The conventional approach for assessing HHR is time-consuming and often associated with errors in calculating hazard quotients (HQ) and hazard indices (HI). In this research, MLP-ANN is suggested to overcome these limitations. In the MLP-ANN modeling, the data were divided into two parts training (80%) and validation (20%), with NO3 and F concentration as inputs and HQ and HI as outputs. The performance of the resulting models was tested using root mean square error (RMSE) and coefficient of determination (R2). The model provided a satisfactory result with a maximum RMSE of 4% and R2 higher than 97% for training and validation. As a result, obtained HIs suggested that 97.3% of the groundwater samples in the study area are suitable for human consumption. The non-carcinogenic HHR is successfully assessed using machine learning algorithms, and the results have led to the conclusion that this approach is highly recommended for effectively managing groundwater resources.

Hydrochemical Appraisal and Driving Forces of Groundwater Quality and Potential Health Risks of Nitrate in Typical Agricultural Area of Southwestern China

Elucidating the hydrogeochemical processes and quality assessment of groundwater holds significant importance for its sustainable development. In this paper, 53 groundwater samples were collected from a typical agricultural area in the northeastern Chongqing municipality in SW China. The integration of multivariate statistical analysis, ion ratio analysis, geomodelling analysis, the entropy water quality index, health risks assessment, and sensitivity analysis was carried out to explore the hydrochemical processes and quality assessment of groundwater in this study. The statistical results reveal that the cationic concentrations followed the order of Ca2+ &gt; Mg2+ &gt; Na+ &gt; K+, while the anionic components were in the order of HCO3− &gt; SO42− &gt; NO3− &gt; Cl−. Based on the Piper trilinear diagram, the hydrochemical types were shown as Ca-HCO3 and Ca-Mg-HCO3 types. Hierarchical cluster analysis indicated that the groundwater samples could be categorized into three groups. The hydrochemical compositions were primarily influenced by water–rock interactions (e.g., carbonate dissolution and silicate weathering). In terms of irrigation suitability, the sodium adsorption ratios (SARs) ranged from 0.05 to 1.82, and the electrical conductivity (EC) varied from 116 to 1094 μs/cm, indicating that most groundwater samples were suitable for irrigation. The entropy-weighted water quality index ranged from 15 to 94, suggesting that the groundwater samples were suitable for drinking purposes. Non-carcinogenic human health risks followed the order of children &gt; adult females &gt; adult males, within the average values of 0.30, 0.21, and 0.18, respectively. Sensitivity analysis showed that the parameters had the weight order of NO3 &gt; body weight (BW) &gt; ingestion rate (IR) &gt; exposure frequency (EF). Hence, we recommend prioritizing the management of areas with high salinity levels, while avoiding the excessive use of nitrogen fertilizers, raising awareness among local residents about safe groundwater, and providing robust support for the sustainable development of groundwater in typical agricultural areas.

A validated ICP-MS method for the screening and quantitative analysis of heavy metal contaminants in home-brewed alcoholic beverages of Botswana

A method for the analysis of heavy metals in homemade alcoholic beverages using an Inductively Coupled Plasma-Mass spectrometry (ICP-MS) was developed and validated for accuracy, precision, linearity, limit of detection and quantification. Linearity was discovered to be in the concentration range of 10–50 (ppb) with correlation coefficient (R2) of above 0.99 for all the seven detected metals. The method is precise with %RSD values ≤ 5 %. Limits of detection and quantification were 0.01–0.16 and 0.10–1.6 (ppb), respectively. The accuracy ranged from 95.1 % to 105.3 %. Thirty-two samples of locally brewed homemade alcoholic beverages and five commercial samples were subsequently analysed using the method. The detected metals included manganese, cobalt, chromium, copper, zinc, aluminium, and lead. The concentrations of Aluminium and Lead in some homemade samples exceeded the set maximum allowable limits (MAL) of the World Health Organisation. The carcinogenic and non-carcinogenic human health risk assessments were also performed for the detected heavy metals. The carcinogenic risk analysis revealed that chromium and lead values were above the safety level of 10−4 set by the United States Environmental Protection Agency (USEPA) in some samples. This suggests that the two metals can pose potential cancer risks to consumers. There were no apparent non-carcinogenic health risks associated with the studied heavy metals. The results obtained from this study will contribute to the growing body of literature regarding the safety of homemade alcoholic beverages around the world.

Hydro-chemometrics of the Nubian Aquifer in Sudan: an integration of groundwater quality index, multivariate statistics, and human health risk assessment

This research employed the groundwater quality index (GWQI), multivariate statistical methods, and human health risk assessment model to investigate the suitability of groundwater for domestic uses in northern Khartoum state, Sudan. The groundwater samples were analyzed for eleven physiochemical parameters, including pH, EC, TDS, TH, Cl−, SO42−, NO3−, Ca2+, Mg2+, Na+, HCO3− and the primary investigation indicated the deviation of these parameters from World Health Organization (WHO) standards. The hydrochemical analysis revealed different groundwater facies with the dominance of Ca–Mg–HCO3 water type. Consequently, the groundwater samples were classified, based on GWQI, into three categories as 76.4% of the samples fall in the excellent water class, 17.6% are projected in the good water class, and 5.9% of groundwater samples are considered unsuitable for human consumption. The multivariate statistical methods were applied, including Pearson’s correlation analysis, principal component analyses (PCA), and hierarchical cluster analysis (HCA). Three principal components (PCs) explaining 86.07% of total variances are extracted. These PCs indicated that rock-water interactions and agricultural practices influence groundwater quality in the study area. Additionally, HCA is used to categorize groundwater samples based on the concentration of the physiochemical parameters. Consequently, three types of groundwater were identified as low, medium, and highly mineralized. In the final stage, the non-carcinogenic human health risk was assessed based on the concentration of NO3− using the United States Environmental Protection Agency (USEPA) models. The obtained hazard quotient for children indicated that 64.7% of groundwater samples are beyond the permissible limit (1 <), and the use of these samples may result in health consequences. Therefore, remedial measures are suggested for the sustainable use of groundwater.

Similarity in human health risk assessment using models of soil-blood lead levels (IEUBK) and non-carcinogenic condition (US EPA 2002)

Soil lead (Pb) concentrations in Sydney estuary (Australia) catchment are substantially elevated and strongly associated with traffic networks. This study compared the health risk predictions of blood Pb levels (BLL) in children using the soil IEUBK model and an independent, non-carcinogenic human health risk (NCR) assessment using the soil US EPA 2002 model. The predictions by the two models were significantly correlated (p < 0.001) and showed similar spatial distributions, but the NCR model may be more stringent in protection of human health when exposed to soil Pb in relation to adverse health effect, as the warning soil Pb concentration from the BLL was 4.6-fold higher than that from the NCR. The empirical IEUBK model considers gastric phase adsorption only and of the three exposure pathways (ingestion, inhalation and dermal) assessed by the theoretical NCR model, ingestion was the major exposure route. The reason for the similarity in outcomes of the two models is unknown, however the close correlation may be due to broadly similar formulations and, or that neurological and non-carcinogenic risks may be related to the adverse effects of Pb on bodily function. Parallel studies of human health risk based on BLL and NCR models have not been attempted previously and this opportunity to compare results from the two health risk assessments employing the same soil metal data is therefore unique.

Potential toxic element contamination and non-carcinogenic risk assessment of groundwater from rapidly growing urban areas in Telangana, India.

Groundwater is a critical resource for drinking purposes that is under pressure and polluted with multiple inorganic contaminants. Among various contaminants, potentially toxic element contamination in groundwater has significant public health concerns due to their toxicity at a low level of exposure. This investigation aimed to assess the toxic element contamination and associated non-carcinogenic human health risk at rapidly growing urban centers in Telangana to ensure potable water and to generate baseline data in the study province. Thirteen potential toxic trace elements (Al, As, B, Cd, Co, Cr, Cu, Fe, Mn, Ni, Pb, Se, and Zn) were determined in 35 groundwater samples collected from the Karimnagar and Siddipet smart cities in lower Manair River basin using inductively coupled plasma mass spectrometry (ICP-MS). The trace element concentration is found in the range for Al (1-112µg/L), As (2-8µg/L), B (34-438µg/L), Cd (bdl-2µg/L), Co (bdl-17µg/L), Cr (bdl-4µg/L), Cu (bdl-216µg/L), Fe (4-420µg/L), Mn (bdl-3311µg/L), Ni (5-31µg/L), Pb (bdl-62µg/L), Se (1-18µg/L), and Zn (3-1858µg/L). Analytical data of groundwater revealed the occurrence of toxic elements observed as above the acceptable limits of Bureau of Indian Standards for drinking purposes found in the order of Al > Ni ≥ Mn > Se ≥ Cu ≥ Pb > Fe with 26% > 14% ≥ 14% > 9% ≥ 9% ≥ 9% > 6% of samples, respectively. The non-carcinogenic health risk to humans upon groundwater ingestion has been evaluated and found to be non-hazardous for all the individual elements studied except for aresenic. However, cumulative hazard quotient observed as > 1 in the category of infants and children might be a major potential health concern. This study provided baseline data and suggested implementing preventive measures to protect human health around the urban areas of lower Manair river basin, Telangana, India.

Impacts of seasonal variations and wastewater discharge on river quality and associated human health risks: A case of northwest Dhaka, Bangladesh

Surface water pollution caused by the discharge of effluents from industrial estates has become a major concern for Dhaka (Bangladesh). This study aims to have a concise look at the severe river water pollution, mainly from effluents discharged from the tannery village. Effluent samples were collected from five ejected points, including the central effluent treatment plant (CETP), twenty adjacent river water, and two pond water nearby Hemayetpur, Savar. Thirty-one parameters have been observed at these sampling points for three seasons, from April 2021 to January 2022. The results obtained from water quality indices, i.e., water quality index (WQI), entropy water quality index (EWQI), and irrigation water quality index (IWQI), show that most studied surface water samples ranked “unsuitable” for consumption, irrigation, and anthropogenic purposes. The highest health risk was observed downstream of Hemayetpur city at the Savar CETP discharge site, indicating higher levels of heavy metal in the river water following the tannery village. Carcinogenic and non-carcinogenic human health risks could be triggered mainly by water consumption as concentrations of arsenic (As), chromium (Cr), nickel (Ni), and lead (Pb) exceeded the upper benchmark of 1 × 10−4 for adults and children. The results of the carcinogenic risk assessment revealed that children were more vulnerable to health hazards, and quick corrective action is required to control the increased levels of heavy metals at all sample locations. Therefore, through bioaccumulation, human health and the environment are affected in these areas. Using river water for consumption, household work, or even irrigation purposes is not advisable. This study's result highlighted that properly implementing compatible policies and programs is required to improve effluent treatment methods and provide biodegradability to the Dhaleshwari River.

Ecological and human health hazards; integrated risk assessment of organochlorine pesticides (OCPs) from the Chenab River, Pakistan

Carcinogenic hazards to human health were investigated through oral and dermal exposure to organochlorine pesticides (OCPs) from water samples (n = 120) of River Chenab, Pakistan. The Pioneering study aimed to employ an integrated geographic information system (GIS) based geostatistical method for the determination of pollution load by GC-ECD from water of River Chenab. The residual levels of OCPs detected from water samples ranged from 0.54 to 122 ng L−1 with significant prevalence of DDE and α-HCH. Results of the Nemerrow pollution index (NeI), single pollution index (SPI), and comprehensive pollution index (CPI) reflected the downstream zone a stern pollution risk zone. The spatial distribution pattern through geostatistical approaches also revealed significantly higher (p < 0.05) OCP levels in the downstream zone. Risk quotient (RQCCC) of surface water quality with respect to heptachlor epitomized a high level of risk (RQCCC > 1). Non-carcinogenic human health risk (Σ HQ) assessment ranged from 8.39 × 10−9 to 1.7 × 10−3, which represented a marginal risk through oral and dermal exposure. However, carcinogenic risks by oral exposure route were ranged from 3.57 × 10−11 to 4.46 × 10−6. Estimated cancer risk (ΣCR) exhibited a considerable carcinogenic risk posed by heptachlor, α-HCH and dieldrin. It is suggested to employ an immediate mitigation strategy for the constant discharge of OCPs in the studied area.

Spatial and Multivariate Statistical Analyses of Human Health Risk Associated with the Consumption of Heavy Metals in Groundwater of Monterrey Metropolitan Area, Mexico

Groundwater is the main source of drinking water supply in most urban environments around the world. The content of potentially toxic elements is increasing in many groundwater systems owing to inadequate groundwater recharge, aquifer overexploitation, natural source release, or various anthropogenic activities that lead to groundwater quality degradation. The ingestion of groundwater contaminated with potentially toxic elements has been reported to have harmful health effects. This study aimed to assess the presence of several potentially toxic elements (Al, As, B, Cr, Cu, Fe, Mn, and Zn) in groundwater of the Monterrey metropolitan area in Northern Mexico and the carcinogenic and noncarcinogenic human health risks associated with exposure. Multivariate statistics and geospatial analysis were applied to identify the causative determinants that modify the groundwater quality along the metropolitan area. Mean concentrations of trace metals remained below drinking water standards and World Health Organization guidelines. The risk of harmful effects on human health due to ingestion of all eight metal(loid)s in groundwater was assessed as 2.52 × 10−2 for adults and 2.16 × 10−2 for children, which can be considered as negligible chronic risk and a very low cancer risk. However, the risks of oral consumption of Cr being carcinogenic to children and adults were 7.9 × 10−3 and 9.2 × 10−4, respectively. As these values exceeded the target risk of 1 × 10−4, it can thus be considered “unacceptable”.

Comprehensive GIS based risk surveillance of organochlorine pesticides (OCPs) in edible fish species of River Chenab, Pakistan

The present study was conducted to evaluate Carcinogenic (TR) and non-carcinogenic (THQ) human health risk of organochlorine pesticides (OCPs) in three edible fish species (Labeo boga, Channa marulius and Wallago attu) of River Chenab, Pakistan using USEPA human health risk assessment model. Holistic GIS (Geographic information system) based Geo-Statistical approach has been employed for the first time in River Chenab, Pakistan to categorize contaminated risk zones of OCPs based on single pollution index. The ∑OCPs concentrations in fish species were ranged from 5.09 to 414 ng/g with the prevalence of dieldrin. Results of single pollution index of DDE, aldrin, dieldrin and ∑endosulfan revealed River Chenab as polluted and risk zone area. Distribution pattern assessed significantly higher (p < 0.05) concentrations of OCPs in downstream area suggesting substantial pollution of surrounded industrial region. The human health risk assessment depicted no harmful non-carcinogenic (THQ) risk except for ΣOCPs concentration of C. marulius. Significant carcinogenic (TR) health risk exhibited by all examined OCPs from maximum of the studied sites. Therefore, the high carcinogenic human health risk had highlighted an immediate removal of continuous disposal of OCPs in the River Chenab.

Isotopic and Elemental Fingerprint of Edible Egg Parts-The Health Risk Assessment Based on Potentially Toxic Elements Content.

The present study investigated the isotopic and elemental profile (by IRMS and ICP-MS) of edible egg parts (29 egg whites and 29 yolks) mainly collected from Romania. In order to differentiate the egg white and yolk coming from different hen rearing systems (backyard and barn), Partial Least Square-Discriminant Analysis (PLS-DA) models were developed. The models' accuracies for the discrimination according to the hen growing system were 96% for egg white and 100% for egg yolk samples, respectively. Elements that proved to have the highest discrimination power for both egg white and yolk were the following: δ13C, Li, B, Mg, K, Ca, Mn, Fe, Co, Zn, Rb, Sr, Mo, Ba, La, Ce, and Pb. Nevertheless, the important compositional differentiation, in terms of essential mineral content, between the edible egg parts (egg white and egg yolk) were also pointed out. The estimated daily intake (EDI), the target hazard quotient (THQ) for Cr, Mn, Fe, Co, Ni, Cu, Zn, Se, Cd, Pb, and As, as well as the hazard index (HI) were used to assess non-carcinogenic human health risks from egg consumption. The obtained results showed no noticeable health risks related to egg consumption for humans from the point of view of the potentially toxic metals.

Occurrence, spatial distribution, and risk assessment of brominated flame retardants in farmland soils of typical provinces in China

In the present study, we investigated the occurrence, distribution, and potential risks of 4 brominated flame retardants in farmland soils across 18 provinces of China. The total mean concentrations of the BFRs were in order as DBDPE > BDE209 > HBB > TBB. DBDPE concentration was highest at 177.208 ng/kg, revealing its long-term use and persistence across the study areas. In parts of China, DBDPE was highest in the south (Sichuan, Shaanxi and Guangdong provinces), BDE209 was highest in the south (Sichuan province) and north (Jilin province), while HBB was highest in the south (Sichuan province) and east (Anhui and Zhejiang provinces) of China. Comparisons of the results in this study to other reported studies in different regions indicated that the studied BFRs concentrations were higher in the studied provinces of China. Pearson correlation between BFRs revealed both positive and negative associations within the BFRs groups and between BFRs and soil properties (SOM, CEC, pH, EC and PS%). The mean hazard quotients (HQ) of ecological risks ranged from 8.76 × 10−6 to 1.16 × 10−2 (HQ < 1) while non-carcinogenic human health risk evaluation for adults ranged from 7.05 × 10−7 - 7.48 × 10−4 (HQ < 1) and for children 2.99 × 10−4 - 4.30 × 10−2 (HQ < 1). Although the risk evaluations of BFRs from farmland soils in this study were low, the results serve as useful indicators of potential cumulative and long-term threats of BFR to rural areas where there is a high conversion of agricultural lands to non-agricultural use.