In this study, the Topp-Leone family of distribution approach was used to modify the Burr Hatke Exponential distribution to provide adequate fits for some engineering and health data which previous existing distributions in the family of Burr Hatke Exponential have failed to do. The new distribution improves the robustness of Burr Hatke Exponential distribution by making it capable of modeling emerging new world complex data with varying features, possesses greater capacity and flexibility to model lifetime data, has better goodness of fit. Some mathematical properties of the derived distribution such as quantile function, moments, order statistics, entropies, etc were obtained and discussed. Some non-Bayesian estimation approaches like maximum likelihood estimation (ML), maximum Product spacing estimation (MPSE), Least squares estimation (LS), weighted least squares estimation (WLS), Cramer-von-Mises estimation (CVM), Anderson-Darling estimation (AD), and right-tailed Anderson Darling estimation (RTAD), as well as Bayesian method under independent gamma priors were adopted to estimate the parameters of the model and the various methods proved efficient. From the simulation results, the bias and root mean squared error for the parameters are relatively small and the become smaller as the sample size becomes larger. This shows convenience and improved estimation accuracy. We further constructed a regression model using the proposed distribution. Extensive simulation studies were used to determine the efficiency of the method in both the estimation of its parameters and that of the regression model. The TL-BHE regression was fitted on censored CD4 count data of HIV/AIDs patients. The competitiveness, applicability, and usefulness of the model were demonstrated using datasets and the results validate the theoretical findings. The results indicate that the TL-BHE distribution achieved better results than the baseline distribution and other variants of the classical distributions.