Abstract We consider locally stabilized, conforming finite element schemes on completely unstructured simplicial space-time meshes for the numerical solution of parabolic initial-boundary value problems with variable coefficients that are possibly discontinuous in space and time. Distributional sources are also admitted. Discontinuous coefficients, non-smooth boundaries, changing boundary conditions, non-smooth or incompatible initial conditions, and non-smooth right-hand sides can lead to non-smooth solutions. We present new a priori and a posteriori error estimates for low-regularity solutions. In order to avoid reduced rates of convergence that appear when performing uniform mesh refinement, we also consider adaptive refinement procedures based on residual a posteriori error indicators and functional a posteriori error estimators. The huge system of space-time finite element equations is then solved by means of GMRES preconditioned by space-time algebraic multigrid. In particular, in the 4d space-time case, simultaneous space-time parallelization can considerably reduce the computational time. We present and discuss numerical results for several examples possessing different regularity features.