In this paper, we introduce the notions of crossed modules of associative conformal algebras, two-term strongly homotopy associative conformal algebras, and discuss the relationship between them and the third Hochschild cohomology of associative conformal algebras. We classify the non-abelian extensions by introducing the non-abelian cohomology. We show that non-abelian extensions of an associative conformal algebra can be viewed as Maurer–Cartan elements of a suitable differential graded Lie algebra, and prove that there is a one-one correspondence between the Deligne groupoid of this differential graded Lie algebra and the non-abelian cohomology. For any two associative conformal algebras [Formula: see text] and [Formula: see text], we provide the condition that a pair of automorphisms in Aut(A) × Aut(B) can be extended to an automorphisms of the non-abelian extension algebra of [Formula: see text] by [Formula: see text], and give the fundamental sequence of Wells in the context of associative conformal algebras.