Quantifying the effect of window openings on composite noise reduction of building façades is useful for evaluation with respect to noise regulations that prescribe indoor sound level limits with open window conditions. There are historical documents that indicate overall sound level reductions of open and closed windows, but there is little data available in octave band or one-third octave band resolution, or on the effect of the opening size. A series of Outdoor-Indoor Noise Reduction measurements were performed on a residential façade with closed-window and various open-window configurations. The test room was normally furnished with an approximate room volume of 64 m3. The open window areas ranged from approximately 1 to 13% of the total façade area. In addition to presenting one-third octave band results, the overall noise reduction ratings were computed using the reference sound spectrum from ASTM E1332. The overall noise reduction results show a trend of higher reduction with smaller open window area as expected. The results of the measurements also show that the slope of the trend varies with frequency.