Laterally spreading tumors (LSTs) of the nongranular pseudopressed type and LSTs of the granular mixed type have a high risk of submucosal invasion, so it is advisable to resect them en bloc in order to perform an adequate histologic study.1Bogie R.M.M. Veldman M.H.J. Snijders L.A.R.S. et al.Endoscopic subtypes of colorectal laterally spreading tumors (LSTs) and the risk of submucosal invasion: a meta-analysis.Endoscopy. 2018; 50: 263-282Crossref PubMed Scopus (51) Google Scholar Endoscopic submucosal dissection (ESD) allows optimal endoscopic treatment of this type of lesion. This technique is difficult to perform when the lesion is giant. There are different methods to facilitate ESD, such as immersion in saline solution2Nagata M. Usefulness of underwater endoscopic submucosal dissection in saline solution with a monopolar knife for colorectal tumors.Gastrointest Endosc. 2018; 87: 1345-1353Abstract Full Text Full Text PDF PubMed Scopus (24) Google Scholar and the pocket-creation method.3Hayashi Y. Miura Y. Yamamoto H. Pocket-creation method for the safe, reliable, and efficient endoscopic submucosal dissection of colorectal lateral spreading tumors.Dig Endosc. 2015; 27: 534-535Crossref PubMed Scopus (54) Google Scholar, 4Sakamoto H. Hayashi Y. Miura Y. et al.Pocket-creation method facilitates endoscopic submucosal dissection of colorectal laterally spreading tumors, non-granular type.Endosc Int Open. 2017; 05: E123-E129Crossref Google Scholar The water-jet hydrodissection technique has also shown effectiveness in rectal ESD.5Repici A. Hassan C. Pagano N. et al.High efficacy of endoscopic submucosal dissection for rectal laterally spreading tumors larger than 3 cm.Gastrointest Endosc. 2013; 77: 96-101Abstract Full Text Full Text PDF PubMed Scopus (75) Google Scholar We performed ESD with a combination of immersion in saline solution, the pocket-creation method, and hydrodissection. Saline solution was selected instead of sterile water to reproduce underwater conditions, similarly to those of other studies,2Nagata M. Usefulness of underwater endoscopic submucosal dissection in saline solution with a monopolar knife for colorectal tumors.Gastrointest Endosc. 2018; 87: 1345-1353Abstract Full Text Full Text PDF PubMed Scopus (24) Google Scholar with the aim of improving buoyancy and reducing the risk of water intoxication. Video 1 (available online at www.VideoGIE.org) shows the ESD of a giant polyp in the rectum. The patient was an obese 60-year-old woman with hypertension, who had a positive result to a fecal immunohistochemical test. We performed a diagnostic colonoscopy, which identified a giant rectal lesion with granular nodular mixed LST morphology. The tumor was 5 cm from the dentate line and had an adenomatous pit pattern Narrow-Band Imaging (NBI) International Colorectal Endoscopic classification type 2 (Fig. 1). Therapeutic endoscopy was performed with a retroview colonoscope (EC-3490TLi; Pentax, Tokyo, Japan) with a conical-tip distal attachment cap (DH28GR, 29CR; Fujifilm, Tokyo, Japan), Erbejet 2 hydrodissection system, and a T-type hybrid knife (Erbe Elektromedizin Gmbh, Tubingen, Germany). Thermocautery marks were placed around the edge of the lesion (Fig. 2). We used the hybrid knife in a different way. The T-type hybrid knife was developed for use in an open position, but this ESD device allows its use in a closed position. We have defined this use as hybrid knife “probe mode.” The width of the electrode contact in a closed position and the length of the blade allowed delicate dissection in immersion saline solution. The cutting diameter was 1.5 mm, and the cutting depth was 0.5 mm (Fig. 3). The use of saline solution immersion facilitated a clear endoscopic view, improved vessel identification (Fig. 4), and improved the dissection plane (Fig. 5). The lesion floating effect of the submucosa in immersion generated a “traction” that helped lift the mucosal flap during ESD with the pocket-creation method (Fig. 6).Figure 5Clear endoscopic view improving dissection plane identification.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 6Pocket-creation method in immersion.View Large Image Figure ViewerDownload Hi-res image Download (PPT) After creating the submucosal pocket under most of the surface of the tumor, we made a perimeter cut of the oral side. A suspension bridge was created between the nondissected sides that facilitated traction by flotation (Fig. 7) and was followed by cutting the bridge pillars until en bloc dissection was complete. We observed that the resected area reached up to 80% of the circumference (Fig. 8). There was no perforation or bleeding either during or after the procedure. The procedure time was 241 minutes. The resected specimen size was 120 × 80 mm (Fig. 9).Figure 8Resection surface reaching up to 80% of the circumference.View Large Image Figure ViewerDownload Hi-res image Download (PPT)Figure 9Resected specimen.View Large Image Figure ViewerDownload Hi-res image Download (PPT) Histopathologic examination identified a tubular adenoma of 110 × 70 mm with intramucosal moderately differentiated adenocarcinoma and carcinoma-free lateral and vertical resection margins. At the 24-month follow-up visit, there was no residual adenomatous tissue in the biopsy specimens taken from the scar. In conclusion, this case report illustrates that the combined use of water-jet hydrodissection, saline solution immersion, and the pocket-creation method to perform ESD can be an effective technique to remove colorectal polyps. The use of saline solution immersion facilitates a clear endoscopic view and mucosal flap floating effect, which improves visualization of the submucosal dissection plane. The hybrid knife “probe mode” can be used safely and effectively in saline solution immersion. Prospective and comparative studies with other ESD knives with an injection function are needed to evaluate the efficacy and safety of this new combined method for the treatment of colorectal lesions. All authors disclosed no financial relationships relevant to this publication. The authors thank Sabina Beg, MD, PhD, for her assistance in the narration of the video case report. https://www.videogie.org/cms/asset/a257fb4c-43a2-4288-9047-b2edf194214c/mmc1.mp4Loading ... Download .mp4 (102.38 MB) Help with .mp4 files Video 1Case report of an endoscopic submucosal dissection of a giant polyp in the rectum.