Nino Jesus Research Articles

Clinical characteristics in deciduous teeth associated with age and sex in preschoolers

Objetive : To determine the prevalence of clinical characteristics in deciduous dentition and its association with sex and age in children from 3 to 5 years old. Material and methods : It was an observational, analytical, cross-sectional and prospective study, whose sample consisted of 165 children enrolled in the garden of the “Nino Jesus” school during 2018. All related biosecurity measures and prior informed consent are applied. The data were recorded in clinical records, the observational , structured and participatory technique was use. Respect for the statistical analysis was by means of a descriptive statistic and Pearson’s Chi Square test. Results : they were as follows: the most prevalent molar relationship was the mesial step with 78.5%, as for the Baume arch type it was Iwith 37.6 %, the presence of primate spaces with 62.4% and 69.1% respectively. No diferences were found regarding the relationship with sex and age, since in sex the value was p=0.644 and in age p=0.397. Conclusions : obtained a prevalence of 74.5% of children with at least one clinical characteristic of future predisposition to malocclusion in dentition. There were no statistically specific differences between the association of these clinical characteristic of malocclusion with sex and age.

Factores de riesgo asociados a caries y enfermedad periodontal en Centro de Educación Básica Especial de Huánuco, 2017

Objetivos. Identificar factores de riesgo asociados a caries y enfermedad periodontal en niños de 7-18 años de edad en Centro de Educación Básica EspecialNiño Jesús de Praga” Huánuco 2017. Materiales y métodos. Diseño Observacional, Analítico de casos y controles. Empleándose ficha de recolección tipo encuesta. Muestra de 60 niños especiales (grupo de estudio) y 60 niños no especiales (grupo control). Variable dependiente: caries y enfermedad periodontal (con etiologías más frecuentes en cavidad oral). Variables independientes: índice de higiene oral, tiempo de parto, complicación durante la gestación, Ph salival, ingesta de carbohidratos y tipo de parto. Resultados. Entre los factores de riesgo para caries y enfermedad periodontal, no existe diferencia estadísticamente significativa (p<0,05) con el tiempo de parto, ni los otros factores Se determinó como factores de riesgo para caries: Índice de higiene oral, tiempo de parto y complicación durante la gestación; y factores de riesgo para la Enfermedad periodontal: Ph salival, ingesta de carbohidratos y tipo de parto. Además, no se encontró diferencias significativas (p>0,05) entre los Índices CPOD+ceod para caries (p: 0,36) e índice INTPC para enfermedad periodontal (p: 0,89) para ambos grupos. Conclusiones. Encontramos diferencia significativa entre el factor Tiempo de parto y la caries y enfermedad periodontal que afectan a ambos grupos. Se encontró factores de riesgo específicamente para caries y enfermedad periodontal que no son tan usados para estas enfermedades bucales en ambos grupos y no encontrándose diferencia significativa entre los índices usados.

En busca de un destino cumplido: el padre Eusebio del Niño Jesús O.C.D. y su defensa de la voz pura de Santa Teresa

Se rescata aquí la figura del P. Eusebio del Niño Jesús (1888-1936), carmelita descalzo de formación intelectual y final muy trágico, que luchó denodadamente por reconducir lo que juzgaba excesos interpretativos del espiritismo acerca de la fundadora del Carmelo, para restablecer, en suma, la voz pura de Santa Teresa.

P-120 - MiRNome of epileptic children suggests the involvement of antioxidant pathways in the neuroprotective role of ketogenic diet

Ketogenic diet (KD) has been used as treatment for refractory epilepsy in children since the 1920s. However, the neuroprotective mechanism of this diet is still unknown. Recent evidence points to a multifactorial effect of KD that involves a decrease of oxidative stress. Mononuclear cells from 14 children with refractory epilepsy, from the Paediatric Hospital “Nino Jesus” in Madrid, were obtained before and after treatment with a ketogenic diet for 6 months. A global analysis of miRNA expression (miRNome) indicates that there are 230 miRNAs which are expressed differently before and after the treatment with KD. If additionally, we restrict the miRNAs with a fold change > |1.3|we obtain 11 relevant miRNAs: miR-3978, miR-6726-3p, miR-130a-3p, miR-4758, miR- 6745, miR-532, miR-185-5p (downregulated after the ketogenic treatment) and miR-4538, miR-602, miR-330-5p, miR-4673 (upregulated after the treatment). Many of these miRNAs are involved in antioxidant pathways. For instance, miR-185 upregulation impairs an efficient antioxidant response in human [doi: 10.1186/s12933-016-0390-9], whereas in our patients treated with KD this miRNA is down-regulated. These findings support the role of the prevention of oxidative stress in the neuroprotective effects of the ketogenic diet.

Wilms’ tumour: A review of 15 years recent experience

Abstract Introduction Wilms’ tumour is the most frequent renal tumour in children. Multi-modal treatment includes chemotherapy and surgery, with or without radiotherapy. The survival is excellent, with rates exceeding 90%. A review is presented on our experience over the last 15 years of treating Wilms’ tumour in Hospital Nino Jesus, Madrid. Patients and methods A retrospective study was conducted on 40 consecutive paediatric patients diagnosed with nephroblastoma between 2002 and 2016 in the Hospital Nino Jesus in Madrid. The clinical characteristics, diagnostic methods, treatment, and follow-up were analysed. Results Of the 40 patients, 23 were boys, with a median age at diagnosis of 2.5 years (range, 4 months–15 years). Three patients underwent initial nephrectomy, three received a fine needle aspiration biopsy, followed by chemotherapy, and 34 patients started pre-operative chemotherapy directly. The median follow-up of the patients was 6.75 years (range, 10 months–13.92 years). Two patients died from disease progression. There were no treatment-related deaths. Overall survival and event-free survival at 5 years was 94.6 ± 3.7% and 89.4 ± 5%, respectively. Conclusion Wilms’ tumour treatment is a success of modern medicine, currently achieving a survival rate of 95% in our series.

Síndrome de Mauriac reporte de caso clínico

Se presenta un caso de un niño de 11 años evaluado en el Hospital Niño Jesús de la ciudad de Barranquilla con características de síndrome de Mauriac; dicho síndrome está descrito como una complicación en pacientes con diagnostico de diabetes mellitus tipo I, que no se encuentran metabólicamente controlados y se caracteriza por presencia de hepatomegalias, elevación de transaminasas, retraso puberal y cambios físicos cuchingoides asociados. Son pocas las referencias bibliográficas publicadas en los últimos años, ya que su morbilidad es muy baja debido al auto monitoreo glucémico, la intervención de nuevas insulinas y diagnóstico precoz.

La Guerra Nacional y La Peste que originaron una devoción

This paper addresses the sworn promise to the Dulce Nombre del Nino Jesus initiated circa 1856 as a response to the colera morbus pest that started in Costa Rica after the Battle of Rivas, Nicaragua on April, 11 1856. Costa Rica was at war with the filibuster army organized by U.S. William Walker. Walker was in power in Nicaragua and menaced to invade Costa Rica. In this context the pest was introduced by Costa Rican soldiers into the country. Because of the horrors of the pest and the lack of scientific knowledge to control it, the sworn promise to the Dulce Nombre del Nino Jesus started, a ritual reproduced in a yearly basis since at the church of El Carmen, San Jose.

Intracranial germ cell tumours: A 21-year review

Abstract Introduction Intracranial germ cell tumours are rare in children. They are a heterogeneous group of neoplasms that show different clinical manifestations despite having a common origin. Patients and methods A retrospective analysis was carried out on the epidemiological and histological characteristics, clinical manifestations, and outcomes of 20 patients diagnosed with intracranial germ cell tumours in the Nino Jesus Children's Hospital of Madrid from 1994 to 2014. Results A total of 20 patients were identified: 14 boys and 6 girls. The mean age was 11.1 years (range 2–18 years). Histological confirmation of the diagnosis was obtained in 95% of the patients. Of the 20 patients, 14 were pure germinoma (70%) and 6 non-seminomatous germ cell tumours (30%). The most frequent locations were pineal (45%) and suprasellar (45%). The most frequent clinical symptoms in pineal tumours at diagnosis were headache and vomiting (77.77%), followed by visual disturbances (44.4%). In suprasellar tumours it was polydipsia and polyuria (100%). At diagnosis, 90% of the patients received radiotherapy, and 55% received chemotherapy combined with radiotherapy. There was a relapse in 4 patients (20%), and 3 of them died. Overall survival was 80%; 85.7% for pure germinomas and 60% for non-seminomatous germ cell tumours. Conclusions The most common histological subtype was pure germinoma. Germ cell tumours include heterogeneous disease entities that have a variable prognosis. Thus, an accurate diagnosis is vital for patient counselling and treatment planning.

Significado de las prácticas de cuidado cultural en gestantes adolescentes de Barranquilla (Colombia)

Objetivo: describir el significado de las prácticas de cuidado cultural en un grupo de gestantes adolescentes asistentes al control prenatal del Hospital Niño Jesús de Barranquilla, Colombia, y de su hijo por nacer. Método: estudio cualitativo etnográfico, en el que se aplicó el concepto propuesto por Leininger. Las participantes fueron: 10 gestantes adolescentes entre 15 y 19 años, y 12 enfermeras con experiencia en el área. Las primeras como informantes clave, y las segundas como informantes generales. Resultados: el significado de las prácticas de cuidado cultural, para las gestantes adolescentes, se clasifica en tres temas: 1) prácticas de cuidado transmitidas de generación en generación, predominando la línea femenina; 2) la confianza en Dios y el apoyo de la familia como una forma de cuidarse; 3) dar a luz un hijo sano. Conclusiones: las prácticas de cuidado de las gestantes adolecentes están enraizadas en sus creencias, mitos y valores culturales heredados de generación en generación, lo que muestra patrones de cuidado cultural. Este aspecto debe ser identificado por enfermería para ofrecer cuidados que sean culturalmente congruentes con esta población.

Principales marcadores bioquímicos que actúan como predictores de severidad en pacientes con preeclampsia severa en edades entre 18 y 26 años en el Hospital Niño Jesús de Barranquilla, 2014-2015

El objetivo de la presente investigación fue determinar cuáles de los principales marcadores bioquímicos que forman parte del perfil toxémico presentan mayor asociación con la preeclampsia severa en pacientes de edades entre 18 y 26 años en el Hospital Niño Jesús de Barranquilla en el periodo de diciembre de 2014 a mayo de 2015, es un estudio correlacional descriptivo retrospectivo; en este estudio se revisaron 120 historias clínicas de embarazadas que consultaron en ese Hospital, las cuales presentaron preeclampsia en el periodo antes mencionado, se clasificaron por grupos: Las que se mantuvieron con el diagnóstico de preeclampsia y las pacientes que terminaron en preeclampsia severa. Las variables analizadas fueron: edad, edad gestacional, presión arterial, factores de riesgo y el desarrollo de preeclampsia, resultados del perfil toxémico (creatinina, LDH, transaminasas, plaquetas, bilirrubina total, directa e indirecta, proteinuria al azar y en 24 horas). Los componentes del perfil toxémico que presentaron mayor relación con la preeclampsia severa fueron la LDH (OR 3,35 IC 95 % 0,41-26,84), Plaquetas (OR 0,17 IC 95 % 0,028-1,08) y la proteinuria al azar (OR 0,81 IC 95 % 0,16-4,04). Teniendo en cuenta las características generales de la población gestante estudiada con preeclampsia severa el promedio de edad de presentación fue de 21,6 años presentándose con mayor frecuencia en las pacientes con edades comprendidas entre 18 y 20 años, la mayoría de estas gestantes estaban en su primer embarazo (nulíparas) ; de igual forma la edad gestacional mediana de presentación fue de 36,5 semanas, con el mayor grupo afectado con edad gestacional entre 35 y 39,6 semanas de gestación, dando por finalizado el embarazo en su gran mayoría por vía quirúrgica (parto por cesárea). El factor de riesgo más frecuente fue el antecedente familiar de hipertensión arterial.

Low-grade gliomas: Review of 10 years

Abstract Introduction Central nervous system (CNS) tumours are the most common solid tumours in children. Among these, the low-grade gliomas are the most common type, accounting for up to 30–50% of them. Patients and methods A retrospective analysis was carried out on the epidemiology, clinical characteristics, tumour location, histology, treatment, outcome and long-term sequelae of 111 patients diagnosed with low-grade glioma in the Nino Jesus Children's Hospital of Madrid from January 2002 to December 2011. Results Of the 111 patients, there were 57 boys and 54 girls. The mean age was 7.26 years (range, 2 months–19 years). The most common symptoms of presentation were headache (27%) and vomiting (19%). The most common locations were the cerebral hemispheres (38%), followed by the brainstem (27.4%), and cerebellum (18.5%). Histological examination was performed in 89 patients (80.18%). Pilocytic astrocytoma was the most common histological type. Diagnostic biopsy was performed in 20 patients (22.5%), partial resection in 38 patients (42.7%), and total resection in 31 patients (34.8%). Sixteen patients received chemotherapy (14%), and eighteen patients received radiotherapy (16%). Overall survival was 88.3%. Long term hearing, visual and endocrine sequelae were noted in one, five, and four patients, respectively. Conclusions The most common histological type is pilocytic astrocytoma. Overall survival was 88.3%. Only 9% of patients had some kind or auditory, visual or endocrine sequelae.

Heating does not decrease immunogenicity of goat's and ewe's milk

URE 1. A, SDS-PAGE (A-1) and Western blot analysis (A-2) with u , and EM allergies and milk-tolerant negative control showed high an d (A-3). ALA, a-Lactalbumin; BLG, b-lactoglobulin; CC, cow’s che ecular weight; SA, serum albumin. extensive amino acid sequence identity of milk proteins (85%100%; see Tables E1 and E2 in this article’s Online Repository at www.jaci-inpractice.org) and similar proteome profiles that imply similarity of protein functions. However, selective GM and ewe’s milk (EM) allergy without CMA (GEMA) have been reported, including anaphylaxis to cheeses from GM and EM in CM-tolerant children. GEMA implies existence of unique GM and EM-allergenic epitopes that are different from CMallergenic epitopes. Among children with CMA, >70% can tolerate extensively heated CM in baked products. We sought to determine the effects of heating on the immunogenicity of GM and EM proteins in children with GEMA. We recruited 17 subjects with milk allergy from Spain, Greece, and the United States; 13 were males; median age was 7.2 years, and 25% to 75% interquartile range (IQR) was 4.0 to 9.9 years. The study was approved by the Institutional Review Boards at The Mount Sinai School of Medicine, Pediatric Hospital “P & A Kiriakou,” and Hospital Infantil Universitario Nino Jesus; informed consent was obtained from the subjects. Eight subjects with CM allergy tolerated extensively heated oral milk challenge but reacted to unheated milk challenge. Nine subjects had history of convincing, immediate allergic symptoms on ingestion of GM or EM or both (Table I). The 8

Diferencias entre los perfiles neuropsicológicos del síndrome de Asperger y del síndrome de dificultades de aprendizaje no verbal

The validity of the Asperger syndrome (AS) diagnose continues to be debated due to the lack of consensus on its definition, specially regarding higher-functioning autism. Previous research has suggested that the neuropsychological profile of the non verbal learning syndrome (NVLS) might be utilized to sustain a differential diagnose of the AS with other diseases associated with development. To analyze the neuropsychological profile of children diagnosed with AS and compare with those obtained from children with NVLS. All cognitive domains from 15 children have been evaluated with an extensive variety of tests; 5 were diagnosed with AS and 5 with NVLS, all of them submitted to the Nino Jesus Children's University Hospital. As a control group, another 5 children with no pathology were evaluated. Obtained data shows significant differences between the two groups under study. Profile from individuals under AS shows deficit in linguistic as well as non verbal skills and, when compared to the control group, executive functions seem to be generally more altered. Further investigation is suggested to determine that the NVLS could be an explanation model for AS. On the other hand, we stress the need to deepen the study of the executive functions and their relationship with the mind's theory, as an hypothesis to explain the AS.

Análisis del Concepto de Autogestión a la Luz de una Experiencia Comunitaria en el Barrio "Niño Jesús", Caracas, Venezuela

El objetivo del presente trabajo es revisar criticamente el concepto de autogestion propuesto por los principios basicos de la Psicologia Social Comunitaria latinoamericana. Para ello nos centraremos en algunos momentos del proceso comunitario realizado conjuntamente por personas de la comunidad de Nino Jesus e integrantes de la Asociacion Civil MAIZAL. Analizaremos aspectos concernientes a la definicion que hace la Psicologia Comunitaria acerca de los actores involucrados en la Investigacion Accion Participativa, cuestionando la separacion internos - externos y proponiendo una definicion contextual. situacional y difusa de tales actores. Concebiremos la autogestion como un proceso de p10duccion comunitaria en el que las personas involucradas se responsabilizan de manera individual en la construccion conjunta de un proyecto comunitario, con relativa independencia dentro del mismo grupo. Igualmente, las personas del grupo establecen relaciones con agentes definidos como extremos al proceso; en ellas hay cierta autonomia en la toma, ejecucion y evaluacion de las decisiones, permeada por relaciones dinamicas de igualdad y desigualdad en diferentes momentos y contextos.

Los cuidados de enfermería en la infancia: «el Hospital del Niño Jesús»

The historical scenario in which the Hospital Pediatrico del Nino Jesus was created is analyzed in the present paper, as well as the evolution undertaken in nursing attention to infants.

Spinal A-V Malformation in a Neonate

A newborn male infant with flaccid paraplegia, without contractures, deformities or atrophy, caused by an arteriovenous malformation (AVM) of the dorsal spinal cord, is reported from the Depts Neurosurgery and Pediatrics, Hospital Infantil Nino Jesus and Dept Neuroradiology, Hospital Infantil La Paz, Madrid, Spain.

Toxic Oil Syndrome

The article by Gilsanz et al 1 in this issue provides 12-month follow-up data on victims of the toxic oil syndrome. The tragic story begins in May 1981, when an outbreak of a previously unknown syndrome began to appear in the working-class suburbs of Madrid. 2 The initial clinical features of the syndrome were fever, respiratory distress, headaches, exanthem, pruritus, and myalgias. 2,3 Early deaths were attributed to respiratory insufficiency. Two cases of acute respiratory distress syndrome were recently reported. 4 On June 10, 1981, physicians at the Nino Jesus Children's Hospital, Madrid, determined the probable cause to be ingestion of an illegal cooking oil sold by door-to-door salesmen as an inexpensive substitute for olive oil. 3 By June 30, 1981, the authorities began to seize the bottles of unlabeled cooking oil, and new cases stopped appearing. Unfortunately, in the several months the oil was available, See also p 254.

News and Comment

<h3>UNITED STATES PUBLIC HEALTH SERVICE</h3> The weekly Public Health Reports of the United States Public Health Service now are available to all persons in the United States and its possessions, and in Canada, Cuba and Mexico, for the nominal subscription of $1.50 per year, it was announced in the current issue of the official bulletin of the Post Office Department. Subscriptions should be accompanied by money orders, and sent to the Superintendent of Documents, Government Printing Office, Washington, D. C. <h3>DEATH OF DR. ROLDAN</h3> D. Jacobo Banqueri Roldan, physician at the Hospital del Nino Jesus, Madrid, a distinguished Spanish pediatrician, died recently. <h3>ANOTHER ROENTGEN-RAY VICTIM</h3> Dr. Félix Lobligeois, for twenty years roentgenologist in the children's hospital, Bretonneau, Paris, is another victim of the roentgen rays. He lost the entire right arm following a series of partial amputations. The Croix d'Officier de la Légion d'Honneur and the Médaille de Fondation Bergonié