Niger Delta University Teaching Hospital Research Articles

Molecular Detection of Hepatits B Virus Genotypes in Tertiary Hospitals in Bayelsa State, Nigeria

In Africa, the Hepatitis B Virus (HBV) is considered endemic or even hyper-endemic. However, there is lack adequate comprehensive data regarding the genotypes of HBV and their distribution within Nigeria. This study seeks to identify the prevailing HBV genotypes among patients who sought medical care at the Federal Medical Center, Yenagoa and Niger Delta University Teaching Hospital Okolobiri, Bayelsa State, Nigeria. Between January and June 2022, 656 patients’ blood samples were collected from both hospitals for analysis, consisting of 475 females (72.4%) and 181 males (27.6%). The samples were tested for Hepatitis B surface antigen (HBsAg) and genotyping using immunochromatography and multiplex Polymerase Chain Reaction (PCR) techniques with type-specific primers. Among the 656 patients screened for HBsAg, 66 individuals (10%), comprising 36 females (5.4%) and 30 males (4.6%), tested positive using immunochromatography. These positive cases underwent molecular genotyping using specific primers for genotypes A, B, C, D, E, and F. Of these, 33 (50%) exhibited strong or active positivity. In comparison, the remaining 50% displayed passive positivity due to viral degradation, as HBV is a non-enveloped virus. The results further revealed that HBV genotypes E and B were the predominant types, with a prevalence of 82.4% and 11.8%, respectively, in the study area. Interestingly, the observation showed that co-infections involving HBV/B and HBV/E had a majority of 5.9% and were detected among two female patients aged 26 and 25. It is noteworthy that in the study area and its environs, healthcare providers commonly prescribe tenofovir, a nucleotide analog drug. Previous research by various authors has indicated that HBV genotype E is more responsive to nucleotide analogs, while HBV genotype B responds better to interferon-based therapies. In conclusion, this study highlights the prevalence of HBV genotypes B, E, and B+E coinfection in Yenagoa within the Niger Delta region of Nigeria. This knowledge underscores the importance of healthcare providers accurately diagnosing HBV genotypes before prescribing treatment regimens, particularly considering combination therapy, to optimize the care of infected patients. This approach is vital for effectively managing HBV infections and improving patient outcomes.

Genetic Profiling of Pathogens Associated with Pyroxia of Unknown Origin Treated for Plasmodiasis in Bayelsa State, Nigeria

Antimicrobial resistance of Salmonella is an increasing problem and has become a public health issue worldwide. Moreover the evidences on hazard of therapeutic failure due to the increasing incidence of antimicrobial resistance among typhoidal antibodies and malaria are on the increase. This study was aimed at the genetic profiling of pathogens associated with Pyroxia of unknown origin treated for Plasmodiasis in Bayelsa State, Nigeria. A total of 1200 samples (200 Stool and 1000 blood) were collected from consented subjects in Federal Medical Center and Niger Delta University Teaching Hospital Bayelsa State, Nigeria. Blood samples were used for detection of Malaria parasites and Typhoidal antibodies while the stool samples were used for culturing on Salmonella-Shigella Agar. Antibiotic sensitivity of the pure isolates were carried out using sensitivity disc, biochemical analysis using API 20E was carried out to actually differentiate bacterial from each isolates and finally by genetic profiling of the resistant genes of the pure isolates using polymerase chain reaction. Antibiogram of the isolates showed high resistance to Oxacillin (73.6 %), Ampicillin (66.6%), Tetracycline (60.0%), and Erythromycin (53.3%) while Gentamycin, 22(73.3%), Chloramphenicol 18(60%) and Azithromycin 18(60%) had the highest sensitivity. The distribution of resistant genes from the genetic profiling showed that out of 20 amplified isolates, NDM resistant genes were 17(85%) followed by Bla TEM genes 14(70%) followed by CTXM and SHV genes as 11(55%) and 10(50%) respectively. The bacterial isolates showed high AMR and MDR to the commonly used antimicrobial drugs and the distribution of ESBL genes revealed a high level of resistant genes in Bayelsa State.

The Carriage of Methicillin-Resistant Staphylococcus aureus amongst Pregnant Women Attending Antenatal Clinic at a Tertiary Hospital, South-South Nigeria

Pregnant mothers are exposed to several infections because of their reduced immunity. Infections caused by Staphylococcus aureus among postpartum women and babies are increasing, and a rise in methicillin-resistant Staphylococcus aureus may have fueled this increase. The study was designed to investigate the carriage and resistance pattern of Methicillin-resistant Staphylococcus aureus among pregnant women attending the ante-natal clinic at the Niger Delta University Teaching Hospital, Okolobiri. Fifty urine samples were screened for Staphylococcus aureus on mannitol salt agar. Positive samples were then subjected to antibiotic sensitivity testing using the disc diffusion method, and resistance to Ceftriaxone was considered methicillin resistance. Results showed that 20 (40%) of the urine samples yielded growth of Staphylococcus aureus, 11 (73%) were resistant to Ceftriaxone, and over 70% of the MRSA isolates were multi-drug resistant. Methicillin-resistant Staphylococcus aureus colonisation in pregnant women has dire consequences, and a surveillance system for antimicrobial resistance surveillance system is recommended.

Assessment of OqxA and OqxB Resistance Genes in Escherichia coli and Klebsiella pnuemoniae Clinical Isolates Based on Polymerase Chain Reaction from Niger Delta University Teaching Hospital, Yenagoa, Bayelsa State

Antimicrobial resistance continues to pose serious public health challenges. OqxA and OqxB are multidrug resistance genes that confer Escherichia coli and Klebsiella pneumoniae resistance to more than one antibiotics. The purpose of this study was to detect OqxA in Escherichia coli and OqxB in Klebsiella pneumoniae from clinical samples isolated from Niger Delta University, Yenagoa. A total of 50 samples were collected. The bacterial isolates were identified using a standard bacteriological technique, the genes were detected using Polymerase Chain Reaction while the antibiotic susceptibility testing was done by disc diffusion. Of the 50 clinical isolates, 9(18%) were positive for E. coli while 15(30%) were positive for Klebsiella pnuemoniae. The total number of isolates were 18(36%) from male and 32(64%) from females. The susceptibility pattern of the isolates revealed that Escherichia coli exhibited the highest resistance of 100% to Cefuroxime and Augmentin, followed by Gentamycin and Ofloxacin (.55%) and Ciprofloxacin (11.11%) while Klebsiella pneumoniae Nalidixic Acid, Augmentin Cephalexin and Sulfamethoxazole shows 100% resistance respectively. Of the 9 that were E.coli isolates, 8(88.9%) harboured OqX A while of the 15 that were Klebsiella pneumoniae isolates, 13 (86.7%) harboured the OqxB genes. There was 100% resistance to Nalidixic acid, cefuroxime and sulfamethoxazole, with lowest resitance to meropenem (46.7%) and ciprofloxacin (60%). The report clearly demonstrates an urgent need for surveillance against these bacteria especially as they are pathogens of public health concerns to minimize the increasing pace of multidrug resistance conferred on these bacteria by OxAB genes.

Molecular Detection of PapC and hlyA Virulence Genes in Escherichia coli from Clinical Isolates in Bayelsa State, Nigeria

Escherichia coli, a Gram-negative rod organism and the commonest urinary pathogen causing 60-90% of Urinary infections. Two virulence genes (Pap C and hlyA) had been reported to be involved in Escherichia coli pathogenicity and its resistance to antibiotics. The study aimed at detecting PapC and hlyA in E. coli isolated from clinical specimens in two main Tertiary hospitals (Federal Medical Centre and Niger Delta University Teaching Hospital) in Bayelsa State. One hundred and forty-five specimens were collected and analyzed using the standard Bacteriological technique. Antibiotics Susceptibility testing was carried out using the Kirby Bauer method and Polymerase Chain Reaction (PCR) was employed using ABI 970 amplified Biosystem thermal cycler. The susceptibility pattern showed that 18(90%) isolates were resistant to Nalixidic acid, 16(80%) to Ampicillin, 15(75%) to Ceporex, 14(70%) to Septrin and Augmentin, 12(60%) to Reflacine, 11(55%) to Ciprofloxacin, 9(45%) to Gentamycin, 8(40%) to Tarivid and 4(20%) to Streptomycin. Fifteen PCR products were resolved on 1.0% agarose gel, out of which 8(53.3%) harboured Pap C while 1(6.7%) harboured hlyA. Seven of the eight Pap C-carrying isolates were susceptible to Ciprofloxacin while the HlyA virulence gene enhances the resistance of the organism to Ciprofloxacin. Therefore, the E. coli Pap C gene may be incorporated into Ciprofloxacin production to curb antibiotic resistance.

The Contribution of Respiratory Diseases to Mortality in Niger Delta University Teaching Hospital (NDUTH), Bayelsa State Nigeria

The Contribution of Respiratory Diseases to Mortality in Niger Delta University Teaching Hospital (NDUTH), Bayelsa State Nigeria

Factors Influencing Work-Life Balance and the Challenges on the Mental Health of Nurses in Niger Delta University Teaching Hospital, Okolobiri Bayelsa State, Nigeria.

This study assessed the factors influencing the work-life balance of Nurses and the challenges to their mental health in Niger Delta University Teaching Hospital, (NDUTH) Okolobiri, Yenagoa, Bayelsa State, Nigeria. This study adopted a descriptive research design. The study objectives were: to identify the factors influencing work-life balance among nurses in NDUTH; and to assess the challenges of work-life balance on the mental health of nurses in NDUTH. A simple random sampling technique was used to select a total of 96 participants which was used accordingly in the study. Data was collected using self-structured questionnaires which were distributed by the researchers, after which questionnaires were retrieved from participants, and data was recorded. Data were analyzed using SPSS version 25 and analyzed data was presented in frequency, percentages, and tables. The study findings show the following factors were found to be influencing the nurses’ mental health in this setting; Social, health-related issues, nurses’ roles, and managerial factors. However, the majority of the nurses in NDUTH were able to identify the factors influencing on the work-life balance of nurses, and the effects and challenges that work-life imbalance poses on their mental health. Furthermore, the majority of the nurses agreed with the appropriate measures that can be taken to enhance the work-life balance of nurses. Therefore, it was recommended that nurse managers and hospital administrators should focus on improving the quality of nurses’ work life in order to improve their professional commitment, subsequently retain qualified staff nurses and decrease turnover by designing programs to teach staff nurses how to cope with work and life stress.

Factors Influencing Work-Life Balance and the Challenges on the Mental Health of Nurses in Niger Delta University Teaching Hospital, Okolobiri Bayelsa State, Nigeria.

Factors Influencing Work-Life Balance and the Challenges on the Mental Health of Nurses in Niger Delta University Teaching Hospital, Okolobiri Bayelsa State, Nigeria.

Evaluation of cotrimoxazole use as prophylaxis among HIV/AIDs patients in Niger Delta University Teaching Hospital Okolobiri, Bayelsa State

Evaluation of cotrimoxazole use as prophylaxis among HIV/AIDs patients in Niger Delta University Teaching Hospital Okolobiri, Bayelsa State

Evaluation of cotrimoxazole use as prophylaxis among HIV/AIDs patients in Niger Delta University Teaching Hospital Okolobiri, Bayelsa State

Evaluation of cotrimoxazole use as prophylaxis among HIV/AIDs patients in Niger Delta University Teaching Hospital Okolobiri, Bayelsa State

Awareness, Willingness to Accept and Factors Influencing Covid-19 Vaccination Amongst Antenatal Attendees at a Nigerian Tertiary Hospital

COVID-19 infection can become severe in pregnancy. When fear enshrouds antenatal use of the vaccine, pregnant women and their unborn babies become at risk and at the same time act as the disease’s reservoirs. This study is aimed at determining the awareness, willingness to accept COVID- 19 vaccination among antenatal attendees as well as factors influencing COVID-19 vaccination at the Niger-Delta University Teaching Hospital, Okolobiri. The study was a descriptive cross sectional study. Three hundred and fifty pregnant women were interviewed after informed consent. The data acquired included the awareness and source of information on COVID-19 vaccine, its acceptance, reasons for vaccine hesitancy and side effects. Three hundred and thirty-eight pregnant women (96.6%) indicated awareness of the availability of the COVID-19 vaccine. Only 13 of the 350 pregnant women in this study had received the vaccine (3.7%). The television was the leading source of information about COVID-19 vaccines, (51.4%). The topmost reason for not been vaccinated was concern about the safety of the vaccines (39.2%). Age, religion, level of education and occupation were significantly associated with acceptance of COVID-19 vaccine. Eleven out of thirteen study subjects (84.6%) who have been vaccinated against COVID-19 had side effects. The commonest side effect of COVID-19 vaccination was malaise (84.6%). COVID-19 vaccine awareness in this study was optimal. However, its uptake in pregnancy was poor. Socio-demographic characteristics of antenatal attendees influences their use of COVID-19 vaccine. The COVID-19 vaccination side effects in pregnancy are mainly not life-threatening.

Clinical applicability of peak expiratory flow measured with peak flow metre compared to spirometer in a resource-limited setting

Background: Peak Expiratory Flow (PEF) is the maximum flow produced during a forced expiration following a full inspiration. It is useful in the management of lung diseases especially the domiciliary assessment of disease control in patients with Asthma. PEF can be measured with either a peak flow meter or a spirometer. We aimed at comparing PEF measured using a Mini Wright peak flow meter with PEF measured using Spirolab III spirometer in order to assess its clinical applicability in resource-limited settings.Method: A method-comparison study with records of PEF values at the Niger-Delta University Teaching Hospital, Okolobiri. Hypotheses were formulated and tested after data was analyzed using the IBM SPSS version 25 software.Results: PEF readings of a total of 100 adults were analyzed. Mean age was 48.90 ± 19.77 years. Males (51%) were slightly more than females (49%). One- sample t-test showed no statistical difference in the mean PEF values measured with the two devices (p = 0.295). There was significant correlation between the PEF values measured with the two devices (p<0.0001) with demonstration of agreement and absence of proportional bias in the PEF values measured by the two methods following linear regression analysis (p = 0.959).Conclusion: PEF values obtained from the Mini wright PEF meter and the Spirolab III spirometer are comparable. Therefore, the Mini Wright peakflow meter may be effectively used in the diagnosis and monitoring of Asthma and other lung diseases in resource-limited settings.

Sexual behaviours and clinical course of human monkeypox in Spain

Sexual behaviours and clinical course of human monkeypox in Spain

Comparison of paracetamol and diclofenac as prophylactic analgesics during hysterosalpingography in Bayelsa State, South-South Nigeria: a randomized controlled trial

<p><strong>Background: </strong>Hysterosalpingography is the investigative modality of choice for the evaluation of the uterine cavity, fallopian tubes, and adjacent peritoneal cavity. Objective<strong> </strong>were to compare the effectiveness of paracetamol and diclofenac in pain relief during hysterosalpingography.</p><p><strong>Methods: </strong>This trial was conducted at the radiology departments and infertility clinics of the Federal Medical Centre, Yenagoa, and Niger Delta University Teaching Hospital, Okolobiri, both in Bayelsa State, Nigeria, from June 2021-March, 2022, and 380 infertile women undergoing hysterosalpingography were equally randomised into two groups. Group I received paracetamol, while group II received diclofenac prior to the procedure. Data were analysed using statistical product and service solutions for Windows® version 25. Student’s t-test was used to compare sample means, and the Chi-square test was used to compare the proportions.</p><p><strong>Results: </strong>The women experienced the least pain during insertion of speculum, with an overall mean pain score at this step of 0.8±0.9, while the most painful step was instillation of contrast, the overall mean pain score at this step being 4.3±1.9. While 38, 20.0%, women in the paracetamol group expressed severe pain during contrast instillation, only 14, 7.4%, women in the diclofenac group expressed severe pain at this step, and this was statistically significant (ꭓ<sup>2</sup>=22.05; p=0.001). The mean pain scores at all steps of the procedure were significantly higher in the paracetamol group than in the diclofenac group (p≤0.005).</p><p><strong>Conclusions: </strong>Compared to paracetamol, diclofenac is a more effective analgesic for pain relief during hysterosalpingography.</p>

Alterations in Some Coagulation Factors (F VII and F XII), PT, APTT and D-Dimer) in Newly Infected Tuberculosis Patients from South-Southern Nigeria

Tuberculosis (TB) is a major health concern as well as leading infectious killer disease in man caused by the bacterium Mycobacterium tuberculosis. This study was carried out to assess the effect of tuberculosis on some specific coagulation factors (F VII and F XII), PT, APTT and D-Dimer). It wias caried out at the Tuberculosis and Leprosy Hospital Igbogene, the Federal Medical Center (FMCY) and Niger Delta University Teaching Hospital (NDUTH) all in Yenagoa Local Govt Area of Bayelsa state, Nigeria. Ethical approval and participant’s informed consent were obtained. Fifty (50) newly diagnosed TB subjects and 50 apparently healthy control subjects participated in this study. Specimens used were Sputum and blood. PT was assayed by the Quick one stage method. Fortress diagnostics reagents were used for the APTT assay while D-Dimer was tested by the sandwish immunodetection method by ICHROMAX. The data gathered from this research were analyzed using SPSS statistical software version 20.0. The results for the haemostatic parametres shows significantly higher (p<0.05) PT, APTT, and D-Dimer values, but significantly lower (p<0.05) F VII in newly diagnosed TB subjects when compared to controls group. There was no significant difference (P>0.05) in F XII in newly diagnosed TB subjects when compared to the controls. The results from this research indicates that Tuberculosis disease greatly altered almost all the, haemostatic, parameters studied, except coagulation factor XII that was virtualy unaltered.

Effectiveness of paracervical block for pain relief in women undergoing hysterosalpingography in Bayelsa State, South-South Nigeria: a randomized control trial

<p><strong>Background: </strong>One of the major short comings of hysterosalpingography is discomfort and/or pain for the patient during or after the investigative modality; and this is a major cause of anxiety for many patients.<strong> </strong>Objectives were to compare the effectiveness of paracervical block with 2% lignocaine and placebo in pain reduction when undergoing hysterosalpingography.<strong></strong></p><p><strong>Methods: </strong>This randomised control trial was conducted at the radiology departments and infertility clinics of the Federal Medical Centre, Yenagoa and Niger Delta University Teaching Hospital, Okolobiri, both in Bayelsa State, Nigeria, from July 2021-February 2022. Three hundred and eighty infertile women undergoing hysterosalpingography were assigned into two groups. Women in group I received paracervical block, while the women in group II received placebo. Data were analysed using statistical product and service solutions for windows® version 25. Results were presented in frequencies and percentages for categorical variables; mean and standard deviation for continuous variables. Student’s t-test was used to compare sample means; and Chi-square for associations.<strong></strong></p><p><strong>Results: </strong>The mean pain score ± SD for group I was 3.8±2.6, while that in group II was 6.2±2.2. The difference between the means was statistically significant (t=9.77; p=0.001). While 140 (73.7%) women experienced moderate pain in group II, 70 (36.8%) women in Group I experienced moderate pain.<strong></strong></p><p><strong>Conclusions: </strong>Our study revealed that paracervical block improved the overall pain score of women undergoing hysterosalpingography, although a significant proportion of the women expressed some pain during instillation of contrast media.</p><p> </p>

Effect of paracetamol as a prophylactic analgesic in infertile women undergoing hysterosalpingography in Bayelsa State, South-South Nigeria: a randomised controlled trial

<p><strong>Background: </strong>Hysterosalpingography is the primary investigative modality of choice for the evaluation of the uterine cavity, fallopian tubes, and adjacent peritoneal cavity. Objective were to compare the effectiveness of paracetamol and placebo in pain reduction during hysterosalpingography.</p><p><strong>Methods: </strong>This randomised controlled trial was conducted at the radiology departments and infertility clinics of the Federal Medical Centre, Yenagoa and Niger Delta University Teaching Hospital, Okolobiri, both in Bayelsa State, Nigeria, from February, 2021-July, 2021. Three hundred and eighty infertile women were assigned into two groups. Women in group I received paracetamol, while the women in group II received placebo. Data were analysed using statistical product and service solutions for Windows<sup>®</sup> version 25. Student’s t-test was used to compare sample means; and the Chi-square test was used to compare the proportion of women who expressed pain at the different steps of the procedure.</p><p><strong>Results: </strong>Pain ratings among women in the placebo group were higher than those of women in the paracetamol group at all the stages of the procedure. The highest pain scores were recorded during the instillation of contrast media in both study groups, but higher in patients in the placebo group.<strong></strong></p><p><strong>Conclusions: </strong>Our study revealed that paracetamol was superior to placebo in the control of hysterosalpingography-associated pain. However, pain scores high in the 2 groups during instillation of contrast media into uterine cavity.</p><p> </p>

Predictive Factors for the Severity of Procedure-Associated Pain in Infertile Women Undergoing Hysterosalpingography in Bayelsa State, South-South Nigeria

Background: Hysterosalpingography is the most commonly used investigative modality for the evaluation of tubal patency. It is cheap, readily available and reliable. However, its main drawback is associated pain.
 Objective: To determine the predictive factors for the severity of procedure-associated pain in infertile women undergoing hysterosalpingography.
 Materials and Methods: This prospective, descriptive, cross-sectional study was conducted at the infertility clinics and radiology departments of the Federal Medical Centre, Yenagoa and Niger Delta University Teaching Hospital, Okolobiri, both in Bayelsa State, Nigeria, between July, 2021 and February, 2022. Hysterosalpingography was done after written informed consent by the patient. The Visual Analogue Scale and Numerical Rating Scale were used to grade pain levels during and after the procedure, respectively. Data were analysed using Statistical Product and Service Solutions for Windows®, version 25. Results were presented in frequencies and percentages for categorical variables, and mean and standard deviation for continuous variables. Student’s t-test was used to compare sample means, and Chi-square, for testing associations.
 Results: The odds of experiencing pain increased with increasing age (Crude OR = 3.48 – 5.34; p = < 0.05). Women with tertiary level of education were three times more likely to report pain (Crude OR = 3.58; p = 0.029) than those with primary level of education. Parity (ꭓ2 = 19.85; p – 0.001), type of infertility (ꭓ2 = 5.93; p = 0.015) and duration of infertility (ꭓ2 = 11.08; p = 0.004) had significant relationships with the severity of pain perception. Dysmenorrhoea (Crude OR = 1.99; p = 0.001) was also significantly associated with pain perception. Pain was two times more likely to be experienced by women with abnormal hysterosalpingography findings.
 Conclusion: Our study established that the predictors of pain perception in hysterosalpingography were age, level of education, duration of marriage, duration of infertility, parity, number of children, type of infertility, dysmenorrhoea and abnormal findings on hysterosalpingography.

Effect of diclofenac as a prophylactic analgesic during hysterosalpingography in Bayelsa State, South-South Nigeria: A randomized controlled trial

Background: Pain is the most frequent side effect of hysterosalpingography, with up to 72% – 80% of women reporting varying degrees of pain during and after the procedure. Objective: To evaluate the efficacy of diclofenac for pain relief in infertile women undergoing hysterosalpingography. Materials and Methods: This randomised controlled trial was conducted at the Radiology Departments and Infertility Clinics of the Federal Medical Centre, Yenagoa, and Niger Delta University Teaching Hospital, Okolobiri, both in Bayelsa State, Nigeria, from July 2021 – March, 2022. Three hundred and eighty infertile women undergoing hysterosalpingography were randomised into two groups. Women in Group I were administered diclofenac, while the women in Group II received placebo, prior to the procedure. Pain scores at different steps of the procedure were recorded using the Visual Analog and Numerical Rating Scales. Data were analysed using the Statistical Product and Service Solutions for Windows®, version 25. Student’s t-test was used to compare sample means, while the chi-square test was used to compare the proportion of women in the two study groups, who expressed pain at the different steps of the procedure. Results: Insertion of speculum was the step associated with the least pain during the procedure, the mean pain score at this step being 1.14 ± 1.25. Instillation of contrast media had the highest mean pain score of 4.72 ± 2.13. The pain scores at all steps of the procedure, 30 minutes and 24 hours after the procedure, were significantly lower in the diclofenac group compared to the placebo group (p=0.001).Conclusion: Diclofenac is superior to placebo for the control of hysterosalpingography-associated pain.

Mental health well -being of Frontline Health Care Professionals (FHCP) managing Covid-19 cases in two selected tertiary hospitals in Bayelsa and Edo States, Nigeria

This study investigated the mental health well-being of frontline health care professionals managing COVID-19 cases in two selected tertiary hospitals in Bayelsa and Edo States. The descriptive analytical survey design was adopted. The population of this study comprises of all health care professionals managing COVID -19 cases in Bayelsa and Edo States. The purposive sampling technique was utilized to sample 181 respondents made up of 39 from Niger Delta University Teaching Hospital (NDUTH) Okolobiri, Bayelsa and 142 from Irrua Specialist Hospital, Edo State. The instrument for data collection is a questionnaire titled “Warwick-Edinburgh Mental Well-being Scale (WEMWBS) and New Well-being Measure Tools adapted by the researchers”. The responses were structured into Likert four-point scale of Every time (ET), Often (O), Rarely (R) and Never (N). The instrument was validated by the researchers and other experts. The reliability of the instrument was ascertained using the Cronbach alpha statistic to obtain a reliability coefficient of 0.87. One research question was raised and three hypotheses formulated to guide the direction of this study. The ethical clearance was obtained from relevant authorities. The data collected were analyzed using descriptive statistics of mean, standard deviation, bar chart and inferential statistics of t-test, and One-way analysis of variance. The study found among others that participants in Bayelsa and Edo States have a negative mental health well-being in managing COVID 19 cases. It was concluded amongst others the need for training and re-training of health care professionals, incentives and allowances be given to health care professionals, etc.