Many farming households in Nigeria are deprived, and poor, hence, the need for economic empowerment intervention. Sweetpotato production, due to its short cycle and low input requirement could be projected on a larger scale for farming households’ economic empowerment. However, data regarding ability of sweetpotato farming for farming households’ economic empowerment is scarce. Therefore, farming households’ sweetpotato production and economic empowerment in Nigeria’s Niger-Delta Area was investigated. 364 sweetpotato farming households were chosen through a five-stage sample process. Descriptive statistics, Pearson Product Moment Correlation, T-test, and multiple regression were used to analyze the data that interview schedule was used to collect. Most respondents were female and aged 42.7±11.9 years. Farm size; farming experience; and income from sweetpotato, other crops, and non-crop livelihood activities were 2.6±3.4 hectares; 17.2±12.4 years; and ₦1,327,723.0±1,639,414.0 yearly, ₦2,385,815.0±2,615,273.0 yearly, and ₦1,828,004.0±2,336,270.0 yearly, respectively. The sweetpotato production and economic empowerment were low and high amongst farming households, respectively. Age, farm size and income from sweet potato were significantly related to economic empowerment. The economic empowerment status of high and low sweetpotato producers differed significantly. Between farming households with low and high income from sweetpotato production, their economic empowerment status significantly differed. Farming households’ economic empowerment was mostly predicted by farming experience; and income from sweetpotato, and non-crop livelihood activities. Sweetpotato production influenced farming households' ability to prosper economically. Agricultural policies oriented towards improving economic empowerment should be promoted to emphasize increased sweetpotato production.