s1 May 1967Nicotine Mediated Release of Myocardial Cell and Lysosomal Enzymes.Norman Brachfeld, M.D., F.A.C.P., Peter Kuehn, M.D., Masaka Kawade, M.D., Erdogan Oran, M.D.Norman Brachfeld, M.D., F.A.C.P.Search for more papers by this author, Peter Kuehn, M.D.Search for more papers by this author, Masaka Kawade, M.D.Search for more papers by this author, Erdogan Oran, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-66-5-1034_1 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptMechanisms responsible for the documented cardiotoxicity of nicotine are unknown and are complicated by the diverse effects of this complex agent. It has been shown to release catecholamines from ganglia and from stores and to stimulate release of antidiuretic hormone. In the brain, nicotine toxicity may be expressed as an interference with cellular respiratory metabolism. Experiments were designed to dissect its diffuse activity and to evaluate its primary hemodynamic and cardiometabolic actions at low and elevated dose levels on the isolated, perfused, beating rat heart. Effects on lysosomal, mitochondrial, and supernatant enzyme systems of the myocardium were studied. There was... This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: New York, New York PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics 1 May 1967Volume 66, Issue 5Page: 1034-1034KeywordsAntidiuretic hormoneBrainCatecholaminesEnzymesGangliaHeartHemodynamicsMyocardiumNicotineToxicity Issue Published: 1 May 1967 PDF DownloadLoading ...