This article addresses the issues of next-generation CDMA technologies for B3G wireless communications. To engineer a CDMA system whose performance will no longer be interference-limited, many challenging issues should be tackled, such as novel CDMA code sets, efficient spreading and carrier modulation schemes, and signaling format for high-speed burst traffic. This article reviews our ongoing research on next-generation CDMA technologies. In particular, we propose a new CDMA code design methodology, real environment adapted linearization (REAL), which can generate CDMA code sets with inherent immunity against multipath interference and multiple access interference for both uplink and downlink transmissions. It is also shown that interference-free CDMA can only be implemented with the help of orthogonal complementary codes. The article goes further to reveal that cell-wise capacity for such interference-free CDMA is equal to the number of element codes assigned to each user, making OFDM a natural choice to implement interference-free CDMA. Several other issues of OCC-CDMA, such as its system implementation and performance, are also addressed in this article.