Newton Centre Research Articles

Shock Management Without Formal Fluid Responsiveness Assessment: A Retrospective Analysis of Fluid Responsiveness and Its Outcomes.

In order to quantify fluid administration and evaluate the clinical consequences of conservative fluid management without hemodynamic monitoring in undifferentiated shock, we analyzed previously collected data from a study of carotid Doppler monitoring as a predictor of fluid responsiveness (FR). This study was a retrospective analysis of data collected from a single tertiary academic center from a previous study. Seventy-four patients were included for post-hoc analysis, and 52 of them were identified as fluid responsive (cardiac output increase > 10% with passive leg raise) according to NICOMTM bioreactance monitoring (Cheetah Medical, Newton Center, MA, USA). Treating teams provided standard of care conservative fluid resuscitation but were blinded to independently performed FR testing results. Outcomes were compared between fluid responsive and fluid non-responsive patients. Primary outcome measures were volume fluids administered and net fluid balance 24- and 72-hour post-FR assessment. Secondary outcome measures included change in vasopressor requirements, mean peak lactate levels, length of hospital/intensive care unit stay, acute respiratory failure, hemodialysis requirement, and durations of vasopressors and mechanical ventilation. Mean fluids administered within 72 hours were similar between fluid non-responsive and fluid responsive patients (139 mL/kg [95% confidence interval [CI]: 102.00-175.00] vs.136 mL/kg [95% CI: 113.00-158.00], p = 0.92, respectively). We observed an insignificant trend toward higher 28-day mortality among fluid non-responsive patients (36% vs.19%, p = 0.14). Volume of fluids administered significantly correlated with adverse outcomes such as increased hemodialysis requirements (32 patients, 43%), (odds ratio [OR] = 1.7200, p = 0.0018). Subgroup analysis suggested administering ≥ 30 mL/kg fluids to fluid responsive patients had a trend toward increased mortality (25% vs.0%, p = 0.09) and a significant increase in hemodialysis (55% vs.17%, p = 0.024). Without formal FR assessment, similar amounts of total fluids were administered in both fluid responsive and non-responsive patients. As greater volumes of intravenous fluids administered were associated with adverse outcomes, we suggest that dedicated FR assessment may be a beneficial utility in early shock resuscitation.

Commentary: A Scoping Review of Burnout in Neurosurgery.

Commentary: A Scoping Review of Burnout in Neurosurgery T Forcht Dagi, MD, DMedSc, DHC, FRCSEd T Forcht Dagi, MD, DMedSc, DHC, FRCSEd Correspondence: T. Forcht Dagi, MD, DMedSc, DHC, FRCSEd, Queen's University Belfast and the William J. Clinton Leadership Institute, 423 Commonwealth Avenue, Newton Centre, MA 02459, USA. Email: tfdagi@gmail.com https://orcid.org/0000-0002-0344-1384 Search for other works by this author on: Oxford Academic Google Scholar Neurosurgery, Volume 88, Issue 5, May 2021, Pages E379–E380, https://doi.org/10.1093/neuros/nyaa575 Published: 27 January 2021 Article history Received: 12 November 2020 Accepted: 15 November 2020 Published: 27 January 2021

Precision and consistency of the passive leg raising maneuver for determining fluid responsiveness with bioreactance non-invasive cardiac output monitoring in critically ill patients and healthy volunteers.

ObjectiveThe passive leg raising (PLR) maneuver has become standard practice in fluid resuscitation. We aim to investigate the precision and consistency of the PLR for determining fluid responsiveness in critically ill patients and healthy volunteers using bioreactance non-invasive cardiac output monitoring (NiCOM™, Cheetah Medical, Inc., Newton Center, Massachusetts, USA).MethodsThis study is prospective, single-center, observational cohort with repeated measures in critically ill patients admitted to the medical intensive care unit and healthy volunteers at a tertiary academic medical center. Three cycles of PLR were performed, each at 20–30 minutes apart. Fluid responsiveness was defined as a change in stroke volume index (ΔSVI) > 10% with each PLR as determined by NiCOM™. Precision was the variability in ΔSVI after the 3 PLR’s, and determined by range, average deviation and standard deviation. Consistency was the same fluid responsiveness determination of “Yes” (ΔSVI > 10%) or “No” (ΔSVI ≤ 10%) for all 3 PLR’s.ResultsSeventy-five patients and 25 volunteers were enrolled. In patients, the precision was range of 17.2±13.3%, average deviation 6.5±4.0% and standard deviation 9.0±5.2%; and for volunteers, 17.4±10.3%, 6.6±3.8% and 9.0±6.7%, respectively. There was no statistical difference in the precision measurements between patients and volunteers. Forty-nine (65.3%) patients vs. twenty-four (96.0%) volunteers had consistent results, p < 0.01. Among those with consistent results, twenty-four (49.0%) patients and 24 (100%) volunteers were fluid responsive.ConclusionsThe precision and consistency of determining ΔSVI with NiCOM™ after PLR may have clinical implication if ΔSVI > 10% is the absolute cutoff to determine fluid responsiveness.

Ultrasound Assessment of the Change in Carotid Corrected Flow Time in Fluid Responsiveness in Undifferentiated Shock.

Adequate assessment of fluid responsiveness in shock necessitates correct interpretation of hemodynamic changes induced by preload challenge. This study evaluates the accuracy of point-of-care Doppler ultrasound assessment of the change in carotid corrected flow time induced by a passive leg raise maneuver as a predictor of fluid responsiveness. Noninvasive cardiac output monitoring (NICOM, Cheetah Medical, Newton Center, MA) system based on a bioreactance method was used. Prospective, noninterventional study. ICU at a large academic center. Patients with new, undifferentiated shock, and vasopressor requirements despite fluid resuscitation were included. Patients with significant cardiac disease and conditions that precluded adequate passive leg raising were excluded. Carotid corrected flow time was measured via ultrasound before and after a passive leg raise maneuver. Predicted fluid responsiveness was defined as greater than 10% increase in stroke volume on noninvasive cardiac output monitoring following passive leg raise. Images and measurements were reanalyzed by a second, blinded physician. The accuracy of change in carotid corrected flow time to predict fluid responsiveness was evaluated using receiver operating characteristic analysis. Seventy-seven subjects were enrolled with 54 (70.1%) classified as fluid responders by noninvasive cardiac output monitoring. The average change in carotid corrected flow time after passive leg raise for fluid responders was 14.1 ± 18.7 ms versus -4.0 ± 8 ms for nonresponders (p < 0.001). Receiver operating characteristic analysis demonstrated that change in carotid corrected flow time is an accurate predictor of fluid responsiveness status (area under the curve, 0.88; 95% CI, 0.80-0.96) and a 7 ms increase in carotid corrected flow time post passive leg raise was shown to have a 97% positive predictive value and 82% accuracy in detecting fluid responsiveness using noninvasive cardiac output monitoring as a reference standard. Mechanical ventilation, respiratory rate, and high positive end-expiratory pressure had no significant impact on test performance. Post hoc blinded evaluation of bedside acquired measurements demonstrated agreement between evaluators. Change in carotid corrected flow time can predict fluid responsiveness status after a passive leg raise maneuver. Using point-of-care ultrasound to assess change in carotid corrected flow time is an acceptable and reproducible method for noninvasive identification of fluid responsiveness in critically ill patients with undifferentiated shock.

Market and Regional Segmentation and Risk Premia in the First Era of Financial Globalization

Chambers acknowledges financial support from his Keynes Fellowship, the Newton Centre for Endowment Asset Management and the Cambridge Endowment for Research in Finance, Sarkissian acknowledges financial support from the Social Sciences & Humanities Research Council of Canada, and Schill acknowledges financial support from the Darden School Foundation.

Therapeutic Targeting of Nuclear Export Inhibition in Lung Cancer

Intracellular compartmentalization and trafficking of molecules plays a critical role in complex and essential cellular processes. In lung cancer and other malignancies, aberrant nucleocytoplasmic transport of tumor suppressor proteins and cell cycle regulators results in tumorigenesis and inactivation of apoptosis. Pharmacologic agents targeting this process, termed selective inhibitors of nuclear export (SINE), have demonstrated antitumor efficacy in preclinical models and human clinical trials. Exportin-1 (XPO1), which serves as the sole exporter of several tumor suppressor proteins and cell cycle regulators, including retinoblastoma, adenomatous polyposis coli, p53, p73, p21, p27, forkhead box O, signal transducer and activator of transcription 3, inhibitor of κB, topoisomerase II, and protease activated receptor 4—is the principal focus of development of SINE. The most extensively studied of the SINE to date, the exportin-1 inhibitor selinexor (KPT-330 [Karyopharm Therapeutics, Inc., Newton Centre, MA]), has demonstrated single-agent anticancer activity and synergistic effects in combination regimens against multiple cancer types, with principal toxicities of low-grade cytopenias and gastrointestinal effects. SINE may have particular relevance in KRAS-driven tumors, for which this treatment strategy demonstrates significant synthetic lethality. A multicenter phase 1/2 clinical trial of selinexor in previously treated advanced KRAS-mutant NSCLC is under way.

Acute Effects of an External Pneumatic Compression Device on Local and Systemic Resistance Vessel Reactivity and Limb Blood Flow

High pressure external pneumatic compression (e.g. EECP) has been shown to have marked benefits on vascular reactivity and biology. However it is expensive, uncomfortable, and not easily accessible. Alternatively, low pressure EPC is commercially available, does not require medical supervision, and is low risk.PurposeThe purpose of this study was to determine the acute effects of low pressure EPC on resting limb blood flow and resistance vessel reactivity in compressed and non‐compressed limbs of healthy young subjects.MethodsTen (n=10) apparently healthy subjects (aged 27.0 ± 10.2 years) were enrolled in this randomized, crossover design study. Subjects reported in the morning, fasted, for two visits separated by at least 24‐hours. Prior to and immediately following application of EPC or sham for 60 minutes, forearm (FBF) and calf blood flow (CBF) were evaluated at baseline and during 3 minutes of reactive hyperemia (RH) using venous occlusion plethysmography. A peristaltic pulse dynamic compression device was employed for EPC treatment with target inflation pressures of ~70 mmHg applied to the lower limbs.ResultsEPC significantly improved peak CBF, but no differences in resting FBF, peak FBF, resting CBF, total CBF and total FBF were observed. imageConclusionsEPC significantly improves acute resistance vascular reactivity in compressed limbs, but not non‐compressed limbs, following 60 minutes of treatment. Therefore, application of low pressure EPC may be efficacious in situations where local alterations of resistance vessel reactivity is desirable.Partial support for this study was provided by the Quinnipiac University Interdisciplinary Program for Research &amp; Scholarship and by NormaTec (Newton Centre, MA)

Relativistic quantum mechanics and relativistic entanglement in the rest-frame instant form of dynamics

A new formulation of relativistic quantum mechanics is proposed in the framework of the rest-frame instant form of dynamics, where the world-lines of the particles are parametrized in terms of the Fokker-Pryce center of inertia and of Wigner-covariant relative 3-coordinates inside the instantaneous Wigner 3-spaces, and where there is a decoupled (non-covariant and non-local) canonical relativistic center of mass. This approach: (a) allows us to make a consistent quantization in every inertial frame; (b) leads to a description of both bound and scattering states; (c) offers new insights on the relativistic localization problem; (d) leads to a non-relativistic limit with a Hamilton-Jacobi treatment of the Newton center of mass; (e) clarifies non-local aspects (spatial non-separability) of relativistic entanglement connected with Lorentz signature and not present in its non-relativistic treatment.

An Automated Sleep-Analysis System Operated through a Standard Hospital Monitor

Sleep disordered breathing (SDB), a cause of clinically important cardiovascular comorbidity, is often not recognized and diagnosed. An automated system that detects SDB using signals from a standard hospital monitor might provide useful information about the presence and severity of SDB without the need to evaluate the patient in a sleep laboratory and without additional hardware. The aim of this study was to examine the feasibility and accuracy of routine overnight sleep testing for SDB detection by an automated analysis system that operates by analyzing signals derived from standard hospital monitors. Comparison of SDB detection by simultaneous "gold-standard" polysomnography and by Morpheus Hx (WideMed, Ltd., Herzliya, Israel), a bedside computerized analysis system (CAS) connected to a standard hospital monitor (ECG, respiratory impedance, end-tidal carbon dioxide (ETCO2), and SpO2). A total of 53 subjects were examined, 36 men and 17 women, all with suspected SDB. Each subject underwent an overnight sleep study, scored both by polysomnography and by CAS. The study was conducted in Brigham and Women's Hospital, Newton Center, MA. CAS-derived values for apnea-hypopnea index and total sleep time, were each found to be highly correlated with the corresponding polysomnography results, with linear regression values of r = 0.96 and r = 0.82, respectively. Mean apnea-hypopnea index values were also quite similar (CAS of 15.5 +/- 20.0 vs polysomnography of 15.4 +/- 24.0). An automated sleep-analysis system utilizing signals derived from a standard hospital monitor can be considered as a feasible and accurate method to detect and quantify SDB.

A Working Theology of the New

Click to increase image sizeClick to decrease image size Notes Such as pedagogy; see for example, P. Garrigan et al., “Change in Two Academic Cultures,” in The Management of Independent Learning, eds. J. Taut and P. Knight (London: Cogan Page, 1996). This example is very close to our “Sung Morning Prayer: Songs and Hymns from the Americas” version, arranged by Patrick Evans. Many synopses of this basic pattern exist; this particular one is taken from The Book of Common Worship (PCUSA) (Louisville: Westminster John Knox Press, 1993). Such is the basic message of eco-feminist theologies; for a recent and thoroughgoing presentation of the sort of doctrine of creation I am relying upon, see J. Morales, El ministerial de la creation (Pamplona: Ediciones Universidad de Navarra, 1994). See, for example, John L. Bell, The Singing Thing: A Case for Congregational Song (Glasgow: Wild Goose Publications, 2000). See, for example, Acts 5:20 or Romans 6:4. See, for example, Don Saliers, Worship as Theology: Foretaste of Glory Divine (Nashville: Abingdon Press, 1994); L. A. Hoffman, The Art of Public Prayer: Not for Clergy Only (Washington, D.C.: Pastoral Press, 1988); The Constitution on the Sacred Liturgy (Sacrosanctum concilium) of the Second Vatican Council (promulgated December 4, 1963), re: participation, from Protestant, Jewish, and R.C. points of view respectively. I developed these ideas in “Worship as the Life of God—and Why Participation Matters,” the keynote address for Andover Newton's 2006 Institute of Worship and the Arts (June 2006. Newton Centre, Massachusetts: Andover Newton Theological School). For more on intersubjectivity see Siobhán Garrigan, Beyond Ritual: Sacramental Theology after Habermas (Abingdon: Ashgate Press, 2004). For a recent and broad-ranging discussion of language-formation and worship, see Graham Hughes, Worship as Meaning: A Liturgical Theology for Late Modernity (Cambridge, UK; New York: Cambridge University Press, 2003). See, for example, Leanne McCall Tigert and Maren C. Tirabasi, Transgendering Faith: Identity, Sexuality and Spirituality (Cleveland: The Pilgrim Press, 2004). One study that proposes such fluidity as the new norm for some is Susan Ross's description of Roman Catholic women and their various ritual outlets. Susan Ross, Extravagant Affections: A Feminist Sacramental Theology (New York: Continuum, 1998). See, for example, Ronald L. Grimes, Reading, Writing, and Ritualizing: Ritual in Fictive, Liturgical and Public Places (Washington, D.C.: The Pastoral Press, 1993), throughout, but especially p. 53. See for example, Brian McLaren, A Generous Orthodoxy (London: Zondervan, 2006), 214: “I believe that we must always be reforming, not because we've got it wrong and we're closer and closer to finally getting it right, but because our mission is ongoing and our context is dynamic.”

The Promise and Politics of Stem Cell Research. By Pam Solo and , Gail Pressberg; Foreword by Mary Tyler Moore. Praeger Publishers. Published by Greenwood Publishing Group, Westport (Connecticut), in cooperation with the Civil Society Institute, Newton Centre (Massachusetts). $39.95. xvii + 171 p; ill.; index. ISBN: 0‐275‐99038‐9. 2007.

<i>The Promise and Politics of Stem Cell Research.</i> <i>By </i>Pam Solo<i> and </i>, Gail Pressberg<i>; Foreword by Mary Tyler Moore. Praeger Publishers. Published by Greenwood Publishing Group, Westport (Connecticut), in cooperation with the Civil Society Institute, Newton Centre (Massachusetts).</i> $39.95. xvii + 171 p; ill.; index. ISBN: 0‐275‐99038‐9. 2007.

Observer with evolutionary-programming-based optimal digital tracker for analog neutral multiple time-delay systems

In this paper, the finite-time optimal hybrid tracking control problem for analog neutral systems with multiple discrete and distributed time delays is formulated and studied. A novel approach that combining the evolutionary programming (EP) algorithm and the high-gain property for analog neutral multiple time-delay systems is proposed to achieve the “best” tracking performance for the first time. First, the Newton center interpolation formula and the linear interpolation formula, together with a modified rectangular rule and an augmented state vector, are utilized to construct the equivalent digital linear models. Next, according to the separation principle, the control gains of the digital tracker and the digital observer are designed separately by the discrete-time optimal control theory and prediction-based digital redesign method, and then combined together to form an observer-based optimal time-varying digital tracker. Eventually, the process is to combine the high-gain property with EP algorithm to search the optimal weighting matrices in the performance index to form an observer with EP-based low-gain digital tracker to achieve the objective of optimal tracking control. An example is given for illustrating the effectiveness of the new tracker design method.

Suite for Horn and Piano, and: Suite (Twelve Duets) for Horn and Tuba, and: Horn Sonata, and: Horn! for Horn in F and Piano, and: Sonata for Horn and Piano (review)

Alec Wilder. Suite for Horn and Piano [1956]. Newton Centre, MA: Margun Music, c1964. [About the composer, 1 p.; score, p. 3-20; and part. Pub. no. MM111. Duration, 11 min. $16.] Alec Wilder. Suite (Twelve Duets) for Horn and Tuba [1978]. Newton Centre, MA: Margun Music, c1996. [About the composer, 1 p.; score, p. 2-25; and 2d score. Pub. no. MM113. Duration, 10 min. $15.] Robert Baksa. Horn Sonata [1983; rev. 1993]. Bryn Mawr, PA: Composers Library Editions; sole agent: Theodore Presser Co., c1996. [Score, 30 p.; and part. Pub. no. CLE-26; 494-02045. $21.65.] Thomas Benjamin. Horn! for Horn in F and Piano. San Antonio, TX: Southern Music Co., c1997. [Performance notes, composer biography, 1 p.; score, p. 3-20; and part. Pub. no. SU343. $10.] Margaret Brouwer. Sonata for Horn and Piano. New York: Pembroke Music Co., c2000. [Performance notes, 1 p.; score, p. 3-21; composer biography, p. 22; music of M. Brouwer, p. 23; and part. ISBN 0-8258-0767-0; pub. no. PCB139. Duration, 15 min. $19.95.] The French horn holds an important place in orchestral and chamber music, where composers consistently exploit its particular expressive qualities to great effect. The solo repertoire for the horn, however, remains small and of generally un-even quality, with only a few works (notably by Wolfgang Amadeus Mozart, Robert Schumann, Richard Strauss, and Paul Hindemith) that engage musicians and audiences at large. In an aggressive attempt to increase the quality and quantity of solo horn writing, the International Horn Society (IHS) commissions works, maintains an assistance fund to help hornists fund their own commissions, and holds composition competitions. These initiatives, along with the more personal endeavors of a few enterprising composers, have greatly increased the number of high-quality works written for the horn in recent years, including the five works collected in this review. The American composer and songwriter Alec Wilder (1907-1980) has become a favorite among brass players for his melodic gifts and eccentric syntheses of jazz, classical, and popular elements. Until recently, the extent and variety of Wilder's output was underappreciated, largely because many of his manuscripts were dispersed among friends and acquaintances. Today, however, the Alec Wilder Archive at the Sibley Music Library (Rochester, NY) and books by Desmond Stone (Alec Wilder in Spite of Himself: A Life of the Composer [New York: Oxford University Press, 1996]) and David Demsey and Ronald Prather (Alec Wilder: A Bit-Bibliography, Bit-Bibliographies in Music, 45 [Westport, CT: Greenwood Press, 1993]) afford new insights into Wilder's personality, compositional process, and influences. In addition, his friend and advocate Gunther Schuller, who founded Margun Music (now under the auspices of the Music Sales Group), has made much of Wilder's work commercially available. Wilder willingly embraced what Schuller calls underdog instruments (Stone, 112), producing a large and interesting corpus of works for brass instruments that still has parallel. His great reputation among horn players largely stems from his close friendship with renowned hornist John R. Barrows (1913-1974), a distinguished performer and teacher who held posts with the Minneapolis Symphony, the Army Air Forces Band, the New York City Opera, the New York City Ballet, and the Casals Festival Orchestra, as well as teaching positions at Yale University, New York University, and the University of Wisconsin, Madison. Barrows, who championed both classical and jazz horn, pressed Wilder to produce new works for his instrument--a demand to which Wilder, of course, acquiesced. Over the ensuing years, Barrows received many new horn works, including three large sonatas and a wide variety of shorter pieces that have become standard repertoire for the horn, and essential to any serious horn performance collection. For his part, Wilder was also profoundly influenced by the partnership, noting no matter what the circumstances or for whom I was ostensibly composing, everything I've ever written since I met John Barrows was written for him (In Memoriam: John R. …

How can the Academy lobby for increased remuneration for pediatricians’ services without appearing to be self-serving?

Eileen M. Ouellette, M.D., J.D., FAAP ![Figure][1] Newton Center, Mass. Access, quality and reimbursement are inextricably intertwined. Adequate reimbursement is vital to guarantee pediatricians’ ability to provide continuous, comprehensive quality health care. Access: Increased

From Hiawatha to Wa-Wan: Musical Boston and the Uses of Native American Lore

When in 1901 Arthur Farwell embarked upon the publication of his music serial, the Wa-Wan Press, out of Newton Center, Massachusetts, his stated objective was to make available serious compositions by American composers. In his lengthy and often philosophical introductory essays, Farwell (1872-1952) sought to justify his music publishing efforts. Partly he wanted to offer new paths of influence and creativity by turning to America's indigenous cultures, while at the same time distancing himself from former efforts to do so. While most of the works he published exerted little long-term influence on the mainstream of American concert music, the Wa-Wan issues themselves were striking for their original appearance. To avoid associations with the flowery drawing-room covers typical of much sheet music of the time, Farwell worked with Berkeley Updike to design the crisp graphic for the cover.1 The title of the serial was intended to evoke a truly indigenous American experience: an Omaha pipe-smoking ceremony. With this choice in iconography, Farwell made a decisive move away from the conventional pattern of representing the American Indian in the mold of Longfellow's Hiawatha, the latter an iconic cultural symbol whose influence spread outward from New England in the midto late nineteenth century. A publishing approach more common to the spirit of the times was Arthur P. Schmidt's 1902 edition of Edward MacDowell's New Eng-

Discretisation of two degree-of-freedom controller and system with state, input and output delays

An interpolation method for discretisation of a two degree-of-freedom analogue controller and system with state, input and output delays is presented. A Newton centre interpolation formula is used for discretisation of a continuous-time system with state, input and output delays. Also, a Newton backward extrapolation formula and Chebyshev quadrature formula are employed to carry out output-feedback digital redesign of a two degree-of-freedom controller for the delayed analogue system. The developed digital redesign method is then extended to perform discretisation of a Smith predictor for an input-delayed analogue system. The newly developed output-feedback state-matching digital redesign method provides an alternative methodology for indirect digital design of a continuous-time system with state, input and output delays.

Unity in Fullness

The Ecumenical ReviewVolume 50, Issue 2 p. 149-156 Unity in Fullness A Reflection on the Theme for the Eighth Assembly of the World Council of Churches S. Mark Heim, S. Mark Heim S. Mark Heim is professor of Christian theology at Andover Newton Theological School, Newton Centre, Massachusetts, USA. He is an ordained minister of the American Baptist Churches in the USA and represents that communion as a member of the WCC commission on Faith and Order and the National Council of Churches of Christ USA commission on Faith and Order. He is the author of Salvations: Truth and Difference in Religion and the editor of Faith to Creed: Ecumenical Perspectives on the Affirmation of the Apostolic Faith in the Fourth Century and Grounds for Understanding: Ecumenical Resources for Response to Religious Pluralism.Search for more papers by this author S. Mark Heim, S. Mark Heim S. Mark Heim is professor of Christian theology at Andover Newton Theological School, Newton Centre, Massachusetts, USA. He is an ordained minister of the American Baptist Churches in the USA and represents that communion as a member of the WCC commission on Faith and Order and the National Council of Churches of Christ USA commission on Faith and Order. He is the author of Salvations: Truth and Difference in Religion and the editor of Faith to Creed: Ecumenical Perspectives on the Affirmation of the Apostolic Faith in the Fourth Century and Grounds for Understanding: Ecumenical Resources for Response to Religious Pluralism.Search for more papers by this author First published: 26 March 2009 https://doi.org/10.1111/j.1758-6623.1998.tb00341.x Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Volume50, Issue2April 1998Pages 149-156 RelatedInformation

5541081 Process for assessing oocyte and embryo quality : Hardy R Ia; Golan David E; Biggers John D Newton Centre, MA, United States Assigned to President and Fellows of Harvard College; Brigham and Women's Hospital Inc

5541081 Process for assessing oocyte and embryo quality : Hardy R Ia; Golan David E; Biggers John D Newton Centre, MA, United States Assigned to President and Fellows of Harvard College; Brigham and Women's Hospital Inc

5543498 Peptides to overcome inhibition of nerve growth : Fishman Mark C; Igarashi Michihiro; Strittmatter Stephen M Newton Centre, MA, United States Assigned to The General Hospital Corporation

5543498 Peptides to overcome inhibition of nerve growth : Fishman Mark C; Igarashi Michihiro; Strittmatter Stephen M Newton Centre, MA, United States Assigned to The General Hospital Corporation

Communicating With The Public About Radon Risk

This Roundtable discussion took place Oct. 13, 1992, in Chicago, Ill. Panel moderator was Joan Dent, director of public information for American Water Works Association, 6666 West Quincy Avenue, Denver. CO 80235. Other participants were Carolyn M. Iglesias, director of corporate communications for Hackensack Water Company, 200 Old Hook Road, Harrington Park. NJ 07640; Thomas Jackson, director of public affairs for Regional Water Authority, 90 Sargent Drive, New Haven, CT 06511; L.D. McMullen, general manager of Des Moines Water Works, 2201 Valley Drive, Des Moines. IA 50321‐1190; Frederick W. Pontius, associate director for regulatory affairs at American Water Works Association, 6666 West Quincy Avenue, Denver, CO 80235; Peter Sandman, professor at Rutgers University, New Brunswick, N.J., founder and former director of the Environmental Communications Research Program there, and consultant, 54 Gray Cliff Road, Newton Centre, MA 02159; Michael Tubbs, director of Tucson Water, City of Tucson, 310 West Alameda Ave., Tucson, AZ 85701; and Ross D. Walker, director of communications services for Portland Bureau of Water Works, 1120 S.W. 5th, Room 600, Portland, OR 97204.