Background Neonatal mortality is defined as the death of live born within the first 28 days of life. It represents a great burden on the health and community. Many risk factors are associated with neonatal mortality. Aim Evaluate perinatal admission risk factors and their relation to neonatal mortality in newborns admitted to neonatal care units participating in the Egyptian Neonatal Network (EGNN). Patients and methods This retrospective study included 4621 newborns admitted to Neonatal Care Units participating in the Egyptian Neonatal Network over 3 years (2014–2016). The record of the cases was revised to determine the maternal characteristics, the incidence of neonatal mortality, and the associated risk factors associated with mortality. Results Among the studied factors, increased gravidity, parity, and number of live children and lower gestational age, birth and, admission weight, length, and HC, are associated with increased neonatal mortality in neonatal intensive care unit (NICUs) (P value<0.001). Conclusion Determination of risk factors in neonatal death can help to identify sick neonates who are more likely to die in NICUs and provide on-time care. Help doctors to tell parents what possibly happened to their babies. And used as a tool to compare the outcome of different NICUs and evaluate their performance.