New Synthesis Of Methyl Research Articles

MONOSACCHARIDE DERIVATIVES: SYNTHESIS, ANTIMICROBIAL, PASS, ANTIVIRAL AND MOLECULAR DOCKING STUDIES AGAINST SARS-COV-2 MPRO INHIBITORS

Several carbohydrate-based drugs are currently being used to treat a number of diseases in humans worldwide. Thus, our research group has focused on the synthesis of new methyl α-D-mannopyranoside (MDM) derivatives and their antimicrobial evaluation through computational studies. A series of MDM derivatives (2-6) were synthesized through facile regioselective acylation, using the direct method affording 6-O-(3-chlorobenzoyl) derivatives. This isolated 6-O-derivative was further transformed to 2,3,4-tri-O-acyl derivatives, bearing a wide variety of functionalities in a single molecular framework. The structures of the newly designed molecules were elucidated with the aid of IR, 1H NMR, mass spectroscopy, and elemental analysis. The prediction of the activity spectra for the compounds (PASS) and their in vitro antimicrobial evaluation were performed, demonstrating them to be potential antimicrobial agents. The antimicrobial tests demonstrated that the compounds 3 and 5 were the most potent with the minimum inhibitory concentration (MIC) values, ranging from 0.312±0.01 to 1.25±0.03 mg/mL, and minimum bactericidal concentration (MBC) values, ranging from 0.625±0.02 to 2.50±0.05 mg/mL. A quantum chemical study was performed to calculate the thermodynamic, molecular orbital and electrostatic potential properties of the designed compounds. Molecular docking simulation was carried out against SARS-CoV-2 Mpro protein 7BQY and 6Y84 to investigate their binding energy and binding tactics with the viral protein, and better binding affinity than that of the parent drug was observed. Also, pharmacokinetic prediction revealed an improved drug-likeness profile for all MDM derivatives.

7-Imidazolyl-substituted 4'-methoxy and 3',4'-dimethoxy-containing polyfluoroflavones as promising antiviral agents

A simple and convenient method for the synthesis of new methyl 2-(4-methoxyphenyl)- and 2-(3,4-dimethoxyphenyl)-4-oxo-4H-polyfluorochromen-3-carboxylates as analogs of natural methoxy-containing flavones is proposed. As a result of their directed modification under basic conditions, 7-imidazolyl-substituted derivatives were obtained. In aqueous-organic medium under basic conditions, 5,6,7,8-tetrafluoro-3-(methoxycarbonyl)flavones were transformed into 6,8-difluoro-5-hydroxy-7-(1H-imidazol-1-yl)-3-(methoxycarbonyl)flavones as a result of flavone-5-hydroxyflavone rearrangement, while 6,7,8-trifluorinated analogs underwent a flavone-coumarin rearrangement to give 6,8-difluoro-3-(hydroxyarylidene)-7-(1H-imidazol-1-yl)coumarins under the same conditions. Acid hydrolysis of methyl polyfluoroflavone-3-carboxylates allowed to obtain 2-aryl-4H-polyfluorochromen-4-ones. Evaluation of the antiviral activity of the synthesized compounds against influenza A (H1N1) and Coxsackie B3 viruses showed that 2-(3,4-dimethoxyphenyl)-5,6,8-trifluoro-7-(1H-imidazol-1-yl)-4H-chromene-4-one has the most promising properties.

ChemInform Abstract: New Synthesis of Methyl 1,3-Butadiene-2-carboxylate by the Cheletropic Extrusion of Carbon Monoxide from 3-Carbomethoxy-3,4-pentadienal and a Study of Its Dimerization To Give Dimethyl Mikanecate (Dimethyl 4-Ethenyl-1-cyclohexene-1,4-

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: Utility of 3-Aminocrotononitrile in the Synthesis of New Methyl 1,4-Dihydropyridine, Methylquinoline, and Thiophene Derivatives: Reactivity of the Methyl Function in Alkyl 1,4-Dihydropyridine and Methyl Quinoline Derivatives Towards S

The methyl function in some newly prepared methyl 1,4-dihydropyridine and methyl quinoline derivatives proves to be highly active towards some electrophiles.

ChemInform Abstract: New Synthesis of Methyl 5‐Aryl or Heteroaryl Pyrrole‐2‐carboxylates by a Tandem Sonogashira Coupling/5‐endo‐dig‐Cyclization from β‐Iododehydroamino Acid Methyl Esters and Terminal Alkynes.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

ChemInform Abstract: A New Synthesis of Methyl 3‐Oxo‐2‐pentyl‐1‐cyclopentene‐1‐acetate.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

A New Synthesis of Methyl 3-Oxo-2-pentyl-1-cyclopentene-1-acetate

The 92 : 8 equilibrium mixture of (±)-trans-methyl dihydrojasmonate (1) and its cis-isomer is transformed in 63% overall yield into the title compound 4 by epoxidation of the derived enol acetate 2 with peracetic acid/Na2CO3 in toluene and heating the resulting α-acetoxy epoxide 3 in MeOH in the presence of catalytic amounts of methanesulfonic acid.

Utility of 3-Aminocrotononitrile in the Synthesis of New Methyl 1,4-Dihydropyridine, Methylquinoline and Thiophene Derivatives: Reactivity of the Methyl Function in Alkyl 1,4-Dihydropyridine and Methyl Quinoline Derivatives towards Some Electrophilic Reagents

The methyl function in some newly prepared methyl 1,4-dihydropyridine and methyl quinoline derivatives proves to be highly active towards some electrophiles.

L-Amino Acid Esters Studies: Part I: Synthesis Of New Methyl N -(Dimethoxy / 3,5 -Diacetoxybenzoyl) -L- Amino Acid Ester Derivatives

A series of new methyl N-(dimedioxy / 3,5-diacetoxybenzoyl)-L-amino acid esters have been synthesized by two methods.

Utility of 3-Aminocrotononitrile in the Synthesis of New Methyl 1,4-Dihydropyridine, Methylquinoline and Thiophene Derivatives: Reactivity of the Methyl Function in Alkyl 1,4-Dihydropyridine and Methyl Quinoline Derivatives Towards Some Electrophilic Reagents

The methyl function in some newly prepared methyl 1,4-dihydropyridine and methyl quinoline derivatives proves to be highly active towards some electrophiles.

Synthesis of some new highly functionalized C 6-synthons

Starting with ε-caprolactone a new synthesis of methyl 6-hydroxy-2-hexenoate, 2a, is described. The preparation of the new highly functionalized C 6-synthons methyl 6-acyloxy-4-oxo-2-hexenoates, 1b and 1c, methyl 6-benzoyloxy-4-hydroxy-2-hexenoate, 13, and methyl 6-benzoyloxy-4-oxohexanoate, 14, is also reported.

ChemInform Abstract: A New Synthesis of Methyl 3‐Amino‐3,4‐dideoxy‐β‐D‐xylo‐ hexopyranoside.

AbstractChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 100 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.

New synthesis of methyl 1,3-butadiene-2-carboxylate by the cheletropic extrusion of carbon monoxide from 3-carbomethoxy-3,4-pentadienal and a study of its dimerization to give dimethyl mikanecate (dimethyl 4-ethenyl-1-cyclohexene-1,4-dicarboxylate)

ADVERTISEMENT RETURN TO ISSUEPREVArticleNEXTNew synthesis of methyl 1,3-butadiene-2-carboxylate by the cheletropic extrusion of carbon monoxide from 3-carbomethoxy-3,4-pentadienal and a study of its dimerization to give dimethyl mikanecate (dimethyl 4-ethenyl-1-cyclohexene-1,4-dicarboxylate)Michael E. Jung and Craig N. ZimmermanCite this: J. Am. Chem. Soc. 1991, 113, 20, 7813–7814Publication Date (Print):September 1, 1991Publication History Published online1 May 2002Published inissue 1 September 1991https://doi.org/10.1021/ja00020a082RIGHTS & PERMISSIONSArticle Views615Altmetric-Citations25LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (295 KB) Get e-Alerts Get e-Alerts

Synthetic investigations on illudinine: a new synthesis of methyl 8-methoxy-2,2-dimethyl-7-oxo-1,2,3,5,6,7-hexahydro-s-indacene-4-carboxylate

A new strategy for the total synthesis of methyl 8-methoxy-2,2-dimethyl-7-oxo-1,2,3,5,6,7-hexahydro-s-indacene-4-carboxylate 4, a key intermediate in the synthesis of illudalanes, is reported. The key step in this strategy is a new method of preparation of indanones from tetralones. Thus, the furfurylidene derivative of 6-methoxy-3,4-dihydronaphthalen-1-(2H)-one is oxidised to the dicarboxylic acid 9a which is cyclodehydrated to methyl 7-methoxy-1-oxoindan-4-carboxylate 10. Similar reactions on the tetrahydronaphthalenone 25, obtained from 6-methoxy-1,2,3,4-tetrahydronaphthalene-7-carbaldehyde 11 by sequential transformations including a regiospecific benzylic oxidation resulted in the hexahydro-s-indacenone 4, thus completing a formal synthesis of illudinine 1.

ChemInform Abstract: A New Synthesis of Methyl α‐Acetolactate Based on Thiazolium Chemistry and Modelled on the Enzymatic Synthesis of α‐Acetolactate Catalyzed by Acetolactate Synthase.

AbstractTreatment of the benzothiazolium salt (IV), prepared from benzothiazole (I), with triethylamine in methanol results in decomposition, forming the benzothiazole (II), the hydroxyacetopropionate (V), and the dihydrobenzothiazole (VI).

ChemInform Abstract: Condensed Pyrazoles: Synthesis of New Methyl and Amino Pyrazolo(1,5‐a)pyrimidines and of Pyrazolo(5,1‐c) (1,2,4)triazines.

AbstractAs a part of a biological chemistry project the title compounds, e.g. (III), (V), (VI) and (IX), are synthesized.

Studies on condensed pyrazoles: Synthesis of new methyl and amino pyrazolo[1,5-a]pyrimidines and of pyrazolo[5,1-c][1,2,4]triazines

A variety of 3-arylazo 5-amino and 7-aminopyrazolo[1,5-a]pyrimidines were obtained via reacting Ia-Id with cinnamonitriles. The structure of products was confirmed via 1H NMR. Both 5-amino- and 7-amino-3-arylazo pyrazolo[1,5-a]pyrimidines reacted, with protons in acetic acid-sulphuric acid mixture to yield the corresponding 3-unsubstituted acetylaminopyrazolo[1,5-a]pyrimidines. Diazotized Ia and Ib coupled with a variety of active methylene reagents to yield pyrazolo[5,1-c][1,2,4]triazines.

Branched-chain Sugars. XXXVI. A New Synthesis of Methyl 4-O-Benzoyl-3-benzoylamino-2,3,6-trideoxy-3-C-methyl-α-l-xylo-hexopyranoside, a Derivative of the Branched-chain Amino Sugar of Antibiotic A35512B

Abstract The title compound was synthesized from methyl 4-O-benzyl-2,6-dideoxy-β-l-threo-hexopyranosid-3-ulose (19) through cyanomesylation, reductive spiro aziridine formation, and reductive ring-opening. When (2-methoxyethoxymethyl) group was used as the protecting group at O-4 of the above intermediate, it could not be removed at the final stage.

Synthesis of new methyl O-acetyl-α- and -β- d-xylopyranosides

Synthesis of new methyl O-acetyl-α- and -β- d-xylopyranosides

ChemInform Abstract: A NEW SYNTHESIS OF METHYL α‐L‐MYCAROSIDE

Chemischer InformationsdienstVolume 10, Issue 1 Natural Products ChemInform Abstract: A NEW SYNTHESIS OF METHYL α-L-MYCAROSIDE J. THIEM, J. THIEMSearch for more papers by this authorJ. ELVERS, J. ELVERSSearch for more papers by this author J. THIEM, J. THIEMSearch for more papers by this authorJ. ELVERS, J. ELVERSSearch for more papers by this author First published: January 2, 1979 https://doi.org/10.1002/chin.197901321Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat No abstract is available for this article. Volume10, Issue1January 2, 1979 RelatedInformation