New Framework For Understanding Research Articles

Microscale Chaotic Mixing as a Driver for Chemical Reactions in Porous Media.

Mixing-induced reactions play a key role in a large range of biogeochemical and contaminant transport processes in the subsurface. Fluid flow through porous media was recently shown to exhibit chaotic mixing dynamics at the pore scale, enhancing microscale concentration gradients and controlling mixing rates. While this phenomenon is likely ubiquitous in environmental systems, it is not known how it affects chemical reactions. Here, we use refractive index matching and laser-induced fluorescence imaging of a bimolecular redox reaction to investigate the consequence of pore scale chaotic mixing on the reaction rates. The overestimation of measured reaction rates by the classical macrodispersion model highlights the persistence of incomplete mixing on the pore scale. We show that the reaction product formation is controlled by microscale chaotic mixing, which induces an exponential increase of the mixing interface and of the reaction rates. We derive a reactive transport model that captures experimental results and predicts that chaotic mixing has a first order control on reaction rates across a large range of time scales and Péclet and Damköhler numbers. These findings provide a new framework for understanding, assessing, and predicting mixing-induced reactions and their role on the fate and mobility of environmental compounds in natural porous media.

Natural fabrics of a hornblende-rich amphibolite: Implications for hornblende crystallographic preferred orientation and seismic anisotropy of the lower crust

The relation of seismic anisotropy to the deformation and flow of the lower crust relies on the intrinsic properties of the minerals in the crust and on the formation of crystallographic preferred orientation (CPO). Hornblende is an important constituent of the continental and oceanic lower crust and often exhibits a strong CPO. However, the formation of CPO in hornblende is not well understood, and it is difficult to uniquely relate its texture and anisotropy to conditions of metamorphism-deformation. We present a petrofabric analysis, using electron backscatter diffraction, of two hornblende-rich amphibolites from the Mamonia complex (Cyprus) with peak pressure and temperature of 0.6 GPa and 610 ± 40 °C. We distinguish between microstructures with varied strains and show that, while the common hornblende CPO—in which the [001] is aligned with lineation—is independent of strain, its symmetry does depend on strain: it is hexagonal (axial-[001]) under low strains but becomes orthorhombic ([001] and (100) parallel to the lineation and foliation normal of the deformation, respectively) under increasing strains. This transition is correlated with a decrease in the shape-preferred orientation and an increase in the intragrain misorientation, whose rotation is consistent with the easy slip system (100)[001] of hornblende. Thus, we interpret the hexagonal CPO to represent a metamorphic fabric (a texture formed under quasi-static conditions) and the orthorhombic CPO to represent a solid-state deformation fabric (a texture formed by strain accommodated via dislocation-mediated deformation). We consider the seismic anisotropy of the natural hornblende textures and compare two tectonic scenarios of lower crust deformation - crust thickening and channel flow with marked differences in the expected seismic anisotropy between the two scenarios. Taken together, the dataset presented here can be used as a new framework for understanding and interpreting natural textures and seismic anisotropy from the lower crust.

Influence of El Niño on the variability of global shoreline position

Coastal zones are fragile and complex dynamical systems that are increasingly under threat from the combined effects of anthropogenic pressure and climate change. Using global satellite derived shoreline positions from 1993 to 2019 and a variety of reanalysis products, here we show that shorelines are under the influence of three main drivers: sea-level, ocean waves and river discharge. While sea level directly affects coastal mobility, waves affect both erosion/accretion and total water levels, and rivers affect coastal sediment budgets and salinity-induced water levels. By deriving a conceptual global model that accounts for the influence of dominant modes of climate variability on these drivers, we show that interannual shoreline changes are largely driven by different ENSO regimes and their complex inter-basin teleconnections. Our results provide a new framework for understanding and predicting climate-induced coastal hazards.

Antecedents of economic empowerment: an empirical study of working women in Delhi-NCR

PurposeWomen’s economic empowerment (WEE) has emerged as a key component at national and international policy-making agendas. The purpose of this paper is to examine and validate the antecedents of WEE for urban working women.Design/methodology/approachThis study used a descriptive and exploratory research design. A total of 286 responses from women working in the formal sector of Delhi-NCR were collected through self-administered questionnaires on a five-point Likert scale using non-probability quota sampling technique. The sample was controlled for the employment sector, that is, healthcare, education and information technology. Exploratory factor analysis has been performed in the first step to test the data’s dimensionality with the goal of producing a set of items that reflect the meaning of the relative construct. Thereafter, confirmatory factor analysis has been used for data analysis.FindingsDigital banking usage (DBU) has been identified as the most significant contributor to WEE.Practical implicationsBesides digital banking, government support has also emerged as a key indicator of WEE, necessitating a government policy review to improve WEE. Research findings indicate that, if WEE initiatives are to reach their full potential, they must individually address the extracted factors. This study offers a new framework for understanding and enhancing WEE for urban working women in India.Originality/valueTo the best of the authors’ knowledge, this study is the first of its kind to use factor analysis to explore the multi-dimensionality of WEE using the novel dimensions of DBU, women’s agency and government support, in addition to the established variables of financial literacy, social norms and workplace human resource policies.

Digital hostility, subjectivity and ethics: Theorising the disruption of identity in instances of mass online abuse and hate speech

The experience of hostility, hate speech and adversarial behaviour in everyday online spaces has increased substantially in recent years, with known health and mental health outcomes for users. This paper argues that due to the ‘massified’ form of contemporary hostility experienced in the internet ‘pile on’, a new framework for understanding and remedying hostility is required. This paper draws on Judith Butler’s theories of identity to present an account of digital hostility as cultural and as having a negative effect on the identities and selfhood of users. It discusses the impact of the online pile-on, shaming and the ways in which hostility positions victims as ungrievable subjects. The essay recommends new ethical approaches grounded in the recognition of subjects as vulnerable, arguing that cultural ethics approaches are valuable not only as public pedagogies but for development of technological solutions and moderation interventions to help prevent hostility and hate speech.

A mitochondrial contribution to anti-inflammatory shear stress signaling in vascular endothelial cells.

Atherosclerosis, the major cause of myocardial infarction and stroke, results from converging inflammatory, metabolic, and biomechanical factors. Arterial lesions form at sites of low and disturbed blood flow but are suppressed by high laminar shear stress (LSS) mainly via transcriptional induction of the anti-inflammatory transcription factor, Kruppel-like factor 2 (Klf2). We therefore performed a whole genome CRISPR-Cas9 screen to identify genes required for LSS induction of Klf2. Subsequent mechanistic investigation revealed that LSS induces Klf2 via activation of both a MEKK2/3-MEK5-ERK5 kinase module and mitochondrial metabolism. Mitochondrial calcium and ROS signaling regulate assembly of a mitophagy- and p62-dependent scaffolding complex that amplifies MEKK-MEK5-ERK5 signaling. Blocking the mitochondrial pathway in vivo reduces expression of KLF2-dependent genes such as eNOS and inhibits vascular remodeling. Failure to activate the mitochondrial pathway limits Klf2 expression in regions of disturbed flow. This work thus defines a connection between metabolism and vascular inflammation that provides a new framework for understanding and developing treatments for vascular disease.

Subsurface Mixing Dynamics Across the Salt‐Freshwater Interface

AbstractMixing along the salt‐freshwater interface is critical for geochemical reactions, transport, and transformation of nutrients and contaminants in coastal ecosystems. However, the mechanisms and controls of mixing are not well understood. We develop an analytical model, based on the coupling between flow deformation and dispersion, which predicts the mixing dynamics along the interface for steady‐state flow in coastal aquifers. The analytical predictions are compared with the results of detailed numerical simulations, which show that nonuniform flow fields, inherent to seawater intrusion in coastal aquifer, result in a non‐monotonic evolution of mixing width and mixing rates along the interface. The analytical model accurately captures these dynamics over a range of freshwater flow rates and dispersivities. It predicts the evolution of the mixing width and mixing rates along the interface, offering a new framework for understanding and modeling mixing and reaction processes in coastal aquifers.

The emerging role of proteases in α1-antitrypsin deficiency and beyond.

α1-Antitrypsin deficiency (AATD) has been historically under-recognised and under-diagnosed; recently it has begun to receive greater interest in terms of attempts at deeper elucidation of pathology and treatment options. However, the concept of disease phenotypes within AATD (emphysema, chronic bronchitis, bronchiectasis or a combination of phenotypes) has not been proposed or studied. Of the three neutrophil serine proteases, neutrophil elastase was historically believed to be the sole contributor to disease pathology in AATD. Recently, Proteinase-3 has been increasingly studied as an equal, if not greater, contributor to the disease process. Cathepsin G, however, has not been extensively evaluated in this area. Matrix metalloproteinases have also been mentioned in the pathogenesis of AATD but have not been widely explored. This article considers the available evidence for differential protease activity in patients with AATD, including the contribution to distinct phenotypes of the disease. Owing to limited literature in this area, extrapolations from studies of other chronic lung diseases with similar phenotypes, including COPD and bronchiectasis, have been made. We consider a new framework of understanding defined by protease-driven endotypes of disease which may lead to new opportunities for precision medicine.

Development of a 3-D confinement-dependent dilation model for brittle rocks; Part 1, derivation of a Cartesian plastic strain increments ratios approach for non-potential flow rules

The viability and success of a deep mining or tunnelling project is dependent on a safe, reliable support design. In highly-stressed brittle rock, this design must properly account for the excessive deformations and bulking that can occur due to stress-induced extensional fracturing (referred to as spalling or slabbing) near the excavation boundary. Important is the recognition that stress-induced brittle fracturing is dominated by an extensional fracture mode with a directional dilation component that is highly sensitive to 3-D confinement. This behaviour differs from that represented by popular elastoplastic yield and dilation models used in commercial numerical modelling software (e.g., Mohr-Coulomb) that have been developed based on experiences involving ductile behaviour and shear in soils and weak rocks. Recent experiences suggest that these are inappropriate for robust design in brittle rock and can be dangerously misleading. The importance of the dilation model and its implementation through a flow rule – which determines the relative incremental plastic straining under a specific stress state and at a specific plastic straining history – has particularly been overlooked. Numerical analyses in most cases adopt the oversimplifying assumption of a uniform dilation model (that is independent of confinement and plastic strain history), using as input a constant dilation angle ψ. This imposes significant limitations in modelling the extent of the yielding zone and the resulting displacements. More advanced dilation models exist. However, they suffer from two key deficiencies: i) most do not account for the influence of the intermediate principal stress, σ2, on the directionality and magnitude of dilation; and ii) many require numerous empirical parameters or variables that do not have physical meaning (neither phenomenologically, nor micro-mechanically), making it difficult for practitioners to intuitively understand the influence and sensitivity of each parameter on the modelled response. This paper, presented in two parts, reviews the mathematical expression of the flow rule and its physical meaning in relation to brittle fracturing, and addresses the deficiencies in current dilation models by developing a new non-potential flow rule that accounts for the directionality and 3-D confinement-dependency of dilation (i.e., both σ3- and σ2-dependency), and uses parameters/variables that have physical meaning. In Part 1, we present a new framework for understanding and modelling the 3-D directionality of plastic deformations in Cartesian coordinates using what we call Plastic Strain Increments Ratios (PSIRs). The 3-D PSIRs are phenomenologically meaningful as they describe relative plastic straining. More importantly, we show that they are micro-mechanically meaningful as they associate the 3-D directionality of dilation with the different 3-D fracturing modes observed in intact brittle rock under various polyaxial stress states. In the Part 2 companion paper, we use these PSIRs to develop and derive the formulation of a new dilation model involving a non-potential 3-D confinement-dependent flow rule.

The Ratio of Toxic-to-Nontoxic miRNAs Predicts Platinum Sensitivity in Ovarian Cancer.

Ovarian cancer remains one of the deadliest gynecologic malignancies affecting women, and development of resistance to platinum remains a major barrier to achieving a cure. Multiple mechanisms have been identified to confer platinum resistance. Numerous miRNAs have been linked to platinum sensitivity and resistance in ovarian cancer. miRNA activity occurs mainly when the guide strand of the miRNA, with its seed sequence at position 2-7/8, is loaded into the RNA-induced silencing complex (RISC) and targets complementary short seed matches in the 3' untranslated region of mRNAs. Toxic 6mer seeds, which target genes critical for cancer cell survival, have been found in tumor-suppressive miRNAs. Many siRNAs and short hairpin RNAs (shRNA) can also kill cancer cells via toxic seeds, the most toxic of which carry G-rich 6mer seed sequences. We showed here that treatment of ovarian cancer cells with platinum led to increased RISC-bound miRNAs carrying toxic 6mer seeds and decreased miRNAs with nontoxic seeds. Platinum-tolerant cells did not exhibit this toxicity shift but retained sensitivity to cell death mediated by siRNAs carrying toxic 6mer seeds. Analysis of RISC-bound miRNAs in tumors from patients with ovarian cancer revealed that the ratio between miRNAs with toxic versus nontoxic seeds was predictive of treatment outcome. Application of the 6mer seed toxicity concept to cancer relevant miRNAs provides a new framework for understanding and predicting cancer therapy responses. SIGNIFICANCE: These findings demonstrate that the balance of miRNAs that carry toxic and nontoxic 6mer seeds contributes to platinum resistance in ovarian cancer.

The effect of substrate curvature on capacitance and current–voltage characteristics in thin-film transistors on flexible substrates

Mechanically flexible electronics are devices designed to operate under significant physical deformations such as bending, twisting, and stretching. While the materials systems and devices compatible with flexible substrates have been extensively studied, the mathematical framework for analysis remains identical to that of traditional planar silicon-based electronics. However, the non-planar and dynamic form factors desired from flexible electronics invalidate assumptions made in these models. For electronic devices to be predictable and ultimately commercially viable, they must be understood in any physical form. Here we employ the method of moments to calculate the capacitance between two electrical conductors of arbitrary shape. Combined with a model for source–drain current in thin-film transistors (TFTs) on the surface of a cylinder, we are able to calculate the current–voltage characteristics in curved TFTs as a function of bending angle. We demonstrate how deformations to device geometry are expected to lead to non-negligible changes in current–voltage characteristics. This work represents the first step towards a new framework for understanding and characterizing electronics with any physical form factor, ultimately bringing flexible electronics closer to commercial viability.

A framework for culturally diverse teams and the importance of agility: findings from a qualitative study

In this study, we investigated the conditions for successful collaboration in culturally diverse teams from a Positive Organizational Scholarship perspective. As a result of globalization, organizations increasingly rely on culturally diverse teams. Based on 19 semi-structured interviews with international managers of a large German car manufacturer, we analyzed how these teams work together and which factors promote collaboration. Our findings result in a new framework for understanding culturally diverse teams, which indicates that agile team behavior is an important factor for performance in culturally diverse teams. Agile forms of collaboration enable better adaption to change through iterative learning processes. Agile methods have strong structural elements, but in between, allow the greatest possible scope for continuous adjustment. These structuring and flexible elements seem to meet the requirements of culturally diverse teams in particular. The minimal structure provides the opportunity to bring in all perspectives and views of a culturally diverse team. In addition, we confirm the influence of well-studied factors such as openness, perspective taking and leadership behavior. Our findings help to further sharpen the understanding of culturally diverse teams and point to a fruitful future research direction on agile behavior and cultural diversity in teams.

(Re) Conceptualizing Neglect: Considering the Overrepresentation of Indigenous Children in Child Welfare Systems in Canada

The current overrepresentation of Indigenous children in Canadian child welfare systems continues a history of government policies that have separated Indigenous families over the course of many generations. Political and legal developments in recent years are creating the possibility to both disrupt Indigenous children’s overrepresentation in child welfare proceedings and support Indigenous self-determination in decision-making related to child welfare. However, the potential to reduce the overrepresentation of Indigenous children in Canadian child welfare systems is still limited, in part, by the absence of a comprehensive framework for transforming existing child welfare legislation. Because the disproportionate representation of Indigenous children is driven largely by investigations of child neglect, there is particular need for a framework for understanding and shifting away from the current approach to assessing neglect cases. In this article, we examine theoretical and legislative conceptualizations of child neglect in terms of their relationship to the disproportionate involvement of Indigenous children in child welfare across Canada and, more specifically, in Quebec. We also briefly examine the concepts of child well-being and cultural safety which we see as useful complements to the current conceptualization of neglect. Our goal is to support ongoing critical dialogue related to the overrepresentation of Indigenous children in Canada’s child welfare systems, and in so doing contribute to the development of a new framework for understanding and operationalizing “neglect” in Indigenous contexts which at its core could bolster Indigenous self-determination.

Reconsidering early parental grief following the death of a child from cancer: a new framework for future research and bereavement support.

Parents of children that die from cancer are at increased risk of significant long-term psychosocial and physical morbidities. Less, however, is known about the experience of parents early in the grief process. Currently used frameworks and instruments used to understand and assess outcomes in parents early in the grief experience are inadequate and may serve to pathologize the normal grief response. Through review of the literature, previously conducted qualitative work, and extensive clinical experience working with bereaved parents, we developed a new framework for understanding, assessing, and studying parental grief during the first 2years following the death of a child from cancer. Our novel longitudinal framework hypothesizes that short- and long-term psychosocial sequalae in parents following the death of a child from cancer depend not only on pre-death factors but on the support present through the disease experience and the oscillation between protective factors and risk factors in the post-death period. We further hypothesize that protective factors and risk factors may be modifiable, making them key potential targets for supportive interventions aimed at augmenting protective factors and diminishing the effect of risk factors. This is a new framework for understanding and assessing the grief experience of parents within the first 2years of a child's death. Many questions about how best to support parents following the death of a child from cancer remain providing ample opportunities for future research and development of interventions to improve both short- and long-term outcomes in bereaved parents.

A social–product–process framework for construction

ABSTRACT This paper introduces a new framework for understanding, modelling and software engineering in construction information activities. The current framework is based on understanding that products are the results of processes, which are performed by actors. Such frameworks are influenced by the available technology. The Internet of today is supporting also other kinds of human activities: communication and social interactions among humans. The construction industry uses them as well but without having a proper understanding of their role. There is a gap in the current framework. In this paper, the relevant theories to specify this gap in terms of what could exist in theory and what is offered by technology are analysed. As a result, a new framework of construction information activities that fills the gap is proposed. The key concepts and relations among them are identified and elaborated within the existing framework. The framework introduces the third major integrative element of the otherwise fragmented construction information activities – the social network – the existing two being the physical building and its digital twin. The framework provides a theoretical and conceptual basis for designing, planning, creating, monitoring and evaluating construction-related online services that include a strong social component and use social media services.

The Theory of Knowledge Fields: A Thermodynamics Approach

The emergence of knowledge economy and knowledge management revealed the need for reconsidering the concept of knowledge in a larger framework than that created by philosophers from ancient times. While the epistemology as a theory of knowledge and justification considers knowledge as a justified true belief, experts in knowledge management consider knowledge as a strategic resource. The new economic interpretation of knowledge as a strategic resource and a key contributor to achieving a competitive advantage generated a search of new metaphors to supply the attributes needed in constructing the new framework of understanding and operating with a working concept of knowledge in management. The most widespread knowledge metaphors are based on analogies with stocks, flows, and stock-and-flows. These metaphors induce, beyond some useful attributes, the Newtonian mechanics paradigm which is limited by the properties of linear spaces and reversible processes. The purpose of this paper is to show how we can enrich the theory of knowledge by introducing the concepts of knowledge fields and knowledge dynamics based on metaphorical thinking and the thermodynamics principles. The focus of our research is the energy metaphor which considers energy as a source semantic field. The main outcome of the present research is that knowledge can be considered as a field, which is manifesting in different forms like energy. This thermodynamics framework opens new directions for research in knowledge management, decision-making and leadership.

Toward a better assessment of perceived social influence: The relative role of significant others on young athletes.

The purpose of this three-study paper was to develop and validate the Perceived Social Influence in Sport Scale-2 (PSISS-2) that aimed to resolve the limitations of PSISS-1 in assessing the relative social influence of significant others in youth sport. In Study 1, a pool of 60 items generated from revisiting a qualitative dataset about significant others of young athletes were examined by two expert panel reviews in terms of content validity, clarity, coverage, and age-appropriateness, leading to the development of 16 items of the PSISS-2. In Study 2, multi-group exploratory structural equation model for PSISS-2 was conducted among 904 young athletes, and the results supported a model comprising positive influence (ie, conditional and unconditional positive influence combined), punishment (ie, conditional negative influence), and dysfunction (ie, unconditional negative influence) as three factors. The goodness of fit of the three-factor model was acceptable and invariant across the coach-, father-, mother-, and teammates-versions of PSISS-2. In support of the criterion validity of PSISS-2, the three factors explained substantial variance of young athletes' perceived competence, effort, enjoyment, and trait anxiety in sport. Study 3 examined the relationship between PSISS-2 factors, psychological need support, and controlling behaviors in a subsample of 452 young athletes, and the findings supported the concurrent validity and discriminant validity of the scale. In conclusion, the data are supportive of PSISS-2. The three factors of the scale (ie, positive influence, punishment, and dysfunction) may form a new framework for understanding and comparing the relative role of significant others in youth sport.

Mindsets Matter: A New Framework for Harnessing the Placebo Effect in Modern Medicine.

The clinical utility of the placebo effect has long hinged on physicians deceptively administering an objective placebo treatment to their patients. However, the power of the placebo does not reside in the sham treatment itself; rather, it comes from the psychosocial forces that surround the patient and the treatment. To this end, we propose a new framework for understanding and leveraging the placebo effect in clinical care. In outlining this framework, we first present the placebo effect as a neurobiological effect that is evoked by psychological processes. Next, we argue that along with implicit learning and expectation formation, mindsets are a key psychological process involved in the placebo effect. Finally, we illustrate the critical role of the social environment and treatment context in shaping these psychological processes. In doing so, we offer a guide for how the placebo effect can be understood, harnessed, and leveraged in the practice of modern medicine.

The Policy Coherence for Development Index: measuring the Agenda 2030 from the policy coherence for development perspective

The article presents the Policy Coherence for Development Index (PCDI) which is, as a whole, a new framework for understanding and interpreting the challenges of the Agenda 2030 and the public policies its approach requires. It provides also an ambitious monitoring system to assess countries’ compliance with the agreed commitments from the policy coherence for development perspective. Previously, the article exposes how the 2030 Agenda requires a new conceptual and instrumental framework in order to consolidate a new narrative about the development challenges based on the universality, integrality and multidimensionality, including also the global interdependencies and interconnections that characterize today’s world. This framework must also provide a solid measurement of progress and setbacks regarding the Sustainable Development Goals and targets internationally agreed.

Potential Applications of the National Institute of Mental Health's Research Domain Criteria (RDoC) to Clinical Psychiatric Practice: How RDoC Might Be Used in Assessment, Diagnostic Processes, Case Formulation, Treatment Planning, and Clinical Notes.

Offering a new framework for understanding and studying basic dimensions of normal and abnormal human functioning and mental disorders, the National Institute of Mental Health (NIMH) has initiated the Research Domain Criteria (RDoC) project in which a series of higher order domains, representing major systems of emotion, cognition, motivation, and social behavior, and their constituent operationally defined constructs serve as organizing templates for further research and inquiry, eg, to discover validated biomarkers and endophenotypes. Cutting across traditional DSM diagnoses, the domains are defined as Negative Valence Systems, Positive Valence Systems, Cognitive Systems, Systems for Social Processes, and Arousal/Regulatory Systems. To inform educators, trainees, and practitioners about RDoC, alert them to potential practical applications, and encourage their broad exploration in clinical settings, this article reviews the RDoC domains and their subsystem constructs with regard to potential current clinical considerations and applications. We describe ways in which the RDoC domains and constructs offer transdiagnostic frameworks for complementing traditional practice; suggest clinical questions to help elucidate salient information; and, translating RDoC domains and constructs headings into clinically friendly language, offer a template for the psychiatric review of systems that can serve in clinical notes.