Recent technologies such as artificial intelligence, machine learning, and big data are essential for supporting healthcare monitoring systems, particularly for monitoring Monkeypox confirmed cases. Infected and uninfected cases around the world have contributed to a growing dataset, which is publicly available and can be used by artificial intelligence and machine learning to predict the confirmed cases of Monkeypox at an early stage. Motivated by this, we propose in this paper a new approach for accurate prediction of the Monkeypox confirmed cases based on an optimized Long Short-Term Memory (LSTM) deep network. To fine-tune the hyper-parameters of the LSTM-based deep network, we employed the Al-Biruni Earth Radius (BER) optimization algorithm; thus, the proposed approach is denoted by BER-LSTM. Experimental results show the effectiveness of the proposed approach when assessed using various evaluation criteria, such as Mean Bias Error, which is recorded as (0.06) using BER-LSTM. To prove the superiority of the proposed approach, six different machine learning models are included in the conducted experiments. In addition, four different optimization algorithms are considered for comparison purposes. The results of this comparison confirmed the superiority of the proposed approach. On the other hand, several statistical tests are applied to analyze the stability and significance of the proposed approach. These tests include one-way Analysis of Variance (ANOVA), Wilcoxon, and regression tests. The results of these tests emphasize the robustness, significance, and efficiency of the proposed approach.
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