Nevus Sebaceous Research Articles

Unveiling Squamous Papilloma Resembling Verruca Vulgaris in a Case of Nevus Sebaceous: A Diagnostic Challenge

This case report details the unusual presentation of a 6-year-old male child who had an asymptomatic, well-defined, brown raised lesion over the vertex area of the scalp since birth. His parents noticed a new growth with finger-like projections over existing old lesions for 1 year. With an initial diagnosis of growth of verruca over nevus sebaceous (NS), a sample for histopathology study was sent which revealed findings consistent with squamous papilloma occurring on NS. This is reported to emphasize that any growth over NS should be confirmed histopathologically due to the rarity of this association and to reduce the possibility of its malignant potential. The article emphasizes how crucial histological analysis is to clarifying mistaken cutaneous lesions and refining an accurate diagnosis.

Successful Management of a Rare Giant Sebaceous Nevus of Hemifacial Region

This case report describes a 36-year-old woman who presented with a giant sebaceous nevus affecting her right periauricular area, right facial region, and neck. Excision of all lesions was performed. The remaining defect was reconstructed using local tissue flaps and full-thickness skin grafting, resulting in a favorable aesthetic outcome.

Combined Melanocytic Nevus and Nevus Sebaceus: A Case Series and Review of the Literature.

Nevus sebaceus is a rare congenital hamartoma with clinical and histopathological features that change with puberty. It has been associated with a number of secondary neoplasms, most of which are thought to derive from follicular germ cells. In this article, the authors describe a total of 3 cases of combined melanocytic nevus and nevus sebaceus to highlight this rare finding.

Dermoscopy of Nevus Comdonicus

Nevus sebaceous or comedo naevus is a rare benign hamartoma of the folliculo-sebaceous unit. It is characterized by bundles of papules having dilated follicular openings and keratinous plugs within. We report a case of nevus comedonicus diagnosed based on clinical-histopathological & dermoscopic findings in a 12-year-old male child treated who showed mild improvement with topical retinoids.

Nevus Sebaceous of Jadassohn’s Misdiagnosed as a Vascular Anomaly: a Pediatric Case Report

Nevus Sebaceous of Jadassohn’s Misdiagnosed as a Vascular Anomaly: a Pediatric Case Report

Giant Cerebriform Nevus Sebaceous of Jadassohn in an Infant

Nevi are hamartomatous growth of skin or mucosa that usually present at the time of birth or soon after. Nevus sebaceous (NS) is an epidermal nevus comprised predominantly of sebaceous glands. It presents at the time of birth, as yellow-tan-colored plaque, which usually remains constant till puberty and thereafter it increases in size due to the hormonal influence on sebaceous glands. Here, we are reporting a case of giant cerebriform NS of Jadassohn in a 2-month-old male child. Such giant and cerebriform appearance of NS is rarely seen.

Concurrent Development of Syringocystadenocarcinoma Papilliferum and Sebaceous Carcinoma on a Pre-existing Sebaceous Nevus.

Concurrent Development of Syringocystadenocarcinoma Papilliferum and Sebaceous Carcinoma on a Pre-existing Sebaceous Nevus.

Calcified Sclero-Choroidal Choristomas in Mosaic RASopathies: A Description of a New Imaging Sign

PurposeTo evaluate the imaging and clinical features of unusual calcified lesions seen in the fundus of mosaic RASopathy patients. DesignSingle-center retrospective observational study. SubjectsTen eyes with calcified fundus lesions in 7 mosaic RASopathy patients. MethodsThe lesions were evaluated with fundus photography, oral fundus fluorescein angiography, B-scan ultrasonography, Magnetic Resonance Imaging (MRI), and Computed Tomography (CT) scan where available. Main Outcome MeasuresThe imaging characteristics of calcified fundus lesions were assessed. ResultsWe found seven patients with mosaic RASopathies, 5 males and 2 females (3 with Linear Sebaceous Nevus Syndrome, 3 with Oculoectodermal Syndrome, and 1 with Encephalocraniocutaneous Lipomatosis) with molecular confirmation in 5 cases, all 5 having KRAS-pathogenic variants. Calcified fundus lesions were identified in 10 eyes (bilateral in 3 patients), appearing as slightly elevated, creamy-yellow lesions around or adjacent to the optic nerve, extending supero-nasally; all but two of these lesions involved both the choroid and sclera, with two of them only involving the sclera at the time of examination. One case developed a choroidal neovascular membrane (CNV) necessitating intravitreal bevacizumab injections. All 7 patients had B-scan ultrasonography and the lesion appeared as a hyperechogenic area with an acoustic shadow posteriorly despite reduced gain. Five patients had MRI, and where fundus lesions were present, there was a focal defect in the sclero-choroidal layer. Four patients had a CT scan and all four showed calcifications affecting both the posteromedial sclero-choroid and adjacent medial rectus muscle. Two of these patients had normal eye movements, one had a unilateral fixed adducted eye and a vestigial fibrous medial rectus muscle seen in imaging and intraoperatively, and the fourth had marked exotropia with a right gaze deficit affecting both eyes. ConclusionsWe propose that the lesions seen in this cohort are calcified sclero-choroidal choristomas (CaSCCs) and should be suspected in mosaic RASopathies when creamy-yellow lesions are seen in the fundus. If identified, the possibility of choroidal neovascularization should be considered during follow-up. In all cases where a CT scan was performed, a novel sign of sclero-muscular calcification involving the medial rectus muscle was seen.

An Atlas of Lumps and Bumps, Part 35: Nevus Sebaceous

An Atlas of Lumps and Bumps, Part 35: Nevus Sebaceous

Dermoscopy of Nevus Sebaceous.

Dermoscopy of Nevus Sebaceous.

Nevus Sebaceous Syndrome: A Case Report and Literature Review of the Associated Neurological Complications

The epidermal nevus syndromes (ENS) are a heterogeneous group of congenital anomalies characterized by epidermal or sebaceous nevi that are associated with extracutaneous manifestations that most often involve the central nervous system (CNS), ocular, and skeletal systems. We report a case of an 18-month-old female with widespread nevus sebaceous and brain and eye abnormalities.

Nevus Sebaceous Associated with Trichoblastoma in the Upper Lip: A Rare Presentation

Nevus Sebaceous Associated with Trichoblastoma in the Upper Lip: A Rare Presentation

8-year-old child's Nevus sebaceous of Jadassohn (clinical case)

Nevus sebaceous of Jadassohn is a rare congenital malformation of the adnexal structures of the skin. The prevalence of this pathology is 0.3% of the total number of formations on the skin of newborns and young children. Using a clinical case as an example, the clinical picture, diagnostic criteria and modern approaches to the treatment of sebaceous nevus are considered.

Case Report: Leathery black plaque on the temple and scalp

Background Epidermal nevus sebaceous, commonly known as the nevus sebaceous of Jadassohn, is a congenital sebaceous hamartoma. It typically manifests as a single yellowish plaque across the head and neck and is composed of sebaceous glands. It commonly occurs during infancy and grows during puberty. Usually, it follows a benign course; however, in a few cases, it can be malignant. This is the case of a 13-year-old child with verrucous plaques on the temple and scalp. Case report We report the case of a 13-year-old boy with a steadily developing hyperpigmented verrucous plaque on the scalp and ipsilateral side of his face. A dermoscopic examination revealed ridges and fissures in a cerebriform pattern with yellowish-gray globules and a papillary appearance. Physical examination and laboratory tests revealed no abnormalities. Biopsies were taken from the scalp and temple area, and the findings were consistent with the diagnosis of nevus sebaceous. The patient was referred to a plastic surgeon for a staged excision. Conclusions We describe a unique example of a sebaceous nevus that affected the scalp and ipsilateral side of the face. As this hamartomatous growth carries the risk of cancer development, a dermatologist must identify the condition and begin treatment before malignant transformation occurs. This example of multiple verrucous plaques is an exception.

Squamous Cell Carcinoma Arising in a Nevus Sebaceus in a 10-Year-Old Male

The patient is a 10-year-old male who presented to a dermatologist regarding a bleeding plaque on the right scalp. The initial pathology report demonstrated an atypical endophytic squamous proliferation with an infiltrative pattern, raising concern for squamous cell carcinoma versus pseudoepitheliomatous hyperplasia. Physical exam showed a painless 4.4 x 1.2 cm elliptical, rough, orange-to-pink plaque with waxy superficial scale on the left forehead. Wide local excision was performed, and pathology confirmed no residual carcinoma. Squamous cell carcinoma arising in a nevus sebaceous in a pediatric patient is exceedingly rare, but as demonstrated by this case, does occur, emphasizing the need for improved guidelines for management to optimize treatment in the pediatric population.

Linear alopecia in pediatrics: RCM and dermoscopy reveal diagnostic cues.

Alopecia areata (AA), trichotillomania (TM), nevus sebaceous (NS), and linear scleroderma en coup de sabre (LSCS) can all present with a patch of linear alopecia, making diagnosis challenging. The purpose of this study was to combine reflectance confocal microscopy (RCM) and dermoscopy in the diagnosis of these lesions in children. A total of 36 patients with linear alopecia were enrolled, of whom 14 had AA, seven had TM, nine had NS, and six had LSCS. We evaluated the characteristics and distinguishing features of the four conditions using RCM and dermoscopy. The key to differential diagnosis was the dermal Hair follicle density in the dermis was decreased in AA, and the size and density of the follicular openings were normal in TM. In NS, the major features were petal-like and frogspawn-like structures. In LSCS, dermal papillary rings, sebaceous glands, and follicles were partially or completely missing, and abundant fibrous material was distributed in the dermis. Dermoscopy revealed alopecia, and all four conditions resulted in decreased hair density. AA patients exhibited yellow dots, black dots, and exclamation mark hairs. TM patients presented with irregularly broken hairs and blood spots. Both NS and LSCS patients exhibited an absence of follicular openings; NS patients demonstrated whitish and yellowish round structures, while an atrophic area with white patches, linear vessels, and no yellow or black dots was observed in LSCS patients CONCLUSION: RCM combined with dermoscopy can provide additional information on disease states and differentiate between AA, TM, NS, and LSCS.

Sebaceous gland diseases: clinical picture risk factors and treatment

Sebaceous glands are present in almost every part of the skin or body except the palms and soles, and the primary function of these glands involves the generation of sebum. However, numerous diseases, both benign and malignant, have been linked to abnormal sebaceous gland activity. Sebaceous gland disorders are a class of widespread dermatological conditions with numerous aetiologies. Diseases in which the primary involvement is associated with sebaceous glands comprise conditions such as steatocystoma, sebaceous gland hyperplasia, sebaceoma, sebaceous adenoma, nevus sebaceous, and sebaceous carcinoma. Additionally, sebaceous glands play a secondary role in androgenic alopecia, acne vulgaris, and seborrheic dermatitis. Steatocystoma simplex or multiplex is a non-cancerous growth that arises either sporadically or through inheritance in an autosomal dominant manner, originating from mutations in the keratin 17 gene. Sebaceous gland hyperplasia refers to the non-malignant enlargement of sebaceous lobules, which presents as papules exhibiting a yellowish color and telangiectatic features. Common treatment methods for sebaceous gland hyperplasia include the application of topical retinoids, the administration of oral isotretinoin, and the surgical removal of the affected lesions. Nevus sebaceus also referred to as a nevus of Jadassohn or organoid nevus, represents a congenital skin hamartoma originating from mosaic mutations. While acne vulgaris is a highly prevalent and complex disorder influenced by various factors, one of which is the increased production of sebum. Acne can be managed using approaches like topical or systemic antibiotics, hormonal therapies, cautery-based lesion removal, and phototherapy techniques such as laser treatment. The purpose of this research is to review the sebaceous gland diseases: clinical picture, risk factors, and treatment.

Proliferating Trichilemmal Tumour Arising from a Naevus Sebaceus of Jadassohn

Proliferating Trichilemmal Tumour Arising from a Naevus Sebaceus of Jadassohn

Woolly Hair Nevus Associated with Sebaceous Nevus and Linear Pigmentation

Abstract The term woolly hair nevus was first described and coined in 1927 by Fred Wise. It is a nevoid condition characterized by a circumscribed patch of unruly and curled hair with an altered texture and may be associated with other nevoid conditions. This paper reports a case of a 7-year-old girl with woolly hair nevus overlying nevus sebaceous associated with linear pigmentation.

Ocular findings in Schimmelpenning–Feuerstein–Mims syndrome

Schimmelpenning–Feuerstein–Mims syndrome (SFM), also known as organoid nevus syndrome or linear nevus sebaceous of Jadassohn, is a rare congenital phacomatosis. It includes cutaneous sebaceous nevus along with skeletal, neurological, cardiovascular, and ocular abnormalities. We report a case of a 14-year-old boy with this rare SFM syndrome. We highlight the various ocular features observed in this patient such as epibulbar choristoma, symblepharon, and choroidal osteoma along with the systemic features and discuss the management of each.