We discuss heavy quark contributions to the neutrino-nucleon total cross section at very high energies, well above the real top production threshold. The top-bottom weak current is found to generate strong left-right asymmetry of neutrino-nucleon interactions. We separate contributions of different helicity states and make use of the κ-factorization to derive simple and practically useful formulas for the left-handed (F L ) and right-handed (F R ) components of the conventional structure function 2xF 3 = F L − F R in terms of the integrated gluon density. We show that F L ≫ F R and, consequently, xF 3 ≈ F T , where F T is the transverse structure function. The conventional structure function F 2 = F S + F T at Q 2 ≪ m 2 t appears to be dominated by its scalar (also known as longitudinal) component F S and the hierarchy F S ≫ F L ≫ F R arises naturally. We evaluate the total neutrino-nucleon cross section at ultra-high energies within the color dipole BFKL-formalism.