Neutral Medium Research Articles

Synthesis, Characterization, and Hydrogen Evolution Reaction Activity of MoS2 Nanostructures Prepared Using Nonionic Surfactant

Molybdenum disulfide (MoS2) has garnered significant interest as an auspicious catalytic material for the hydrogen evolution reaction (HER). Here, MoS2 nanostructures are synthesized using the hydrothermal method with ammonium molybdate tetrahydrate ((NH4)6Mo7O24∙4H2O) as the Mo source; thioacetamide (CH3CSNH2) as the reducing agent and S source; and nonylphenols 9, nonylphenols 40, and polysorbate 80 as the surfactants. The impact of the different nonionic surfactants on the materials is comprehensively investigated. Moreover, the MoS2 fine structure was characterized using Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy, scanning electron microscopy (SEM), and transmission scanning microscopy (TEM). The HER characteristics of the MoS2 composites are assessed through electrochemical experiments, including linear sweep voltammetry and chronoamperometry measurements. Among the prepared specimens, MoS2/NP 9 exhibits the best electrocatalytic performance in a neutral medium. Furthermore, 240 mV is required to reach the current density of 10 mAcm−2.

Electron-donable heterojunctions with synergetic Ru-Cu pair sites for biocatalytic microenvironment modulations in inflammatory mandible defects

The clinical treatments of maxillofacial bone defects pose significant challenges due to complex microenvironments, including severe inflammation, high levels of reactive oxygen species (ROS), and potential bacterial infection. Herein, we propose the de novo design of an efficient, versatile, and precise electron-donable heterojunction with synergetic Ru-Cu pair sites (Ru-Cu/EDHJ) for superior biocatalytic regeneration of inflammatory mandible defects and pH-controlled antibacterial therapies. Our studies demonstrate that the unique structure of Ru-Cu/EDHJ enhances the electron density of Ru atoms and optimizes the binding strength of oxygen species, thus improving enzyme-like catalytic performance. Strikingly, this biocompatible Ru-Cu/EDHJ can efficiently switch between ROS scavenging in neutral media and ROS generation in acidic media, thus simultaneously exhibiting superior repair functions and bioadaptive antibacterial properties in treating mandible defects in male mice. We believe synthesizing such biocatalytic heterojunctions with exceptional enzyme-like capabilities will offer a promising pathway for engineering ROS biocatalytic materials to treat trauma, tumors, or infection-caused maxillofacial bone defects.

Fluorine-Doped Graphene Oxide-Modified Graphite Felt Cathode for Hydrogen Peroxide Generation

Electrochemical oxygen reduction via the two-electron pathway (2e-ORR) is an emerging method for producing H2O2. It is cleaner, safer, and more convenient compared to the anthraquinone process. Graphite felt is one of the cathode candidates for large-scale cells due to its excellent mechanical properties. However, commercial graphite felt often fails to achieve the desired hydrogen-peroxide yield because of its low catalytic selectivity for the 2e-ORR pathway. Fluorine-doped carbon materials are expected to enhance 2e-ORR selectivity. This is because the electronic structure of carbon atoms adjacent to fluorine atoms may facilitate the production of hydrogen peroxide while hindering its further reduction. In this study, fluorine-doped graphene oxide (FGO) was prepared by the hydrothermal method. Subsequently, graphite felt modified with FGO was fabricated and used as the cathode for H2O2 production. The results indicated that in alkaline media, the graphite felt modified with FGO achieved a catalytic selectivity of 93% and a generation rate of 8.91 mg cm⁻2 h⁻¹. In comparison, commercial graphite felt had a catalytic selectivity of 75% and a generation rate of 2.10 mg cm⁻2 h⁻¹. Moreover, graphite felt modified by FGO also exhibited excellent electrocatalytic performance for H2O2 generation in neutral media. This research provides a fundamental study to promote the application of graphite felt in the environmentally friendly electrocatalytic production of hydrogen peroxide in industries.

Spherical Ru/FeOx composite as a bifunctional electrocatalyst for overall water splitting in neutral media

Electrochemical water splitting stands out as a promising technology for H2 production, due to its simplicity and high energy conversion efficiency. Therefore, it is a key issue to develop and design efficient catalysts for overall water splitting (OWS), especially in neutral media. Herein, the present study presents a stable bifunctional electrocatalyst, namely a spherical structure consisting of ruthenium and iron oxide composite supported on iron foam (Ru/FeOx), which was prepared using a simple two-step process. In 1.0M PBS, the optimized Ru/FeOx-300 demonstrates low overpotentials of 30 and 212mV for hydrogen evolution reaction (HER) and oxygen evolution reaction (OER) at 10mAcm-2, respectively. More impressively, Ru/FeOx-300 requires only 1.505V to achieve a current density of 10mAcm-2 and exhibits superior electrochemical stability for 24h in a two-electrode neutral electrolyzer. The outstanding catalytic performance and stability of Ru/FeOx-300 nanospheres for water splitting are attributed to the binder-free integrated structure, the enhanced charge transfer facilitated and the synergistic effect between Ru and FeOx. This study offers a novel approach to the development of high-efficiency electrocatalysts for overall water splitting in neutral media.

Unveiling graphite anodic expansion: Insights from electrochemical techniques, mass spectrometry, and kinetic modelling

Anodic expansion of graphite at different pH has been studied by coupling a mass spectrometer to an electrochemical cell. The mass spectrometry technique permits to follow the electrochemical gasification of graphite as well as the reaction products formed from the electrolyte. The current and mass spectrometry signals suggest that the neutral medium is the least aggressive for expansion. In addition, chronoamperometric expansion of graphite at different potentials has been carried out using the neutral medium. This experimental approach permits to get detailed information about the reaction mechanism that produces graphene-oxide based materials. The effect of potential and electrolyte concentration have been studied, and it has been observed that the degree of oxidation of the graphene oxide material obtained can be controlled. In addition, a kinetic model based on a phase-moving boundary has been used to describe the chronoamperometric experiments. Two types of graphene oxide materials have been obtained with the anodic synthesis and have been classified as few-layer graphene oxide (FLGO) and graphene oxide quantum dots (GOQDs). The physicochemical and electrochemical properties of both products have been studied.

In Silico Drug Encapsulation Using 2-Hydroxypropyl-β-CD, Tyrosine Kinase and Tyrosinase Inhibition of Dinuclear Cu(II) Carboxylate Complexes

In recent years, copper carboxylate complexes have garnered significant interest for biological applications. This study focuses on 20 Cu(II) carboxylate complexes selected from our previous research. Due to the hydrophobic nature of these complexes, the 2-hydroxypropyl-β-cyclodextrin (2HPβCD) was employed as a carrier to reduce toxicity and increase solubility for controlling drug delivery. Monte Carlo calculations were performed to confirm the interaction between the optimized structures of Cu(II) complexes and 2HPβCD, forming a host-guest system. All the structures were simulated and optimized using DFT-D calculations in Material Studio 2017. The results indicated that a neutral medium is more favorable for the adsorption of these complexes into 2HPβCD. More negative binding energy values suggested strong and energetically favorable adsorption on 2HPβCD. Complexes 4, 5, and 7 exhibited the highest interaction, making them excellent candidates for drug delivery systems. DFT-D calculations were also used to investigate the release of complexes, revealing that complexes 5, 14, and 19 were difficult to release due to their lowest energy. In contrast, complexes 8, 9, and 16 were found to be most efficient to release due to weak non-covalent interactions with 2HPβCD as we can predict from binding energy obtained by DFT-D. No specific trend was observed in the interaction of the complexes with 2HPβCD. Additionally, the effects of these complexes on c-kit tyrosine kinase and Mushroom tyrosinase were studied by molecular docking. The results demonstrated that all the complexes interacted with the active site of respective receptors through hydrophobic interactions. Complexes containing 1,10-phenanthroline and 2,2-bipyrdine were identified as having a strong, spontaneous binding ability with receptors.

Super-hybrid transition metal sulfide nanoarrays of NiS nanoparticle/WS2 nanosheet/Ni3S4 nanoparticle with abundant plane- and edge-type active interfaces for robust all-pH hydrogen evolution

Transition metal sulfides (TMSs) are primitive composition of biocatalysts that are active for molecular hydrogen production. The development of non-precious TMSs with appropriate spatial ordering has great potentials to contribute high-level hydrogen generation. Herein, super-hybrid transition metal sulfide nanoarrays of NiS nanoparticle/WS2 nanosheet/Ni3S4 nanoparticle (Super-NiS/WS2/Ni3S4) with high spatial ordering and abundant plane- and edge-type WS2-NiS and WS2-Ni3S4 heterointerfaces were elaborately constructed though manipulating the sequential dissociation of phosphotungstic acid (PW12) as W precursor and nickel foam as Ni precursor in one pot. When evaluated for the electrocatalytic hydrogen evolution reaction (HER), the Super-NiS/WS2/Ni3S4 only required overpotentials of 57, 95, and 151 mV to drive HER in alkaline, acid, and neutral media, respectively, and presented favorable reaction kinetics and test stability. The theoretical and experimental results verify the adsorption and dissociation of water molecules are preferential on WS2-plane-related heterointerfaces. The Gibbs free energy (ΔGH*) analysis indicated the WS2-plane-NiS interface is thermodynamically optimal for HER. Moreover, the collaborations of the abundant plane- and edge-type active interfaces, the open nanosheet-based vertical array, and the phosphorus doping in Super-NiS/WS2/Ni3S4 strengthen mass transport and electron transfer in electrocatalysis. The polyoxometalates-based synthetic strategy will inspire the new vision for the rational design and construction of advanced functional materials.

Migration of para-Nitrophenyl Groups in Methyl Pyranosides: Configuration and Conformation Determine the Kinetics.

para-Nitrophenyl (PNP) ethers of glycosides are important building blocks en route to functional carbohydrates. They are stable in neutral media, however, under basic conditions such as during the Zemplén deacylation of sugars, aryl migration is frequently observed. We have employed a library of O-PNP-substituted methyl glycosides of the manno-, galacto-, gluco- and altro-series to study the kinetics of aryl migration in MeOH/sodium methoxide using NMR spectroscopy revealing that migration between cis-oriented OH groups is faster than between trans-oriented ones. The rate constants of migration decrease in the order of Alt>Man>Gal>Glc and are related to the energy barriers of chair conformation inversion. The energy profile of the 3 to 4-PNP migration in methyl mannoside was calculated using DFT methods suggesting the Meisenheimer complex is an intermediate of PNP migration and that coordination of the sodium cation has a major impact on the energy profile.

Revisiting the Vertical Distribution of H i Absorbing Clouds in the Solar Neighborhood. II. Constraints from a Large Catalog of 21 cm Absorption Observations at High Galactic Latitudes

The cold neutral medium (CNM) is where neutral atomic hydrogen (H i) is converted into molecular clouds, so the structure and kinematics of the CNM are key drivers of galaxy evolution. Here we provide new constraints on the vertical distribution of the CNM using the recently developed kinematic_scaleheight software package and a large catalog of sensitive H i absorption observations. We estimate the thickness of the CNM in the solar neighborhood to be σ z ∼ 50–90 pc, assuming a Gaussian vertical distribution. This is a factor of ∼2 smaller than typically assumed, indicating that the thickness of the CNM in the solar neighborhood is similar to that found in the inner Galaxy, consistent with recent simulation results. If we consider only structures with H i optical depths τ > 0.1 or column densities N(H i) > 1019.5 cm−2, which recent work suggests are thresholds for molecule formation, we find σ z ∼ 50 pc. Meanwhile, for structures with τ < 0.1 or column densities N(H i) < 1019.5 cm−2, we find σ z ∼ 120 pc. These thicknesses are similar to those derived for the thin- and thick-disk molecular cloud populations traced by CO emission, possibly suggesting that cold H i and CO are well mixed. Approximately 20% of CNM structures are identified as outliers, with kinematics that are not well explained by Galactic rotation. We show that some of these CNM structures—perhaps representing intermediate-velocity clouds—are associated with the Local Bubble wall. We compare our results to recent observations and simulations, and we discuss their implications for the multiphase structure of the Milky Way’s interstellar medium.

On the interaction of glucose with ammonium molybdate (Hager-Gawalowsky test)

Glucose is an Analyte. Thus, several tests for its detection in urine have been developed. In the present communication the reaction route of the Hager-Gawalowsky test for glucose is provided. Each step is fully commented and the electron flow is also given. The test is based on the interaction of glucose with ammonium molybdate in neutral medium, a blue colour is produced on heating. The active hydrogen in glucose is removed by the inorganic anion, and the resulting enolate from an enediol reacts with the mono-anion just formed. A hydroxylate is eliminated via open-close of a Mo-O double bond. Hydrion switch forms a second enolate that produces a concerted mechanism affording 2-ketoglucose and molybdenum dioxide by a redox reaction.

Methanol, ethylene glycol, and glycerol photoelectrochemical oxidation reactions on BiVO4: Zr,Mo/Pt thin films: A comparative study

The green H2 production plays a key role in the energy transition, however it still needs improvements to be applied in a large scale. The water oxidation reaction, as an anodic process to provide both protons and electrons for H2 production, possesses kinetic limitations. Therefore, the use of an alternative process like the oxidation of biomass-derivative species is extremely desired to replace water oxidation during H2 production. In this work, we provide a comparative study of different small organic molecules (methanol, ethylene glycol (EG), and glycerol) as alternatives to water oxidation at pristine BiVO4, Mo-Zr dopped BiVO4, and Pt co-catalyst BiVO4 photoanodes in neutral media. While the band energy diagram and surface morphology are similar for the distinct materials, the presence of Zr-Mo increases the charge carriers density. The presence of Pt acts as co-catalyst for the organic molecules. Regardless of the material employed, the activity order for each organic molecule reaction was: jwater< jmethanol < jEG < jglycerol affeered by both linear potential sweep and chronoamperometry at 1.23 V vs RHE. The presence of both Zr-Mo and Pt increases the photoactivity for the alcohol's oxidation, however the presence of Pt is more advantageous for glycerol oxidation than for other species, maintaining 80 % of activity after 24 h electrolysis. The reactivity of alcohols can be tentatively explained by the greater stability of radicals formed from larger molecules.

Filamentary Molecular Cloud Formation via Collision-induced Magnetic Reconnection in a Cold Neutral Medium

We have investigated the possibility of molecular cloud formation via the collision-induced magnetic reconnection (CMR) mechanism of the cold neutral medium (CNM). Two atomic gas clouds with conditions typical of the CNM were set to collide at the interface of reverse magnetic fields. The cloud–cloud collision triggered magnetic reconnection and produced a giant 20 pc filamentary structure that was not seen in the control models without CMR. The cloud, with rich fiber-like substructures, developed a fully molecular spine at 5 Myr. Radiative transfer modeling of dust emission at far-infrared wavelengths showed that the middle part of the filament contained dense cores over a span of 5 pc. Some of the cores were actively forming stars and typically exhibited both connecting fibers in dust emission and high-velocity gas in CO line emission, indicative of active accretion through streamers. Supersonic turbulence was present in and around the CMR filament due to inflowing gas moving at supersonic velocities in the collision midplane. The shocked gas was condensed and transported to the main filament piece by piece by reconnected fields, making the filament and star formation a bottom-up process. Instead of forming a gravitationally bounded cloud that then fragments hierarchically (top-down) and forms stars, the CMR process creates dense gas pieces and magnetically transports them to the central axis to constitute the filament. Since no turbulence is manually driven, our results suggest that CMR is capable of self-generating turbulence. Finally, the resulting helical field should show field reversal on both sides of the filament from most viewing angles.

Electrospun Co-MoC Nanoparticles Embedded in Carbon Nanofibers for Highly Efficient pH-Universal Hydrogen Evolution Reaction and Alkaline Overall Water Splitting.

The construction of highly efficient and self-supported electrocatalysts with abundant active sites for pH-universal hydrogen evolution reaction (HER) and alkaline water splitting is significantly challenging. Herein, Co and MoC nanoparticles embedded in nitrogen-doped carbon nanofibers (Co-MoC/NCNFs) which display a bamboo-like morphology are prepared by electrospinning followed by the carbonization method. The electrospun MoC possesses an ultrasmall size (≈5nm) which can provide more active sites during electrocatalysis, while the introduction of Co greatly optimizes the electronic structure of MoC. Both endow the Co-MoC/NCNFs with superior HER performances over a wide pH range, with low overpotentials of 86, 116, and 145mV to achieve a current density of 10mAcm-2 in alkaline, acidic, and neutral media, respectively. Additionally, the catalyst exhibits remarkable alkaline oxygen evolution reaction (OER) activity with an overpotential of 254mV to reach 10mAcm-2. Density functional theory calculations confirm that electron transfer from Co to MoC regulates the adsorption free energy for hydrogen, thereby promoting HER. Moreover, an electrolyzer assembled with Co-MoC/NCNFs requires only a cell voltage of 1.59V at 10mAcm-2 in 1m KOH. This work opens new pathways for the design of high-efficiency electrocatalysts for energy conversion applications.

α-MnO2 with a cryptomelane structure for the non-enzymatic glucose electrooxidation in a neutral medium

A high demand for non-enzymatic glucose sensors and continuous glucose monitoring systems encourages the development of stable and active catalysts for the enzymeless anodic oxidation of glucose in the neutral medium. In regard to this reaction, we analyze the prospects of alpha manganese dioxide with a cryptomelane structure synthesized via an aqueous chemical route. To provide various specific surface area, the hydrated α-MnO2 oxide is annealed in a wide temperature range from 60 to 700 °C. Furthermore, we investigate the influence of the oxide annealing temperature on the amount of crystal water, chemical composition, morphology, electrochemical recharging behavior, electrocatalytic activity and stability in the glucose oxidation carried out in an isotonic NaCl-based phosphate-buffered saline (pH 7.40). To solidly determine potentials of the irreversible cathodic dissolution of α-MnO2 as well as O2/Cl2 evolution on α-MnO2, a rotating ring-disk electrode is applied. For the most active α-MnO2 sample with the 100 μg cm−2geo loading the glucose oxidation current of ca. 40 μA cm−2geo after 1 h at +0.8 V (SCE) for 7 mM of glucose is achieved. The linear concentration dependence in a physiological glucose range (1–30 mM) with the sensitivity of ca. 17.8 μA mM−0.5 cm−2geo at 25 °C is observed. Finally, glucose selectivity of α-MnO2 in relation to fructose, galactose, xylose, ribose, urea, lactic acid, acetone, ascorbic acid and paracetamol is revealed.

Electrokinetics of Nitrite to Ammonia Conversion in the Neutral Medium Over A Platinum Surface.

Polycrystalline Pt electrode was employed to selectively convert nitrite ions ( ) into useful nitrogenous compound through electrochemical reduction reaction in neutral medium. According to adsorptive stripping analysis, the reduction process produced nitric oxide (NO) on the surface of Pt electrode. The spectroscopic test and gas chromatographic studies discovered the presence of ammonia (NH3) in the electrolyzed solution, suggesting the transformation of adsorbed NO into NH3 during the reverse scan. Scan rate dependent investigation was performed to elucidate kinetic information relating to this reaction on Pt surface. From Ep vs scan rate (υ) and jp vs υ (logarithmic plot), it was found that the conversion of ion into NO is an irreversible reaction which relies on the diffusion of ions to electrode surface. The Tafel analysis unveiled that the first electron transfer sets the overall reaction rate, having formal reduction potential, E0'=-0.46 V and standard heterogeneous rate constant, k0= cm s-1. Reductive transfer coefficient (α) is another kinetics parameter, which was found to be approximate 0.77 from the difference between Ep and Ep/2 of the voltammograms obtained over scan rate range 0.005 V s-1 to 0.250 V s-1, indicating a stepwise process. According to temperature-dependent voltammograms, the nitrite reduction reaction on Pt had a calculated activation energy of about 19.8 kJ mol-1 and a pre-exponential factor of about 8.39×103 mA cm-2.

Solvent-free and efficient heterogeneous Biginelli reactions catalyzed by copper (II)-incorporated iminophenol-based porous organic polymer

The copper (II)-incorporated iminophenol containing porous polymer (Cu-TAzo-TAPB), which was reported to be a recyclable catalyst for click reactions, is now exploited as an efficient catalyst in the solvent-free one-pot process to make 3,4-dihydropyrimidinone derivatives (DHPMs) by a three-component condensation reaction of urea/thiourea, aldehydes, and active methylene compounds. Usually, these reactions are complicated to carry out in a neutral medium. We describe here an eco-friendly method to produce Biginelli products with 5 mol% catalyst loading with a simple isolation technique. The high product yields show the effective Biginelli reaction technique. The catalyst is highly stable and easily recoverable for reuse without significant loss of catalytic efficiency.

Novel Thiourea Ligands—Synthesis, Characterization and Preliminary Study on Their Coordination Abilities

Two series of polydentate N,O,S-ligands containing thiourea fragments attached to a p-cresol scaffold, unsymmetrical mono-acylated bis-amines and symmetrical bis-thioureas, are obtained by common experiments. It is observed that the reaction output is strongly dependent on both bis-amine and thiocarbamic chloride substituents. The products are characterized by 1D and 2D NMR spectra in solution and by single crystal XRD. A preliminary study on the coordination abilities of selected products is performed by ITC at around neutral media.

Modelling of long gamma-ray burst host galaxies at cosmic noon from damped Lyman-α absorption statistics

ABSTRACT We study the properties of long gamma-ray burst (GRB) host galaxies using a statistical modelling framework derived to model damped Lyman-$\alpha$ absorbers (DLAs) in quasar spectra at high redshift. The distribution of $N_{\rm H\, {\small I}}$ for GRB-DLAs is $\sim$10 times higher than what is found for quasar-DLAs at similar impact parameters. We interpret this as a temporal selection effect due to the short-lived GRB progenitor probing its host at the onset of a starburst where the interstellar medium may exhibit multiple overdense regions. Owing to the larger $N_{\rm H\, {\small I}}$, the dust extinction is larger with 29 per cent of GRB-DLAs exhibiting $A(V)\gt 1$ mag in agreement with the fraction of ‘dark bursts’. Despite the differences in $N_{\rm H\, {\small I}}$ distributions, we find that high-redshift $2 \lt z \lt 3$ quasar- and GRB-DLAs trace the luminosity function of star-forming host galaxies in the same way. We propose that their differences may arise from the fact that the galaxies are sampled at different times in their star formation histories, and that the absorption sightlines probe the galaxy haloes differently. Quasar-DLAs sample the full H i cross-section, whereas GRB-DLAs sample only regions hosting cold neutral medium. Previous studies have found that GRBs avoid high-metallicity galaxies ($\sim$0.5 $Z_{\odot }$). Since at these redshifts galaxies on average have lower metallicities, our sample is only weakly sensitive to such a threshold. Lastly, we find that the modest detection rate of cold gas (H$_2$ or C i) in GRB spectra can be explained mainly by a low volume filling factor of cold gas clouds and to a lesser degree by destruction from the GRB explosion itself.

Hydration‐effect Boosted Active Hydrogen Facilitates Neutral Ammonia Electrosynthesis from Nitrate Reduction

AbstractElectrocatalytic nitrate reduction to ammonia (NO3RR) in a neutral medium is a green and effective strategy for treating nitrate pollution meanwhile producing ammonia. However, the insufficient active hydrogen (H*) on the catalyst surface resulting from the sluggish Volmer step (H2O → H+ + OH−), and the competitive hydrogen evolution reaction (HER) caused by H* coupling severely restrict the enhancement of NO3RR activity. Herein, a hydration‐effect boosted H*‐rich strategy facilitating neutral ammonia electrosynthesis from nitrate reduction is proposed. The introduction of the hydration‐effect‐promoting element aluminum into the copper‐based catalyst forming CuAlO2, which adjusts the electron density distribution in the catalyst system, and the resulting hydration‐effect significantly promotes the H* generation in a neutral medium. Moreover, the rapid charge transfer at the CuO/CuAlO2 interface facilitates the reaction kinetics and the H* diffusion. More importantly, the introduction of Al weakens the overly strong adsorption of intermediates by CuO, thereby accelerating the hydrogenation process and suppressing HER. Thus, under neutral conditions, CuO/CuAlO2 reached a Faradaic efficiency and an ammonia yield as high as 97.81 ± 1.94% and 10.21 ± 0.64 mg h−1 cm−2 at −1.0 V versus RHE toward NO3RR.

Interfacial Acid‐Like Microenvironment and Orbital Modulating Strategy toward Efficient Hydrogen Evolution in Neutral High‐Salinity Wastewater/Seawater

Electrochemical high‐salinity wastewater splitting is a promising technology for green hydrogen (H2) production. However, the kinetics of hydrogen evolution reaction (HER) in neutral media is slow, and the high theoretical potential of oxygen evolution reaction leads to large energy losses. Herein, an iron‐based electrocoagulation‐coupled hydrogen production integrated system (IEHPS) is constructed, which is realized by coupling low‐potential anodic iron oxidation reaction with cathodic HER. The non‐noble metal HxWO3‐Ni catalyst is synthesized by fabricating a proton sponge HxWO3 to achieve an interfacial acid‐like microenvironment and doping it with Ni heteroatom to modulate the 4d orbital of W, thereby weakening the adsorption strength of the W site toward hydrogen. Consequently, the HxWO3 Ni demonstrates remarkable performance characteristics, boasting a mere 131 mV overpotential at 10 mA cm−2 and Tafel slope of 44 mV dec− in neutral media. Operating at an applied voltage of 1.5 V, the IEHPS exhibits a high hydrogen production rate of 235 mL g−1 min−1 in seawater. It achieves nearly complete removal of contaminants like rhodamine B and heavy metal ions within a rapid 8–20 min, with an energy consumption of only 3.7 kWh Nm−3. This study provides a promising pathway for efficient and energy‐saving production of high‐purity hydrogen and effective treatment of high‐salinity wastewater.