Abstract Objective The Tuberous Sclerosis Associated Neuropsychiatric Disorders (TAND) checklist is a screening tool developed to assist in clarifying behavioral, psychiatric, neuropsychological, and psychosocial manifestations experienced by individuals with Tuberous Sclerosis Complex (TSC). TSC is a multisystem disorder, impacting 1 in 6000 children annually, caused by mutations in the TSC1/TSC2 genes that results in tumor growth throughout the body associated with widespread adverse medical and neurological outcomes including cognition. We present the use of the TAND checklist in a child referred for cognitive evaluation in the context of TSC to explore its potential use within neuropsychological assessment. Method Eleven-year-old female with TSC, referred by neurology, was seen for outpatient neuropsychological evaluation. Comprehensive neuropsychological testing and completion of the TAND checklist with parent were completed. Results Evaluation revealed variable cognitive performances with strengths in fluid reasoning and relative weakness in working memory. Academic performances were low average with weakness in reading. Overall slowed and disrupted processing impacted performance across domains. TAND checklist helped elucidate parental report about cognitive and psychological difficulties. Conclusions This eleven-year-old girl’s profile was variable across domains, consistent with research findings that TSC is a multisystemic disorder presenting in widespread dysfunction. Implementing the TAND checklist was helpful in efficiently eliciting symptomology across domains from parent collateral informant, demonstrating its augmentative value to comprehensive neuropsychological assessment in children with TSC. This is an important next step in validating the TAND checklist in neuropsychological settings.
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