Article1 January 1933Oral Administration of Metaphen in the Treatment of Gastric and Duodenal UlcersCLARENCE MORTON TRIPPE, A.M., M.D., F.A.C.P.CLARENCE MORTON TRIPPE, A.M., M.D., F.A.C.P.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-6-7-901 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe opinion is at present generally held that many patients with ulcer belong to the spasmophilic-vasoneurotic type, and therefore antispasmodic drugs, such as atropine and belladonna, in conjunction with the Sippy diet, are used in the treatment of ulcers and nervous dyspepsia. However, it is the opinion of the author (and also that of many other neurologists) that more attention must be paid to direct treatment of the stomach and the intestines, and that one should not rely exclusively on the above and on general methods of psychotherapy and physiotherapy, as, for instance, drug sedatives and stimulants. In the direct...References1 AARON CD: Diseases of the digestive organs with special reference to their diagnosis and treatment, 1918, Lea & Febiger, Philadelphia, 448. Google Scholar2 RAIZISSSEVERAC GWM: A new organic mercury compound with powerful germicidal properties, Jr. Lab. and Clin. Med., 1923, ix, 71-80. Google Scholar3 RAIZISSSEVERAC GWM: Metaphen (4-nitro-3, 5-biacetoxymercuri-2-cresol) and its bactericidal properties, Jr. Infect. Dis., 1927, xl, 447-452. CrossrefGoogle Scholar4 BIRKHAUG KE: Metaphen (4-nitro-3, 5-biacetoxymercuri-2-cresol); comparative study of commonly used disinfectants and antiseptics; histologic changes produced by intravenous administration of metaphen in rabbits, Jr. Am. Med. Assoc., 1930, xcv, 917-923. CrossrefGoogle Scholar5 HIRSCHFELDERWRIGHT ADHN: Studies on colloid chemistry of antisepsis and chemotherapy; ultramicroscopic examination of neoarsphenamine and of certain antiseptics, and their effects upon protein solutions, Jr. Pharmacol. and Exper. Therap., 1930, xxxix, 13-27. Google Scholar6 YORK DA: First aid and after treatment of minor injuries, Texas State Jr. Med., 1927, xxii, 709-710. Google Scholar7 THOREK M: The etiology, prevention and treatment of post-operative wound infections, Ill. Med. Jr., 1926, 1, 477-483. Google Scholar8 BLEDSOE RE: Metaphen locally and intravenously, Jr. Chemotherapy, 1928, v, no. I, 37. Google Scholar9 FISKE S: Metaphen in streptococcic lymphangitis and adenitis (a case report), Clin. Med and Surg., 1927, xxxiv, 378-379. Google Scholar10 SPOTTS SD: Metaphen in treatment of peritonitis, Jr. Chemotherapy, 1927, iv, no. 2., 48-50. Google Scholar11 FISHER R: Ruptured appendix and peritonitis treated with metaphen (a case report), Clin. Med. and Surg., 1927, xxxiv, 857-858. Google Scholar12 JAMES F: The etiology and treatment of Vincent's angina, Jr. Chemotherapy, 1929, vi, no. 1, 4-8, and no. 3, 9. Google Scholar13 SYMON WG: Metaphen in the treatment of Vincent's angina, Clin. Med. and Surg., 1931, xxxviii, 825-826. Google Scholar14 BROWN IC: Metaphen in the prevention and treatment of colds, Clin. Med., 1925, xxxii, 181. Google Scholar15 SULLIVAN EC: The treatment and prevention of colds with metaphen, Clin. Med., 1925, xxxii, 150-151. Google Scholar16 FENTON RA: Dyestuff antiseptics in rhinology, Ann. Otol., Rhin. and Laryngol., 1925, xxxiv, 884-886. Google Scholar17 GORMAN JR: Non-operative treatment of chronic otitis media suppurativa, Virginia Med. Monthly, 1926, liii, 378-382. Google Scholar18 DUBOIS LC: Acute prostatitis—a new conception of its etiology and treatment, Clin. Med. and Surg., 1928, xxxv, 331-332. Google Scholar19 BERNSTINE JB: Metaphen in the treatment of puerperal septicemia and other blood stream infections, Am. Jr. Obst. and Gynec., 1929, xviii, 220-229. CrossrefGoogle Scholar20 ROSENOW EC: The production of ulcer of the stomach by injection of streptococci, Jr. Am. Med. Assoc., 1913, lxi, 1947-1950. CrossrefGoogle Scholar21 ROSENOW EC: Relation of and the lesion produced by various forms of streptococci with special reference to arthritis, Jr. Am. Med. Assoc., 1913, lxi, 2007. Google Scholar22 ROSENOW EC: The causation of gastric and duodenal ulcers, by streptococci, Jr. Infect. Dis., 1916, xix, 333-362. CrossrefGoogle Scholar23 ROSENOW EC, Etiology of spontaneous ulcer of stomach in domestic animals, Jr. Infect. Dis., 1923, xxxii, 384-399. CrossrefGoogle Scholar24 CELLERTHALHIMER HLW: Bacteriological and experimental studies on gastric ulcer, Jr. Exper. Med., 1916, xxiii, 791-812. CrossrefGoogle Scholar25 DUVAL P: Note sur la rôle de l'infection dans l'évolution des ulcères gastro-duodenaux et sur les indication thérapeutiques qui peuvent en résulter, l'Acad. de med., 1924, xcii, 1257-1259. Google Scholar26 DUVALROUXMOUTIER PJCF: Rôle de l'infection dans l'évolution des ulcères gastro-duodenaux; indications thérapeutiques, Presse méd., 1925, xxxiii 3. Google Scholar27 ASKANAZY M: Über Bau und Entstehung des chron. Magengeschwürs, sowie Soorpilzbefund in ihm, Virchows Arch. f. path. Anat., 1921, ccxxxiv, 111-178. CrossrefGoogle Scholar28 SMITHIES F: Observations upon the nature, diagnosis and clinical management of gastric ulcers with suggestions for a rational regimen of treatment, Am. Jr. Med. Sci., 1923, clxvi, 781-801. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Asbury Park, New Jersey PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetails Metrics Cited ByCertain newer methods of treating peptic ulcer 1 January 1933Volume 6, Issue 7Page: 901-912KeywordsAtropineDietDrug psychotherapyDrugsDuodenal ulcersGastric ulcersOral administrationPhysiotherapySedativesStomach Issue Published: 1 January 1933 PDF DownloadLoading ...
Read full abstract