Negative Response Research Articles

Disrupted one-carbon metabolism in heifers negatively affects their health and physiology.

The objective of this study was to determine the dose-dependent response of one-carbon metabolite (OCM: methionine, choline, folate, and vitamin B12) supplementation on heifer dry matter intake on fixed gain, organ mass, hematology, cytokine concentration, pancreatic and jejunal enzyme activity, and muscle hydrogen peroxide production. Angus heifers (n = 30; BW = 392.6 ± 12.6kg) were individually fed and assigned to one of five treatments: 0XNEG: Total mixed ration (TMR) and saline injections at d 0 and 7 of the estrous cycle, 0XPOS: TMR, rumen protected methionine (MET) fed at 0.08% of the diet dry matter, rumen protected choline (CHOL) fed at 60g/d, and saline injections at d 0 and 7, 0.5X: TMR, MET, CHOL, 5-mg B12, and 80-mg folate injections at d 0 and 7, 1X: TMR, MET CHOL, 10-mg vitamin B12, and 160-mg folate at d 0 and 7, and 2X: TMR, MET, CHOL, 20-mg vitamin B12, and 320-mg folate at d 0 and 7. All heifers were estrus synchronized but not bred, and blood samples were collected on d 0, 7, and at slaughter (d 14) during which tissues were collected. By design, heifer ADG did not differ (P = 0.96). Spleen weight and uterine weight were affected cubically (P = 0.03) decreasing from 0XPOS to 0.5X. Ovarian weight decreased linearly (P < 0.01) with increasing folate and B12 injection. Hemoglobin and hematocrit percentage were decreased (P < 0.01) in the 0.5X treatment compared with all other treatments. Plasma glucose, histotroph protein, and pancreatic α-amylase were decreased (P ≤ 0.04) in the 0.5X treatment. Heifers on the 2X treatment had greater pancreatic α-amylase compared with 0XNEG and 0.5X treatment. Interleukin-6 in plasma tended (P = 0.08) to be greater in the 0XPOS heifers compared with all other treatments. Lastly, 0XPOS-treated heifers had reduced (P ≤ 0.07) hydrogen peroxide production in muscle compared with 0XNEG heifers. These data imply that while certain doses of OCM do not improve whole animal physiology, OCM supplementation doses that disrupt one-carbon metabolism, such as that of the 0.5X treatment, can induce a negative systemic response that result in negative effects in both the dam and the conceptus during early gestation. Therefore, it is necessary to simultaneously establish an optimal OCM dose that increases circulating concentrations for use by the dam and the conceptus, while avoiding potential negative side effects of a disruptive OCM, to evaluate the long-term impacts of OCM supplementation of offspring programming.

Family influence on stigma internalisation in people with severe mental illness: A grounded theory study.

The internalisation of stigma has adverse effects on the recovery and quality of life of people with severe mental illnesses. Studies have shown that life experiences in one's close environment are highly relevant in explaining the onset and development of self-stigma. Families play a critical role in the daily care of people with severe mental illness and have a profound impact on patient recovery. This qualitative study explored the influence of family on stigma internalisation among people with severe mental illness in the context of Chinese culture. A grounded theory design was used. Semi-structured interviews were conducted with 20 patients with severe mental illness and 10 family members, and observations were carried out among five of the families. The data analysis followed three steps (open, axial and selective coding) and involved the use of a constant comparative method and memo writing. The COREQ reporting checklist was used to report the results. Our findings revealed that families can facilitate and impede stigma internalisation in people with severe mental illness via negative or positive daily interactions. A theoretical framework was developed to present the potential effects of the identified family factors on stigma internalisation. Three major family factors influencing patients' internalised stigma were identified, namely, "beliefs of family members" at the individual level, "responses within the family" at the intrafamilial level and "differentiated family environment" at the level of the whole family system, in which "biased beliefs of family members" could bring about "negative responses within the family" and further result in patients' internalised stigma. Our findings suggested that mental health stigma internalised by ill people should be viewed within the broad context of the family. Family-based programs aimed at improving positive interactions and support within the family need to be developed and launched, with particular attention given to interventions for affiliate stigma, coping with stigma and families' negative responses towards people with severe mental illness to prevent the internalisation of stigma by patients.

Legal restrictions are a specific method of legal regulation

The analysis of scientific sources provides grounds to assert that legal regulation is the regulation of social relations carried out through law and the entire set of legal means. The concept of «regulation» (from Latin regulo - rule) implies organization, adjustment, and bringing something into conformity with something else. In our view, to regulate means to define the behavior of individuals and their collectives, to direct their functioning and development, to provide certain limits, and to organize them purposefully. Alongside this, some scholars relate the term «regulation» solely to law as a system of norms and some other specific legal phenomena (legal relations, acts of law implementation). They disagree with the existing understanding of the regulation of social relations as the rigid and authoritative norming by the state and law, as, in their opinion, the category of «regulation» is not synonymous with coercion, rigid, and authoritative prescription. The legal norm establishes only a model of relations in which social interests must be correlated with the interests of society members, and alongside this, law widely uses such means of influencing people’s behavior as stimulation, encouragement, granting rights, etc. It is argued that to transition to the definition of legal regulation, it is necessary to refer to the theory of law, which provides explanations for the concepts of «legal influence» and «legal regulation». Legal influence is considered a broader concept, as it includes the normative-organizational influence on social relations not only through a system of special legal means (those that directly regulate these relations - legal norms, legal relations, acts of implementation and application of law), but also through other legal phenomena – legal consciousness, legal culture, legal principles, law-making process, etc. A proposed definition states that legal regulation is the authoritative influence on social relations carried out by the state through all legal means for the purpose of their organization, establishment, protection, and development. Besides such (regulatory) influence, law also exerts a spiritual-ideological influence on individual and social consciousness (both in the process of legal regulation and beyond). «Restrictions» and «prohibitions» as legal categories have been analyzed. The etymology of the words «restriction» and «prohibition,» their relationship to each other and to adjacent and synonymous concepts, have been explored, and an original interpretation of the content and essence of these concepts has been proposed. A number of features characterizing restrictions and prohibitions as legal categories have been identified (defined in normative legal acts; established to prevent potential abuses of law; associated with a «narrowing» of an individual’s legal status; presuppose a specific model of behavior, specifically restrictions entail active behavior, meaning to do only what is defined within limits; prohibitions entail passive behavior, meaning to refrain from doing prohibited actions; they perform a protective function in social relations; non-compliance with them is accompanied by a negative response from the state. The concept, characteristics, classification, and a systematic analysis of restrictions and prohibitions as means of legal regulation have been defined. Based on the analysis of dictionary, reference, encyclopedic literature, as well as specialized legal sources, the article formulates original definitions of «restriction». The specificity of these particular restrictions and prohibitions lies in their special area of application (they apply to individuals when exercising their powers within the civil service); they apply to specific subjects (directly to individuals who have the legal status of civil servants); their application is determined by a special purpose; they are characterized by specific, comprehensive normative legal regulation; their application is ensured by state coercion. Distinctive features inherent to restrictions and prohibitions in the field of legal regulation have been identified: individual character; preventive nature; limiting aspect; coercive nature; the presence of a special subject; connection to professional activity; relation to delict norms, and their essence has been explained. The normative basis for defining and applying restrictions and prohibitions as means of legal regulation has been characterized (substantive legislation, procedural legislation, sub-legislative normative legal acts). A classification of restrictions and prohibitions has been conducted, and it is proposed to conditionally divide them into three groups (personal, property, and mixed).

Experiences of UK clinical scientists (Physical Sciences modality) with their regulator, the Health and Care Professions Council: results of a 2022 survey.

In healthcare, regulation of professions is an important tool to protect the public. With increasing regulation however, professions find themselves under increasing scrutiny. Recently there has also been considerable concern with regulator performance, with high profile reports pointing to cases of inefficiency and bias. Whilst reports have often focused on large staff groups, such as doctors, in the literature there is a dearth of data on the experiences of smaller professional groups such Clinical Scientists with their regulator, the Health and Care Professions Council. This article reports the findings of a survey from Clinical Scientists (Physical Sciences modality) about their experiences with their regulator, and their perception of the quality and safety of that regulation. Between July-October 2022, a survey was conducted via the Medical Physics and Engineering mail-base, open to all medical physicists & engineers. Questions covered typical topics of registration, communication, audit and fitness to practice. The questionnaire consisted of open and closed questions. Likert scoring, and thematic analysis were used to assess the quantitative and qualitative data. Of 146 responses recorded, analysis was based on 143 respondents. Overall survey sentiment was significantly more negative than positive, in terms of regulator performance (negative responses 159; positive 106; significant at p < 0.001). Continuous Professional Development audit was rated median 4; other topics were rated as neutral (fitness to practice, policies & procedures); and some as poor (value). The Clinical Scientist (Physical Sciences) professional registrants rated the performance of their regulator more negatively than other reported assessments (by the Professional Standards Authority). Survey respondents suggested a variety of performance aspects, such as communication and fitness to practice, would benefit from improvement. Indications from this small dataset, suggest a larger survey of HCPC registrants would be useful.

The role of the basic state in the climate response to future Arctic sea ice loss

There is great uncertainty in the atmospheric circulation response to future Arctic sea ice loss, with some models predicting a shift towards the negative phase of the North Atlantic Oscillation (NAO), while others predicting a more neutral NAO response. We investigate the potential role of systematic model biases in the spread of these responses by modifying the unperturbed (or ‘control’) climate (hereafter referred to as the ‘basic state’) of the Canadian Earth system model version 5 (CanESM5) in sea ice loss experiments based on the protocol of the Polar Amplification Model Intercomparison Project. We show that the presence or absence of the stratospheric pathway in response to sea ice loss depends on the basic state, and that only the CanESM5 version that shows a weakening of the stratospheric polar vortex features a strong negative NAO response. We propose a mechanism that explains this dependency, with a key role played by the vertical structure of the winds in the region between the subtropical jet and the stratospheric polar vortex (‘the neck region winds’), which determines the extent to which anomalous planetary wave activity in response to sea ice loss propagates away from the polar vortex. Our results suggest that differences in the models’ basic states could significantly contribute to model spread in the simulated atmospheric circulation response to sea ice loss, which may inform efforts to narrow the uncertainties regarding the impact of diminishing sea ice on mid-latitude climate.

Hidden Barriers to Marketplace Disability Accessibility: An Empirical Analysis of the Role of Perceived Trade-Offs

Abstract Disability is a basic human condition that affects a significant proportion of the world’s population, yet many disability- and accessibility-relevant issues remain pressing and insufficiently addressed. With three experiments, the current research investigates potential reasons for why marketplace disability accessibility has not been universally accepted. Potential barriers to greater accessibility in marketplaces may arise because such efforts appear at odds with other salient priorities, at micro (i.e., consumer) and macro (i.e., firm, policy, or societal) levels. In the proposed framework and resulting experiments, micro-level trade-offs prompt perceptions of personal cost and macro-level trade-offs prompt perceptions of firm morality. In turn, these perceptions mediate firm evaluations, showing that consumers at baseline respond negatively to accessibility. Critically, however, several practical interventions emerge from these processes. Marketers can mitigate consumers’ negative responses to accessibility by employing simple framing choices such as emphasizing who benefits or noting what the purpose of the offering is. By demonstrating one way to better understand perceptions of the full spectrum of the consumer population, this research provides pathways for consumer researchers to further delve into disability-related research in the future.

Assessing School District Decision-Making: In-Person Schooling and COVID-19 Transmission

Abstract Recent controversies have highlighted the importance of local school district governance, but little empirical evidence exists evaluating the quality of district policymakers or policies. In this paper, we take a novel approach to assessing school district decision-making. We posit a model of rational decision-making under uncertainty that emphasizes districts learning over time. We test the predictions from the model using data on a set of highly visible and consequential decisions facing school district leaders—the choice of learning mode during the 2020-21 school year. We find that district behavior is consistent with a Bayesian learning process in several key respects. Districts respond on the margin to health risks: all else equal, a marginal increase in new cases reduces the probability that a district offers in-person instruction the next week. This negative response is magnified when the district was in-person the prior week and attenuates in magnitude over the school year, suggesting districts learn from experience about the effect of in-person learning on disease transmission in schools. We also find evidence that districts are influenced by the learning mode decisions of peer districts, but not their peers' experiences with in-person instruction and disease transmission, which implies that some important frictions exist.

Neuroprotective effects of apigenin on retinal ganglion cells in ischemia/reperfusion: modulating mitochondrial dynamics in in vivo and in vitro models

BackgroundRetinal ischemia/reperfusion (RIR) is implicated in various forms of optic neuropathies, yet effective treatments are lacking. RIR leads to the death of retinal ganglion cells (RGCs) and subsequent vision loss, posing detrimental effects on both physical and mental health. Apigenin (API), derived from a wide range of sources, has been reported to exert protective effects against ischemia/reperfusion injuries in various organs, such as the brain, kidney, myocardium, and liver. In this study, we investigated the protective effect of API and its underlying mechanisms on RGC degeneration induced by retinal ischemia/reperfusion (RIR).MethodsAn in vivo model was induced by anterior chamber perfusion following intravitreal injection of API one day prior to the procedure. Meanwhile, an in vitro model was established through 1% oxygen and glucose deprivation. The neuroprotective effects of API were evaluated using H&E staining, spectral-domain optical coherence tomography (SD-OCT), Fluoro-Gold retrograde labeling, and Photopic negative response (PhNR). Furthermore, transmission electron microscopy (TEM) was employed to observe mitochondrial crista morphology and integrity. To elucidate the underlying mechanisms of API, the terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assay, flow cytometry assay, western blot, cell counting kit-8 (CCK-8) assay, lactate dehydrogenase (LDH) assay, JC-1 kit assay, dichlorofluorescein-diacetate (DCFH-DA) assay, as well as TMRE and Mito-tracker staining were conducted.ResultsAPI treatment protected retinal inner plexiform layer (IPL) and ganglion cell complex (GCC), and improved the function of retinal ganglion cells (RGCs). Additionally, API reduced RGC apoptosis and decreased lactate dehydrogenase (LDH) release by upregulating Bcl-2 and Bcl-xL expression, while downregulating Bax and cleaved caspase-3 expression. Furthermore, API increased mitochondrial membrane potential (MMP) and decreased extracellular reactive oxygen species (ROS) production. These effects were achieved by enhancing mitochondrial function, restoring mitochondrial cristae morphology and integrity, and regulating the expression of OPA1, MFN2, and DRP1, thereby regulating mitochondrial dynamics involving fusion and fission.ConclusionAPI protects RGCs against RIR injury by modulating mitochondrial dynamics, promoting mitochondrial fusion and fission.

Empathy and Coping Strategies Predict Quality of Life in Japanese Healthcare Professionals

Empathy and Coping Strategies Predict Quality of Life in Japanese Healthcare Professionals

Non-enzymatic sensor based on doped polyindole/multi-walled carbon nanotube for detecting neurotransmitter acetylcholine

A facile non-enzymatic acetylcholine sensor composed of doped-polyindole/multi-walled carbon nanotube (dPIn-MWCNT) composite was designed, fabricated, and presented here. The negative current response toward acetylcholine concentration was first found and reported here. The confirmation of acetylcholine detection mechanism was elucidated by XPS, where the acetylcholine interaction resulted in a decrease in the % (dPIn doping level and an increase of the dPIn structural defect. The response optimizations with dPIn concentrations, applied potentials, and incubation times were systematically investigated. The 45dPIn-15MWCNT operated at + 0.6 V vs. Ag/AgCl with 5 min of incubation time was the optimum condition to obtain the highest acetylcholine current response. Chronoamperometric acetylcholine detection revealed two distinct current regimes from the acetylcholine surface interaction and the de-doping of dPIn. Regime I was related to the diffusion-controlled process as observed in the low concentration range of 10−8–10−5 M. Regime II corresponded to the mixed diffusion-controlled and adsorption-controlled process as observed in the concentration range of 10−5–10−2 M. For regime I, the calculated LOD was as low as 1.27 nM with a very high acetylcholine response sensitivity. Regime I is suggested for the point-of-care utility, where the detectable concentration range covered the acetylcholine level normally found in the healthy human blood. Regime II can be applicable and useful in the treatment monitoring of neurological diseases.

Bioassay predictive values for chemical health risks in drinking water

Bioanalytical tools can be used for assessment of the chemical quality of drinking water and its sources. For water managers it is important to know the probability that a bioassay response above an established health-based ‘effect-based trigger value’ (EBT) indeed implies a harmful chemical (mixture) concentration. This study presents and applies a framework, based on Bayes’ theorem, to derive such risk probabilities for bioassay responses. These were evaluated under varying (in silico) chemical mixture concentrations relevant to drinking water (sources), with toxicity data for six in vitro assays from the ToxCast database. For single chemicals and in silico mixtures, the negative predictive value (NPV) was 100 % for all assays. For water managers, this means that when a bioassay response is below the EBT, a chemical risk is reliably absent, and no further action is required. The positive predictive value (PPV) increased with increasing chemical concentrations (2 µg/L) up to 40–80 %, depending on the assay. For in silico mixtures of increasing numbers of chemicals, the PPV did not increase until higher sum concentrations (>2–10 µg/L). Hence, the ability to accurately signal a harmful chemical (mixture) using bioassays will be lowest for highly diverse, low-concentration chemical mixtures. For water managers, this means in practice that further investigations after an EBT exceedance will, in many cases, not reveal chemicals at harmful concentrations. A solution offered is to increase the trigger value for positive responses to achieve a higher PPV and maintain the EBT for negative responses to ensure an optimal NPV.

The effect of orthodontic Force Application and Tooth Movement on Dental Pulp

This systematic review aimed to conclusively investigate the effect of continuous intrusive force application on human pulpal blood flow (PBF). It is a well-established fact that applying a severe orthodontic force for an extended period can cause irreversible pulpitis and necrosis in the pulp by accelerating the inflammation process. In contrast, utilizing moderate and intermittent forces allows for ample tooth movement, limits pulp damage, and facilitates pulp healing. Materials and methods: A comprehensive search of published studies was conducted in several electronic databases such as MEDLINE, PubMed, EMBASE, Scopus, Web of Science, CINAHL, and the Cochrane Database of Systematic Reviews, as well as Google Scholar. The search was conducted without limitations to find published studies. The results showed that orthodontic forces can lead to a decrease in pulpal blood flow, which causes a reduction in tooth sensitivity. This reduction is indicated by an increase in response thresholds and more negative responses to tooth sensitivity tests. Conclusion: applying a severe orthodontic force over a prolonged period of time can lead to irreversible pulpitis and necrosis in the pulp due to an increase in the inflammation process. However, using moderate and intermittent forces can facilitate sufficient tooth movement while minimizing damage to the pulp. This highlights the importance of the endodontic-orthodontic interface and the need to consider dental pulp health during orthodontic treatment to avoid dental trauma.

Social axioms and psychological toll: A study of emotional, behavioral, and cognitive responses across 35 cultures during the COVID‐19 pandemic

AbstractThe COVID‐19 pandemic has significantly affected the psychological well‐being of individuals worldwide. Previous research has indicated that values and beliefs, particularly social axioms, are associated with psychological responses during crises. However, most of the studies have focused on specific regions; the impact of social axioms on a global scale remains unclear. We conducted a multinational study comprising stratified samples of 18,171 participants from 35 cultures. Using multilevel modeling, we examined the associations between social axioms, personal worry, normative concerns, trust, and individuals' psychological responses to the pandemic. The results showed that greater personal worry and normative concerns predicted more negative psychological responses. Furthermore, the study also identified significant buffering effects at the societal level, as cultures with higher overall levels of fate control, religiosity, or reward for application exhibited weaker associations between personal worry and negative responses. Our findings reveal the influence of social axioms on psychological responses during the pandemic, with varying effects across cultures. The buffering effects of fate control, religiosity, and reward for application underscore the importance of considering cultural differences and individual variability when examining the impact of social axioms on psychological outcomes.

An additional record of hematophagy by the Yellow-headed Caracara Daptrius chimachima on a domestic horse from Venezuela

Hematophagy is a practice in which animal organisms feed on blood. Among birds, few species are known to practice it, including rapacious birds such as Caracaras. Here, an hematophagy event by a Yellow-headed Caracara on a wounded domestic horse from northern Venezuela is described, taking notes about the visit frequency, number of visitors, the horse’s interaction with the caracara, the blood consumption type (direct, indirect), and hematophagy tactics (active or passive). Over six continuous days, once a day, a Yellow-headed Caracara arrived on the back of a wounded domestic horse between 08:00–10:00 h and perched without any negative response from the quadruped. After arriving, the bird remained motionless for a few minutes and then approached the open wound. After sucking blood for about 4–7 minutes, the bird of prey inspected the rest of the animal for ectoparasites and then it left the area for the rest of the day. Once, an adult and a juvenile Yellow-headed Caracaras visited the horse to feed on blood together. This is the first report of hematophagy for the Yellow-headed Caracara in Venezuela. My observations suggest that the Yellow-crested Caracara is a passive hematophagous bird, and direct hematophagy in this species occurs because its opportunistic behavior is stimulated by wounds made accidentally or by other active hematophagous animals such as Vampire Bats.

Relationships between body image, dyadic coping and post-traumatic growth in breast cancer patients: a cross-sectional study

BackgroundThe diagnosis and treatment of cancer triggers not only a negative psychological response for the patient, but also a positive psychological outcome. Positive dyadic coping, as a form of coping for mental health outcomes, can maintain or reestablish internal stability between the patient and his or her spouse, resulting in positive physical and psychological changes. However, there is a paucity of research on body image, dyadic coping, and post-traumatic growth in breast cancer patients. The purpose of this study was to explore the relationship and pathways between body image, dyadic coping, and post-traumatic growth in breast cancer patients.MethodsA cross-sectional study was conducted from November 2022 to November 2023 at a tertiary care hospital in Wuxi, Jiangsu, China. This study was conducted among 154 breast cancer patients treated at the Affiliated Hospital of Jiangnan University, all of whom completed demographic and clinical information questionnaires, Body image self-rating questionnaire for breast cancer (BISQ-BC), Dyadic Coping Inventory (DCI) and Post Traumatic Growth Inventory (PTGI). A Pearson correlation analysis was used to explore the relationship between body image, dyadic coping, and post-traumatic growth. Structural equation modeling was used to analyze the path relationships among the three and to explore the mediating role of dyadic coping.ResultsThe level of body image was negatively correlated with post-traumatic growth (r = −0.462, p &amp;lt; 0.01); and the level of body image was negatively correlated with dyadic coping (r = −0.308, p &amp;lt; 0.01). And dyadic coping was positively associated with post-traumatic growth (r = 0.464, p &amp;lt; 0.01). The structural equation modeling results supported the mediation model with the following model fit indices, chi-square to degrees of freedom ratio (χ2/df = 2.05), goodness of fit index (GFI = 0.93), comparative fit index (CFI = 0.99), canonical fit index (NFI = 0.93), incremental fit index (IFI = 0.99), non-canonical fit index (TLI = 0.99) and the root mean square of the difference in approximation error (RMSEA = 0.03). Body image and dyadic coping directly affected post-traumatic growth (β = −0.33, p &amp;lt; 0.05; β = 0.43, p &amp;lt; 0.05). And body image indirectly influenced post-traumatic growth through dyadic coping (β = −0.17, p &amp;lt; 0.05).ConclusionInterconnections between body image, dyadic coping, and post-traumatic growth in breast cancer patients. A preliminary validation of the mediating role of dyadic coping between body image and post-traumatic growth, body image can have an impact on dyadic coping, which in turn can have an impact on post-traumatic growth. Whereby higher levels of dyadic coping in patients may also be associated with higher levels of post-traumatic growth, whereas body image disturbance may impede levels of post-traumatic growth.

Haematochemical Profile of Healthy Dogs Seropositive for Single or Multiple Vector-Borne Pathogens

Background: the present study aimed to investigate the immunological response to common vector-borne pathogens and to evaluate their impact on haematochemical parameters in owned dogs. Methods: Blood samples were collected from 400 clinically healthy dogs living in an endemic area (Sardinia Island, Italy). All dogs were serologically tested for VBDs and divided into groups based on their negative (Neg) or positive response towards Ehrlichia (Ehrl), Rickettsia (Rick), Leishmania (Leish), Borrelia (Borr), Anaplasma (Anapl), and Bartonella (Barto). A Kruskall–Wallis’s test, followed by Dunn’s post hoc comparison test, was applied to determine the statistical effect of negativity and single or multiple positivity on the studied parameters. Results: the group of dogs simultaneously presenting antibodies towards Leishmania, Ehrlichia, and Rickettsia showed higher values of total proteins, globulins, creatine phosphokinase, aspartate aminotransferase, alanine aminotransferase, and amylase than dogs that tested negative or dogs with antibodies toward a single pathogen investigated herein. Conclusions: Our results seem to suggest that exposure to more vector-borne pathogens could lead to greater liver function impairment and a greater inflammatory state. Further investigations are needed in order to better clarify how co-infections affect haematochemical patterns in dogs living in endemic areas of VBDs.

The Effects of Oil Price on Energy Production and the Ecuadorian Economy

Through an empirical analysis of the impact of variations in the international price of oil on the economic production of different strategic sectors and on energy production from various sources in Ecuador, the study seeks to show evidence on the economic effects of the price of oil. in a Latin American economy strongly linked to oil production. For this, relevant data were collected on production in different economic sectors, on the type of ownership in oil production and on energy production in various energy sources in Ecuador and statistical analyzes were carried out to evaluate the relationships between these and the international oil price. The results indicate that the effect of the oil price varies between the economic sectors of Ecuador. Some sectors, such as financial services and construction, show positive responses, while others, such as agriculture and fishing, appear less affected. The oil and mining sector in Ecuador is strongly linked to variations in the price of oil. The positive and significant response of the Oil and Mines GDP underlines the sensitivity of this sector to changes in international prices. Furthermore, energy production in Ecuador exhibits heterogeneous responses to variations in the price of oil. Forms of energy such as wind, solar, and thermal energy show positive and significant responses, while hydropower presents a negative response in some periods. Positive responses in forms of energy such as wind, solar, and thermal may indicate that the increase in the price of oil positively influences investment decisions in these energy sources. The study provides a significant contribution to the field of energy economics in oil-exporting countries and, particularly, in developing countries, as well as highlights the importance of energy diversification for these types of economies.

The impact of facial attractiveness and alleged personality traits on fairness decisions in the ultimatum game: Evidence from ERPs.

In the mind of the beholder the personality and facial attractiveness of others are interrelated. However, how these specific properties are processed in the neurocognitive system and interact with each other while economic decisions are made is not well understood. Here, we combined the ultimatum game with EEG technology, to investigate how alleged personality traits and the perceived facial attractiveness of proposers of fair and unfair offers influence their acceptance by the responders. As expected, acceptance rate was higher for fair than unfair allocations. Overall, responders were more likely to accept proposals from individuals with higher facial attractiveness and with more positive personality traits. In ERPs, words denoting negative personality traits elicited larger P2 components than positive trait words, and more attractive faces elicited larger LPC amplitudes. Replicating previous findings, FRN amplitudes were larger to unfair than to fair allocations. This effect was diminished if the proposer’s faces were attractive or associated with positive personality traits. Hence, facial attractiveness and the valence of personality traits seem to be evaluated independently and at different time points. Subsequent decision making about unfair offers is similarly influenced by high attractiveness and positive personality of the proposer, diminishing the negative response normally elicited by “unfair” proposals, possibly due a “reward” effect. In the ERPs to the proposals the effect of positive personality and attractiveness were seen in the FRN and P300 components but for positive personality traits the effect even preceded the FRN effect. Altogether, the present results indicate that both high facial attractiveness and alleged positive personality mitigate the effects of unfair proposals, with temporally overlapping but independent neurocognitive correlates.

HRM practices in app work: exploring training and feedback in the food delivery ecosystem

Purpose This study aims to explore the human resource management (HRM) practices related to training and feedback in the app work industry, specifically in online food delivery service, and investigate the emotional and behavioral responses of gig workers. Design/methodology/approach This study adopts a qualitative approach by interviewing 19 gig workers from six food delivery firms operating in different countries. Findings The results show limited training and feedback opportunities are provided to app workers, although the complexity of training and delivery methods differ across platforms. To address this shortage, app workers developed response strategies relying on social interaction. Research limitations/implications This study adds to the research on HRM practices in the gig economy by portraying the way in which training and feedback unfold in the food delivery app ecosystem and by disclosing the gig workers’ emotional and behavioral responses to it. Practical implications This study shows that the way training activities are currently designed may provide little value to the ecosystem and are likely to produce negative emotional responses in gig workers. Thus, platform providers may make use of these findings by introducing more transparent feedback and social learning opportunities. Originality/value To the best of the authors’ knowledge, this study is among the first empirical studies on online delivery gig workers addressing specific HRM practices. It reveals significant insights for training and feedback, suggesting app economy characteristics strongly affect training and feedback practices for app workers.

From love to betrayal? When your team’s sponsor decides to also sponsor your rival

PurposeThe aim of this research was to investigate fans’ responses toward a sponsor that has had a long-standing sponsorship deal with a club and decided also to sponsor the club’s rival.Design/methodology/approachA long-term sponsorship deal between a retsina wine company and a popular football club and a newly established deal between the company and the main rival club were selected as the research setting. Data were collected from a total sample of 302 participants, fans of the two teams, using an online survey and PLS-SEM was employed to test the relationships of the proposed structural model.FindingsThe results provided evidence for the importance of the inclusion of perceptions of fit for both teams to the model as it impacted the responses in the joint sponsorship. Team identification emerged significant for improving fans perceptions of fit between the sponsor and their favorite club but also led fans of the long-term sponsored club to feel betrayed from the sponsor. The sense of betrayal impacted the level of fit, the rejection of sponsorship but did not emerge significant for driving negative responses toward the sponsor’s brand. The same held for the rejection of the joint sponsorship.Originality/valueThis is the very first study that incorporated the effects of the perceptions of fit of two rival clubs to test the effect of sponsorship for a sponsor brand of a deal that includes a longtime sponsored football club and its rival as a newly sponsored one. It is also one of the first attempts that explores relationships between perceptions of fit, sense of betrayal and rejection of a joint sport sponsorship in a rivalry context, highlighting the importance of preventing fans' betrayal.