Negative Regression Coefficient Research Articles

Caregiver Employees' Mental Well-Being in Hong Kong.

The rapidly aging global population has increased the demand for caregivers. Many caregivers simultaneously engage in paid employment, and the dual role makes the needs of caregiver employees conceivably more remarkable. However, there is a gap in the literature about the specific needs of caregiver employees. Caregiver employees (n = 1205) across Hong Kong caring for those ≥65 years were recruited for a cross-sectional face-to-face survey from December 2021 to January 2022, to evaluate mental well-being measured by the Short Warwick -Edinburgh Mental Well-being Scale. Univariate and multivariate analyses were conducted; significant variables (p < 0.05) were included in multiple linear regression, along with caregiver-friendly workplace policies' availability, to understand their association with their mental well-being. The mean score of the Short Warwick-Edinburgh Mental Well-being Scale among caregiver employees in this study was 24.9, with 7.2% indicative of probable clinical depression and 10.0% possible mild depression. In addition, the current study showed that 30.2% of the caregiver employees felt distressed about the caregiving role. Among external factors, family support (measured by the Lubben Social Network Scale) and workplace culture (measured by the Marshall Supervision Subscale) positively correlated with mental well-being with regression coefficients of 0.252 (p < 0.001) and 0.482 (p < 0.001), respectively. In the fully adjusted model, a negative regression coefficient was observed for overall spillover (-0.050, p < 0.001) and Short Warwick-Edinburgh Mental Well-being Scale scores, while positive regression coefficients were observed for overall self-rate (0.041, p < 0.001), Lubben (0.124, p < 0.001), and corporate culture (0.365, p < 0.001). Better Short Warwick-Edinburgh Mental Well-being Scale scores were observed when caregiver-friendly workplace policies were clearly stated than when they were made on a case-by-case discretionary basis. Caregiver-friendly workplace policies may be critical to Hong Kong's sustainable future, both economically and socially, as they ensure a healthy and productive workforce to support an aging population.

Masseter Muscle Thickness in Relation to Facial Form in Angle’s Normal Occlusion and Malocclusions: An Observational Study

ABSTRACT Background: Various clinical studies performed in adults have shown the relationship between craniofacial morphology and masticatory muscle function. However, the growth of the masticatory muscle has not received such attention, when compared with the volume of studies on the skeletal growth of face. With this background and considering the widespread use of ultrasonography (USG), the following study was undertaken to provide some insights into the relationship between muscle and bone and facial morphology. Methods: This was a prospective, observational study conducted over a period of three years from 2012 to 2015 to assess the correlation between the thickness of the masseter muscle in Angle’s normal occlusion and the various malocclusions of the dental arch as well as the facial form. Patients with a full complement set of teeth, normal tooth morphology, Angle’s normal occlusion, Angle’s class I-III malocclusion, those with a history of third molar extraction, and impaction were included in the study. Those with a history of any prior orthodontic treatment, restorations, or any missing teeth (except the third molar) were exempted from the study. The greater thickness of masseter muscle in relaxed and clenched state was recorded on USG. Facial morphology was determined with the aid of facial photographs. Results: The study was conducted on 140 patients. The class I normal occlusion group had the thickest masseter muscle, while the class III malocclusion group had the thinnest masseter muscle. Facial parameters showed highly significant gender-wise differences in class I normal occlusion, class I malocclusion, and class II division II malocclusion. There was a significant negative co-relation between the thickness of masseter muscle and facial forms in all the categories of Angle’s classification as indicated by a negative regression coefficient B (P &lt; 0.05) Conclusion: The masseter muscle thickness correlated directly with male gender and normal occlusion, and inversely with the degree of malocclusion and facial form.

Unraveling the genetic evolution of SARS-CoV-2 Recombinants using mutational dynamics across the different lineages.

Recombination serves as a common strategy employed by RNA viruses for their genetic evolution. Extensive genomic surveillance during the COVID-19 pandemic has reported SARS-CoV-2 Recombinant strains indicating recombination events during the viral evolution. This study introspects the phenomenon of genome recombination by tracing the footprint of prominent lineages of SARS-CoV-2 at different time points in the context of on-going evolution and emergence of Recombinants. Whole genome sequencing was carried out for 2,516 SARS-CoV-2 (discovery cohort) and 1,126 (validation cohort) using nasopharyngeal samples collected between the time period of March 2020 to August 2022, as part of the genomic surveillance program. The sequences were classified according to the different lineages of SARS-CoV-2 prevailing in India at respective time points. Mutational diversity and abundance evaluation across the 12 lineages identified 58 Recombinant sequences as harboring the least number of mutations (n = 111), with 14 low-frequency unique mutations with major chunk of mutations coming from the BA.2. The spontaneously/dynamically increasing and decreasing trends of mutations highlight the loss of mutations in the Recombinants that were associated with the SARS-CoV-2 replication efficiency, infectivity, and disease severity, rendering them functionally with low infectivity and pathogenicity. Linkage disequilibrium (LD) analysis revealed that mutations comprising the LD blocks of BA.1, BA.2, and Recombinants were found as minor alleles or as low-frequency alleles in the LD blocks from the previous SARS-CoV-2 variant samples, especially Pre-VOC. Moreover, a dissipation in the size of LD blocks as well as LD decay along with a high negative regression coefficient (R squared) value was demonstrated in the Omicron and BA.1 and BA.2 lineages, which corroborated with the breakpoint analysis. Together, the findings help to understand the evolution and emergence of Recombinants after the Omicron lineages, for sustenance and adaptability, to maintain the epidemic spread of SARS-CoV-2 in the host population already high in immunity levels.

Retrospective cohort study comparing success of medical management of early pregnancy loss in pregnancies conceived with and without medical assistance

To compare the success rates of medical management using a combined mifepristone and misoprostol protocol in cases of early pregnancy loss (EPL) between women who conceived without medical assistance and those who conceived through invitro fertilization (IVF), after fresh or frozen embryo transfer, and evaluate for the predictive factors of success, time to first passage of tissue, and time to complete resolution of pregnancy. Retrospective cohort study. University hospital. Women who presented with EPL below 13 weeks of gestation between June 2013 and July 2021 who were managed medically with mifepristone 200 mg orally and misoprostol 800 mcg vaginally were included in the study. Medical management with mifepristone and misoprostol; conception without medical assistance vs. post-IVF, after fresh or frozen embryo transfer. We evaluated overall success and performed subgroup analysis according to the mode of conception and compared fresh vs. frozen-thawed embryo transfers for IVF pregnancies. In all groups, we also calculated success according to gestational age and compared the time to first passage of tissue. The potential predictive factors of treatment success were analyzed. The side effects and complications of treatment were recorded. A total of 930 women were included in the study, 99 (11%) of whom achieved pregnancy after IVF. The overall success of medical treatment was 89% with no statistically significant difference according to the mode of conception (89% vs. 89%) or type of transfer (fresh 89% vs. frozen 89%). Only lower gestational age by sonography was independently predictive of treatment success, showing a negative regression coefficient of β = -0.333 and an odds ratio of 0.717. The mean time to first passage of tissue was 5.0 ± 2.1 hours. Altogether, 666 women (72%) showed pregnancy resolution on the day of medication administration, an additional 110 women at 1-week follow-up, and a further 74 women after ≥4 weeks on ultrasound. Medical management of EPL with mifepristone and misoprostol is a highly successful treatment option that results in completed abortion in a timely fashion in both pregnancies conceived without medical assistance and those conceived after IVF.

Could information and communication technology (ICT) reduce carbon emissions? The role of trade openness and financial development

Information and communication technology (ICT) is one of the fastest growing new industries in the world. This study aims to understand the nonlinear impact of ICT on carbon emissions more systematically. To this end, a threshold panel regression model is developed based on panel data of 92 countries. ICT is the explanatory variable, carbon emission is the explained variable, and trade openness and financial development are the threshold variables. The results show that: (i) When taking trade openness as threshold variable, both low- and high-income group have passed the double threshold test, the negative regression coefficient of ICT and carbon emissions firstly decreases, and then turns into positive effect when crossing the second threshold value in low-income group. While in high-income group, this effect shows a sustained growing positive trend. (ii) Taking financial development as threshold variable, this negative effect firstly turns positive which then increases when passing the second threshold in low-income group. While in high-income group, the positive impact of ICT on CO2 shows a sustained growth which is similar to the situation when trade openness is taken as threshold variable. (iii) Income levels are set as a categorical variable, the impact of ICT on CO2 presents a "U" shape under the influence of financial development and trade openness. The "U"-shaped turning point occurs in the low-income band and when the level of trade development and financial development is low.

Analysis of the Level of Political Participation of the Kenduri Cinta Community in Jakarta

This research was conducted to determine the level of political participation of the Kenduri Cinta community as an urban Sufism community in DKI Jakarta. The method used in this research is a quantitative method by distributing questionnaires to the Kenduri Cinta community who were selected by purposive sampling. The independent variables used in this research are political concern; political motivation; political situation and environment; political education; and political orientation. This study explains how these independent variables affect the political participation of the Kenduri Cinta community. The 503 questionnaires obtained were processed by the SPSS application version 25. The Principal Component Analysis method was used in multiple linear regression to analyse how independent variables affect their political participation. The F test result shows that all independent variables simultaneously affect the level of political participation of the Kenduri Cinta community. Meanwhile, the t test result shows that four independent variables are significant and three of them have positive regression coefficients. Interestingly, political motivation has a negative regression coefficient even though it is significant. This means the higher their political motivation, the lower their political participation.

PENGARUH KURS RUPIAH, INFLASI DAN SUKU BUNGA TERHADAP EKSPOR UDANG INDONESIA

This study analyzes the influence of exchange rates, inflation, and interest rates on shrimp exports in Indonesia from 1999 to 2019 using multiple linear regression. The research findings indicate that the exchange rate and inflation positively influence shrimp exports, whereas the interest rate negatively impacts them.&#x0D; The regression coefficient for the exchange rate is 10.015, which indicates that each depreciation of the rupiah by 1 rupiah per year will increase shrimp exports by 10.015 tons per year. Conversely, the interest rate has a negative regression coefficient of -3519.690, suggesting that each 1% increase in interest rates will reduce shrimp exports by 3.519,690 tons per year. Inflation has a positive regression coefficient of 3.333,168, indicating that each 1% increase in inflation will increase shrimp exports by 3.333,168 tons per year.&#x0D; However, only the exchange rate shows a significant relationship, with inflation and interest rates not significantly impacting shrimp exports.&#x0D; The model's coefficient of determination is 58.3%, meaning that approximately 58.3% of the variation in shrimp exports can be explained by the exchange rate, inflation, and interest rates. This study provides crucial insights for policy makers and the shrimp industry in considering the factors affecting shrimp exports for the creation of applicable policies and strategies.

Dynamics of the demineralization of temporary teeth using ultrasonic shadow velosymmetry and autofluorescence microscopy &lt;i&gt;in vitro&lt;/i&gt;

BACKGROUND: Given the high prevalence of caries in preschool children, additional methods for diagnosing hidden carious foci with deep structural demineralization of the hard tissues of temporary teeth without generating X-rays must be updated.&#x0D; AIM: To improve methods for studying the demineralization of hard tissues of primary teeth using ultrasonic shadow velosymmetry and autofluorescence microscopy.&#x0D; MATERIALS AND METHODS: The study included primary second molars (n=11). Samples of primary teeth were placed in a test tube with a demineralizing solution on days 1, 4, 8, 21, and 31. The samples were examined by autofluorescence microscopy and ultrasonic shadow velosymmetry according to the exposure time. The rate of acid demineralization of the primary teeth samples was assessed using our score scale. The averages were compared using the Wilcoxon W-test (p 0.05). Pearson correlation analysis was used, taking into account the statistical significance of the correlation coefficients for p 0.05.&#x0D; RESULTS: Analysis of samples of hard tissues of primary teeth by ultrasonic shadow velosymmetry showed that the velocity of the ultrasonic wave passage decreases with increasing exposure to the demineralizing solution and acquires a linear character with a negative regression coefficient. The decrease in the ultrasonic wave velocity in the enamel and dentin of the samples directly correlated with the degree of demineralization.&#x0D; CONCLUSION: The conducted experiment on the hard tissues of primary teeth showed that demineralization not only leads to micromorphological structural changes in the hard tissues of enamel and dentin but also affects the physical and acoustic properties of the samples.

Relationships between health literacy, self-efficacy, and medication adherence in older people with polypharmacy: A cross-sectional study

Purpose: This study identified the relationships between health literacy, self-efficacy, and medication adherence among older people with polypharmacy and analyzed the factors affecting medication adherence. Methods: This was a cross-sectional study using a survey of 95 participants who were on five or more drugs, 65 years or older, and visited one community center in Seoul between August 5, 2019 and August 7, 2019. Data were collected using a questionnaire and analyzed with descriptive statistics, t-test, ANOVA, Tukey test, Pearson's correlation coefficient, and multiple regression via the IBM SPSS 23.0 program. Results: The participants took on average 8.32±3.90 drugs daily. Their health literacy was very low at 3.53±2.07. Self-efficacy and medication adherence were high at 33.63±5.36 and 15.03±3.27, respectively. Health literacy differed based on age and education levels, whereas self-efficacy differed depending on the frequency of medication. No demographic or medication-related factors caused a difference in medication adherence. Health literacy did not correlate with self-efficacy and medication adherence. Self-efficacy showed a negative correlation with medication adherence (r=-.52, p&lt;.001). However, as a lower medication adherence score indicates greater adherence, a negative correlation means higher self-efficacy is linked with better adherence. Self-efficacy influenced medication adherence (β=-0.52, p&lt;.001) with an explanatory power of 27.0% (F=17.01, p&lt;.001) in this group. Also, the negative regression coefficient means higher self-efficacy was associated with better adherence. Conclusion: Medication adherence was generally high, with self-efficacy being the main influencing factor. Hence, intervention programs that promote self-efficacy should be implemented for older people with polypharmacy.

Simulasi Model Sambungan Mekanis dengan Menggunakan Coupler Untuk Beton Pracetak

The use of mechanical joints can improve the performance of the connection and make the time more efficient. The purpose of this study was to determine the maximum tensile force, failure pattern and effect of epoxy thickness on the maximum tensile force, epoxy-bar bonding stress, and epoxy-coupler bonding stress of each splice type Grouted Coupler Connector. The research specimens were 6 pieces with varying thicknesses of epoxy and diameter of reinforcing steel. Software that supports the pullout test simulation is ANSYS and the research data processing method uses Simple Linear Regression Analysis. The output from the pullout test simulation is the maximum tensile force with a thickness of 25mm epoxy on the reinforcing steel D16, D22, and D25 of 91.156 kN; 148,090 kN, and 203,295 kN. All the test specimens have an epoxy coupler slip failure pattern. And the concluded from the simple linear regression analysis is a significant effect between the thickness of the epoxy on the maximum tensile force and bond stress, with a negative regression coefficient value. The optimum value of using thick epoxy with a varying diameter of reinforcing bars is 25mm.

Adapting entrepreneurial orientation for business performance of medium-sized business in South-West Nigeria

Entrepreneurial orientation as a concept has gained the attention of scholars over the last decade. It also became interesting to find out its relationship with business performance in South-West Nigeria. This study set out to find out any measure of influence that entrepreneurship as well as entrepreneurial orientation may assert on the performance of medium size businesses, with South-West Nigeria as the sample location. The results showed that pro-activeness (β = 0.145), competitive aggressiveness (β = 0.231), risk-taking (β = 0.087), and autonomy (β = 0.119) all had positive regression coefficients while innovativeness (β = -0.028) had a negative regression coefficient.

Multi-Scale Geographically Weighted Elasticity Regression Model to Explore the Elastic Effects of the Built Environment on Ride-Hailing Ridership

Understanding the relationship between the built environment and the ride-hailing ridership is crucial to the prediction of the demand for ride-hailing and the formulation of the strategy for upgrading the built environment. However, the existing studies on ride-hailing ignore the scale effect and zone effect of the modifiable area unit problem (MAUP), and show a lack of consideration for the elastic relationship with spatial heterogeneity between built environment variables and ride-hailing ridership. Taking Chengdu as an example, this paper selects 12 independent variables based on the “5Ds” (density, diversity, design, destination accessibility and distance to transit) of the built environment, the dependent variables are the density of ride-hailing pick-ups in the morning and evening peak hours, and 11 spatial units are proposed according to different scales and zoning methods for the aggregation of built environment variables and ride-hailing pick-ups. With the goal of global optimal goodness-of-fit, we determined the optimal spatial unit by using the log-linear Ordinary Least-Squares (OLS) model. A multi-scale geographically weighted elastic regression (MGWER) model is formulated to explore the relative effect of the built environment on the ride-hailing ridership and spatial heterogeneity. The average value of positive elastic local regression coefficient of different variables is used to measure the relative positive impact of built environment factors, and the absolute value of the average value of negative elastic local regression coefficient is used to measure the relative negative impact of built environment factors. The results show that: (1) The MGWER model under the community unit division has the best global goodness-of-fit. (2) Different built environment variables have different elastic impacts on the demand for ride-hailing. For the morning peak hours and evening peak hours, the top three built environment factors with positive impacts are ranked as follows: commercial POI density &gt; average house price &gt; population density, and distance to CBD has the highest negative impacts on pick-up ridership. (3) The different local elasticity coefficients of the built environment factors at different stations are discussed, which indicate the spatial heterogeneity of the ride-hailing ridership. The optimal community zoning method can provide a basis for the zoning and scheduling management of ride-hailing. The results of the built environment variables with greater impact are conducive to the formulation of targeted urban renewal strategies in the process of adjusting the ridership of ride-hailing.

Emotional Regulation, Self-Compassion, Medication Adherence and Quality of Life in Dermatologic Patients

Aim: To investigate the relationship between emotional regulation, self-compassion, medication adherence, and quality of life in dermatologic patients. Method: The sample consisted of 150 young adults (males=51 (34%) and females=99 (66%)). The quantitative data was gathered via self-reported questionnaires including Emotion Regulation Questionnaire1, Neff’s Self-Compassion Scale (Short-Form)2, Medication Adherence Rating Scale3, Quality of Life Scale4, and a demographic information form. Results: Significant positive associations were explored among emotional regulation, self-compassion, and quality of life. In contrast, negative significant associations were found between self-compassion, medication adherence, and quality of life. The multiple regression analysis suggested a positive regression coefficient of self-compassion and a negative regression coefficient of medication adherence on the quality of life in dermatologic patients with a 41% variation. The results of the independent sample t-test specified non-significant gender differences in terms of emotional regulation, self-compassion, medication adherence, and quality of life in dermatologic patients. However, the significant difference was explored in the marital status (unmarried and married) in terms of i.e.,self-compassion, medication adherence, and quality of life. Conclusion and Implications: The study’s findings have contributed to the gap of literature in the domains of psychology, dermatology, and clinical studies in Pakistan. The result of the study would be helpful for psychologists and dermatologists to make plans for enhancing emotional regulation, self-compassion, medication adherence, and quality of life in dermatologic patients. Keywords: Emotional Regulation, Self-Compassion, Medication Adherence, Quality of Life, and Dermatologic Patients.

Wavelet analysis of the EMG signal to assess muscle fatigue in the lower extremities during symmetric movement on a rowing ergometer

Purpose The aim of this publication is to propose a methodology to determine changes in fatigue in selected muscle groups of the lower extremity during dynamic and cyclical motion performed on a rowing ergometer. The study aims to use the discrete wavelet transform (DWT) to analyze electromyographic signals (EMG) recorded during diagnostic assessment of muscle and peripheral nerve electrical activity (electroneurography) using an electromyography device (EMG). Methods The analysis involved implementing calculations such as mean frequency (MNF) and median frequency (MDF) using the reconstructed EMG signal through DWT. The study examined the efficacy of DWT analysis in assessing muscle fatigue after physical exertion. Results The study obtained a negative regression coefficient for DWT analysis in all muscles except for the right gastrocnemius (GAS). The results suggest that DWT analysis can be an effective tool for evaluating muscle fatigue after physical exertion. Conclusions The use of DWT in the analysis of EMG signals during rowing ergometer exercises has shown promising results in assessing muscle fatigue. However, additional investigations are necessary to confirm and expand these findings. This publication addresses the literature gap on the determination of muscle fatigue considering motion analysis on a rowing ergometer using the discrete wavelet transform. Previous studies have extensively compared and analyzed methods such as the Fourier transform (FFT), short-time Fourier transform (STFT), and wavelet transform (WT) for muscle fatigue analysis. However, no previous work has specifically examined the assessment of muscle fatigue by incorporating DWT analysis with motion analysis on a rowing ergometer.

Impact of UP3AI Values on Islamic Religious Education Values and Physics Values in the Qur'an of Physics Education Students

This study aims to determine whether there is an effect of the UP3AI value on the value of Islamic Religious Education and Physics in the Qur'an of physics education students from the 2016 and 2017 batches of the syiah Kuala university. This study uses a quantitative approach. The data used is secondary data with data collection using documentation techniques. The population is all students of physical education class 2016 and 2017 who have completed UP3AI, PAI, and FISQUR courses. At the same time, the sample is as many as 54 samples obtained by the slovin technique from the entire population. Data processing was carried out with multiple regression analyses assisted by the SPPS version 26 application. The results showed an effect of the UP3AI value on the PAI value with a positive regression coefficient of 1.070, stating that for every 1% addition to the UP3AI value, the PAI value increased by 1.070. While the results of the regression of the UP3AI value on the FISQUR value, a negative regression coefficient of -0.331 means that there is no effect of the UP3AI value on the FISQUR value.

Pengaruh Kesiapan Siswa dan Pemanfaatan Teknologi Informasi Komunikasi terhadap Kebijakan Merdeka Belajar Menyongsong Era Industri 5.0

This study examines the effect of student readiness and the use of ICT on the implementation of independent learning policies in welcoming the industrial era 5.0. This type of research is descriptive quantitative with a survey approach. Data collection techniques were carried out by observation, questionnaires and documentation. The population of this study were all teachers of SMA Negeri 20 Makassar City. Determination of the sample was carried out by purposive sampling using accidental sampling technique, then as many as 40 teacher respondents were recruited who got the task of providing online learning systems to their students. Data analysis was carried out quantitatively with the stages of validity and reliability test analysis, classical assumption test and multiple linear regression analysis. The results of the study found that: 1) simultaneously the variables of student readiness and the use of ICT had a positive and significant effect on the independent learning policy in welcoming the industrial era 5.0; 2) partially each variable, namely student readiness and use of ICT, has a positive and significant influence on the policy of independent learning in welcoming the industrial era 5.0; 3) the dominant student readiness variable has a positive and significant effect on the independent learning policy in welcoming the industrial era 5.0; and 4) the independent learning policy variable shows a negative regression coefficient value, so it is interpreted to have decreased. This means that not all education actors understand the policy of free learning in welcoming the industrial era 5.0.

Longitudinal Trends in Severe Traumatic Brain Injury Inpatient Rehabilitation.

The goal of this study is to describe national trends in inpatient rehabilitation facility (IRF) discharges for the most severely disabled cohort of patients with traumatic brain injury (TBI). Data from the Uniform Data System for Medical Rehabilitation for patients discharged from an IRF between January 1, 2002, and December 31, 2017, with a diagnosis of TBI and an admission Functional Independence Measure of 18, the lowest possible score, were obtained and analyzed. Of the 252 112 patients with TBI discharged during the study period, 10 098 met the study criteria. From 2002 to 2017, the number of patients with an IRF admission Functional Independence Measure of 18 following TBI discharged from IRFs annually decreased from 649 to 488, modeled by a negative regression (coefficient = -2.97; P = .001), and the mean age (SD) increased from 43.0 (21.0) to 53.7 (21.3) years (coefficient = 0.70; P < .001). During the study period, the number of patients with the most severe disability on admission to IRF who were discharged annually as a proportion of total patients with TBI decreased from 5.5% to 2.5% (odds ratio = 0.95; P < .001) and their mean length of stay decreased from 41.5 (36.2) to 29.3 (24.9) days (coefficient = -0.83; P < .001]. The number and proportion of patients with the most severe disability on IRF admission following TBI who are discharged from IRFs is decreasing over time. This may represent a combination of primary prevention, early mortality due to withdrawal of life-sustaining treatment, alternative discharge dispositions, or changes in admitting and reimbursement practices. Furthermore, there has been a decrease in the duration of IRF level care for these individuals, which could ultimately lead to poorer functional outcomes, particularly given the importance of specialized rehabilitative care in this population.

The relationship between depression, anxiety, quality of life levels, and the chronic kidney disease stage in the autosomal dominant polycystic kidney disease.

Decreased quality of life, anxiety, depression, and other negative psychosocial factors in autosomal dominant polycystic kidney disease (ADPKD) may lead to the patient's attitudes that reduce treatment effectiveness. We aimed to evaluate the relationship between the depression, anxiety, perceived social support, genetic psychosocial risk and quality of life levels, and chronic kidney disease (CKD) stage in ADPKD and to investigate the relationship between these variables/parameters and the dietary compliance that is an essential factor in the course of the disease. 100 ADPKD patients were enrolled in this cross-sectional study. EuroQol-5D-3L (EQ-5D-3L) health-related quality of life ındex, EuroQol-5D-3L visual analog scale (EQ-5D-3L VAS), multidimensional scale of perceived social support (MSPSS), patient health questionnaire (PHQ)-9, and genetic psychosocial risk ınstrument (GPRI) were applied to the patients. There is a relationship with negative regression coefficient between the CKD stage and the total scores of the EQ-5D-3L and EQ-5D-3L VAS scales (p < 0.000 and β = - 5.355, p < 0.000, and β = - 8.394, respectively). There is a relationship with positive regression coefficient between the CKD stage and MSPSS total score and level (p < 0.000 and β = 0.364, p < 0.000 and β = 0.331, respectively). There is no relationship between the CKD stage and GPRI total score (p = 0.800). In addition, there is a relationship with positive regression coefficient between the dietary compliance and EQ-5D and EQ-5D VAS total scores (p = 0.006 and β = 2.687, p = 0.004 and β = 3.148, respectively). There is a relationship with negative regression coefficient between the dietary adherence and PHQ-9 total score and CKD stage (p = 0.003, p = 0.006, and β = - 0.692, respectively). As the CKD stage increases in the ADPKD patients, the quality of life decreases, whereas the level of anxiety and depression increases. It has been seen that the ADPKD patients with more depressive complaints have less dietary compliance. In this particular patient group, the early detection and treatment of psychosocial difficulties and the work to improve the quality of life that affect the course of the ADPKD may be as important as the medical treatment. To determine the needs of ADPKD patients with multiple physical and psychosocial difficulties and to perform appropriate interventions, we think that there is a necessity for a specific scale that evaluates these effective components together in the ADPKD process.

ANALYSIS OF THE INFLUENCE OF ASSET QUALITY, LIQUIDITY, AND CAPITAL ON PROFITABILITY

This study is to analyze whether there is an effect of Asset Quality, Liquidity, and Capital on Profitability. Objects taken for this research are Islamic Commercial Banks whose financial reports can be accessed and viewed by each official website of Islamic banks registered with the Financial Services Authority (OJK) for the period 2015 to 2019. This study uses 6 Islamic commercial banks with sample selection using purposive sampling method. The results of this study indicate that Asset Quality has a negative regression coefficient and a significant value smaller than alpha, so it can be said that Asset Quality has a significant effect on profitability. Meanwhile, liquidity has a negative regression coefficient with a significant value greater than alpha, so it can be said that liquidity has no significant effect on profitability.&#x0D; &#x0D; Keywords: Non Performing Financing, Financing To Deposit Ratio, Capital Adequacy Ratio, Return On Assets.

NEW CANDIDATE GENES ASSOCIATED WITH SHOULDER HEIGHT OF SHEEP OF RUSSIAN MEAT MERINO BREED

The search for candidate genes and genetic markers associated with economically valuable traits of productive animals is of great scientific and practical importance for the agro-industrial complex. Of particular interest are studies aimed at finding associations for parametres which characterize features of build and growth of animals. The aim of this work was to search for single nucleotide polymorphisms and candidate genes associated with height at the shoulder, one of the main measurements that allows to judge the conformation characteristics of sheep. The object of the study was 12-month-old Russian Merino meat rams (n = 50), bred on the Stavropol Territory. Animal genotyping was performed using DNA biochips of Ovine Infinium HD BeadChip 600K; genome-wide association analysis was performed using PLINK V.1.07 software. In the course of the work done, significant associations were found between the height at the shoulder and single nucleotide substitutions of 3, 10 and 18 chromosomes of sheep of Russian meat merino breed. Polymorphisms are located in the region of introns of protein-coding genes (rs422409900, rs413412092) and intergenic regions (rs414158152, rs430384069, rs415673748). A negative regression coefficient is observed in five analyzed substitutions. Location of analyzed substitutions in relation to the latest Oar_rambouillet_v1.0 genome annotation allowed to reveal 4 new candidate genes associated with height at the shoulder of sheep: RALGAPA1, MEIS1, AFTPH, SLC25A21. Further studies should be aimed at confirming the effect of the proposed candidate genes on the phenotype of animals, as well as confirming the relationship of rs414158152, rs430384069, rs42240990, rs415673748, and rs413412092 polymorphisms with conformation parametres of sheep.