Negative Version Research Articles

Structure and Evolution of Multi-Trend Faults in BZ19-6 Buried Hill of the Bohai Bay Basin, Eastern China

Defining the structure and evolution of multi-trend faults is critical for analyzing the accumulation of hydrocarbons in buried hills. Based on high-resolution seismic and drilling data, the structural characteristics and evolutionary mechanism of multi-trend faults were investigated in detail through the structural analysis theory and quantitative calculations of fault activity, allowing us to determine the implication that fault evolution exerts on hydrocarbon accumulation in the BZ19-6 buried hill. There are four kinds of strike faults developed on the buried hill: SN-, NNE-, NE–ENE-, and nearly EW-trending, which experienced the Mesozoic Indosinian, Yanshan, and Cenozoic Himalayan tectonic movements. During the Indosinian, the BZ19-6 was in a SN-oriented compressional setting, with active faults composed of SN-trending strike-slip faults (west branch of the Tanlu fault zone) and near EW-trending thrust faults (Zhang-peng fault zone). During the Yanshanian, the NNE-trending normal faults were formed under the WNW–ESE tensile stress field. Since the Himalayan period, the BZ19-6 buried hill has evolved into the rifting stage. In rifting stage Ⅰ, all of the multi-trend pre-existing faults were reactivated, and the EW-trending thrust faults became normal faults due to negative inversion. In rifting stage II, a large number of NE–ENE-trending normal faults were newly formed in the NW–SE-oriented extensional setting, which made the structure pattern more complicated. In rifting stage III, the buried hill entered the post-rift stage, with only part of the NNE- and NE–ENE-trending faults continuously active. Multi-trend faults are the result of the combination of various multi-phase stress fields and pre-existing structures, which have great influence on the formation of tectonic fractures and then control the distribution of high-quality reservoirs in buried hills. The fractures controlled by the NNE- and EW-trending faults have higher density and scale, and fractures controlled by NE–ENE trending faults have stronger connectivity and effectiveness. The superposition of multi-trend faults is the favorable distribution of high-quality reservoirs and the favorable accumulation area of hydrocarbon.

Structural inheritance, morphotectonics and Holocene activity of the Cucalón-Pancrudo extensional fault (Iberian Chain, Spain)

A large active extensional fault is characterized, which will contribute to improve seismic hazard assessment in an intraplate region of the Mediterranean domain whose seismic potential until today has been underestimated. The Cucalón-Pancrudo fault (CPF) is a NNW-SSE striking extensional fault that represents the negative (extensional) inversion of a previous, Late Variscan and Paleogene, transpressional fault. It is part of the Río Grío-Pancrudo fault zone, the largest active structure in the intraplate central-eastern Iberian Chain. This study focuses on characterizing the CPF structure, morphotectonics and paleoseismology. The fault offsets a well-known regional planation surface (lower level of the Fundamental Erosion Surface, FES3, 3.5 Ma), providing a basis for calculating the maximum fault throw (c. 280–300 m, including the contribution of a minor synthetic fault and a gentle accommodation monocline), and hence estimating the net slip (c. 305–325 m) and the long-term slip rate (0.09 mm/a). A trench dug in a Holocene fluvial terrace reveals an ensemble of listric, domino-style ruptures synthetic to the main fault. They were activated during at least two paleoseismic events (X, Z), 14.9 ± 1.4 ka and 6.9 ± 0.4 ka in age. An intermediate event (Y), dated to 11.0 ± 1.0 ka, as an uncertainty because the attribution of their ruptures to event Z cannot be ruled out. The total net slip accumulated during these events (1.15–1.25 m) provides an apparent short-term slip rate of 0.07–0.09 mm/a, very similar to the long-term slip rate. Nevertheless, it is very likely that the faults exposed in the surveyed trench do not represent a complete paleoseismic record. Therefore, the actual slip rate during Late Pleistocene-Holocene times could be significantly higher, approaching that reported for most of the recent extensional faults in the central Iberian Chain. The inclusion of CPF in the map of Active Faults of Iberia (QAFI database) will result in improving seismic hazard assessment in Spain.

Differentiating Gliosarcoma from Glioblastoma: A Novel Approach Using PEACE and XGBoost to Deal with Datasets with Ultra-High Dimensional Confounders.

In this study, we used a recently developed causal methodology, called Probabilistic Easy Variational Causal Effect (PEACE), to distinguish gliosarcoma (GSM) from glioblastoma (GBM). Our approach uses a causal metric which combines Probabilistic Easy Variational Causal Effect (PEACE) with the XGBoost, or eXtreme Gradient Boosting, algorithm. Unlike prior research, which often relied on statistical models to reduce dataset dimensions before causal analysis, our approach uses the complete dataset with PEACE and the XGBoost algorithm. PEACE provides a comprehensive measurement of direct causal effects, applicable to both continuous and discrete variables. Our method provides both positive and negative versions of PEACE together with their averages to calculate the positive and negative causal effects of the radiomic features on the variable representing the type of tumor (GSM or GBM). In our model, PEACE and its variations are equipped with a degree d which varies from 0 to 1 and it reflects the importance of the rarity and frequency of the events. By using PEACE with XGBoost, we achieved a detailed and nuanced understanding of the causal relationships within the dataset features, facilitating accurate differentiation between GSM and GBM. To assess the XGBoost model, we used cross-validation and obtained a mean accuracy of 83% and an average model MSE of 0.130. This performance is notable given the high number of columns and low number of rows (code on GitHub).

Two concepts of apocalypse and apocalyptic history today

ABSTRACT An apocalyptic imaginary appears so frequently in debates on climate change and the Anthropocene that it might be considered the dominant historical narrative of our time. However, when dealing with apocalypticism, biblical references are not always appropriate. In this article, I argue that we are dealing with two different concepts of apocalypticism, and that the new apocalyptic history is not a negative version of the religious apocalypse. Second, I also argue that the new apocalyptic history nevertheless seems to revolve around the idea of the promise as a specific historical way of binding the past, present and future into a coherent history that, ironically, seems to open up a dialogue with the history of theology.

Mesozoic to Cenozoic tectonic evolution in the central Bohai Bay Basin, East China

The Mesozoic and Cenozoic tectonic evolutionary history of the East Asian continental margin has been the focus of many researchers because of the overprinting of multiple tectonic domains. Previous studies have suggested that the westward subduction of the Paleo-Pacific Plate and the Pacific Plate resulted in the deconstruction of the North China Craton and controlled the formation of the related basins on the continental margin of East Asia. However, controversy remains regarding the tectonic transition processes and mechanisms that occurred from the Mesozoic to the Cenozoic. Since the Mesozoic, the Bohai Bay Basin on the eastern margin of the North China Craton of East China has been influenced by multiple tectonic domains of the Paleo-Tethys, Paleo-Pacific, and Pacific oceans, and there are complete records of these tectonic transition processes. The Bozhong Depression is a subbasin in the Bohai Bay Basin, which is a crucial area for researching the tectonic evolution of the Bohai Bay Basin throughout the Mesozoic−Cenozoic and the regional tectonic evolution of the eastern continental margin of China. Based on 3-D seismic data, logging core data, and a balanced cross section in the Bozhong area, combined with data from the apatite fission-track inversion model, we reconstructed the tectonic evolutionary history of central Bohai Bay Basin and established a three-cycle and eight-stage tectonic model of the central Bohai Bay Basin during the Mesozoic−Cenozoic. The three cycles are the Indosinian, the Yanshinian, and the Himalayan. (1) The Indosinian was marked by two stages. During the early Indosinian, NW-trending thrust faults were formed due to the collision and northward subduction of the South China Block underneath the North China Block. In the late Indosinian, the tectonic stress in the central Bohai Bay Basin shifted from compression to extension. Consequently, the thrust faults reversed, leading to the deposition of Early−Middle Jurassic strata. (2) The Yanshanian cycle comprises three main phases. Early Yanshanian transpressional shearing led to the formation of a NE/NNE-trending, left-lateral strike-slip fault due to NWW-directed subduction of the Paleo-Pacific Plate. Middle Yanshanian transtensional shearing was driven by Paleo-Pacific Plate rollback and resulted in regional extension and the negative inversion of previous compressive faults. Late Yanshanian compression gave rise to the basin reversion, which resulted from an increased subduction speed of the Paleo-Pacific Plate and a transition from a high angle to a low angle. (3) The Himalayan cycle was marked by three phases. During the early Paleogene, the region was characterized mainly by extension, and NE-trending, right-lateral strike-slip normal faults began to form. This coincided with a decrease in the Pacific Plate’s subduction speed. In the late Paleogene, the subduction rate of the Pacific Plate increased, resulting in the change of the central Bohai Bay Basin from an extensional environment to one marked by regional differential compression. In the Neogene, regional thermal subsidence and depression sedimentation occurred, which were probably induced by the increasing subduction speed and rollback of the Pacific Plate. The Bozhong Depression has experienced multiple stages of tectonic evolution, which indicates the concurrent and superimposed effects and transition of multiple tectonic domains.

Атеология Жоржа Батая и негативная суверенность

The article presents a brief essay on the analysis of three key concepts in the philosophy of Georges Bataille – heterology as the logic of exclusion, (a-)theology as an atheistic understanding of the death of God and the concept of ‘negative’ or ‘sacrificial’ Sovereignty. It seems that the key to understanding the various and heterogeneous philosophical, literary-poetic, cultural-anthropological and socio-economic concepts of the French thinker is the prism of the heterological logic of exclusion, which opposes the internalization of the dominant ontological discourse. The heterology or ‘logic of exclusion’ used by Georges Bataille, is not so much a negative version of the traditional logic of ‘inclusion’, but is a logic of alternative extremes. It is precisely by striving to overcome the dominant metaphysical universalism of the general order of being (embodied, according to Bataille, in the concept of ‘being’ / ‘die Existenz’ in the philosophy of Martin Heidegger). In an effort to overcome the dominant metaphysical universalism of the general order of being, Bataille turns to various kinds of ‘denials’ and extremes – the left sacred or the sanctity of ‘foulness’, the metaphorical of the disgusting, erotic and violent forms of transgression, the cultivation of the experience of inner abandonment and ultimate despair, and, also, to his own concept of ‘sacrifice’, serving as a guide to the world of sovereign domination. Thus, developing his concept of metaphysical ‘sovereignty’, Bataille turns not only to the existential, but also to the political sphere, largely contrasting his ‘metaphysics of sacrifice’ with the concept of ‘metaphysical domination’ of the German political and legal theorist Carl Schmitt. The nihilistic energy drawn from Friedrich Nietzsche and the ‘metaphysical negation’ taken from Hegel’s dialectic through the interpretation of Alexander Kozhev is used by Bataille for the purposes of his own ‘heterological’ logic of exclusion, desubjectivization and dissolution. However, negation for Bataille is not a target for itself, but a methodological tool on the way to the ‘Other’ excluded from any ontosemantic order.

Negative PPs and Negative Inversion

This study explores various issues related to negative PPs, focusing on (i) why some negative PPs trigger negative inversion, whereas some do not, (ii) why negative phrases can have scope beyond their c-domain, and (iii) why the distribution of negative PPs is restricted. This study is divided into two parts. The first part demonstrates that negative phrases exhibit a pattern similar to wh-phrases. They cooccur with a zero morpheme NEGø, which carries out the function of extending their restriction. Just as Q extends the restriction of a wh-operator and triggers pied-ping, NEGø extends the restriction of a negative operator, enabling it to have scope beyond its c-domain. The second part argues that English employs covert negative concord in that in negative sentences T must be merged with a covert head called Polarity, which has the feature [u(ninterpretable) Neg]. Additionally, it suggests that (i) the [uNeg]-feature on Polarity can be deleted via a mutual c-command relationship with a NegP, and (ii) when the [uNeg]-feature on it cannot be deleted in situ, it triggers head movement as a last resort. This claim provides a principled account for negative inversion and the distribution of negative PPs.

Militant primitivism of F.I. Girenok and the logic of “cultural” self-awareness

The article analyzes the speech of F.I. Girenok at the Philosophical Council in 2022. The author identifies two components in Girenko’s position. The first is primitivism in thinking. The author examines the logic of sociocultural primitivism in its many historical manifestations, highlighting its ideal-typical form. The logic of primitivism is revealed as a response to the negatively understood complexity of sociocultural existence. The second component is “cultural” self-awareness. The author reveals the logic of this type of self-awareness, contrasting it with “postcultural-intercultural” self-awareness. At the same time, the logic of the sociocultural development of humanity is affirmed as moving in a “postcultural” direction. The author reveals a negative version of “cultural” self-awareness as a closure on one’s system of ultimate ideas about the world. Girenko's philosophical position is considered as a combination of an extreme version of primitivism with an extreme version of “cultural” self-awareness.

Width Helps and Hinders Splitting Flows

Minimum flow decomposition (MFD) is the NP-hard problem of finding a smallest decomposition of a network flow/circulation X on a directed graph G into weighted source-to-sink paths whose weighted sum equals X . We show that, for acyclic graphs, considering the width of the graph (the minimum number of paths needed to cover all of its edges) yields advances in our understanding of its approximability. For the version of the problem that uses only non-negative weights, we identify and characterise a new class of width-stable graphs, for which a popular heuristic is a O (log Val(X))-approximation (Val(X) being the total flow of X ), and strengthen its worst-case approximation ratio from \(\Omega (\sqrt {m}) \) to Ω ( m /log m ) for sparse graphs, where m is the number of edges in the graph. We also study a new problem on graphs with cycles, Minimum Cost Circulation Decomposition (MCCD), and show that it generalises MFD through a simple reduction. For the version allowing also negative weights, we give a (⌈log ‖ X ‖⌉ + 1)-approximation (‖ X ‖ being the maximum absolute value of X on any edge) using a power-of-two approach, combined with parity fixing arguments and a decomposition of unitary circulations (‖ X ‖ ≤ 1), using a generalised notion of width for this problem. Finally, we disprove a conjecture about the linear independence of minimum (non-negative) flow decompositions posed by [17], but show that its useful implication (polynomial-time assignments of weights to a given set of paths to decompose a flow) holds for the negative version.

Weight loss: when the body image does not keep up

The body image, defined as an individual's 'inner vision' of himself, stems from the combination of multiple factors. The body dissatisfaction, which represents its negative version, is associated with eating disorders, a sedentary lifestyle and weight gain. Several patients suffering from obesity consider weight loss as a strategy to work on their body image. Multiples studies confirm a positive association between weight loss and improved body images. Nevertheless, few elements seem to predispose to body dissatisfaction persistence, such as a history of strict diets, eating disorders or other psychopathologies. To treat body dissatisfaction, we need to focus our attention on self-esteem, a balanced lifestyle, and media education.

Non-trivial topological phases in transition metal rich half-Heusler oxides

Topological insulators with gapless surface states and insulating bulk in non-centrosymmetric cubic systems have been extensively explored following the discovery of two-dimensional quantum spin hall effect in zincblende HgTe. In such systems the negative band inversion strength E (= E E 0) governs the robustness of the non-trivial topological states at ambient conditions. Hence, realizing large negative values of E has been a guiding motivation of several investigations reported in literature. Here, we present a material design approach which can be employed to realize large negative values of E in cubic materials such as half-Heusler (HH) oxides with 18 valence electron configurations. We explore 27 HH oxides of the form ABO (A = Li, K, Rb; B = Cu, Ag, Au) in α-, β-, and γ-phase (by placing transition metal atom at different Wyckoff positions) for their non-trivial topological phase. Off these three phases, we found that, the α-phase of nine HH oxides (wherein the transition metal atoms occupy 4a Wyckoff positions in the crystal structure) is the most promising with non-trivial topological phase which is governed by the mass-Darwin fully-relativistic effects enhancing E. Whereas the other phases were found to be either trivial semiconductors or semimetals or metals and most of them being dynamically unstable. We focus on RbAuO in α-phase with E of −1.29 eV and the effect of strain fields on the topological surface states of this compound. We conclude that the α-phase of HH oxide presented here can be synthesized experimentally for diverse room temperature applications in spintronics and nanoelectronics.

A Deformed Wedge‐Top Basin Inverted During the Collapse of the Variscan Belt: The Permo‐Carboniferous Lorraine Basin (NE France)

AbstractA new structural model is presented for the Permo‐Carboniferous Lorraine Basin (NE France), a major intramountain basin that developed during the latest stages of the Variscan orogeny (ca. 315–270 Ma). Digitalized well logs and reprocessed seismic data were used to decipher the kinematic evolution of this basin located along the Rhenohercynian orogenic suture zone. The basin was initiated during the late collision stage (Early to Middle Pennsylvanian) in a wedge‐top position upon the Saxothuringian retro‐wedge. The syn‐orogenic sequence is delimited to the north by the major SE‐verging Metz Thrust, which is part of the backthrust system that propagated during Middle Pennsylvanian (Late Westphalian). Seismic data provide evidence of negative tectonic inversion, allowing the formation of syn‐rift depocenters (Late Pennsylvanian‐Early Permian) above the former anticlines. Erosion of these anticlines results in a major unconformity marking the onset of post‐orogenic collapse. The late Early Permian shortening (Saalian phase) is suggested to reactivate former thrusts and normal faults, thus generating late uplift of the basin. The post‐orogenic phase is complex and diachronous at basin scale, and both compression and extension can be recorded in the same area over a short period (<10 Myr). The Late Carboniferous negative tectonic inversion along the Rhenohercynian suture zone is proposed to result from the lithospheric delamination of the Variscan orogenic roots. The associated upwelling of asthenospheric material is recorded by intense magmatic activity, and can be, in turn, considered as the main trigger for the subsequent thermal subsidence of the Mesozoic Paris Basin.

Evidence for selective emotional memory enhancement in a mock witness paradigm.

Elucidating the effects of negative emotion on eyewitness memory is an important part of understanding how witnesses remember and report criminal events. Extant research in this area has been inconsistent in its methodology and conclusions, thus warranting further empirical investigation. In the current experiment, participants (N = 204) viewed either a Negative or Neutral version of a video of a staged social interaction and had their memory assessed either immediately or 1 week later. Memory assessment consisted of both recall and recognition (lineup identification) components. The Negative video group showed enhanced recall for some aspects of the video compared to the Neutral group, but no enhancement (or impairment) of lineup identification performance. Theoretical and practical implications are discussed. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

Myc-regulated miRNAs modulate p53 expression and impact animal survival under nutrient deprivation.

The conserved transcription factor Myc regulates cell growth, proliferation and apoptosis, and its deregulation has been associated with human pathologies. Although specific miRNAs have been identified as fundamental components of the Myc tumorigenic program, how Myc regulates miRNA biogenesis remains controversial. Here we showed that Myc functions as an important regulator of miRNA biogenesis in Drosophila by influencing both miRNA gene expression and processing. Through the analysis of ChIP-Seq datasets, we discovered that nearly 56% of Drosophila miRNA genes show dMyc binding, exhibiting either the canonical or non-canonical E-box sequences within the peak region. Consistently, reduction of dMyc levels resulted in widespread downregulation of miRNAs gene expression. dMyc also modulates miRNA processing and activity by controlling Drosha and AGO1 levels through direct transcriptional regulation. By using in vivo miRNA activity sensors we demonstrated that dMyc promotes miRNA-mediated silencing in different tissues, including the wing primordium and the fat body. We also showed that dMyc-dependent expression of miR-305 in the fat body modulates Dmp53 levels depending on nutrient availability, having a profound impact on the ability of the organism to respond to nutrient stress. Indeed, dMyc depletion in the fat body resulted in extended survival to nutrient deprivation which was reverted by expression of either miR-305 or a dominant negative version of Dmp53. Our study reveals a previously unrecognized function of dMyc as an important regulator of miRNA biogenesis and suggests that Myc-dependent expression of specific miRNAs may have important tissue-specific functions.

Development and validation of a scale assessing parental varied responses to Chinese adolescents' negative emotions.

Parental responses to children's negative emotions (PRCNE) constitute a critical construct in the study of emotion socialization in children and adolescents. The objective of this research was to develop and validate a concise scale for assessing how adolescents perceive PRCNE in a Chinese context, resulting in the creation of the parental varied responses to Chinese adolescents' negative emotions (PVRCANE) scale. The PVRCANE aims to evaluate seven forms of PRCNE, including the six types encompassed by the commonly used Coping with Children's Negative Emotions Scale-Adolescent Version (CCNES-AV), as well as an additional, culturally specific category frequently seen in Chinese families: didactic talk and teaching. In Study 1, a group of participants (N = 901, Mage = 13.39 years, SD = 0.92) completed the initial PVRCANE and the CCNES-Adolescent Version. In Study 2: A separate group of participants (N = 320, Mage = 13.54 years, SD = 0.57) filled in PVRCANE and scales evaluating parental socialization goals and adolescents' depressive symptoms. In Study 1, factor analyses showed that a four-factor structure best fit the data, leading to the final version of the PVRCANE, which includes 35 items. PVRCANE scores exhibited good internal consistency (Omega > 0.79) and convergent validity, demonstrated by their close correlation with traditional CCNES scores. Study 2 confirmed the PVRCANE's measurement invariance for both male and female parents and demonstrated criterion validity by showing significant relationships between PVRCANE scores, parental socialization goals, and adolescents' symptoms of depression. The PVRCANE is a brief, valid, and reliable scale for assessing PRCNE in Chinese adolescents. The study concludes with a discussion on future directions and how this research enhances the existing literature on emotion socialization, with a particular emphasis on the scale's potential application in other cultural settings.

Effects of Organized Hypocrisy Strategy on the Establishment of Political Relation of Rama I and Emperor Qianlong

The paper deploys and develops the organized hypocrisy theory to account for the effect of organized hypocrisy strategy on the establishment of the political relation between Rama I and Emperor Qianlong from 1782 to 1787. Using the case study of Rama, I and Emperor Qianlong and a historical analysis, the paper shows that the logic of consequences of Rama I seek China’s economic and military leads to Sino-Thai conflicting logics of appropriateness. Thailand uses the organized hypocrisy strategy to respond to this situation with two mutually negative versions of royal letters and transliterated terms. The key decoupling mechanism of the strategy is that the Thailand monarch conducts diplomatic interactions that maintain his status, while the Chinese in Thailand act as intermediaries to handle interactions that damage Thailand Monarch’s prestige. Organized hypocrisy strategy allows Thailand to maintain Rama I’s claim of universal kingship and meet the demand of Emperor Qianlong investing Rama I at the same time. Rama I and Emperor Qianlong formed a nominal tributary relationship on this premise. Thailand's organized hypocrisy strategy is largely the political hypocrisy of a small country dealing with a big one. Emperor Qianlong practicing the doctrine of ‘no rule’ and not sending envoys for investiture makes the hypocrisy strategy play a positive role. This study informs our theoretical understanding of Sino-Thai friendly official relations by introducing a focus on the organized hypocrisy strategy hitherto lacking.

The “Hart-Dworkin” Debate: Critical Capacity for Russian Legal Theory

This article is devoted to an analysis of the early arguments within the Anglo-American philosophical and legal discussion, known in the academic literature as the “Hart-Dworkin” debate. The key theses attributed by R. Dworkin to the legal positivism of H. Hart and his proponents are examined: the pedigree thesis, the discretion thesis, the obligation thesis and the separability thesis. R. Dworkin’s criticism of these theses, on the basis of legal positivists’ undervaluing of the role of legal principles, as well as the capacity of these arguments for reconsideration of the key assumptions of mainstream Russian legal theory, is characterized. The central statements of the exclusive (hard) and inclusive (soft) legal positivism as two strategies of reaction to R. Dworkin’s critique are analysed. The separability thesis is discussed through the framework of J. Coleman’s distinction between positive and negative versions of the positivist legal theory. The conclusion that the nature of the nexus between moral and legal norms has not been properly problematised in contemporary Russian legal theory and that the arguments in the Hart-Dworkin debate have critical capacity to challenge dogmatism on this issue is justified.

Timing, Thrusting Mode, and Negative Inversion Along the Circeo Thrust, Apennines, Italy: How the Accretion‐To‐Extension Transition Operated During Slab Rollback

AbstractThe evolution of the Apennine wedge has seen the time‐space migration of the forebulge, foredeep, thrust wedge, and back‐arc extension phases in the wake of the Eastward rollback of the subducting Adria slab. In this framework, thrusting and post‐orogenic extensional faulting have occurred in two parallel forelandward‐migrating ribbons, with extensional deformation overprinting or partly exploiting anisotropies of the inherited thrust system. Here, we explore the tectonic framework and the timing of thrusting and subsequent negative inversion of the Circeo thrust, one of the major thrusts in the inner portion of the central Apennines, with the main aim to constrain the timing and mode of the compression to extension switch. Structural analysis, carbonate C and O and clumped isotopes analysis, X‐ray diffraction of clay minerals, and U‐Pb dating of calcite slickenfibers have been integrated with seismic interpretation, cross‐section balancing, and 1D burial and thermal modeling. We show that the Circeo thrust developed during Langhian‐Serravallian time. Its extensional reactivation is dated at the Serravallian, during the stacking of an underlying thrust slice, before the onset of Pliocene back‐arc extension in the area. Combination of our data with the age of thrusts, extensional basins, and base of the foredeep infill of the central Apennines, demonstrates that forelandward migration of the foredeep‐thrust system occurred at variable velocities. Accelerations and decelerations are synchronous, respectively, with the opening of the Liguro‐Provençal and Tyrrhenian back‐arc basins and with the interluding quiescent period.

Phenotypes controlled by the Brucella abortus two component system BvrR/BvrS are differentially impacted by BvrR phosphorylation.

Brucella abortus is a zoonotic pathogen whose virulence depends on its ability to survive intracellularly at the endoplasmic reticulum derived compartment. The two-component system BvrR/BvrS (BvrRS) is essential for intracellular survival due to the transcriptional control of the type IV secretion system VirB and its transcriptional regulator VjbR. It is a master regulator of several traits including membrane homeostasis by controlling gene expression of membrane components, such as Omp25. BvrR phosphorylation is related to DNA binding at target regions, thereby repressing or activating gene transcription. To understand the role of BvrR phosphorylation we generated dominant positive and negative versions of this response regulator, mimicking phosphorylated and non-phosphorylated BvrR states and, in addition to the wild-type version, these variants were introduced in a BvrR negative background. We then characterized BvrRS-controlled phenotypes and assessed the expression of proteins regulated by the system. We found two regulatory patterns exerted by BvrR. The first pattern was represented by resistance to polymyxin and expression of Omp25 (membrane conformation) which were restored to normal levels by the dominant positive and the wild-type version, but not the dominant negative BvrR. The second pattern was represented by intracellular survival and expression of VjbR and VirB (virulence) which were, again, complemented by the wild-type and the dominant positive variants of BvrR but were also significantly restored by complementation with the dominant negative BvrR. These results indicate a differential transcriptional response of the genes controlled to the phosphorylation status of BvrR and suggest that unphosphorylated BvrR binds and impacts the expression of a subset of genes. We confirmed this hypothesis by showing that the dominant negative BvrR did not interact with the omp25 promoter whereas it could interact with vjbR promoter. Furthermore, a global transcriptional analysis revealed that a subset of genes responds to the presence of the dominant negative BvrR. Thus, BvrR possesses diverse strategies to exert transcriptional control on the genes it regulates and, consequently, impacting on the phenotypes controlled by this response regulator.

Adaptation at the Syntax-Semantics Interface: Evidence From a Vernacular Structure.

Expanding on psycholinguistic research on linguistic adaptation, the phenomenon whereby speakers change how they comprehend or produce structures as a result of cumulative exposure to less frequent or unfamiliar linguistic structures, this study asked whether speakers can learn semantic and syntactic properties of the American English vernacular negative auxiliary inversion (NAI) structure (e.g., didn't everybody eat, meaning "not everybody ate") during the course of an experiment. Formal theoretical analyses of NAI informed the design of a task in which American English-speaking participants unfamiliar with this structure were exposed to NAI sentences in either semantically ambiguous or unambiguous contexts. Participants rapidly adapted to the interpretive properties of NAI, selecting responses similar to what would be expected of a native speaker after only limited exposure to semantically ambiguous input. On a separate ratings task, participants displayed knowledge of syntactic restrictions on NAI subject type, despite having no previous exposure. We discuss the results in the context of other experimental studies of adaptation and suggest the implementation of top-down strategies via analogy to other familiar structure types as possible explanations for the behaviors observed in this study. The study illustrates the value of integrating insights from formal theoretical research and psycholinguistic methods in research on adaptation and highlights the need for more interdisciplinary and cross-disciplinary work in both experimental and naturalistic contexts to understand this phenomenon.