This study explored the evolution of friction-induced vibration (FIV) and wear in high-speed train friction braking through experiments, theoretical analysis, and numerical simulation. Experimental tests revealed that vibration behavior transitions from high-frequency modes at high speeds to low-frequency stick-slip at lower speeds. Theoretical analysis indicated that brake disc speed, coefficient of friction (COF), and contact stiffness affect system stability. Specifically, the system experiences high-frequency vibrations at high speeds due to mode coupling, and the friction block surface primarily undergoes abrasive wear mechanisms. At lower speeds, the system demonstrates low-frequency stick-slip vibrations induced by the combined effects of mode coupling and negative friction velocity slope (NFVS) characteristics, and the friction block surface mainly experiences adhesive wear mechanisms.