Need For Pain Relief Research Articles

Ion Current Rectification Activity Induced by Boron Hydride Nanosheets to Enhance Magnesium Analgesia.

The limited analgesic efficiency of magnesium restricts its application in pain management. Here, we report boron hydride (BH) with ion currents rectification activity that can enhance the analgesic efficiency of magnesium without the risks of drug tolerance or addiction. We synthesize MgB2, comprising hexagonal boron sheets alternating with Mg2+. In pathological environment, Mg2+ is exchanged by H+, forming two-dimensional borophene-analogue BH sheets. BH interacts with the charged cations via cation-pi interaction, leading to dynamic modulation of sodium and potassium ion currents around neurons. Additionally, released Mg2+ competes Ca2+ to inhibit its influx and neuronal excitation. In vitro cultured dorsal root neurons show a remarkable increase in threshold potential from the normal -35.9 mV to -5.9 mV after the addition of MgB2, indicating potent analgesic effect. In three typical pain models, including CFA-induced inflammatory pain, CINP- or CCI-induced neuropathic pain, MgB2 exhibits analgesic efficiency approximately 2.23, 3.20, and 2.0 times higher than clinical MgSO4, respectively, and even about 1.04, 1.66, and 1.95 times higher than morphine, respectively. The development of magnesium based intermetallic compounds holds promise in addressing the non-opioid medical need for pain relief.

Ion Current Rectification Activity Induced by Boron Hydride Nanosheets to Enhance Magnesium Analgesia

AbstractThe limited analgesic efficiency of magnesium restricts its application in pain management. Here, we report boron hydride (BH) with ion currents rectification activity that can enhance the analgesic efficiency of magnesium without the risks of drug tolerance or addiction. We synthesize MgB2, comprising hexagonal boron sheets alternating with Mg2+. In pathological environment, Mg2+ is exchanged by H+, forming two‐dimensional borophene‐analogue BH sheets. BH interacts with the charged cations via cation‐pi interaction, leading to dynamic modulation of sodium and potassium ion currents around neurons. Additionally, released Mg2+ competes Ca2+ to inhibit its influx and neuronal excitation. In vitro cultured dorsal root neurons show a remarkable increase in threshold potential from the normal −35.9 mV to −5.9 mV after the addition of MgB2, indicating potent analgesic effect. In three typical pain models, including CFA‐induced inflammatory pain, CINP‐ or CCI‐induced neuropathic pain, MgB2 exhibits analgesic efficiency approximately 2.23, 3.20, and 2.0 times higher than clinical MgSO4, respectively, and even about 1.04, 1.66, and 1.95 times higher than morphine, respectively. The development of magnesium based intermetallic compounds holds promise in addressing the non‐opioid medical need for pain relief.

Decision-Making Experiences to use Medicinal Cannabis: Perspectives from Patients with Knee Osteoarthritis and Their Care Providers.

This study investigated the experience of making a decision to use medicinal cannabis among patients with knee osteoarthritis and their care providers. This qualitative research used a phenomenological approach to collect information by purposive sampling. Informants included 7 patients with knee osteoarthritis and 18 care providers in Khon Kaen municipality. Data were collected from June until December 2021using in-depth interviews, field records and participatory observation. After 6 months of data collection, the modified Colaizzi’s seven-step method was used for data analysis. The results show that the content from all informants can be categorized into 7 distinct themes about their decision-making on using medicinal cannabis (MC): 1) The needs for MC: Recognizing the painful nature of osteoarthritic pain and the limited treatment options available 2) Beliefs and attitudes towards MC with two sub-themes identified as 2.1) Belief in the MC’s efficacy that denotes informants’ positive perception and 2.2) Attitudes towards MC that show doubt, hesitation, or lack of confidence in MC’s effectiveness 3) Evidence on efficacy and safety of MC products: Considering cannabis as a viable treatment option 4) Trustworthiness of information and communication about MC. 5) Influence of other people: Three key influencers in the decision-making process including 5.1) Patients themselves 5.2) Friends and peers 5.3) Doctors and healthcare professionals 6) Legitimacy status of MC and 7) Product designs regarding forms of therapeutic use. The findings yielded 7 distinct themes concerning the decision to use medicinal cannabis (MC). The most important component is the need for pain relief among knee osteoarthritis patients. They clearly need MC for relieving their symptoms. Evidence on efficacy and legalization status of MC are also the main factors, while other 4 components are less important or not the vital factors for making decision on MC’s utilization. Policies on MC need to address these factors.

Arteriovenöz Fistül Cerrahisinde Rejyonal ve Lokal Anestezi Karşılaştırması: Tek Merkezli Bir Araştırma

Background: This retrospective study aimed to compare the outcomes of regional anesthesia and local anesthesia techniques in arteriovenous fistula operations, focusing on early patency rates, operation time, and postoperative pain. Methods: A total of 77 arteriovenous fistula and arteriovenous graft operations performed between April 2020 and April 2023 on adult patients with chronic renal failure were analyzed. The patients were divided into two groups based on the anesthesia technique: Group-1 (n=49) received local anesthesia, while Group-2 (n=28) received regional anesthesia. Results: The majority of operations in the local anesthesia group involved radio-cephalic arteriovenous fistula, while brachio-cephalic, brachio-basilic arteriovenous fistula, and arteriovenous grafts were predominantly performed in the regional anesthesia group. There was no significant difference in operation time between the two groups. However, the regional anesthesia group had a significantly lower need for pain relief within the first 24 hours postoperatively. There were no significant differences in early postoperative fistula failure or bleeding/hematoma between the groups. One case of local wound infection was observed in each group during post-discharge follow-up. Conclusion: This retrospective analysis suggests that regional anesthesia provides superior pain control in the first 24 hours following arteriovenous fistula surgery compared to local anesthesia. Regional anesthesia is a safe and effective technique and may be preferred for more sophisticated arteriovenous fistula procedures.

The opioid crisis fuelled by health systems: how will future physicians fare?

The opioid crisis continues to affect many areas worldwide, raising questions regarding prescribing indications. There is no consensus on negotiating the need for pain relief and the potential for medically prescribed opioid-related harm/addiction. These issues present an enormous educational challenge to physicians in training, particularly those whose mandate is to understand and respond to varying forms of pain. This article examines the perspectives and educational challenges faced by two psychiatry residents from different parts of the globe during the crisis. Is the educational experience of future psychiatrists sufficient to prepare them for the responsibilities that lie ahead?

Dysmenorrhea Clinical Pharmacology: Dose Finding of Physiological Modulators in Foods or Capsules

Background: Dysmenorrhea is a disease, which occurs in about 45% of women in childbearing age. Objective: Dose finding study to evaluate the activity of specific physiological modulators (PMs) aimed at protecting GABAA receptors and CaSRs (calcium sensing receptors) against oxidative stress (OS) and at reducing the discomfort caused by dysmenorrhea. Methods: The discomfort was measured using a score of from 0 to 5 and plasma antioxidant capacity was determined using a plasma antioxidant test (PAT). The PMs were combined and administered at low doses in the form of specific foods (SFs) and capsules. Twenty women with a score of ≥ 3 took part in the study during 5 sessions of 4 hours. In session 1, the women were treated with placebo, whereas in sessions from 2 to 5 they alternated between capsules and SFs containing the same amount of PMs. In sessions 4 and 5, the PM doses were double those taken in sessions 2 and 3. At the end of each sessions, women were asked about the need of pain relief as an indirect measurement of treatment efficacy. Results: The SFs and capsules reduced the discomfort in 60% and 75% of cases respectively. However, the effect with capsules was more rapid and lasted longer than with SFs. The need for pain relief was lower after treatment with capsules than it was with SFs. The increase in PAT was similar for both treatments. Conclusions: PMs taken as SFs or capsules showed similar activity, but capsules had a significantly more rapid and longer lasting effect.

Chronic Pelvic Pain in Endometriosis: Cross-Sectional Associations with Mental Disorders, Sexual Dysfunctions and Childhood Maltreatment.

The aim of this cross-sectional study was to compare the rates of mental disorders, sexual dysfunctions and childhood maltreatment (CM) in women with endometriosis with either chronic pelvic pain (CPP) or minimal to no pelvic pain. Additionally, two models to predict a current mental disorder were tested, including pelvic-pain-related or psychosocial predictor variables. We examined 100 women with confirmed endometriosis (group CPP, n = 50; group NOPAIN, n = 50). Participants responded to a comprehensive questionnaire and the Childhood Trauma Questionnaire. The Diagnostic Interview for Mental Disorders was used to assess mental disorders according to DSM-5 and to screen for sexual dysfunctions. The mean age was 28.8 ± 5.6 (CPP)/2.7 ± 6.3 (NOPAIN). Participants with CPP had higher rates of current mental disorders (p = 0.019), lifetime mental disorders (p = 0.006) and sexual dysfunctions (p < 0.001), but not CM (p = 0.074). In two binary-logistic regression analyses, a greater need for pain relief (aOR = 4.08, p = 0.026) and a sexual dysfunction (aOR = 2.69, p = 0.031) were significant predictors for a current mental disorder. Our findings confirmed the crucial role of pelvic pain for mental and sexual well-being in endometriosis. They highlight the need for pain relief and interdisciplinary care in the treatment of endometriosis.

Managing Pain from the Head and Heart

There continues to be significant attention to more comprehensive approaches to pain management. Pharmacologic and interventional options have increased, non-pharmacologic approaches have been endorsed, nursing and medical specialties have developed, and patients have been more engaged in their plans of care. Clinicians are balancing the need for pain relief in a more stringent legal and regulatory environment while balancing institutional constraints. In a related field there is developing knowledge and understanding of the Mind Body Syndrome, which espouses that pain triggering pathways become a well-learned cycle by the brain and body even in the absence of pathology.

THE DIFFERENCE OF ANXIETY IN INTRAPARTUM MOTHERS WITH NORMAL AND SECTIO CAESAREA

Background: Due to the painful nature of childbirth and its maternal and neonatal complications, the woman needs support in this phase of their life. The anxiety felt by women before caesarean delivery caused psychological problems, the increased of surgical pain therefore increased the need for pain relief, and prolong hospitalization. This study aimed to investigate the difference of anxiety in intrapartum mothers with normal and sectio caesarea. Subjects and Method: A cross sectional study was conducted at Haji hospital, Surabaya, East Java, Indonesia. A sample of 34 intrapartum mothers was selected by consecutive sampling. The dependent variable was anxiety. The independent variables were normal and section cesarea birth delivery. The data were collected by questionnaire and analyzed by independent t test. Results: There was no difference of anxiety in intrapartum mothers with normal birth delivery (Mean= 56.82; SD= 15.02) and mother those with section cesarea (Mean= 58.19; SD= 12.02). Conclusion: There is no difference of anxiety in intrapartum mothers with normal birth delivery and mother those with section cesarea.

Personalized behavior management as a replacement for medications for pain control and mood regulation

A lack of personalized approaches in non-medication pain management has prevented these alternative forms of treatment from achieving the desired efficacy. One hundred and ten female patients with fibromyalgia syndrome (FMS) and 60 healthy women without chronic pain were assessed for severity of chronic or retrospective occasional pain, respectively, along with alexithymia, depression, anxiety, coping strategies, and personality traits. All analyses were conducted following a ‘resource matching’ hypothesis predicting that to be effective, a behavioral coping mechanism diverting or producing cognitive resources should correspond to particular mechanisms regulating pain severity in the patient. Moderated mediation analysis found that extraverts could effectively cope with chronic pain and avoid the use of medications for pain and mood management by lowering depressive symptoms through the use of distraction mechanism as a habitual (‘out-of-touch-with-reality’) behavior. However, introverts could effectively cope with chronic pain and avoid the use of medications by lowering catastrophizing through the use of distraction mechanism as a situational (‘in-touch-with-reality’) behavior. Thus, personalized behavior management techniques applied according to a mechanism of capturing or diverting the main individual ‘resource’ of the pain experience from its ‘feeding’ to supporting another activity may increase efficacy in the reduction of pain severity along with decreasing the need for pain relief and mood-stabilizing medications.

Pain management with methoxyflurane (Penthrox®) in Swedish ambulance care – An observational pilot study

BackgroundIn ambulance care, patients are often classified as high-risk, particularly when they are in immediate need of pain relief. It has been shown that, after ambulance nurses administer intravenous analgesic drugs, patients delivered to the emergency department tend to complain of moderate to severe pain. Aims and objectivesThe present study aimed to evaluate the overall patient-perceived pain during treatment with methoxyflurane (MTX) in an ambulance-care setting. We also explored potential demographic variations. MethodsThis prospective observational study included 50 patients in need of ambulance care that perceived acute pain, defined as a Numeric Rating Scale (NRS) value ≥4 (scale range: 1–10). We monitored the vital parameters of patients and MTX treatment characteristics, including the total number of inhaled MTX breaths and the average number of treatment sequences. ResultsAmong the 50 patients initially assessed, we excluded 8 patients (16%), due to MTX contraindications. We excluded 10 patients (24%), due to discontinued treatment. The remaining cohort (n = 32) that fulfilled the pain-relieving procedure, included equal numbers of men and women. The average time spent in ambulance care was 29 ± 15 min. The NRS scores for pain measured at the scene (median 8.0, interquartile range [IQR]: 7.25–10.0) were significantly higher than those measured at hospital admission (median 5.0, IQR: 4.0 7.0; p = .001). The median NRS scores measured at the hospital were different between sexes (men: 6.0, IQR: 5–7.25; women: 4.0, IQR: 3.76–6.0; p = .036). The average number of treatment sequences was 2. The overall average number of inhaled breaths was 17 ± 9. ConclusionThis study demonstrates that MTX provided clinically significant lower pain scores among patients in ambulance care without significant effects on vital parameters. However, the pharmacological characteristics of MTX appeared to affect the potential of achieving standardized treatment objectives.

Femoral nerve versus adductor canal block for early postoperative pain control and knee function after anterior cruciate ligament reconstruction with hamstring autografts: a prospective single-blind randomised controlled trial.

The optimal pain management strategy for postoperative pain after anterior cruciate ligament reconstruction (ACLR) remains unclear. This study compared femoral nerve block (FNB) and adductor canal block (ACB) for pain management of early postoperative pain, knee function, and recovery of activity of daily living (ADL) after ACLR using hamstring autografts. In this prospective, single-blind, randomised controlled trial, 64 patients aged 12-56years who underwent anatomical double-bundle ACLR with a hamstring autograft between August 2019 and May 2020 were randomised to undergo preoperative FNB (n = 32) or ACB (n = 32). The peripheral nerve block was performed by a single experienced anaesthesiologist under ultrasound guidance. The primary outcomes were postoperative pain as evaluated using the visual analogue scale (VAS) at 3, 6, 12, 24, and 48h postoperatively and the need for pain relief. The secondary outcome was knee function, including the recovery of range of motion, contraction of the vastus medialis, and stable walking with a double-crutch (ADL), as evaluated by blinded physical therapists. There were no significant differences in patient demographics between the two groups. The VAS scores, need for pain relief, knee function, and ADL did not significantly differ between the groups. FNB and ACB provided comparable outcomes related to early postoperative pain, knee function, and ADL after double-bundle ACLR using hamstring autografts. Further research is necessary to evaluate the mid- to long-term effect of each block on recovery of knee function and ADL. I.

RETRACTED: Smart IoT data platform in hospital and postoperative analgesic effects of orthopedic patients

IOT test this large donor control engineering data can relieve postoperative pain is discussed. One human operation, closed-loop, postoperative analgesic things large data system is designed to alleviate chronic pain. In this system the need of pain relief, when the patient presses the button. Computer interface buttons, the patient's IOT large data after pump. Patients with pain models have been developed to describe the kinetics of chronic pain in people's physiological and psychological reactions. Further including analgesic pharmacokinetic model. Pain model parameters have been adjusted, so that large data things validated self-management of pain behavior mimics a real button, presses the record. Unfortunately, if the adhesion is removed, the inflammation process begins; it is the foundation of a new adhesion causes, creating a vicious cycle difficult to break. Is achieved by electrical stimulation therapy of the small intestine contraction is applied. The results have not been entirely successful, it does not complete the verification of transcutaneous electrical nerve stimulation. However, this idea, a new method is reliable become the treatment of adhesive intestinal obstruction. Effective use of long things big data, as of this site, are, first aid and coherent knowledge of post-operative care, and people to help taking the right medicine for the patient, such research index regret believe that to reduce the occurrence of cans distinguish the analgesic efficacy of the use of different large amounts and compositions of the networking data six hundred and seventy and 9 vertical abdomen, spine and limbs procedures.

Analgesia for vaginal birth: Secondary analysis from the WHO Multicountry Survey on Maternal and Newborn Health.

To evaluate the use of analgesia during labor in women who had a vaginal birth and to determine the factors associated with its use. A secondary analysis was performed of the WHO Multicountry Survey on Maternal and Newborn Health, a cross-sectional, facility-based survey including 359 healthcare facilities in 29 countries. The prevalence of analgesia use for vaginal birth in different countries was reported according to the Human Development Index (HDI). Sociodemographic and obstetric characteristics of the participants with and without analgesia were compared. The prevalence ratios were compared across countries, HDI groups, and regions using a design-based χ2 test. Among the 221345 women who had a vaginal birth, only 4% received labor analgesia, mainly epidural. The prevalence of women receiving analgesia was significantly higher in countries with a higher HDI than in countries with a lower HDI. Education was significantly associated with increased use of analgesia; nulliparous women and women undergoing previous cesarean delivery had a significantly increased likelihood of receiving analgesia. Use of analgesia for women undergoing labor and vaginal delivery was low, specifically in low-HDI countries. Whether low use of analgesia reflects women's desire or an unmet need for pain relief requires further studies.

Actinic keratosis area and severity index is not correlated with photodynamic therapy procedural pain.

The Actinic Keratosis Area and Severity Index (AKASI) is a validated quantitative tool used to measure the severity of actinic keratoses. Given the success of AKASI in measuring outcomes and therapies related to actinic damage, we hypothesized that AKASI would be correlated to photodynamic therapy (PDT)-related pain. The aim of this study was to evaluate AKASI's correlation with PDT-associated pain for patients with AKs being treated with 5-Aminolevulinic acid (ALA) PDT. Thirty consecutive patients being treated for AKs with ALA PDT on the face and/or scalp were recruited from a single center. The AKASI of the treated areas were collected. The patient underwent a standard treatment with ALA-PDT for a total of 10 J/cm2 to treated area. Immediate post-procedural pain scores were measured using a visual-analog pain scale. Pain and AKASI scores were analyzed using Pearson's correlation coefficient. AKASI was not correlated to pain score (Pearson correlation coefficient was 0.027, p = 0.87). In sub-group analyses, there was no strong correlation between the scalp AKASI or face AKASI and respective pain scores (p = 0.59 and p = 0.38, respectively). Furthermore, there was no strong correlation between the individual components of AKASI and pain score: distribution (p = 0.26), erythema (p = 0.66) and thickness (p = 0.43). There is no correlation between the AKASI score and perceived pain from PDT. Therefore, the need for pain relief using a fan and evaporative cooling should be anticipated for all patients. We feel that this negative result is noteworthy as it supports mechanisms outside of AK destruction as the cause of immediate PDT-related pain.

Comparison of adductor canal block and local infiltration analgesia techniques for postoperative analgesia in gonarthrosis patients receiving a total knee prosthesis

Aim: Total knee arthroplasty (TKA) is a major orthopaedic surgery, and patients experience severe postoperative pain. Local infiltration anaesthesia and/or peripheral nerve blocks are often used for analgesia after TKA. The aim of this study was to compare the analgesic efficacy of the local infiltration anaesthesia and adductor canal block (ACB) techniques in the first postoperative 24 hours after TKA.Material and Methods: Sixty patients of both sexes who were aged 40-80 years, in the ASA I-III group and undergoing TKA were included in this study after approval of the local ethics committee. Spinal anaesthesia was achieved with 15 mg 0.5% heavy bupivacaine in all patients. In Group I, nerve blocks were applied under ultrasonography with a 20 mL 0.25% bupivacaine. In Group II, a 60 ml cocktail was injected into the periarticular area and subcutaneous tissue. Postoperative pain was evaluated at 0, 1, 2, 8, 12, and 24 hours with a visual analogue scale (VAS). When the VAS score was &amp;gt;4 or the patient reported a need for pain relief, intravenous analgesics were administered, and the analgesia requirement time was recorded. Statistical analysis was performed with IBM SPSS 23.0 software. A value of p&amp;lt;0.05 was accepted as significant.Results: No statistically significant differences were determined between groups with respect to the demographic data or VAS values (p&amp;gt;0.05). All patients in Group I and 28 patients in Group II required additional analgesia at 10.0±4.9 hours and 8.7±6.02 hours. These differences were not statistically significant (p&amp;gt;0.05).Conclusion: The study showed that both methods provided effective analgesia and can be used for a multimodal analgesia method postoperatively in the first 24 hours after TKA operations.

Автоматизация ведения регио- нального реестра лиц, нуждающихся в паллиативной медицинской помощи в Краснодарском крае

The relevance of improving the management of the palliative care system in the Krasnodar region, the direct provision of medical care and the interaction of public health authorities is due to the processing of large amounts of data on the need for pain relief and equipment. In each municipality of the Territory, registers of patients suffering from chronic pain syndrome are maintained. The purpose of the article is to develop a methodology for integration municipal registers into a single register of people needed palliative care, and automation of management at the regional level. The paper discusses approaches to create a unified database (registers) of patients suffering from chronic pain syndrome receiving palliative care in order to assess the compliance of medical care with modern clinical guidelines. The possibilities of a unified information system for extracting and dispensing preferential recipes for the implementation of the technology for automated management of the regional registry along with the registers of federal and regional beneficiaries, orphan diseases are shown.

Spinal cord stimulation in failed back surgery syndrome

Introduction. A common cause of chronic pain after back surgery is failed back surgery syndrome, characterized by the development, persistence or recurrence of neuropathic pain in the absence of clear anatomical complications from the surgery. One of the most effective treatment methods for failed back surgery syndrome is permanent spinal cord stimulation. Study aim. To assess the efficacy and safety of chronic spinal cord stimulation in failed back surgery syndrome. Materials and methods. In our study, after a stimulation trial final neurostimulation was performed in 34 patients with neuropathic pain and lack of improvement from the pharmacological treatment. Results. Six months after the operation, there was a reduction in the average scores on the visual analogue scale for the daily average and maximum pain, as well as a reduction in the severity of neuropathic pain as measured by the PainDetect scale (by 54.4% 50.7% and 57.3%, respectively), which corresponds to the method’s efficacy criteria found in the literature. The majority of patients noted a significant improvement in their quality of life and a reduced need for pain relief. Complications occurred in 26.4% of patients overall, including intraoperative damage to the dura mater, infection at the generator implantation site, and electrode displacement relative to the initial position, requiring correction. None of the patients experienced worsening of the neurological symptoms.

Gamma Knife Radiosurgery for Primary and Secondary Trigeminal Neuralgia

Abstract INTRODUCTION Trigeminal neuralgia has always been a disease of conflict from pathological and management perspectives. Despite advances in the radiological imaging, evidence from autopsy studies, and intraoperative findings, concrete answers are not in sight. GKRS has been a strong contender among available treatment options for the management of trigeminal neuralgia. METHODS All patients were evaluated on clinical criteria, BNI scale for intensity of pain, and facial hypoesthesia (if any) in a protocol-based manner. Only patients with BNI III to V were offered GKRS as a treatment modality. The Marseille point was targeted with a 70 to 90 Gy dose at 50% isodose. Patients were informed about all available treatment options with long-term prognosis and pain control rates. Patients in need of an immediate pain relief, in failed GKRS, and in a severe pain jeopardizing routine life and eating habits were not offered GKRS and were managed with microvascular decompression. RESULTS A total of 108 (65 males, 43 females) patients received GKRS with the Perfexion model since 2009. Eighty-two percent of the patients received GKRS for primary trigeminal neuralgia, while the rest received GKRS for secondary trigeminal neuralgia due to skull base lesions (meningioma, schwannoma, cerebellar AVM, etc). A total of 78% of the patients had preoperative BNI scale IV, while 19% and 3% of the patients had grade III and V scale pain, respectively. Ninety-four percent patients gained BNI scale III intensity pain within 3 mo of GKRS. The 3-yr pain control rate (BNI I-II) could be attained in 81% of the patients. Twelve percent of the patients remained in BNI grade III. Two patients needed redo GKRS for their pain recurrence. CONCLUSION It remains uncontested that MVD provides the best long-term pain-free control in patients of trigeminal neuralgia; however, GKRS remains a valuable feasible option for a selected group of patients. GKRS should be offered as an alternative treatment modality in patients not in urgent need of pain relief. In failed GKRS, authors did not encounter any difficulty in microvascular decompression.

Лучевая терапия остеохондродисплазии у шотландских вислоухих кошек

Osteochondrodysplasia in the Scottish Fold cats is the genetic disease, inherited according to the autosomal-dominant type; it is manifested by the deformation of bones and cartilages of the skeleton in the form of unhealthy bone growths in the region of the wrist, metacarpal, fetlock, mesopodial and phalanx joints of breast and pelvic extremities, and also tailed vertebrae.&#x0D; &#x0D; Purpose of research. To assess the effectiveness of radiation therapy in the treatment of Scottish fold cats with osteochondrodysplasia.&#x0D; &#x0D; Materials and methods. 10 Scottish Fold cats (3 males, 7 females; age ― from 5 months to 10 years) with osteochondrodysplasia were treated from 2013 to 2017. All patients had clinical signs of disease in the form of skeletal growths in the wrist, metacarpus, finger bones, lumbar, sacral or tail spine. Most of them (9 of 10) were lame. All patients were examined clinically and radiologically before the treatment. Radiation therapy was carried out on gamma therapy unit «AGAT-R» with inclusion of the affected limbs to the middle of the shoulder or thigh. Immobilization was achieved either by general anesthesia or by means of physical restraint. Fraction doses used were 1.5 Gy up to total doses of 15.0 Gy, 2 to 3 fractions per week.&#x0D; &#x0D; Results. In 9 of 10 cases (90 %) there is a subjective improvement in mobility and regression of lameness after 6 months and furthermore after treatment. Two patients in the group died within 8 and 12 months from extraneous causes, others are alive and well for the time being with no need for pain relief. In three cases a radiological control of skeletal growths was performed, with no signs of progression 6.15 and 71 months after treatment. The maximum observation period is 2196 days, the observation median is 705 days.&#x0D; &#x0D; We used a questionnaire to improve the objectiveness of cat’s mobility and pain assessment before and after treatment. Based on animal owners’ answers the score for each symptom was assigned from 0 (severe dysfunction) to 2 (function not impaired). Scores from individual cases were summed, and the averaged total results were compared. Generally, after radiation therapy, animals’ mobility improved significantly (the averaged mobility score in the group imcreased from 3.0 to 6.5).&#x0D; &#x0D; Conclusion. The radiation therapy is an effective pathogenetic and symptomatic method of treatment of Scottish fold cats with osteochondrodysplasia: in most cases it leads to pain relief and increased mobility of the animal. According to clinical and radiological (in three cases) criteria, it can also be assumed that radiation therapy leads to suppression of the skeletal growths enlargement. The effect of treatment develops within 6 months after its completion and is persistent (lasts for many months and years). The technique involves the use of small total doses, so it does not cause complications and is practically safe for the patient.