Neck Region Research Articles

Solitary large malignant lymphoma in the head and neck region.

The present study examined the clinical characteristics of patients with a final diagnosis of solitary large malignant lymphoma of the head and neck after surgery. Between January 2015 and December 2022, 13 patients with a final diagnosis of solitary large malignant lymphoma of the head and neck after surgery were enrolled. The most common symptom of solitary large malignant lymphoma was a neck mass (n=11; 84.6%). The most common sites of the head and neck were neck level II (eight patients), neck level IV (two patients), parotid glands (two patients) and the tongue (two patients). The number of malignant lymphomas was as follows: 11 patients had one large tumor and two patients had two large tumors. The mean tumor size was 4.0±1.3 cm (range; 2.7-6.8 cm). Among the two patients with two lymphomas, the size of the second neck mass was 3.2 cm in one patient and 2.7 cm in the other patient. The most common type of solitary large malignant lymphoma was diffuse large B-cell lymphoma (n=6, 46.2%). A total of 12 patients are currently under follow-up without disease recurrence after treatment completion and one patient diagnosed 1 month ago is currently undergoing radiation therapy. The follow-up period was 47.3±19.0 months (range; 1-62 months). The possibility of solitary large malignant lymphoma of the head and neck should be considered. As it is difficult to accurately diagnose solitary large malignant lymphoma before surgery, surgical resection is required for differentiation from other diseases.

PRIMARY MALIGNANT MELANOMA OF THE PAROTID GLAND, A RARE ENTITY: A CASE REPORT

The prevalence of primary malignant tumors of the salivary gland is 1 per 100,000 people. Most salivary gland tumors originate in the parotid gland (80%), of which 25% are malignant. Adenoid cystic carcinoma, mucoepidermoid carcinoma and acinar duct carcinoma are among the most common types of salivary gland cancer [1]. Around 25% of parotid tumors are metastatic, originating mainly in the head and neck region. The main metastatic tumors of the parotid gland are squamous cell carcinoma and malignant melanoma [2]. Parotid melanoma is generally secondary to a primary location on the skin of the head and neck. When its primary site cannot be found, we speak of primary melanoma of the parotid gland, an even rarer entity. Here, we report the case of a primary malignant melanoma of parotid gland in a 66-year-old male subject.

Evaluation of changes caused by HR-HPV infection in squamous cell carcinoma of the head and neck using Raman microspectroscopy in combination with multivariate statistical analysis

Abstract Introduction: Squamous cell carcinoma of the head and neck region (HNSCC), with a positive status for high oncogenic potential human papillomavirus (HR-HPV), represents a clinically distinct disease entity compared to HPV-independent cases. Patients exhibit variations in prognosis and proposed therapy regimens. A prompt and reliable diagnosis of the presence of HPV infection could optimize the treatment for these patients. Currently employed treatment methods are long-term, expensive, and lack specificity, especially when administered separately. Material and methods: The research objective of this study is to explore significant differences in the Raman spectra of biological samples taken from patients with HNSCC, facilitating the confirmation of HPV virus presence. Study groups were delineated based on histopathological diagnosis and molecular biology tests, confirming the biological activity of the virus and the presence of the HR-HPV form with a diagnosis of a specific subtype. Results: To identify high oncogenic potential human papillomavirus (HR-HPV) infection as a crucial factor in squamous cell carcinoma of the head and neck region, an effective automatic data analysis system was established, relying on Raman microspectroscopy and multivariate analysis. Our results showed clear ranges of the Raman spectrum that differentiated between HPV-associated and non-HPV-associated cancers. Conclusions: In conclusion, our experience shows a great diagnostic potential of Raman confocal microscopy with multidimensional statistical analysis. In the future, the use of this method may allow for the creation of an effective and automated HR-HPV detection system in neoplastic tissue.

Multiple squamous cell carcinomas of temporal bone years after radiotherapy for malignancy glottis-report of a rare case with review of literature

Larynx is unique in its anatomy. It is critical to map the lesions accurately so that the patient may benefit from the strategy most likely to preserve a functional larynx with the lowest likelihood of recurrence and the least morbidity. We describe a case of 60-year-old male with malignancy glottis diagnosed at the age of 43, treated with external beam radiotherapy, presented 15 years after with swelling in the right upper part of the face, lateral to the eye. Radiological investigations suggested neoplasm in the skin over the right zygomatic part of the temporal bone. Biopsy confirmed malignancy, basal cell carcinoma type. Wide local excision of the lesion with split skin grafting was done. After 2 years, he presented with right ear pain, discharge, and hard of hearing. Examination and radiological investigations confirmed a mass in the external auditory canal, infiltrating through the temporal bone. Biopsy revealed an acantholytic variant of squamous cell carcinoma (SCC). The patient was advised about treatment options and radiotherapy was chosen. Further, a literature search was conducted to detect similar cases. We describe the incidence and prevalence of radiation-induced temporal bone malignancy, an exceedingly rare and late complication of head and neck irradiation. Radiation induced SCCs are highly malignant secondary neoplasms in the head and neck region. It constitutes a therapeutic challenge because of its anatomy and the known side effects of radiation. Timely intervention with a multidisciplinary approach is necessary.

Robotic Surgery for Head and Neck Tumors: What are the Current Applications?

The journey from radical treatments to the precision of robotic surgery underscores a commitment to innovation and patient-centered care in the field of head and neck oncology. This article provides a comprehensive overview that not only informs but also stimulates ongoing discourse and investigation into the optimization of patient care through robotic surgery. The literature on current robotic applications within head and neck region was systematically reviewed. Thirty-four studies with a total of 1835 patients undergoing robotic surgery in head and neck region were included. Clinical staging, histological types, operative duration, postoperative complications, functional recovery and survival outcomes were compared and evaluated. Clinical outcomes have shown promising results and thus the indication on the robotic usage has no longer been limited to oropharyngeal region but from skull base to neck dissection. The latest advancement in robotic surgery further refines the capabilities of surgeons into previously difficult-to-access head and neck regions and heralds a new era of surgical treatment for head and neck oncology.

Local intralesional talimogene laherparepvec therapy with complete local response in oral palatine mucosal melanoma: a case report

BackgroundMucosal melanoma, an aggressive type of malignancy different from the cutaneous melanomas commonly seen in the head and neck region, represents < 1% of all malignant melanomas. The pathogenesis of mucosal melanoma is unknown. Targetable mutations commonly seen in cutaneous melanoma, such as in the BRAF and NRAS genes, have a lower incidence in mucosal melanoma. Mucosal melanoma carries a distinct mutational pattern from cutaneous melanoma. Surgery with negative margins is the first-line treatment for mucosal melanoma, and systemic therapy is not well defined. Talimogene laherparepvec, an oncolytic viral immunotherapy, is United States Food and Drug Administration approved for the treatment of advanced malignant cutaneous melanoma, with local therapeutic benefits. Mucosal melanoma was initially excluded from talimogene laherparepvec’s initial phase III clinical trial.Case presentationWe present the case of a white female patient in her 40s with past medical history of systemic lupus erythematous, scleroderma, and estrogen-receptor-positive invasive ductal breast carcinoma. Following a bilateral mastectomy, the patient was found to have BRAF-negative mucosal melanoma of her hard palate with a soft palate skip lesion. Owing to the presence of a skip mucosal lesion as well as the anticipated defect and need for free-flap reconstructive surgery, nonsurgical management was considered. The patient was referred to medical oncology, where—based on the patient’s complicated medical history and the risk of immunotherapy possibly worsening her prior autoimmune diseases—local talimogene laherparepvec injections were chosen as the primary therapy for her mucosal lesions. Though talimogene laherparepvec is approved for the treatment of cutaneous melanoma, there are limited data available on the use of talimogene laherparepvec in mucosal melanomas.ConclusionThe patient had a complete local tumor response at both the primary lesion as well as the skip lesion with the local injections. She had no side effects and maintained a high quality of life during treatment.

Preliminary Failure Analyses of Loaded Hot Water Bottles

Hot water bottles are widely utilised for their therapeutic advantages, such as relieving muscle tension and imparting warmth. However, the increasing frequency and potential risks associated with bursting or failure necessitate a detailed examination of the contributing factors as their failure is not fully understood in a scientific manner. With the apparent lack of analysis of hot water bottles in the literature, this study employs, for the first time, a dual methodology involving finite-element (FE) analysis conducted in ABAQUS and experimental validation to systematically investigate the underlying mechanisms leading to failure incidents. Through FE modelling and analysis, the stress and strain distribution within typical hot water bottles is modelled under compression loading conditions, facilitating the identification of vulnerable areas prone to failure. Experimental validation encompasses uniaxial loading compression tests on distinct specimens, generating load–displacement curves that elucidate material responses to compressive forces and highlight variations in load-bearing capacities. The study explores diverse failure modes, attributing them to stress concentration at geometric transitions and contact regions. Stress–strain curves contribute valuable insights into material characteristics, with ultimate stress values as crucial indicators of resistance to deformation and rupture. The FE analysis simulation results visualise deformation patterns and stress concentration zones. The findings illustrate that the highest stress concentration areas exist in the internal boundary of hot water bottles near the neck and cap region. This is experimentally confirmed through the bursting failures of four samples, with three failures occurring in this specific region. The findings support the guidance that users should avoid sleeping with a hot water bottle as it may fail under compression if they lay on top of it. Meanwhile, this result guides manufacturers to strengthen the weak areas of hot water bottles around the nicks and edges. This study significantly enhances our understanding of hot water bottle mechanics, thereby guiding design practice to improve overall performance and user safety. In summary, hot water bottles are commonly used but have not been investigated scientifically regarding external loading conditions and their related failure, as the current study has achieved. Identifying the weak points through experiment and simulation directs manufacturers towards required improvements in particular regions, such as the bottleneck and edge reinforcement during the design and manufacturing phases.

Study of late toxicity biomarkers of locally advanced head and neck cancer patients treated with radiotherapy plus cisplatin or cetuximab points to the relevance of skin macrophages (TOX-TTCC-2015-01).

Radiotherapy (RT) with concomitant cisplatin (CRT) or cetuximab (ERT) are accepted treatment options for locally advanced squamous cell carcinoma of the head and neck (LA-SCCHN). Long-term adverse events (AEs) have a vast impact on patients' quality of life. This study explored tissue biomarkers which could help predict late toxicity. Single-institution prospective study including patients aged ≥ 18 with histologically confirmed newly diagnosed LA-SCCHN treated with RT and either concomitant cisplatin q3w or weekly cetuximab, according to institutional protocols. All patients underwent pre- and post-treatment skin biopsies of neck regions included in the clinical target volume. Angiogenesis, macrophages, and extracellular matrix (ECM) markers were evaluated by immunohistochemistry (IHC). From April 15, 2016, to December 11, 2017; 31 patients were evaluated [CRT = 12 (38.7%) and ERT = 19 (61.3%)]. 27 patients (87%) had received induction chemotherapy. All patients finished RT as planned. IHC expression of vasculature (CD34) and collagen (Masson's Trichrome) did not differ significantly between and within CRT and ERT arms. Conversely, an increased CD68 and CD163 macrophage infiltration expression was observed after treatment, without significant impact of treatment modality. Patients with higher late toxicity showed lower expression of macrophage markers in pre-treatment samples compared with those with lower late toxicity, with statistically significant differences for CD68. Angiogenesis and ECM biomarkers did not differ significantly between CRT and ERT. Macrophage markers increased after both treatments and deserve further investigation as predictors of late toxicity in LA-SCCHN patients. [Protocol code: TOX-TTCC-2015-01/Spanish registry of clinical studies (REec): 2015-003012-21/Date of registration: 27/01/2016].

Mutational Profiles of Cutaneous Squamous Cell Carcinomas with Different Patterns of Clinical Aggression from Head and Neck Regions

Cutaneous squamous cell carcinoma is a prevalent malignancy with a rising incidence and a notably high mutational load. Exploring the genetic nuances of cSCC and investigating molecular approaches stands as a potential avenue for improving outcomes in high-risk patients. This retrospective case-control study involved two cohorts, one of 14 patients (the “discovery cohort”) and the other of 12 patients (the “validation cohort”), with cSCC located in the head/neck anatomical region and diagnosed at the pT2 stage. Overall, cases developed early local relapses of the disease, whereas controls never relapsed during the entire follow-up period. A next-generation sequencing (NGS) approach conducted on histological samples revealed that TP53 and CDKN2A were the most frequently mutated genes in our series. No specific mutations were identified as potential prognostic or therapeutic targets. Controls exhibited a tendency toward a higher mutational rate compared to cases. It is possible that an increased number of mutations could prompt the cSCC to expose more antigens, becoming more immunogenic and facilitating recognition by the immune system. This could enhance and sustain the immunological response, potentially preventing future recurrences.

Investigating the relationship between body structure status, work activity type, and the prevalence of musculoskeletal disorders among detergent industry workers.

The physical condition of workers' body structure and assigned duties, can contribute to the prevalence of musculoskeletal disorders. This study aimed to investigate the relationship between body structure status, type of work activity, and the prevalence of musculoskeletal disorders among workers in the detergent industry. This cross-sectional study involved 148 industrial workers selected based on inclusion criteria and their medical checkup records. Data collection for the study included a demographic information questionnaire, a body map questionnaire, and an assessment of the workers' musculoskeletal system conducted by three physiotherapists simultaneously. 54.1% of the participants had a total body structure score classified as poor or fair. The neck region showed the highest prevalence of musculoskeletal disorders (51.4%), followed by the lower back region (35.1%). Significant associations were found between abnormalities in the upper and middle limbs of the body and the prevalence of pain in the right shoulder region (Fisher/F = 9.29, P≤0.05) as well as the intermediate back region (F = 10.28, P≤0.01). Office workers experienced a higher prevalence of neck pain than workers in the product line and technical roles, with a statistically significant Odds Ratio (OR) ranging between 2.7 and 6.6 times. Conversely, industrial workers who operate powered machinery showed a higher prevalence of pain in the left shoulder (OR = 3.93) and left foot (OR = 4.07). Meanwhile, workers involved in loading and unloading tasks had a higher prevalence of pain in the middle back (OR = 3.61) and right foot (OR = 4.5) compared to office workers. The prevalence of pain in the right shoulder and middle back may be due to abnormalities in the upper and intermediate body structure. Production line workers reported a higher prevalence of pain in the left shoulder, middle back, and foot compared to office workers.

Central giant cell granuloma in the posterior region of mandible mimicking a fibro-osseous lesion and hemangioma: a case report

BackgroundA central giant cell granuloma (CGCG) is a benign, proliferative, intraosseous, and non-odontogenic lesion occurring primarily in children and young adults. On the histological level, it is characterized by numerous multinucleated giant cells scattered randomly throughout a sea of spindle-shaped mesenchymal stromal cells which are dispersed throughout the fibrovascular connective tissue stroma containing areas of haemorrhage. When it comes to radiographic features, CGCG can have an array of variations, ranging from well-defined expansile lesions to ill-defined and destructive lesions, with or without expansion.Case presentationThis case report reviews an 11-year-old Caucasian patient with a chief complaint of slow-growing swelling involving the right posterior mandibular region. The cone beam computed tomography (CBCT) revealed an ill-defined mixed lesion mimicking both fibro-osseous lesion and hemangioma. However, microscopic examination revealed multinucleated giant cells in a fibrous stroma suggestive of central giant cell granuloma.ConclusionOur intent in reporting this case is to highlight the importance of thorough clinical, radiographical and histopathological examination for accurate diagnosis and therapeutic interventions as well as to emphasize the importance of taking different possibilities into consideration when examining bony swellings in the head and neck region.

Soft Palate Pleomorphic Adenoma of a Minor Salivary Gland: An Unusual Presentation

Tumors of salivary glands are less frequent in the head and neck region. Pleomorphic adenoma (PA) is a benign tumor of major and accessory salivary glands. The soft palate is one of the most frequent sites among accessory salivary glands. This tumor can increase in size and cause oropharyngeal obstruction with a risk of asphyxia, endangering the patient's life. Treatment is based on complete tumor excision and it’s sometimes difficult. Histopathological examination confirms the diagnosis. In this study, we present a case of a large pleomorphic adenoma of the accessory salivary glands located in the soft palate, successfully treated with intraoral excision surgery after an initial tracheostomy.

The role of the basic state in the climate response to future Arctic sea ice loss

There is great uncertainty in the atmospheric circulation response to future Arctic sea ice loss, with some models predicting a shift towards the negative phase of the North Atlantic Oscillation (NAO), while others predicting a more neutral NAO response. We investigate the potential role of systematic model biases in the spread of these responses by modifying the unperturbed (or ‘control’) climate (hereafter referred to as the ‘basic state’) of the Canadian Earth system model version 5 (CanESM5) in sea ice loss experiments based on the protocol of the Polar Amplification Model Intercomparison Project. We show that the presence or absence of the stratospheric pathway in response to sea ice loss depends on the basic state, and that only the CanESM5 version that shows a weakening of the stratospheric polar vortex features a strong negative NAO response. We propose a mechanism that explains this dependency, with a key role played by the vertical structure of the winds in the region between the subtropical jet and the stratospheric polar vortex (‘the neck region winds’), which determines the extent to which anomalous planetary wave activity in response to sea ice loss propagates away from the polar vortex. Our results suggest that differences in the models’ basic states could significantly contribute to model spread in the simulated atmospheric circulation response to sea ice loss, which may inform efforts to narrow the uncertainties regarding the impact of diminishing sea ice on mid-latitude climate.

Incidental pigmented basal cell carcinoma discovered on positron emission tomography (PET)

Incidental pigmented basal cell carcinoma discovered on positron emission tomography (PET)

Epithelioid Angiosarcoma: A Diagnostic Dilemma with Clinically and Histopathologically Overlapping Features

Cutaneous angiosarcoma is a rare malignancy of endothelial cell origin that commonly presents in the head and neck region of elderly individuals and is known for high rates of lymph node metastasis and mortality. There is significant variability in the histopathologic features, and immunohistochemistry is necessary to help differentiate epithelioid angiosarcoma from lesions it may clinically mimic. Here, we report a rare case of poorly differentiated epithelioid angiosarcoma on the trunk initially diagnosed as poorly differentiated squamous cell carcinoma (SCC) on shave biopsy. A 56-year-old man presented for a full-body skin examination significant for a 5.6 x 2.8 mm brown-black macule on the left superomedial posterior trunk and a 5.0 x 2.7 mm pink, ulcerated papule on the right inferior posterior trunk. On histopathology, one lesion was found to be melanoma in situ, and the other showed ulcerated and infiltrative, poorly differentiated SCC. Post-excision histologic analysis of the right inferior back lesion revealed tumor cells immunoreactive to vimentin, ERG, and CD31 (PECAM-1). These findings suggested that the lesion previously diagnosed as SCC was an invasive, poorly differentiated epithelioid angiosarcoma. The patient underwent 40 sessions of radiotherapy. Epithelioid angiosarcoma occurring outside of the conventional epidemiologic profile is believed to portend higher mortality rates. This case highlights the importance of thorough clinical evaluation and appropriate histopathologic diagnosis of an aggressive neoplasm unlikely to present in this location. Further studies are required to explore potential risk factors, effective treatments, and long-term outcomes in patients with epithelioid angiosarcoma.

Stretch-forming characteristics of austenitic material stainless steel 304 at hot working temperatures

Abstract The need for sheet metal forming using highly resistant materials such as titanium alloys and stainless steel has increased recently. These materials possess elevated mean flow stress values, which make them difficult to draw at room temperature. To achieve a homogeneous distribution of strain in the stretched component, reduce the load required for plastic deformation, and greatly improve material formability, hot forming is helpful. The goal of the current study is to conduct stretch-forming experiments to investigate the forming characteristics of Austenitic material Stainless Steel (ASS) 304 at Hot working temperatures. Stretch forming experiments have been conducted on the Servo electrical sheet press test machine at 650 and 800°C. The formability has been estimated by constructing a Fracture forming diagram (FFLD), limiting the height of the dome (LDH) and the distribution of the strain of stretched cups. It has been discovered that the limit of forming bounds rises with the temperature reaching 800°C, while the DSA effect causes the necking region – the area between the safe and fracture limits ‒ to decrease with additional temperature rise from 800 to 900°C. Within the experimental limitations, it has been considered that the Hot forming of ASS 304 at 650°C gives the highest strain forming limits with a uniform strain distribution in the stretched cups. From the Formability limit diagram, dome height, and strain distribution, it can be observed that ASS 304 has good limiting strain up to 800°C with lower load application.

Epidemiology of the non-head and neck sebaceous carcinoma and implications for distant metastasis screening.

Extraocular sebaceous carcinoma (SC), particularly those outside the head and neck region, is rare and not well-described. This study aimed to explore the epidemiology and identify the prognostic factors of non-head and neck SC, describe the possible relevant factors of distant metastasis, and provide implications for distant metastasis screening. Data from the 17 registries in the Surveillance, Epidemiology, and End Results database were retrospectively collected for patients with SC outside the head and neck from 2000 through 2020. Overall survival (OS) and disease-specific survival (DSS) were the primary endpoints. Survival analysis was conducted through Kaplan-Meier curves, and multivariate analysis was carried out using Cox proportional hazard models. A total of 1,237 patients with SC outside the head and neck were identified. The mean age at diagnosis of the entire patient cohort was 67.7 years (30 to 90+ years), and the mean tumor size was 2.2 cm (0.1-16 cm). Patients with distant disease experienced the lowest OS (mean, 29.5 months) than those with localized disease and regional disease (p < 0.0001). Multivariate analysis revealed that age, tumor size, and stage were independent determinants of OS; age, stage, and primary site were independent determinants of DSS. Tumor grade and lymph node status had less prognostic value for survival. Undifferentiated tumors have a trend toward distant metastasis, especially those at the primary site of the trunk. The prognosis of the non-head and neck SC is excellent, while the survival of distant disease is very poor. Distant metastasis screening can be considered for undifferentiated tumors, especially those located in the trunk region with large tumor sizes.

Histopathological Study of Kidney and Liver of Rats after Induction of Poisoning by Nitrate

The purpose of this research is to investigate the effects of nitrate as a calcium appearance on the hepatic and renal histology. Iraqi fertilizer firm in supplied the calcium nitrate tetrahydrate was used in this study. Twenty-four male albino wistar rats weighing 220 ± 25 g were kept under conditions of natural photoperiod, humidity 50±10%, and temperature 25±2° C. These were divided into 3 groups: G1 control group, G2 received 200 mg/kg, G3 received 400 mg/kg. Rats were administered calcium nitrates orally for thirty days after the salts were dissolved in mineral water. Animals were then sacrificed by being beheaded in the neck region. Organs such as the kidneys and liver were taken for histological analysis. Liver and kidney samples were taken from rats that were given varying amounts of calcium nitrate for a duration of 30 days. The liver sections showed regular histological architecture with hexagonal lobules and visible capillary sinusoids. The livers of the 200 mg/kg group showed mild histological damage, while the 400 mg/kg doses showed significant vascular dilatation, congestion, hepatocyte degeneration, bleeding, and lipid vacuolation. The kidneys showed severe histopathological changes, including glomerular atrophy, intra-glomerular hemorrhage, and vascular congestion, compared to the G2 which showed mild renal lesions. In conclusion, nitrate induced significant alterations in the kidneys and liver architecture that were dose-dependent. Finally, greater dosages of calcium nitrate used excessively might be harmful to humans and other mammals.

The updated surgical steps of gasless transaxillary endoscopic thyroidectomy with neck level and region orientation for thyroid cancer.

We previously made a detailed expansion to the gasless transaxillary endoscopic thyroidectomy(GTET) procedure described in the previous literatures. In this study, we optimized the procedure focused on the limitation of the approach in terms of trauma and lymph node dissection and made a comparison with the early procedure. This paper gave a detailed description of the updated procedure and prospectively collected data about patients with papillary thyroid carcinoma(PTC) performed by the two procedures from December 2020 to April 2023. The differences in surgical outcome, surgical trauma and parathyroid gland(PG) function protection were analyzed. Of the 302 patients, 184 underwent with early procedure(EP), and 118 underwent with updated procedure(UP). The surgical outcomes of operative time, time of thyroidectomy and central neck dissection, blood loss, drainage and postoperative hospital stay were shorter in UP than that of the EP. The mean number of lymph nodes retrieved and weight of dissection lymphatic tissue in the UP were significantly more than that in EP without increasing the mean number of metastatic lymph nodes. Postoperative complications did not differ between the two procedures. The UP had more advantages in the identification and preservation of the superior parathyroid gland, however, it did not improve the preservation in situ of the inferior parathyroid gland. The visual analog scale score for pain and the changes among inflammation factors was lower in the UP. The UP of GTET could perform safely and efficiently while reducing surgical trauma in selected patients.

The dominance of dorsal scapular artery as the blood supply to muscles of the back in the absence of two primary vessels: a cadaveric case report.

Understanding of rare or unknown anatomical variations of the vasculature of the neck is critical to reduce the risk of complications during surgeries and other invasive procedures in the neck and shoulder regions. Bilateral dissection of the neck and muscles of the back of an 87-year-old Caucasian male donor was performed to demonstrate the origin, course and termination of the arteries that arise in the neck. Several anatomical variations were noted on the right side of the neck of the donor body - (i) only inferior thyroid and ascending cervical arteries originated from the thyrocervical trunk (TCT), from the first part of the subclavian artery (SA), whereas the transverse cervical (TCA) and suprascapular (SSA) arteries were entirely absent, (ii) Dorsal scapular artery (DSA) emerged normally from the third part of the SA. However, after supplying the rhomboids and levator scapulae muscles, DSA provided two additional branches to the trapezius muscle and a branch to the supraspinatus muscle. Interestingly, the branches to the trapezius muscle from the DSA were the only sources of blood supply to the muscle. We report a unique anatomical variation involving the absence of the TCA and SSA from the TCT. The unilateral absence of these major vessels and the branches of DSA supplying the trapezius and supraspinatus muscles have not been reported previously in the literature in a single case report. This case study may provide useful information for head and neck reconstruction and shoulder repair surgeries.