ABSTRACT In this paper, we investigate the invertibility of generalized g-Bessel multipliers. Sufficient and necessary conditions for invertibility are determined depending on the optimal g-frame bounds. Moreover, we show that, for semi-normalized symbols, the inverse of any invertible generalized g-frame multiplier can be represented as a generalized g-frame multiplier with the reciprocal symbol and dual g-frames of the given ones. Furthermore, we investigate some equivalent conditions for the special case, when both dual g-frames can be chosen to be the canonical duals. Finally, we give several approaches for constructing invertible generalized g-frame multipliers from the given ones. It is worth mentioning that some of our results are quite different from those studied in the previous literatures on this topic.