near-IR Light Research Articles

Targeted Molecular Imaging and Therapy Based on Nuclear and Optical Technologies.

Both nuclear and optical imaging are used for in vivo molecular imaging. Nuclear imaging displays superior quantitativity, and it permits imaging in deep tissues. Thus, this method is widely used clinically. Conversely, because of the low permeability of visible to near-IR light in living animals, it is difficult to visualize deep tissues via optical imaging. However, the light at these wavelengths has no ionizing effect, and it can be used without any restrictions in terms of location. Furthermore, optical signals can be controlled in vivo to accomplish target-specific imaging. Nuclear medicine and phototherapy have also evolved to permit targeted-specific imaging. In targeted nuclear therapy, beta emitters are conventionally used, but alpha emitters have received significant attention recently. Concerning phototherapy, photoimmunotherapy with near-IR light was approved in Japan in 2020. In this article, target-specific imaging and molecular targeted therapy utilizing nuclear medicine and optical technologies are discussed.

Molecular Photothermal Conversion Catalyst Promotes Photocontrolled Atom Transfer Radical Polymerization.

Photothermal conversion is a growing research area that promotes thermal transformations with visible light irradiation. However, few examples of dual photothermal conversion and catalysis limit the power of this phenomenon. Here, we take inspiration from nature's ability to use porphyrinic compounds for nonradiative relaxation to convert light into heat to facilitate thermal polymerization catalysis. We identify the photothermal conversion catalytic activity of a vitamin B12 derivative, heptamethyl ester cobyrinate (HME-Cob), to perform atom transfer radical polymerization (ATRP) under irradiation. Rapid polymerization are obtained under photothermal activation while maintaining good control over polymerization with the aid of a photoinitiator to enable light-induced catalyst regeneration. The catalyst exhibits exquisite temporal control in photocontrolled thermal polymerization. Ultimately, the activation of this complex is accessed across a broad range of wavelengths, including near-IR light, with excellent temporal control. This work showcases the potential of developing photothermal conversion catalysts.

Significant Cocoon Emission and Photosphere Duration Stretching in GRB 211211A: A Burst from a Neutron Star−Black Hole Merger

The radiation mechanism (thermal photosphere or magnetic synchrotron) and the progenitor of gamma-ray bursts (GRBs) are under hot debate. Recently discovered, the prompt long-duration (∼10 s, normally from the collapse of massive stars) property of GRB 211211A strongly conflicts with its association with a kilonova (normally from the merger of two compact objects, NS–NS, NS–BH, or NS–WD, duration ≲2 s). In this paper, we find that the probability photosphere model with a structured jet can satisfactorily explain this peculiar long duration, through the duration stretching effect (∼3 times) on the intrinsic longer (∼3 s) duration of an NS–BH merger, the observed empirical 2SBPL spectrum (with soft low-energy index α of ∼−1), and its evolution. In addition, much evidence of the NS–BH merger origin is found, especially the good fit of the afterglow-subtracted optical−near-IR light curves by the significant thermal cocoon emission and the sole thermal “red” kilonova component. Finally, a convincing new explanation for the X-ray afterglow plateau is revealed.

Near-IR Photoinduced Electrochemiluminescence Imaging with Structured Silicon Photoanodes.

Infrared (IR) imaging devices that convert IR irradiation (invisible to the human eye) to a visible signal are based on solid-state components. Here, we introduce an alternative concept based on light-addressable electrochemistry (i.e., electrochemistry spatially confined under the action of a light stimulus) that involves the use of a liquid electrolyte. In this method, the projection of a near-IR image (λexc = 850 or 840 nm) onto a photoactive Si-based photoanode, immersed into a liquid phase, triggers locally the photoinduced electrochemiluminescence (PECL) of the efficient [Ru(bpy)3]2+-TPrA system. This leads to the local conversion of near-IR light to visible (λPECL = 632 nm) light. We demonstrate that compared to planar Si photoanodes, the use of a micropillar Si array leads to a large enhancement of local light generation and considerably improves the resolution of the PECL image by preventing photogenerated minority carriers from diffusing laterally. These results are important for the design of original light conversion devices and can lead to important applications in photothermal imaging and analytical chemistry.

Stellar Half-mass Radii of 0.5 z < 2.3 Galaxies: Comparison with JWST/NIRCam Half-light Radii

We use CEERS JWST/NIRCam imaging to measure rest-frame near-IR light profiles of 435 M ⋆ > 1010 M ⊙ galaxies in the redshift range of 0.5 < z < 2.3. We compare the resulting rest-frame 1.5–2 μm half-light radii (R NIR) with stellar half-mass radii ( RM⋆ ) derived with multicolor light profiles from CANDELS Hubble Space Telescope imaging. In general agreement with previous work, we find that R NIR and RM⋆ are up to 40% smaller than the rest-frame optical half-light radius R opt. The agreement between R NIR and RM⋆ is excellent, with a negligible systematic offset (<0.03 dex) up to z = 2 for quiescent galaxies and up to z = 1.5 for star-forming galaxies. We also deproject the profiles to estimate RM⋆,3D , the radius of a sphere containing 50% of the stellar mass. We present the R−M ⋆ distribution of galaxies at 0.5 < z < 1.5, comparing R opt, RM⋆ , and RM⋆,3D . The slope is significantly flatter for RM⋆ and RM⋆,3D compared to R opt, mostly due to downward shifts in size for massive star-forming galaxies, while RM⋆ and RM⋆,3D do not show markedly different trends. Finally, we show rapid evolution of the size (R ∝ (1 + z)−1.7±0.1) of massive (M ⋆ > 1011 M ⊙) quiescent galaxies between z = 0.5 and z = 2.3, again comparing R opt, RM⋆ , and RM⋆,3D . We conclude that the main tenets of the evolution of the size narrative established over the past 20 yr, based on rest-frame optical light profile analysis, still hold in the era of JWST/NIRCam observations in the rest-frame near-IR.

A Rest-frame Near-IR Study of Clumps in Galaxies at 1 < z < 2 Using JWST/NIRCam: Connection to Galaxy Bulges

A key question in galaxy evolution has been the importance of the apparent “clumpiness” of high-redshift galaxies. Until now, this property has been primarily investigated in rest-frame UV, limiting our understanding of their relevance. Are they short-lived or are they associated with more long-lived massive structures that are part of the underlying stellar disks? We use JWST/NIRCam imaging from the Cosmic Evolution and Epoch of Reionization Survey to explore the connection between the presence of these “clumps” in a galaxy and its overall stellar morphology, in a mass-complete () sample of galaxies at 1.0 < z < 2.0. Exploiting the uninterrupted access to rest-frame optical and near-IR light, we simultaneously map the clumps in galactic disks across our wavelength coverage, along with measuring the distribution of stars among their bulges and disks. First, we find that the clumps are not limited to the rest-frame UV and optical, but are also apparent in near-IR with ∼60% spatial overlap. This rest-frame near-IR detection indicates that clumps would also feature in the stellar-mass distribution of the galaxy. A secondary consequence is that these will hence be expected to increase the dynamical friction within galactic disks leading to gas inflow. We find a strong negative correlation between how clumpy a galaxy is and strength of the bulge. This firmly suggests an evolutionary connection, either through clumps driving bulge growth or the bulge stabilizing the galaxy against clump formation, or a combination of the two. Finally, we find evidence of this correlation differing from rest-frame optical to near-IR, which could suggest a combination of varying formation modes for the clumps.

Palladium (Pd)-based Photocatalysts for Suzuki Coupling Reactions: An Overview

Abstract: Extensive research has been documented in the last few decades on the utilization of near IR, visible and UV light in organic chemical transformations. In this brief review, we provide an overview of the most noteworthy achievements in the area of photocatalytic Suzuki coupling reactions by palladium (Pd)-based catalytic systems. The works on different types of Pd-based photocatalysts for Suzuki coupling reaction and their characteristic as well as catalytic activity in terms of substrate scope, recyclability, TON or TOF are discussed herein.

VVV-WIT-12 and Its Fashionable Nebula: A 4 yr Long-period Young Stellar Object with a Light Echo?

We report the serendipitous discovery of VVV-WIT-12, an unusual variable source that seems to induce variability in its surrounding nebula. The source belongs to the rare objects that we call WITs (short for What Is This?) discovered within the VISTA Variables in the Vía Láctea (VVV) survey. VVV-WIT-12 was discovered during a pilot search for light echoes from distant supernovae in the Milky Way using the near-IR images of the VVV survey. This source has an extremely red spectral energy distribution, consistent with a very reddened (A V ∼ 100 mag) long-period variable star (P ∼ 1525 days). Furthermore, it is enshrouded in a nebula that changes brightness and color with time, apparently in sync with the central source variations. The near-IR light curve and complementary follow-up spectroscopy observations are consistent with a variable young stellar object illuminating its surrounding nebula. In this case the source periodic variation along the cycles produces an unprecedented light echo in the different regions of the nebula.

The SN 2023ixf Progenitor in M101. I. Infrared Variability

Observational evidence points to a red supergiant (RSG) progenitor for SN 2023ixf. The progenitor candidate has been detected in archival images at wavelengths (≥0.6 μm) where RSGs typically emit profusely. This object is distinctly variable in the infrared (IR). We characterize the variability using pre-explosion mid-IR (3.6 and 4.5 μm) Spitzer and ground-based near-IR (JHK s ) archival data jointly covering 19 yr. The IR light curves exhibit significant variability with rms amplitudes in the range 0.2–0.4 mag, increasing with decreasing wavelength. From a robust period analysis of the more densely sampled Spitzer data, we measure a period of 1091 ± 71 days. We demonstrate using Gaussian process modeling that this periodicity is also present in the near-IR light curves, thus indicating a common physical origin, which is likely pulsational instability. We use a period–luminosity relation for RSGs to derive a value of M K = −11.58 ± 0.31 mag. Assuming a late M spectral type, this corresponds to at T eff = 3200 K and to at T eff = 3500 K. This gives an independent estimate of the progenitor’s luminosity, unaffected by uncertainties in extinction and distance. Assuming the progenitor candidate underwent enhanced dust-driven mass loss during the time of these archival observations, and using an empirical period–luminosity–based mass-loss prescription, we obtain a mass-loss rate of around (2–4) × 10−4 M ⊙ yr−1. Comparing the above luminosity with stellar evolution models, we infer an initial mass for the progenitor candidate of 20 ± 4 M ⊙, making this one of the most massive progenitors for a Type II SN detected to date.

Recurrent Symbiotic Nova T Coronae Borealis before Outburst

The results of photometric and spectral observations of T CrB obtained in a wide range of wavelengths in 2011–2023 are presented. We use the near-IR light curves to determine a new ephemeris JDmin=2455828,9+227,55E for the times of light minima when the red giant is located between the observer and the hot component. The flux ratio Ha/Hb varied from -3 to -8 in 2020–2023, which may be due to a change in the flux ratio between the X-ray and optical ranges. It is shown that the value of Ha//Hb anticorrelates with the rate of accretion onto the hot component of the system. Based on high-speed follow-up observations obtained on June 8, 2023, we detected a variability of the He II 4686 line with a characteristic time-scale of -25 min, the amplitude of variability in the B-band was -0.m0,7. Simulations of the near-IR light curves accounting for the ellipsoidal effect allowed us to obtain the parameters of the binary system: the Roche lobe filling factor of the cool component m= 1,0, the mass ratio q=Mcool/Mhot@[0.5,0.77], the orbital inclination i@[55,63]. A comparison of the light curve obtained in 2005–2023 with the 1946 outburst template made it possible to predict the date of the upcoming outburst—January 2024.

Infrared Light-Induced Anomalous Defect-Mediated Plasmonic Hot Electron Transfer for Enhanced Photocatalytic Hydrogen Evolution.

Efficient utilization of infrared (IR) light, which occupies almost half of the solar energy, is an important but challenging task in solar-to-fuel transformation. Herein, we report the discovery of CuS@ZnS core@shell nanocrystals (CSNCs) with strong localized surface plasmon resonance (LSPR) characteristics in the IR light region showing enhanced photocatalytic activity in hydrogen evolution reaction (HER). A unique "plasmon-induced defect-mediated carrier transfer" (PIDCT) at the heterointerfaces of the CSNCs divulged by time-resolved transient spectroscopy enables producing a high quantum yield of 29.2%. The CuS@ZnS CSNCs exhibit high activity and stability in H2 evolution under near-IR light irradiation. The HER rate of CuS@ZnS CSNCs at 26.9 μmol h-1 g-1 is significantly higher than those of CuS NCs (0.4 μmol h-1 g-1) and CuS/ZnS core/satellite heterostructured NCs (15.6 μmol h-1 g-1). The PIDCT may provide a viable strategy for the tuning of LSPR-generated carrier kinetics through controlling the defect engineering to improve photocatalytic performance.

Reconfigurable VO2 metasurfaces with hybrid electro-optical control: manipulating THz radiation with 0.3 W/cm2 light.

Dynamicallyprogrammable metasurfaces capable of manipulating terahertz (THz) wavefronts in various manners depending on external controls are highly desired for next-generation wireless communication systems and new tools for THz diagnostics. Such metasurfaces may utilize the insulator-to-metal transition in V O 2, which can be induced both electrically and optically. Optical control is especially convenient for individual addressing to each meta-atom, but it is hampered by the high optical switching threshold of V O 2. We experimentally realize V O 2-based THz metasurfaces with hybrid electro-optical control when the metasurface is brought close to the transition point by an almost-threshold current, and then is easily switched by unfocused continuous-wave light. We were able to control the metasurface THz transmission by 0.4W/c m 2 near-IR light, while purely optical switching required tightly focused light with an intensity of >3×105 W/c m 2. After correcting for the fact that a tightly focused spot dissipates heat easier, we estimate that the optical switching threshold reduction due to the electric current alone is ∼2 orders of magnitude. Finally, coating the metasurface with Au nanoparticles further reduced the threshold by 30% due to plasmonic effects.

A Novel Photopharmacological Tool: Dual-Step Luminescence for Biological Tissue Penetration of Light and the Selective Activation of Photodrugs.

Conventional pharmacology lacks spatial and temporal selectivity in terms of drug action. This leads to unwanted side effects, such as damage to healthy cells, as well as other less obvious effects, such as environmental toxicity and the acquisition of resistance to drugs, especially antibiotics, by pathogenic microorganisms. Photopharmacology, based on the selective activation of drugs by light, can contribute to alleviating this serious problem. However, many of these photodrugs are activated by light in the UV-visible spectral range, which does not propagate through biological tissues. In this article, to overcome this problem, we propose a dual-spectral conversion technique, which simultaneously makes use of up-conversion (using rare earth elements) and down-shifting (using organic materials) techniques in order to modify the spectrum of light. Near-infrared light (980 nm), which penetrates tissue fairly well, can provide a "remote control" for drug activation. Once near-IR light is inside the body, it is up-converted to the UV-visible spectral range. Subsequently, this radiation is down-shifted in order to accurately adjust to the excitation wavelengths of light which can selectively activate hypothetical and specific photodrugs. In summary, this article presents, for the first time, a "dual tunable light source" which can penetrate into the human body and deliver light of specific wavelengths; thus, it can overcome one of the main limitations of photopharmacology. It opens up promising possibilities for the moving of photodrugs from the laboratory to the clinic.

Plasmon driven super-high HER activity of electronic structure and lattice strain engineered single atomic layer Pd@Au nanorods

The development of efficient catalysts with low energy consumption has always been a key issue for sustainable hydrogen energy. Here, we report a catalyst comprising a single atomic Pd layer deposited on Au nanorods (ML-Pd@Au NRs) that shows a super-high HER activity and ultra-low overpotential under localized surface plasmon resonance condition. The Au NR plays triple determining roles in HER performance via adjusting the electronic structure and lattice strain of Pd that effectively reduces the adsorption energy of H-adatoms, eliminating the penetration of H adatoms in multilayer Pd crystal that decreases the H adatoms diffusion kinetics, and providing high energetic hot charge carriers under near-IR light irradiation that decreases the activation energy and onset potential of HER. The single atomic Pd layer on Au NRs ensures the hot electron transfer as the main dissipation pathway of the plasmonic hot charge carriers for HER. Thus, under near-IR light irradiation, HER on ML-Pd@Au NRs occurs with a high mass activity of 17.47 mA mg−1 at 100 mV and a very low overpotential of 13 mV at 10 mA cm−2, which are superior to the commercial Pd/C and commercial Pt/C catalysts under the same conditions.

Harnessing of low-energy IR photons via oxygen-vacancies in SrTiO3 nanocrystals for photocatalytic hydrogen production

The surface-oxygen vacancies were generated to enhance the near-IR light response of the SrTiO3 photocatalyst by heating SrTiO3 in a highly reducing environment. The UV–visible diffuse reflectance spectra of SrTiO3-Ov revealed strong absorption between 400 and 800 nm, while IPCE response was extended beyond 800 nm, confirming the near-IR light response of SrTiO3-Ov. The hydrogen production rates for SrTiO3-Ov at pH 3.0 under full solar spectrum, visible and IR radiation were 100, 25 and 10 μlg−1h−1, respectively. The respective normalized hydrogen with respect to light intensity were found to be 100, 50 and 33 μlg−1h−1 while hydrogen production of pristine SrTiO3 was less than 2 μlg−1h−1 under full solar spectrum. The mid-gap Ov and Ti3+ states in SrTiO3-Ov are key factors in the origin of the near-IR responses of the catalyst and the feasibility of using low-photonic-energy IR light to produce hydrogen by water splitting was demonstrated.

Highly efficient near-IR cyclohexene cyanine photosensitizers for antibacterial photodynamic therapy

In spite of significant progress in the development of novel photosensitizers for photodynamic therapy (PDT) applications, the search for new approaches for designing organic dyes exhibiting high cytotoxicity upon biologically relevant near-IR light irradiation is still ongoing. Organic dyes such as porphyrins are widely used as photosensitizers, while cyanine dyes exhibiting much better absorption in the near-IR region have been only moderately explored. Herein, we report on a new series of cyclohexene-based cyanine dyes containing two and three indolenine, benzothiazole, and benzoselenazole terminal end-groups. These dyes are investigated for photodynamic inactivation of pathogenic S. aureus and E. coli bacteria. Both di-substituted benzothiazole and benzoselenazole cyanines were found to efficiently eradicate S. aureus and E. coli at nanomolar and micromolar dye concentrations, respectively, and at a low near-IR light dose, while exhibiting tolerable dark toxicity. The commercially available di-indolenine based dye IR786 that is used in many assays and imaging applications exhibits pronounced dark toxicity and phototoxicity to the cells which can substantially affect biomedical experiments utilizing this dye.

High-quality GaSb epitaxially grown on Si (001) through defects self-annihilation for CMOS-compatible near-IR light emitters

Direct epitaxial growth of III-V materials on complementary metal-oxide-semiconductor (CMOS)-compatible Si substrates has long been a scientific and engineering problem for next-generation light-emitters and non-volatile memories etc. The challenges arise from the lattice mismatch, thermal mismatch, and polarity mismatch between these materials. We report a detailed study of growing high-quality GaSb epilayers with low defect density on on-axis silicon substrates by interface engineering through all-molecular beam epitaxy (MBE) technology. We also systematically investigated the defect self-annihilation mechanism of GaSb epitaxially grown on on-axis Si (001) substrates. It was found that the misfit dislocation array was formed at the interface of AlSb/Si; threading dislocations and antiphase domain boundary annihilated at the initial GaSb layer promoted by the high-density AlSb islands, which was confirmed by transmission electron microscopy (TEM) results. Finally, a 2 µm GaSb epilayer with a step-flow surface, root-mean-square (RMS) roughness of 0.69 nm, and a rocking curve full width at half maximum (FWHM) of 251 arcsec was obtained. The photoluminescence in the near-infrared region of the GaSb/AlGaSb quantum well grown on Si substrate was also demonstrated. Our results highlighted the possible step towards the all-MBE direct growth of Sb-based infrared optoelectronic and microelectronic devices on CMOS-compatible Si substrates.

Optical Observation of Spontaneous Heat Burst Phenomena during Hydrogen Desorption from Nano-Sized Metal Composite

We have constructed a photon measurement system to observe the radiant power emitted from an NiCu multilayer film for a wide energy range, from visible light to mid-infrared light. Using the new system, we attempted to measure the radiation from the sample when a heat burst occurred while anomalous excess heat was being continuously generated. About 10 big burst events were observed during the 5-day continuous measurement: it was found that the radiation intensity increased simultaneously as the heater temperature suddenly increased. We have made a comparison of the radiant spectrum of the burst event with the spectrum in normal times. There is no particular difference due to the burst; both spectra can be simply interpreted as grey body radiation emitted from a thermally equilibrated object. The correlation of radiant intensity between near-IR and visible light has been deduced; although it is expected there is a linear correlation between them, two correlation lines can be drawn instead of one. This indicates that the contribution of photon emission from the non-equilibrium stage may have an effect.

Probing Magnetic Fields in Protoplanetary Disk Atmospheres through Polarized Near-IR Light Scattered by Aligned Grains

Magnetic fields play essential roles in protoplanetary disks. Magnetic fields in the disk atmosphere are of particular interest, as they are connected to the wind-launching mechanism. In this work, we study the polarization of the light scattered off of magnetically aligned grains in the disk atmosphere, focusing on the deviation of the polarization orientation from the canonical azimuthal direction, which may be detectable in near-IR polarimetry with instruments such as VLT/SPHERE. We show with a simple disk model that the polarization can even be oriented along the radial (rather than azimuthal) direction, especially in highly inclined disks with toroidally dominated magnetic fields. This polarization reversal is caused by the anisotropy in the polarizability of aligned grains and is thus a telltale sign of such grains. We show that the near-IR light is scattered mostly by μm-sized grains or smaller at the τ = 1 surface and such grains can be magnetically aligned if they contain superparamagnetic inclusions. For comparison with observations, we generate synthetic maps of the ratios of U ϕ /I and Q ϕ /I, which can be used to infer the existence of (magnetically) aligned grains through a negative Q ϕ (polarization reversal) and/or a significant level of U ϕ /I. We show that two features observed in the existing data, an asymmetric distribution of U ϕ with respect to the disk minor axis and a spatial distribution of U ϕ that is predominantly positive or negative, are incompatible with scattering by spherical grains in an axisymmetric disk. They provide indirect evidence for scattering by aligned nonspherical grains.

Radionuclide 131I-labeled albumin-indocyanine green nanoparticles for synergistic combined radio-photothermal therapy of anaplastic thyroid cancer.

ObjectivesAnaplastic thyroid cancer (ATC) cells cannot retain the radionuclide iodine 131 (131I) for treatment due to the inability to uptake iodine. This study investigated the feasibility of combining radionuclides with photothermal agents in the diagnosis and treatment of ATC.Methods 131I was labeled on human serum albumin (HSA) by the standard chloramine T method. 131I-HSA and indocyanine green (ICG) were non-covalently bound by a simple stirring to obtain 131I-HSA-ICG nanoparticles. Characterizations were performed in vitro. The cytotoxicity and imaging ability were investigated by cell/in vivo experiments. The radio-photothermal therapy efficacy of the nanoparticles was evaluated at the cellular and in vivo levels.ResultsThe synthesized nanoparticles had a suitable size (25–45 nm) and objective biosafety. Under the irradiation of near-IR light, the photothermal conversion efficiency of the nanoparticles could reach 24.25%. In vivo fluorescence imaging and single-photon emission CT (SPECT)/CT imaging in small animals confirmed that I-HSA-ICG/131I-HSA-ICG nanoparticles could stay in tumor tissues for 4–6 days. Compared with other control groups, 131I-HSA-ICG nanoparticles had the most significant ablation effect on tumor cells under the irradiation of an 808-nm laser.ConclusionsIn summary, 131I-HSA-ICG nanoparticles could successfully perform dual-modality imaging and treatment of ATC, which provides a new direction for the future treatment of iodine-refractory thyroid cancer.