As the demand for highly efficient yet aesthetically pleasing, complex building envelope structures is rising worldwide, computational analysis and generative design tools are becoming ever so relevant. Previous methods for achieving a natural distribution of structural or shading elements in non-uniform façades are mostly based either on computer-generated pseudo-randomness or a literal biomorphic approach where a naturally occurring pattern is directly projected on the façade surface. As an alternative, this research introduces a novel technique for optimisation that utilises a two-dimensional Power Spectrum Analysis, suitable for numerically assessing the alignment of designed geometry with natural patterns. By integrating this optimisation method into the design process, the façade pattern generation can be automated and optimal design can be selected by evaluating multiple design solutions. Instead of using repetitive geometrical patterns or generated pseudo-randomness, patterns objectively similar to those occurring in nature can be created without directly copying natural structures. The distribution of the structural and shading elements controls the way natural light permeates the building and, considering the data gathered from images of natural scenes, this method can be used to design structures not only with optimal structural and energy performance but also with visual and psychological occupant comfort in mind.