This study proposes a novel biomass-driven multi-generation system composed of five different systems. A gas turbine cycle and a steam Rankine cycle (SRC) are integrated into a system comprised of a modified Kalina cycle in which an expander is used between the two separators, and an LNG regasification system. To recover the waste heat of the Kalina cycle, a thermoelectric generator (TEG) is utilized instead of a condenser for generating electrical power. Total power produced by the expander and TEG is utilized in a proton exchange membrane electrolyzer to produce hydrogen. Domestic hot water and chilled water are, respectively, produced within the condenser of the SRC and the evaporator of the modified Kalina cycle. The results of the base case reveal that the multi-generation system with exergy efficiency of 59.47% is capable of generating power, heating, and cooling rates equal to 44.4 MW, 28.9 MW, and 1.94 MW, respectively. The natural gas mass flow rate is 4.42 kg/s, and the hydrogen flow rate is 5.77 kg/h. Besides, the results demonstrate that the modified Kalina-LNG system in the present configuration is of higher performance than a similar previous research. Finally, it is found that a 100 °C variation in the gas turbine inlet temperature has the greatest effect on the multi-generation exergy efficiency.