Abstract Natural gas-diesel dual-fuel (NDDF) combustion can be a viable method to reduce diesel usage in compression ignition (CI) internal combustion engines. Potential benefits of NDDF engines in comparison to conventional diesel engines include decreases in soot and carbon dioxide emissions. This study focuses on the effect of intake pressure on a dual-fuel engine with intake port injected natural gas (NG) and direct injected diesel at two engine operation conditions – low load-high speed and high load-low speed. The research work was performed on a heavy-duty, single-cylinder engine at a NG-diesel energy ratio of approximately 3:1. The results show that when the intake pressure was increased, the indicated thermal efficiency (ITE) increased for diesel combustion. The trend was similar at the high load-low speed condition but opposite at the low load-high speed condition for NDDF. ITEs of diesel combustion were generally higher than NDDF combustion due to higher unburned hydrocarbon (HC) emissions associated with the latter. For low load-high speed dual-fuel combustion, increasing intake pressure increased the HC and soot emissions, but decreased the nitrogen oxides (NOx) emissions. For high load-low speed case, increasing intake pressure caused the HC emissions to increase and the NOx and soot emissions to decrease. In-cylinder temperature measured at the tip of the diesel injector showed that the injector tip temperatures were higher for NDDF cases compared to diesel cases. These temperatures could be correlated with the combustion phasing and NOx emissions.