here seems to be some recognition of the relevance of dihydrogen oxide (water) in many spheres. Among others, literature in poetry, religious texts and medical science, address the value of water in emotional, physical and psychological healings. To understudy how religion, spirituality and medical science connect and contrast in domesticating water for healing purposes, this article undertook literary research on religious and medical hydro-healings in Christianity, African and Native American traditional religions, and medical science. It presented links, benefits, challenges and contrasts between spiritual healing and medical water therapy as well as inter-religious connections. Based on the literature, the article discovered that spiritual hydro-healing is spiritual, instantaneous and non-scientific, but medical hydrotherapy is organic, naturopathic, gradual and scientific or logical. On the positive side, the article found that indigenous spiritual knowledge is a key motivating factor in the popularity of hydro-healing practices. Whereas, on the negative, it observed the danger of the grey areas of spiritual hydro-healings which include, but are not limited to, unethical practices, commercialisation of healing waters, addiction, river baptism mortality and the quest for instantaneous hydro-healing leading to health hazards and death.Contribution: The article concluded with an urgent call to stakeholders to pay attention to the hydro-healing practices that can compromise public health and safety.